Index

abdominal pain 147, 155 bone diseases 201 acid back-diffusion 151 4, 8, 11, 148 acid secretion 148 brainstem 151 acid sensor 148 Brassica 148 acidosis 148 bronchoconstriction 167, 175 acylamide 4 bronchus 71 afferent neuron 148, 149 after-discharge 125 Ca2+/CaM-dependent kinase II (CaMKII) 32 after-sensation 125 caerulein 152 airway hyperresponsiveness 177 calcitonin-gene-related peptide (CGRP) 10, 16, airway plasma leakage 167 41, 42, 149 airways epithelial cells 44 calmodulin (CaM) 30, 103 alimentary canal 154 cAMP-dependent protein kinase 100 allodynia 118 CB1 receptor 71 anal pruritis 200 cannabinoid CB2 receptor 71 10, 71, 148 desensitization 3, 4, 7 ankyrin repeat 25 capsaicin desensitization, human tongue 7 antagonism, TRPV1 60 capsaicin-sensitive sacral micturition reflex 211 antiinflammatory drugs 16 13, 14, 151, 228 anti-tussives 169 Capsicum 147 appetite 147 cation channel, capsaicin-gated 11, 12 N-arachidonoyl-dopamine 148 C-fiber 40, 167 asthma 169 CGRP 10, 16, 41, 42, 49 atropine 3 CGRP immunoreactivity 42 axon reflex flare 5 CGRP release 41 chemical coding 149 BCTC 235 chilli 147 bladder 45, 198, 199 cholera 147 bladder epithelial cells 45 chronic obstructive pulmonary disease (COPD) bladder pain 198 169 bladder smooth muscle 42 civamide (cis-capsaicin) 201, 202 bombesin 10 Clostridium difficile toxin A 152

245 Index

colitis 152 folklore medicine 147 colon 152 food intake 148 colorectal distension 155 foregut 152 cough 42, 167, 173 Freund’s adjuvant 156 cough reflex 174 functional bowel disorders 147 crythomelalgia 193 functional dyspepsia 147 C-type receptor 13 galanin 10 DD191515 233 gastric acid challenge 155 defunctionalization of afferent nerve fiber 149 gastric acid secretion 151 degeneration of nerve terminals 104 gastric emptying 154 dermis 198 gastroesophageal reflux disease 154, 195 dextrane sulphate 152 gastrointestinal blood flow 149 diabetic neuropathy 194, 198 gastrointestinal effector systems 151 digestion 148 gastrointestinal inflammation 147 digestive system 148 gastrointestinal mucosa 157 discomfort, IBS patients 154 gastrointestinal sensation 151 Doppler flowmetry 132 guinea pig 10 dorsal root ganglion (DRG) 40, 71, 150 gut 147 dura mater 41, 42 gut-brain axis 149 gut function 147 efferent-like function 151 electroencephalographic (EEG) signal 129 H+-sensitive ion channel 148 endovanilloid 71 headache 41 enteric neuron 150 heartburn 154 epidermis 198 heat 29, 98, 148, 154 epigastric pain 155 heat activation 29 epithelial cells 150 high-temperature coefficient (Q10) 10 ergotoxine 3 Hirschsprung’s disease 156 esophagogastroduodenal region 148 histamine 4, 5 esophagus 153 HIV-associated neuropathy 194 ethanol 42, 148 homovanillic acid 12 ethanol-evoked headaches and migraines 41 148 resinifera 12 12-(S)-hydroperoxyeicosatetraenoic acid 58 (12-HPETE) 148 evoked potential 127 15-HPETE 148 excitation 149 hyperalgesia 118, 148, 155 extrinsic denervation 150 hyperalgesia, dynamic 121 hyperalgesia, primary 118 Fabry disease 194 hyperalgesia, punctuate 118 fecal urgency 156 hyperalgesia, secondary 118 flare reaction 132 hyperalgesia, static 121

