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Doing Well? Fulfilling the Promise of Precision Medicine a Paper by the Economist Intelligence Unit
Doing well? Fulfilling the promise of precision medicine A paper by The Economist Intelligence Unit SPONSORED BY Doing well? Fulfilling the promise of precision medicine 2 Contents 3 Acknowledgements 5 Forward 6 Executive summary 10 Understanding precision medicine 27 Public health: The potential and limits of precision medicine 35 The challenges of integrating precision medicine into publicly funded health systems 48 Patient-centricity: The essential complement to precision medicine 59 Turning a vision into a reality 63 Endnotes © The Economist Intelligence Unit Limited 2020 Doing well? Fulfilling the promise of precision medicine 3 Acknowledgements Doing well? Fulfilling the promise of precision Colleges of Nursing medicine is an Economist Intelligence Unit Daryl Pritchard, senior vice president, (The EIU) report that has been commissioned Personalised Medicine Coalition (PMC) by Qatar Foundation. The findings are David Taylor-Robinson, professor of public based on an extensive literature review and health and policy, University of Liverpool a comprehensive interview programme Don Brown, founder & CEO, LifeOmic conducted by The EIU between March and Gemma Bilkey, researcher, Department of September 2020. Health - Western Australia Genya Dana, head of healthcare The EIU bears sole responsibility for the transformation, World Economic Forum content of this report. The findings and views Geoffrey Ginsburg, director, Centre for expressed herein do not necessarily reflect Applied Genomics & Precision Medicine, Duke the views of the partners and experts. University The report was produced by a team of EIU James Morrow, general practitioner, NHS researchers, writers, editors and graphic Kawaldip Sehmi, CEO, International designers, including: Association of Patient Organisations Kelly Gebo, chief medical and scientific Katherine Stewart, Project director Officer, NIH All of Us Program Laura Blackburn, head of science, PHG Antonia Kerle, Project manager Foundation Antonella Bordone, Graphic designer Marc S. -
And Short‐Term Outcomes in Renal Allografts with Deceased Donors
Received: 30 May 2017 | Revised: 28 October 2017 | Accepted: 13 November 2017 DOI: 10.1111/ajt.14594 ORIGINAL ARTICLE Long- and short- term outcomes in renal allografts with deceased donors: A large recipient and donor genome- wide association study Maria P. Hernandez-Fuentes1 | Christopher Franklin2 | Irene Rebollo-Mesa1 | Jennifer Mollon1,33 | Florence Delaney1,3 | Esperanza Perucha1 | Caragh Stapleton6 | Richard Borrows4 | Catherine Byrne5 | Gianpiero Cavalleri6 | Brendan Clarke7 | Menna Clatworthy8 | John Feehally9 | Susan Fuggle10 | Sarah A. Gagliano11 | Sian Griffin12 | Abdul Hammad13 | Robert Higgins14 | Alan Jardine15 | Mary Keogan31 | Timothy Leach16 | Iain MacPhee17 | Patrick B. Mark15 | James Marsh18 | Peter Maxwell19 | William McKane20 | Adam McLean21 | Charles Newstead22 | Titus Augustine23 | Paul Phelan24 | Steve Powis25 | Peter Rowe26 | Neil Sheerin27 | Ellen Solomon28 | Henry Stephens24 | Raj Thuraisingham29 | Richard Trembath28 | Peter Topham9 | Robert Vaughan30 | Steven H. Sacks1,3 | Peter Conlon6,31 | Gerhard Opelz32 | Nicole Soranzo2,33 | Michael E. Weale28 | Graham M. Lord1,3 | for the United Kingdom and Ireland Renal Transplant Consortium (UKIRTC) and the Wellcome Trust Case Control Consortium (WTCCC)-3 1King’s College London, MRC Centre for Transplantation, London, UK 2Welcome Trust Sanger Institute, Human Genetics, Cambridge, UK 3NIHR Biomedical Research Centre at Guy’s and St Thomas’, NHS Foundation Trust and King’s College London, London, UK 4Renal Institute of Birmingham, Department of Nephrology and Transplantation, -
A Genome-Wide Meta-Analysis Yields 46 New Loci Associating with Biomarkers of Iron Homeostasis
