2016 Vaccines in Development
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Vaccination with Recombinant Aspartic Hemoglobinase Reduces Parasitic Load and Blood Loss After Hookworm Infection in Dogs
Open access, freely available online PLoS MEDICINE Vaccination with Recombinant Aspartic Hemoglobinase Reduces Parasite Load and Blood Loss after Hookworm Infection in Dogs Alex Loukas1*, Jeffrey M. Bethony2, Susana Mendez2, Ricardo T. Fujiwara2, Gaddam Narsa Goud2, Najju Ranjit1, Bin Zhan2, Karen Jones2, Maria Elena Bottazzi2, Peter J. Hotez2* 1 Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia, 2 Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, District of Columbia, United States of America Competing Interests: The authors have declared that no competing ABSTRACT interests exist. Background Author Contributions: AL, JMB, MEB, and PJH designed the study. Hookworms infect 730 million people in developing countries where they are a leading cause AL, RTF, GNG, NR, BZ, performed of intestinal blood loss and iron-deficiency anemia. At the site of attachment to the host, adult experiments. AL, PJH, JMB, SM, and hookworms ingest blood and lyse the erythrocytes to release hemoglobin. The parasites KJ analyzed the data. AL, PJH, JMB, and SM contributed to writing the subsequently digest hemoglobin in their intestines using a cascade of proteolysis that begins paper. with the Ancylostoma caninum aspartic protease 1, APR-1. Academic Editor: Maria Yazdanbakhsh, Leiden University Methods and Findings Medical Center, the Netherlands Citation: Loukas A, Bethony JM, We show that vaccination of dogs with recombinant Ac-APR-1 induced antibody and cellular Mendez S, Fujiwara RT, Goud GN, et responses and resulted in significantly reduced hookworm burdens (p ¼ 0.056) and fecal egg al. (2005) Vaccination with counts (p ¼ 0.018) in vaccinated dogs compared to control dogs after challenge with infective recombinant aspartic hemoglobinase reduces parasite larvae of A. -
Pichia Pastoris (Komagataella Phaffii) As a Cost-Effective Tool for Vaccine
bioengineering Review Pichia pastoris (Komagataella phaffii) as a Cost-Effective Tool for Vaccine Production for Low- and Middle-Income Countries (LMICs) Salomé de Sá Magalhães and Eli Keshavarz-Moore * Department of Biochemical Engineering, University College London, Gower Street, London WC1E 6BT, UK; [email protected] * Correspondence: [email protected] Abstract: Vaccination is of paramount importance to global health. With the advent of the more recent pandemics, the urgency to expand the range has become even more evident. However, the potential limited availability and affordability of vaccines to resource low- and middle-income countries has created a need for solutions that will ensure cost-effective vaccine production methods for these countries. Pichia pastoris (P. pastoris) (also known as Komagataella phaffii) is one of the most promising candidates for expression of heterologous proteins in vaccines development. It combines the speed and ease of highly efficient prokaryotic platforms with some key capabilities of mammalian systems, potentially reducing manufacturing costs. This review will examine the latest developments in P. pastoris from cell engineering and design to industrial production systems with focus on vaccine development and with reference to specific key case studies. Keywords: vaccines; LMICs; expression platforms; P. pastoris (Komagataella phaffii) Citation: de Sá Magalhães, S.; Keshavarz-Moore, E. Pichia pastoris (Komagataella phaffii) as a Cost-Effective 1. Introduction Tool for Vaccine Production for Low- and Middle-Income Countries (LMICs). Infectious diseases have a significant global economic and societal impact. As a result, Bioengineering 2021, 8, 119. https:// during the last two centuries, we have witnessed the remarkable success of vaccination doi.org/10.3390/bioengineering8090119 reducing the burden of infectious diseases [1]. -