246 Index

hyperalgesia to heat 98 lipoxygenase 71 hypersecretion 153 lung 42 hypersensitivity 149 hypothermia 43 magnetoencephalographic-evoked response 129 mechanosensitivity 154 IBTU 15 Meissner corpuscles 40 idiopathic forms of overactive bladder, melanoma cells 45 topical bladder application of capsaicin 216 148 idiopathic pruritus ani 155 mesenteric arterial bed 72 ileitis 152 metastatic cancer 201 ileostoma 154 microneurography 125, 192 ileum 152 micturition reflex, sacral 211 indigestion 147 migraine 40, 41, 202 inflammation, gastrointestinal 147 mitochondrial swelling 10, 12 inflammation, mucosal 149 mitogen-activated protein kinase p38 156 inflammation, neurogenic 4–6, 9, 11, 16, 167, MK056 234 175 motor activity 149 inflammatory bladder hyperreflexia 155 mucosal homeostasis 148, 151 inflammatory bowel disease 156 mucosal inflammation 149 inflammatory hyperalgesia 155 mucosal ion transport 149 inflammatory mediators 31 mucosal protection 149 interstitial cystistis (IC) 195, 199 mucosal repair 149 intramuscular capsaicin 134 mucus hypersecretion 175 intravesical TRPV1 agonists, safety 218 mucus secretion 167 intravesical , mechanisms of action mucus secretion feedback regulation of gastric 218 acid secretion 151 5-iodoRTX 233 musculoskeletal pain 200 6-iodo- 234 oil 4–6, 148 irritable (overactive) bladder 155 irritable bowel syndrome (IBS) 147 natural products 58 (mustard oil) 148 nerve growth factor (NGF) 10, 100, 148, 195, 196 jalapeño 147 neural alarm system 157 jejunal distension 155 neuralgia, post-herpetic 194, 198 jejunum 154 neurogastroenterology 148 joint diseases 201 neurogenic inflammation 4–6, 9, 11, 16, 167, 175 keratinocytes 44 neurohumor 4 neurokinin A 176 laser stimuli 124 neurokinin B 176 laser-evoked potential 128 neurolytic procedure 197 leukotriene B4 148 neuroma 193, 194

247 Index

neuropathy, diabetic 194, 198 pro-inflammatory cytokines 195, 196 neuropathy, small-fiber 194 prostaglandin E2 148 neuropeptide 39 protease-activated receptor-2 (PAR2) 151 neurotoxicity 155 protein gene product (PGP 9.5) 194, 199 neurotrophic factor 156 protein kinase A (PKA) 31 3, 4 protein kinase C (PKC) 31, 155 nociception 149 prurigo nodularis 44 nociceptive withdrawal reflex 127 psoriasis 198 nociceptor hyperactivity 192, 194 psychophysical methods 122 nodose 153 pungency 156 nodose ganglion 40, 148 purinoceptor stimulation 148 nodose neuron 40, 148 puritic skin 44 non-mammalian species 6 nostalgia paresthetica 195 rabbit 8 noxious heat 154 rat 9–11, 14, 16 rectal hypersensitivity 156, 195 obstructive forms of overactive bladder, rectosigmoid distension 154 topical bladder application of capsaicin referred hyperalgesia 155 and (RTX) 214, 216 referred somatic pain 154 N-oleoyldopamine 148 resiniferatoxin (RTX) 12–15, 55, 56, 95, 104, 148 155, 199, 200, 212, 216, 219, 233 osteoarthritis (OA) 198, 201, 202 RTX binding sites, loss of 104 RTX, tritiated ([3H]RTX) 39 painful HIV-associated neuropathy 194 pancreas 45, 152 rheumatoid arthritis 201 pancreatitis 152 R-type receptor 13 partial agonism 61 (RR) 13, 14, 229 partial antagonism 61 partial nerve ligation 45 SB-366791 235 peristalis 154 SC0030 234 permeability, cation 30 Schwann cells 195 phosphatidylinositol (4,5)-bisphosphate (PIP2) SDZ 249-665 155 32 sensory modalities 157 phosphorylation state of TRPV1 100 sensory neuron-selective actions 149 4 sensory refractoriness 155 plasma extravasation 175 sensory surveillance system 148 plasma protein extravasation 153 skin 44, 197 polymodal nociceptor 148 somatostatin 16 positron emission tomography (PET) 130 specific binding of resiniferatoxin 95 postherpetic neuralgia 194, 198 specific desensitization 102 post-transcriptional mechanism 156 spinal afferent 150 preoptic/anterior hypothalamus (POAH) 43 spinal cord 41, 151