A Genome-Wide Meta-Analysis Yields 46 New Loci Associating with Biomarkers of Iron Homeostasis Bell, Steven ; Rigas, Andreas S. ; Magnusson, Magnus K. ; Ferkingstad, Egil ; Allara, Elias ; Bjornsdottir, Gyda ; Ramond, Anna ; Sørensen, Erik; Halldorsson, Gisli H. ; Paul, Dirk S. ; Burgdorf, Kristoffer Sølvsten; Eggertsson, Hanne P. ; Howson, Joanna M. M. ; Thørner, Lise W. ; Kristmundsdottir, Snaedis ; Astle, William J. ; Erikstrup, Christian; Sigurdsson, Jon K. ; Vukovic, Dragana; Dinh, Khoa M. ; Tragante, Vinicius ; Surendran, Praveen ; Pedersen, Ole Birger; Vidarsson, Brynja ; Jiang, Tao; Paarup, Helene M.; Onundarson, Pall T. ; Akbari, Parsa ; Nielsen, Kaspar René; Lund, Sigrun H. ; Juliusson, Kristinn ; Magnusson, Magnus I. ; Frigge, Michael L. ; Oddsson, Asmundur ; Olafsson, Isleifur ; Kaptoge, Stephen ; Hjalgrim, Henrik; Runarsson, Gudmundur ; Wood, Angela M. ; Jonsdottir, Ingileif ; Folkmann Hansen, Thomas; Sigurdardottir, Olof ; Stefansson, Hreinn ; Rye, David ; Andersen, Steffen; Banasik, Karina; Brunak, Søren; Burgdorf, Kristoffer ; Erikstrup, Christian; Jemec, Gregor Borut Ernst; Jennum, Poul; Johanssond, Pär I.; Nyegaard, Mette; Petersen, Mikkel; Werge, Thomas; Peters, James E. ; Westergaard, David; Holm, Hilma ; Soranzo, Nicole ; Thorleifsson, Gudmar ; Ouwehand, Willem H. ; Thorsteinsdottir, Unnur ; Roberts, David J. ; Sulem, Patrick; Butterworth, Adam S. ; Gudbjartsson, Daniel F. ; Danesh, John ; Brunak, Søren; Angelantonio, Emanuele Di ; Ullum, Henrik; Stefansson, Kari Document Version Final published version Published in: Communications Biology DOI: 10.1038/s42003-020-01575-z Publication date: 2021 License CC BY Citation for published version (APA): Bell, S., Rigas, A. S., Magnusson, M. K., Ferkingstad, E., Allara, E., Bjornsdottir, G., Ramond, A., Sørensen, E., Halldorsson, G. H., Paul, D. S., Burgdorf, K. S., Eggertsson, H. P., Howson, J. M. M., Thørner, L. W., Kristmundsdottir, S., Astle, W. J., Erikstrup, C., Sigurdsson, J. -
Fountain Issue 30 • Summer 2021
The Fountain Issue 30 • Summer 2021 ‘Reflection’ by keen photographer and final year engineering student Areeg Ashraf Emarah (2017), who features in the Student spot on page 24. © AREEG EMARAH © AREEG 3 Welcome from a Fellow Contents It is my pleasure to welcome you to the Summer Issue 30, Summer 2021 2021 edition of The Fountain as the new Senior REGULARS: Bursar. I am very familiar to Cambridge from my student days so I am humbled to return to this 4–5 beautiful city that holds so many fond memories Alumni News for me. 6–9 This year, we faced unprecedented challenges. I am impressed by how College News the College has come together as a community. Personal highlights include the Masters’ welcome to Freshers in Great Court, my virtual 10–11 fireside chat with the students, and meeting many other Fellows A day in the life of Steven Archer outdoors in the stunning College grounds. 31 One great example of how the Fellowship, students, staff and alumni Cryptic Crossword have engaged is around the important topic of climate change. This 32 year, Trinity has committed to net zero in our endowment by 2050 and pledged to divest from fossil fuel securities by the end of the year, which Events you can read more about in College News on page 6. FEATURES: This summer edition of the magazine is filled with features to update 12–15 you on what has been happening in all corners of the College over A year alone, together the last year – and what a year. -
EMBO Encounters Issue43.Pdf
WINTER 2019/2020 ISSUE 43 Nine group leaders selected Meet the first EMBO Global Investigators PAGE 6 Accelerating scientific publishing EMBO publishing costs Review Commons Making our journals’ platform announced finances public PAGE 3 PAGES 10 – 11 Welcome, Young Investigators! Contract replaces stipend Marking ten years 27 group leaders join the programme EMBO Postdoctoral Fellowships EMBO Molecular Medicine receive an update celebrates anniversary PAGES 4 – 5 PAGE 7 PAGE 13 www.embo.org TABLE OF CONTENTS EMBO NEWS EMBO news Review Commons: accelerating publishing Page 3 EMBO Molecular Medicine turns ten © Marietta Schupp, EMBL Photolab Marietta Schupp, © Page 13 Editorial MBO was founded by scientists for Introducing 27 new Young Investigators scientists. This philosophy remains at Pages 4-5 Ethe heart of our organization until today. EMBO Members are vital in the running of our Meet the first EMBO Global programmes and activities: they screen appli- Accelerating scientific publishing 17 journals on board Investigators cations, interview candidates, decide on fund- Review Commons will manage the transfer of ing, and provide strategic direction. On pages EMBO and ASAPbio announced pre-journal portable review platform the manuscript, reviews, and responses to