Modelling Immunization Strategies with Cytomegalovirus Vaccine Candidates
Epidemiol. Infect. (2011), 139, 1818–1826. f Cambridge University Press 2011 doi:10.1017/S0950268811000343 Modelling immunization strategies with cytomegalovirus vaccine candidates R.S. AZEVEDO1* AND M. AMAKU2 1 Departamento de Patologia & LIM 01 HC, Faculdade de Medicina, Universidade de Sa˜o Paulo, Brazil 2 Departamento de Medicina Veterina´ria Preventiva e Sau´de Animal, Faculdade de Medicina Veterina´ria e Zootecnia, Universidade de Sa˜o Paulo, Brazil (Accepted 16 February 2011; first published online 14 March 2011) SUMMARY In order to analyse the impact of vaccination against cytomegalovirus (CMV) on congenital infection incidence using current vaccines tested in phase II clinical trials, we simulated different scenarios by mathematical modelling, departing from the current vaccine characteristics, varying age at vaccination, immunity waning, vaccine efficacy and mixing patterns. Our results indicated that the optimal age for a single vaccination interval is from 2 to 6 months if there is no immunity waning. Congenital infection may increase if vaccine-induced immunity wanes before 20 years. Congenital disease should increase further when the mixing pattern includes transmission among children with a short duration of protection vaccine. Thus, the best vaccination strategy is a combined schedule: before age 1 year plus a second dose at 10–11 years. For CMV vaccines with low efficacy, such as the current ones, universal vaccination against CMV should be considered for infants and teenagers. Key words: Cytomegalovirus vaccine, immunity waning, immunization strategies, modelling. INTRODUCTION adolescence, when seroprevalence increases again [1, 2]. These observations suggest that the force of Cytomegalovirus (CMV) infection may be the cause of infection, defined as the per capita rate at which mental retardation and deafness in newborns, infec- susceptible individuals acquire infection, may be re- tious mononucleosis syndrome in young adults, and presented by a bimodal pattern. -
Artículos Científicos
Editor: NOEL GONZÁLEZ GOTERA Número 086 Diseño: Lic. Roberto Chávez y Liuder Machado. Semana 010613 - 070613 Foto: Lic. Belkis Romeu e Instituto Finlay La Habana, Cuba. ARTÍCULOS CIENTÍFICOS Publicaciones incluidas en PubMED durante el período comprendido entre el el 1 y el 7 de junio de 2013. Con “vaccin*” en título: 131 artículos recuperados. Vacunas Neumococo (Streptococcus pneumoniae) 98. Is there an authentic increased risk of pneumococcal pneumonia among young mothers whose children were fully vaccinated with PCV7? The role of methodological shortcomings. Castiglia P, Piana A, Sotgiu G. Vaccine. 2013 May 29. doi:pii: S0264-410X(13)00655-5. 10.1016/j.vaccine.2013.05.055. [Epub ahead of print] No abstract available. PMID: 23727001 [PubMed - as supplied by publisher] Related citations Select item 23726847 121. Clonal Expansion within Pneumococcal Serotype 6C after Use of Seven-Valent Vaccine. Loman NJ, Gladstone RA, Constantinidou C, Tocheva AS, Jefferies JM, Faust SN, O'Connor L, Chan J, Pallen MJ, Clarke SC. PLoS One. 2013 May 28;8(5):e64731. doi: 10.1371/journal.pone.0064731. Print 2013. PMID: 23724086 [PubMed - in process] Free Article Related citations Select item 23724021 1 Vacuna Tosferina (Bordetella pertussis) 108. [Pertussis in fully vaccinated infants and children. Are new vaccination strategies required?] Moraga-Llop FA, Mendoza-Palomar N, Muntaner-Alonso A, Codina-Grau G, Fàbregas-Martori A, Campins-Martí M. Enferm Infecc Microbiol Clin. 2013 May 29. doi:pii: S0213-005X(13)00124-9. 10.1016/j.eimc.2013.04.007. [Epub ahead of print] Spanish. PMID: 23725786 [PubMed - as supplied by publisher] Related citations Select item 23725785 125. -
