DEFA1 monoclonal antibody, clone Gene Summary: Defensins are a family of microbicidal B539M and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of Catalog Number: MAB6523 neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, Regulatory Status: For research use only (RUO) urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished Product Description: Mouse monoclonal antibody by a conserved cysteine motif. Several alpha defensin raised against synthetic peptide of DEFA1. genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 1, is found Clone Name: B539M in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It Immunogen: A synthetic peptide (conjugated with differs from defensin, alpha 3 by only one amino acid. Hsp70) corresponding to human DEFA1. [provided by RefSeq] Host: Mouse
Reactivity: Human
Applications: ELISA, WB (See our web site product page for detailed applications information)
Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols
Specificity: Reacts with cyclic human alpha defensins 1, 2 and 3 (NP1, NP2 and NP3) and recognizes linear human defensins 1-3 that are part of recombinant proteins.
Form: Liquid
Isotype: IgG1
Recommend Usage: The optimal working dilution should be determined by the end user.
Storage Buffer: In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction: Store at 4°C.
Entrez GeneID: 1667
Gene Symbol: DEFA1
Gene Alias: DEF1, DEFA2, HNP-1, HP-1, MGC138393, MRS
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