affili- Page 6 8-9 four members describe why they chose to ate journals. A consortium of seventeen journals New members meet in Heidelberg dedicate their time to an EMBO Committee across six publishers (see box) have joined the Fellowships: from stipends to contracts Pages 14 – 15 and what they took away from the experience. n December 2019, EMBO, in partnership with decide to submit their work to a journal, it will project by committing to use the Review Commons Page 7 When EMBO was created, the focus lay ASAPbio, launched Review Commons, a multi- allow editors to make efficient editorial decisions referee reports for their independent editorial deci- specifically on fostering cross-border inter- Ipublisher partnership which aims to stream- based on existing referee comments. -
Degree Congregations
The University of Manchester DEGREE CONGREGATIONS JULY 2015 At The University of Manchester, we focus on making things happen , turning enthusiasm into achievement and ground-breaking theory into cutting-edge practice. Our newest graduates today join a prestigious We encourage our students to take charge of their hall of fame that includes 25 Nobel Prize winners future, finding a voice and forming opinions, getting among our current and former staff and involved and meeting fresh challenges, making the students, and a worldwide community of more most of the multitude of resources and than 280,000 alumni who can be found holding opportunities that we have to offer. top positions in every imaginable field. And we know, with their intelligence, inspiration Over a distinguished history spanning more and ambition, our new graduates will find they have than 180 years, our innovative minds have what it takes to make their future happen. accomplished feats of global importance, including the birth of the modern computer, the splitting of the atom, and the foundation of modern-day economics. Today, our students form a diverse and fascinating community, drawn from all corners of the globe, united in their goal to build a better future via a world-class educational experience of a lifetime. Welcome from the President and Vice-Chancellor I welcome you all – graduands, family members For those of you graduating today, these and friends – to The University of Manchester ceremonies mark not the end of your for this degree congregation. relationship with the University but the start of a new stage. It is my hope that the links This is a time of celebration for all of us and between the University and you will grow ever I very much hope that you find it an enjoyable stronger and I look forward to you becoming an occasion. -
Smutty Alchemy
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2021-01-18 Smutty Alchemy Smith, Mallory E. Land Smith, M. E. L. (2021). Smutty Alchemy (Unpublished doctoral thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/113019 doctoral thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Smutty Alchemy by Mallory E. Land Smith A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENGLISH CALGARY, ALBERTA JANUARY, 2021 © Mallory E. Land Smith 2021 MELS ii Abstract Sina Queyras, in the essay “Lyric Conceptualism: A Manifesto in Progress,” describes the Lyric Conceptualist as a poet capable of recognizing the effects of disparate movements and employing a variety of lyric, conceptual, and language poetry techniques to continue to innovate in poetry without dismissing the work of other schools of poetic thought. Queyras sees the lyric conceptualist as an artistic curator who collects, modifies, selects, synthesizes, and adapts, to create verse that is both conceptual and accessible, using relevant materials and techniques from the past and present. This dissertation responds to Queyras’s idea with a collection of original poems in the lyric conceptualist mode, supported by a critical exegesis of that work. -
2017/18 Annual Report Chapter 1 Table of Contents