Moderna Inc Corporate Analyst Meeting on April 14, 2020 / 12:00PM
Client Id: 77 THOMSON REUTERS STREETEVENTS EDITED TRANSCRIPT MRNA.OQ - Moderna Inc Corporate Analyst Meeting EVENT DATE/TIME: APRIL 14, 2020 / 12:00PM GMT THOMSON REUTERS STREETEVENTS | www.streetevents.com | Contact Us ©2020 Thomson Reuters. All rights reserved. Republication or redistribution of Thomson Reuters content, including by framing or similar means, is prohibited without the prior written consent of Thomson Reuters. 'Thomson Reuters' and the Thomson Reuters logo are registered trademarks of Thomson Reuters and its affiliated companies. Client Id: 77 APRIL 14, 2020 / 12:00PM, MRNA.OQ - Moderna Inc Corporate Analyst Meeting CORPORATE PARTICIPANTS Juan Andres Moderna, Inc. - Chief Technical Operations & Quality Officer Lavina Talukdar Moderna, Inc. - Head of IR Stéphane Bancel Moderna, Inc. - CEO & Director Stephen Hoge Moderna, Inc. - President Tal Zaks Moderna, Inc. - Chief Medical Officer CONFERENCE CALL PARTICIPANTS Alec Warren Stranahan BofA Merrill Lynch, Research Division - Associate Cory William Kasimov JP Morgan Chase & Co, Research Division - Senior Biotechnology Analyst Edward Andrew Tenthoff Piper Sandler & Co., Research Division - MD & Senior Research Analyst Geoffrey Craig Porges SVB Leerink LLC, Research Division - Director of Therapeutics Research, MD & Senior Biotechnology Analyst Hartaj Singh Oppenheimer & Co. Inc., Research Division - Research Analyst Maxwell Nathan Skor Morgan Stanley, Research Division - Research Associate Salveen Jaswal Richter Goldman Sachs Group Inc., Research Division - VP Umer Raffat Evercore ISI Institutional Equities, Research Division - Senior MD & Senior Analyst of Equity Research Yasmeen Rahimi Roth Capital Partners, LLC, Research Division - MD, Senior Research Analyst & Co-Head of Biotechnology Research Andrew Lo Flor Munoz-Rivas Kathryn Edwards Mark Denison Mark R. Denison Paul Heath PRESENTATION Operator Good morning, and welcome to Moderna's Virtual Vaccine Day. -
Harnessing the Immune System to Prevent Cancer: Basic Immunologic Mechanisms & Their Application to Clinical Trials of Vaccines Part 2: the Vaccines Barbara K
Harnessing the Immune System to Prevent Cancer: Basic Immunologic Mechanisms & Their Application to Clinical Trials of Vaccines Part 2: The Vaccines Barbara K. Dunn NCI/Division of Cancer Prevention August 3, 2020 Harnessing the Immune System to Prevent Cancer: Basic Immunologic Mechanisms and Therapeutic Approaches that are Relevant to Cancer Prevention I. Basic immunologic mechanisms II. Application to prevention & treatment of cancer 1. Antibodies: as drugs 2. Vaccines: general principles & your vaccine trials & more… I) Vaccines to prevent cancers caused by infectious agents II) Vaccines to prevent non-infection associated cancer (directed toward tumor associated antigens) Harnessing the Immune System to Prevent Cancer: Basic Immunologic Mechanisms and Therapeutic Approaches that are Relevant to Cancer Prevention I. Basic immunologic mechanisms II. Application to prevention & treatment of cancer 1. Antibodies: as drugs “passive immunity” 2. Vaccines: general principles & your vaccine trials & more… I) Vaccines to prevent cancers caused by infectious agents “active II) Vaccines to prevent immunity” non-infection associated cancer (directed toward tumor associated antigens) Harnessing the Immune System to Prevent Cancer: Basic Immunologic Mechanisms and Therapeutic Approaches that are Relevant to Cancer Prevention I. Basic immunologic mechanisms II. Application to prevention & treatment of cancer 1. Antibodies:Focus as on drugs the Antigen “passive !immunity” 2. Vaccines: general principles & your vaccine trials & more… I) Vaccines -
