Anti-CLDN12 (Aa 26-54) Polyclonal Antibody (CABT-BL4375) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-CLDN12 (aa 26-54) polyclonal antibody (CABT-BL4375) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit Polyclonal antibody to Human CLDN12.

Immunogen Synthetic peptide between amino acids 26-54 from the N terminal region of Human Claudin 12, conjugated to KLH.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB

Format Liquid

Size 100 μg

Buffer PBS

Preservative 0.09% Sodium Azide

Storage Store at 4°C (up to 6 months). For long term storage store at -20°C

BACKGROUND

Introduction This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over- expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D- dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript

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GENE INFORMATION

Entrez Gene ID 9069

Protein Refseq NP_001172002

UniProt ID B2R687

Chromosome Location 7q21

Pathway Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism- specific biosystem; Cell-cell junction organization, organism-specific biosystem; Tight junction interactions, organism-specific biosystem;

Function identical protein binding; structural molecule activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]