Catalogue # Aliquot Size

K425-31CG-20 20 µg K425-31CG-50 50 µg

KDM5C Recombinant human protein expressed in Sf9 cells

Catalog # K425-31CG

Lot # I195 -1

Product Description Purity

Recombinant human KDM5C (1-671) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The accession number is BC054499 .

The purity of KDM5C was Gene Aliases determined to be >80% by densitometry. Approx. MW 118 kDa . JARID1C; DXS1272E; MRXJ; MRXSJ; XE169

Formulation

Recombinant protein stored in 50mM Tris-HCl, pH 7.5,

150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM

DTT, 0.1mM PMSF, 25% glycerol.

Storage and Stability

Store product at –70 oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Scientific Background

KDM5C or lysine (K)-specific 5C is a member of the SMCY homolog family that encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. KDM5C is mainly expressed in brain and skeletal muscle. KDM5C is involved in the regulation of transcription and chromatin KDM5C Protein Recombinant human protein expressed in Sf9 cells remodelling that cause X-linked mental retardation (1). KDM5C is also essential for spermatogenesis and Catalog Number K425-31CG expression of male-specific minor histocompatibility Specific Lot Number I195-1 antigens (2). Purity >80% Concentration 0.1 µ g/ µl References Stability 1yr At –70 oC from date of shipment o Storage & Shipping Store product at –70 C. For optimal 1. Jensen, L. R. et.al: Mutations in the JARID1C gene, which is storage, aliquot target into smaller involved in transcriptional regulation and chromatin quantities after centrifugation and store at recommended temperature. remodeling, cause X-linked mental retardation. Am. J. Hum. For most favorable performance, Genet. 76: 227-236, 2005. avoid repeated handling and multiple 2. Agulnik, A. I. et.al: A mouse Y gene encoded freeze/thaw cycles. Product shipped by a region essential for spermatogenesis and expression of on dry ice. male-specific minor histocompatibility antigens. Hum. Molec. Genet. 3: 873-878, 1994.

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FOR IN VITRO RESEARCH PURPOSES ONLY. NOT INTENDED FOR USE IN HUMAN OR ANIMALS.