The Tangible Effects of COVID-19 in Latin American Countries Boletín Del Colegio Mexicano De UROLOGIA´
Care and management in Urology oncology: The tangible effects of COVID-19 in Latin American countries Boletín del Colegio Mexicano de UROLOGIA´ BOLETÍN DEL COLEGIO MEXICANO DE UROLOGÍA, Vol. 36, año 2021, es una revista de publicación continua editada por el Colegio Mexicano de Urología Nacional, A.C., Montecito No. 38, Piso 33, Oficina 32, Col. Nápoles, C.P. 03810 CDMX, México. Tel. directo: (01-55) 9000-8053. http://www.cmu.org.mx Director: Dr. Héctor Berea Domínguez, Editor responsable: Dr. Erick Sierra Díaz, Co-Editores: Dr. Israel Presteguín Rosas, Dr. Rafael Sandoval Gómez, Asistente editorial: Lic. Angélica M. Arévalo Zacarías. Reservas de Derechos al Uso Exclusivo del título (04-2011-12081034400-106). ISNN: (0187-4829). Licitud de Título Núm. 016. Licitud de Contenido Núm. 008, de fecha 15 de agosto de 1979, ambos otorgados por la Comisión Clasifica- dora de Publicaciones y Revistas Ilustradas de la Secretaría de Gobernación. Los conceptos vertidos en los artículos publicados en este Bletín son responsabilidad exclusiva de los autores, y no reflejan necesariamente el criterio de el Colegio Mexicano de Urología Nacional, A.C. Este número se terminó de imprimir en abril de 2021. Publicación realizada, comercializada y distribuida por Edición y Farmacia SA de CV (Nieto Editores®). Cerrada de Antonio Maceo 68, colonia Escandón, 11800 Ciudad de México. Teléfono: 5678-2811. Queda estrictamente prohibida la reproducción total o parcial de los contenidos e imágenes de la publicación sin pevia auto- rización del Colegio Mexicano de Urología Nacional, A.C. Mesa Directiva 2019-2021 Dr. Ignacio López Caballero Presidente Dr. Héctor Raúl Vargas Zamora Vicepresidente Dr. -
Plant-Based COVID-19 Vaccines: Current Status, Design, and Development Strategies of Candidate Vaccines
Review Plant-Based COVID-19 Vaccines: Current Status, Design, and Development Strategies of Candidate Vaccines Puna Maya Maharjan 1 and Sunghwa Choe 2,3,* 1 G+FLAS Life Sciences, 123 Uiryodanji-gil, Osong-eup, Heungdeok-gu, Cheongju-si 28161, Korea; punamaya.maharjan@gflas.com 2 G+FLAS Life Sciences, 38 Nakseongdae-ro, Gwanak-gu, Seoul 08790, Korea 3 School of Biological Sciences, College of Natural Sciences, Seoul National University, Gwanak-gu, Seoul 08826, Korea * Correspondence: [email protected] Abstract: The prevalence of the coronavirus disease 2019 (COVID-19) pandemic in its second year has led to massive global human and economic losses. The high transmission rate and the emergence of diverse SARS-CoV-2 variants demand rapid and effective approaches to preventing the spread, diagnosing on time, and treating affected people. Several COVID-19 vaccines are being developed using different production systems, including plants, which promises the production of cheap, safe, stable, and effective vaccines. The potential of a plant-based system for rapid production at a commercial scale and for a quick response to an infectious disease outbreak has been demonstrated by the marketing of carrot-cell-produced taliglucerase alfa (Elelyso) for Gaucher disease and tobacco- produced monoclonal antibodies (ZMapp) for the 2014 Ebola outbreak. Currently, two plant-based COVID-19 vaccine candidates, coronavirus virus-like particle (CoVLP) and Kentucky Bioprocessing (KBP)-201, are in clinical trials, and many more are in the preclinical stage. Interim phase 2 clinical Citation: Maharjan, P.M.; Choe, S. trial results have revealed the high safety and efficacy of the CoVLP vaccine, with 10 times more Plant-Based COVID-19 Vaccines: neutralizing antibody responses compared to those present in a convalescent patient’s plasma. -