2017/18 ANNUAL REPORT CHAPTER 1 TABLE OF CONTENTS ENGAGING WITH GOVERNMENTS AND PRACTITIONERS 31 WELCOME 3 Deepening relations with governments and leading policymakers 32 Year in review 4 Leadership programmes 34 Governance of the School 5 Public engagement 35 International Advisory Board 6 The Challenges of Government Conference 36 Academic Advisory Board 7 The Kyoto Prize at Oxford 37 Visiting practitioners and academics 38 RESEARCH WITH IMPACT 8 Research programmes 9 Partnerships 39 New research 14 DEVELOPING THE SCHOOL 40 Awards and new books 16 Finance 41 Thanking our supporters 42 TEACHING TO ADDRESS POLICY CHALLENGES 17 The MPP year 18 Our faculty 43 Master of Public Policy (MPP) 20 Student success 22 MPP student recruitment 23 Alumni 25 DPhil in Public Policy 30 2 Development Forum. In Latin America, the World of the School enabling leaders to take a short WELCOME Economic Forum invited us to co-chair the regional moment away from their current roles to reflect on meeting this year. The Commission on State their practice, benefitting from new research and Fragility, Growth and Development (joint with exchanging ideas, and to build a network that will London School of Economics) published its enable them to tackle the challenges of public recommendations in April which we discussed at leadership. the Commonwealth Heads of Government We are fortunate to benefit from an ever- meeting and at the Annual Meetings of the IMF strengthening partnership with the Africa Initiative and World Bank. Our faculty member Professor for Governance (AIG), which is bringing Pepper Culpepper has just been awarded a €2.5 outstanding Nigerian and Ghanaian students to the million grant from the European Research Council MPP, and a distinguished AIG Fellow to the School for a groundbreaking project on public attitudes to each year: this year Ghana’s Chief Justice banks and mass media. -
8 November 2016 Programme
Programme 8 November 2016 BAFTA, London Huxley Summit Agenda 2016 3 Contents Agenda Agenda page 3 08:30 Registration Chapters page 4 09:00 Chapter 1: State of the nation Trust in the 21st Century page 6 Why trust matters page 8 10:30 Coffee and networking Speakers page 12 11:10 Chapter 2: Who do we trust? Partners page 18 12:20 Lunch and networking Attendees page 19 Round table on corporate sponsored research Round table on reasons for failure 13:50 Chapter 3: Who will we trust? 15:20 Coffee and networking 16:00 Chapter 4: Who should we trust? 17:45 Closing remarks 18:00 Drinks reception A film crew and photographer will be present at the Huxley Summit. If you do not wish to be filmed or photographed, please speak to a member of the team at British Science Association. We encourage attendees to use Twitter during the Summit, and we recommend you use the hashtag #HuxleySummit to follow the conversations. 4 Huxley Summit 2016 Chapters 5 Chapter 1: Chapter 2: Chapter 3: Chapter 4: State of the nation Who do we trust? Who will we trust? Who should we trust? The global events of 2016 have caused Many sections of business, politics and The public need to be engaged and Trust and good reputations are hard many people to question who they trust. public life have had a crisis of public informed on innovations in science won but easily lost. What drives How is this affecting the role of experts trust in recent years, but who do we trust and technology that are set to have consumers’ decision making and how and institutions? How can leaders from with science? And what can we learn a big impact on their lives and the can we drive trust in our businesses across politics, business, science and from the handling of different areas of world around them. -
Letter to Professor Dame Sally Davies Chief Medical Officer Dpt of Health and Social Care
Mo Stewart ________________________________________________________________________________ Phone: Email: Date: 3rd May, 2019 https://www.mostewartresearch.co.uk https://www.researchgate.net/profile/Mo_Stewart/publications Professor Dame Sally Davies DBE, FRS, FMedSci Priority Attention Chief Medical Officer Department of Health and Social Care 39 Victoria Street London SW1H 0EU [Dear Dame Sally] Re: Preventable harm is government policy Further to previous contact, I am writing to alert you to the identified increasing preventable harm created by the flawed assessment model adopted by the Department for Work and Pensions (DWP) to restrict access to the Employment and Support Allowance, the Personal Independence Payment and, most recently, to Universal Credit. You will recall that the commissioned research used by the DWP to justify the adoption of the Waddell-Aylward biopsychosocial (BPS) model for the work capability assessment (WCA) has failed all academic scrutiny (Shakespeare