DEFA1 monoclonal antibody, clone Summary: are a family of microbicidal B539M and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of Catalog Number: MAB6523 neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, Regulatory Status: For research use only (RUO) urinary tract, and vagina. Members of the family are highly similar in sequence and distinguished Product Description: Mouse monoclonal antibody by a conserved cysteine motif. Several raised against synthetic peptide of DEFA1. appear to be clustered on 8. The protein encoded by this gene, defensin, alpha 1, is found Clone Name: B539M in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It Immunogen: A synthetic peptide (conjugated with differs from defensin, alpha 3 by only one . Hsp70) corresponding to human DEFA1. [provided by RefSeq] Host: Mouse

Reactivity: Human

Applications: ELISA, WB (See our web site product page for detailed applications information)

Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols

Specificity: Reacts with cyclic human alpha defensins 1, 2 and 3 (NP1, NP2 and NP3) and recognizes linear human defensins 1-3 that are part of recombinant .

Form: Liquid

Isotype: IgG1

Recommend Usage: The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS, pH 7.4 (0.09% sodium azide)

Storage Instruction: Store at 4°C.

Entrez GeneID: 1667

Gene Symbol: DEFA1

Gene Alias: DEF1, DEFA2, HNP-1, HP-1, MGC138393, MRS

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