2017 Immuno-Oncology Medicines in Development
2017 Immuno-Oncology Medicines in Development Adoptive Cell Therapies Drug Name Organization Indication Development Phase ACTR087 + rituximab Unum Therapeutics B-cell lymphoma Phase I (antibody-coupled T-cell receptor Cambridge, MA www.unumrx.com immunotherapy + rituximab) AFP TCR Adaptimmune liver Phase I (T-cell receptor cell therapy) Philadelphia, PA www.adaptimmune.com anti-BCMA CAR-T cell therapy Juno Therapeutics multiple myeloma Phase I Seattle, WA www.junotherapeutics.com Memorial Sloan Kettering New York, NY anti-CD19 "armored" CAR-T Juno Therapeutics recurrent/relapsed chronic Phase I cell therapy Seattle, WA lymphocytic leukemia (CLL) www.junotherapeutics.com Memorial Sloan Kettering New York, NY anti-CD19 CAR-T cell therapy Intrexon B-cell malignancies Phase I Germantown, MD www.dna.com ZIOPHARM Oncology www.ziopharm.com Boston, MA anti-CD19 CAR-T cell therapy Kite Pharma hematological malignancies Phase I (second generation) Santa Monica, CA www.kitepharma.com National Cancer Institute Bethesda, MD Medicines in Development: Immuno-Oncology 1 Adoptive Cell Therapies Drug Name Organization Indication Development Phase anti-CEA CAR-T therapy Sorrento Therapeutics liver metastases Phase I San Diego, CA www.sorrentotherapeutics.com TNK Therapeutics San Diego, CA anti-PSMA CAR-T cell therapy TNK Therapeutics cancer Phase I San Diego, CA www.sorrentotherapeutics.com Sorrento Therapeutics San Diego, CA ATA520 Atara Biotherapeutics multiple myeloma, Phase I (WT1-specific T lymphocyte South San Francisco, CA plasma cell leukemia www.atarabio.com -
Putting Into Perspective the Future of Cancer Vaccines: Targeted Immunotherapy
Putting into Perspective the Future of Cancer Vaccines: Targeted Immunotherapy Authors: Issam Makhoul,1,2 *Thomas Kieber-Emmons2,3 1. Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA 2. Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA 3. Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA *Correspondence to [email protected] Disclosure: The authors have declared no conflicts of interest. Received: 11.11.19 Accepted: 12.02.20 Keywords: Cancer, cancer vaccine, checkpoint inhibitors. Citation: EMJ. 2020;5[3]:102-113. Abstract Pre-clinical models and human clinical trials have confirmed the ability of cancer vaccines to induce immune responses that are tumour-specific and, in some cases, associated with clinical response. However, cancer vaccines as a targeted immunotherapy strategy have not yet come of age. So, why the discordance after so much research has been invested in cancer vaccines? There are several reasons for this that include: limited tumour immunogenicity (limited targeted antigen expression, antigen tolerance); antigenic heterogeneity in tumours; heterogeneity of individual immune responses; multiple mechanisms associated with suppressed functional activity of immune effector cells, the underlying rationale for the use of immune checkpoint inhibitors; and immune system exhaustion. The success of checkpoint therapy has refocussed investigations into defining relationships between tumours and host immune systems, appreciating the mechanisms by which tumour cells escape immune surveillance and reinforcing recognition of the potential of vaccines in the treatment and prevention of cancer. Recent developments in cancer immunotherapies, together with associated technologies, for instance, the unparalleled achievements by immune checkpoint inhibitors and neo- antigen identification tools, may foster potential improvements in cancer vaccines for the treatment of malignancies. -