et al, 2016), that the brutality of the assessment system together with the excessive use of sanctions is negatively impacting on public mental health (Barr et al 2015; Webster, 2015), and that the assessment model was influenced by corporate America long ago; as this government enforced tyranny has been adopted by consecutive neoliberal governments who imported American social policies (Daguerre, 2004) for political ideology and for no other reason (Stewart, 2019). Given that the infamous ‘Freud Report’, as used by the DWP to justify this tyranny, was discredited within weeks of being published as Freud had ‘misinterpreted his own references’ (Dorling, 2007), then you will I’m sure realise that both government commissioned reports used to justify the adoption of the fatally flawed WCA have been discredited by independent academic excellence. -
Tackling Drug-Resistant Infections Globally: Final Report and Recommendations
TACKLING DRUG-RESISTANT INFECTIONS GLOBALLY: FINAL REPORT AND RECOMMENDATIONS THE REVIEW ON ANTIMICROBIAL RESISTANCE CHAIRED BY JIM O’NEILL MAY 2016 CONTENTS FOREWORD BY JIM O’NEILL . 1 EXECUTIVE SUMMARY . 4 1. THE PROBLEM: WHY TACKLING AMR IS ESSENTIAL . 10 2. WE MUST REDUCE THE DEMAND FOR ANTIMICROBIALS SO THE CURRENT STOCK OF DRUGS LASTS LONGER . 17 INTERVENTION 1: A GLOBAL PUBLIC AWARENESS CAMPAIGN . 19 INTERVENTION 2: IMPROVE SANITATION AND PREVENT THE SPREAD OF INFECTION . 21 INTERVENTION 3: REDUCE UNNECESSARY USE OF ANTIMICROBIALS IN AGRICULTURE AND THEIR DISSEMINATION INTO THE ENVIRONMENT . 24 INTERVENTION 4: IMPROVE GLOBAL SURVEILLANCE OF DRUG RESISTANCE AND ANTIMICROBIAL CONSUMPTION IN HUMANS AND ANIMALS. 32 INTERVENTION 5: PROMOTE NEW, RAPID DIAGNOSTICS TO REDUCE UNNECESSARY USE OF ANTIMICROBIALS . 35 INTERVENTION 6: PROMOTE DEVELOPMENT AND USE OF VACCINES AND ALTERNATIVES . 40 INTERVENTION 7: IMPROVE THE NUMBER, PAY AND RECOGNITION OF PEOPLE WORKING IN INFECTIOUS DISEASE . 44 3. WE MUST INCREASE THE SUPPLY OF NEW ANTIMICROBIALS EFFECTIVE AGAINST DRUG‑RESISTANT BUGS . 47 INTERVENTION 8: A GLOBAL INNOVATION FUND FOR EARLY STAGE AND NON‑COMMERCIAL R&D . 49 INTERVENTION 9: BETTER INCENTIVES TO PROMOTE INVESTMENT FOR NEW DRUGS AND IMPROVING EXISTING ONES . 52 4. HOW TO PAY FOR IT: TACKLING AMR IS AFFORDABLE .. 64 5. IDEAS FOR IMPLEMENTATION AND NEXT STEPS . 69 SUMMARY OF RECOMMENDATIONS . 73 ACKNOWLEDGEMENTS . 76 ACRONYMS AND ABBREVIATIONS AMC Advance Market Commitment IPC Infection prevention and control AMR Antimicrobial resistance -
The Parliamentary and Scientific Committee
The Parliamentary and Scientific Committee An Associate Parliamentary Group Annual Report 2013 The Parliamentary and Scientific Committee An Associate Parliamentary Group Office-holders 2013 President Chairman The Rt Hon the Lord Jenkin of Roding Mr Andrew Miller MP Past Presidents Deputy Chairman The Rt Hon Lord Waldegrave of North Hill Mr Tom Blenkinsop MP The Earl of Selborne KBE FRS HRH The Duke of Edinburgh KG KT FRS Advisory Panel The Lord Soulsby of Swaffham Prior Mr David Youdan Dr Stuart Taylor Vice-Presidents Dr David Dent Mr Paul Ridout Mr Philip Greenish CBE Mr John Slater Dr Stephen Benn Mr Atti Emecz Secretariat Professor Ian Haines Professor Alan Malcolm Dr Guy Hembury Mrs Annabel Lloyd Professor Colin Seabrook MBE 3 Birdcage Walk London SW1H 9JJ Hon Treasurer T: 020 7222 7085 The Lord Willis of Knaresborough F: 020 7222 7189 E: [email protected] Hon Secretary E: [email protected] Mr Stephen Mosley MP www.scienceinparliament.org.uk Council At the end of 2013 the following were members of the Council: Dr Stephen Benn Mr Paul Jackson Mr R G Sell Professor John Bleby The Rt Hon Lord Jenkin of Roding Mr John Slater Mr Tom Blenkinsop MP Professor H Peter Jost The Lord Soulsby of Dr David Dent Mr Andrew Miller MP Swaffham Prior Mr Atti Emecz Mr Stephen Mosley MP Mr Ian Taylor Mr Robert Freer Dr Douglas Naysmith Dr Stuart Taylor Mr Philip Greenish The Lord Oxburgh Dr Desmond Turner Professor Ian Haines Professor Jane Plant Lord Willis of Dr Guy Hembury Mr Paul Ridout Knaresborough The Baroness Hilton of Professor Colin Seabrook MBE Dr Richard Worswick Eggardon The Earl of Selborne Mr David Youdan Dr T D Inch Foreword by the President The Rt Hon the Lord Jenkin of Roding After six years as President of the Parliamentary and Scientific Committee, this report is my ‘valete’.