ISSN: 2320-5407 Int. J. Adv. Res. 6(3), 1363-1370
ISSN: 2320-5407 Int. J. Adv. Res. 6(3), 1363-1370 Journal Homepage: -www.journalijar.com Article DOI:10.21474/IJAR01/6806 DOI URL: http://dx.doi.org/10.21474/IJAR01/6806 RESEARCH ARTICLE A CRITIQUE ON CANCER VACCINE. Sambathkumar R1, Amala Baby2, Sudha M3 and Venkateswaramurthy N2. 1. Department of Pharmaceutics. 2. Department of Pharmacy Practice. 3. Department of Pharmacology J.K.K. Nattraja College of Pharmacy, Kumarapalayam, Tamilnadu - 638183, India. …………………………………………………………………………………………………….... Manuscript Info Abstract ……………………. ……………………………………………………………… Manuscript History The goal of a successful vaccine is to prepare the immune system for invasion of a foreign pathogen and teach them to recognize antigens as Received: 21 January 2018 well as reduce the risk of transmission. In the field of cancer, vaccines Final Accepted: 23 February 2018 are found to be the latest discovery. Provenge® (Sipuleucel-T) is the Published: March 2018 only vaccine approved by Food and Drug Administration for the Keywords:- treatment of cancer. Vaccines are an appealing therapeutic strategy Cancer vaccine, Cells, Treatment. because they are specific. In addition they stimulate the adaptive immune system, thereby producing a memory response allowing for sustained effect without repeated therapy. Revelation of a potential anticancer treatment is as yet a test to the researchers. Thus, the development of effective cancer vaccines require, thoughtful clinical trials, and scientific progress which might induce long-term specific anticancer response and could contribute to effective and lasting elimination of malignant cells. Copy Right, IJAR, 2018,. All rights reserved. …………………………………………………………………………………………………….... Introduction:- Worldwide 6.7 million deaths were reported due to cancer in 2000. But the WHO has predicted this figure to be 15 million by 2020.[1, 2] Despite great efforts to develop better therapy, in 1997 more than 6 million people worldwide died from cancer. -
BANCOVID, the First D614G Variant Mrna-Based Vaccine Candidate Against SARS
bioRxiv preprint doi: https://doi.org/10.1101/2020.09.29.319061; this version posted September 30, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-ND 4.0 International license. 1 BANCOVID, the first D614G variant mRNA-based vaccine candidate against SARS- 2 CoV-2 elicits neutralizing antibody and balanced cellular immune response 3 Juwel Chandra Baray, Md. Maksudur Rahman Khan, Asif Mahmud, Md. Jikrul Islam, Sanat 4 Myti, Md. Rostum Ali, Md. Enamul Haq Sarker, Samir Kumar, Md. Mobarak Hossain 5 Chowdhury, Rony Roy, Faqrul Islam, Uttam Barman, Habiba Khan, Sourav Chakraborty, Md. 6 Manik Hossain, Md. Mashfiqur Rahman Chowdhury, Polash Ghosh, Mohammad Mohiuddin, 7 Naznin Sultana*, Kakon Nag* 8 Globe Biotech Ltd., 3/Ka, Tejgaon I/A, Dhaka – 1208, Bangladesh, 9 *, to whom correspondence should be made. 10 E-mail: [email protected], [email protected] 11 12 13 Key words: COVID, Coronavirus, Lipid nanoparticle, LNP, Vaccination, Immunization, 14 15 16 Abstract 17 Effective vaccine against SARS-CoV-2 is the utmost importance in the current world. More 18 than 1 million deaths are accounted for relevant pandemic disease COVID-19. Recent data 19 showed that D614G genotype of the virus is highly infectious and responsible for almost all 20 infection for 2nd wave. Despite of multiple vaccine development initiatives, there are currently 21 no report that has addressed this critical variant D614G as vaccine candidate. Here we report 22 the development of an mRNA-LNP vaccine considering the D614G variant and 23 characterization of the vaccine in preclinical trial.