248 Index

spinal-cord injury 212 TRPV1-like immunoreactivity (TRPV1-LI) 150 stimulus-response functions 122 TRPV1 channel activity 149 (SP) 9–11, 39, 149, 176 TRPV1 channel blockers 157 TRPV1 expression in A-fibres 45 tachykinin 10, 11, 16 TRPV1 gene expression 149 147 TRPV1 trafficking 101 taste buds 40 trypsin 155 temperature treshold 148 tryptase 155 temperature-gated ion channels 14 temporal summation 125 ulcer pain 147 thermography 132 unmyelinated axon 150 thermoregulation 5 urinary bladder 150 thyroid tissue 42 tissue damage 152 vagal afferent 150 tissues with functional TRPV1 expression 96 147 tongue 6, 7 vanilloid receptor subtype 1 (VR1) 14, 167 tooth-pulp 42 vanillylamine 12 topical capsaicin 201 vasodilation 151 transient receptor potential (TRP) family 14 viscera 42 transient receptor potential (TRP) ion channel visceral hypersensitivity 154 148 visceral pain 157 transient receptor potential channel, vanilloid visceral sensory neuron 150 subfamily member 1, TRPV1 95 visceral structures 135 trigeminal neurons 72 visceromotor response 155 TRPA1 148 voltage-gated Ca2+ channels 12 TRPM8 148 vulnerability of the GI mucosa 157 TRPV1, cellular localization 62 vulvodynia 195, 200 TRPV1, desensitization (inactivation) 155 TRPV1, down-regulation 155 148 TRPV1, point mutations, in the molecule 15 wind-up 125 TRPV1, recognition domains 98 wound healing 44 TRPV1-expressing C-fibres 40 TRPV1-knockout mice 148 zingerone 4, 6

249 The PIR-Series Progress in Inflammation Research

Homepage: http://www.birkhauser.ch

Up-to-date information on the latest developments in the pathology, mechanisms and therapy of inflammatory disease are provided in this monograph series. Areas covered inclu- de vascular responses, skin inflammation, pain, neuroinflammation, arthritis cartilage and bone, airways inflammation and asthma, allergy, cytokines and inflammatory mediators, cell signalling, and recent advances in drug therapy. Each volume is edited by acknowledged experts providing succinct overviews on specific topics intended to inform and explain. The series is of interest to academic and industrial biomedical researchers, drug development personnel and rheumatologists, allergists, pathologists, dermatologists and other clinicians requiring regular scientific updates.

Available volumes: T Cells in Arthritis, P. Miossec, W. van den Berg, G. Firestein (Editors), 1998 Chemokines and Skin, E. Kownatzki, J. Norgauer (Editors), 1998 Medicinal Fatty Acids, J. Kremer (Editor), 1998 Inducible Enzymes in the Inflammatory Response, D.A. Willoughby, A. Tomlinson (Editors), 1999 Cytokines in Severe Sepsis and Septic Shock, H. Redl, G. Schlag (Editors), 1999 Fatty Acids and Inflammatory Skin Diseases, J.-M. Schröder (Editor), 1999 Immunomodulatory Agents from , H. Wagner (Editor), 1999 Cytokines and Pain, L. Watkins, S. Maier (Editors), 1999 In Vivo Models of Inflammation, D. Morgan, L. Marshall (Editors), 1999 Pain and Neurogenic Inflammation, S.D. Brain, P. Moore (Editors), 1999 Anti-Inflammatory Drugs in Asthma, A.P. Sampson, M.K. Church (Editors), 1999 Novel Inhibitors of Leukotrienes, G. Folco, B. Samuelsson, R.C. Murphy (Editors), 1999 Vascular Adhesion Molecules and Inflammation, J.D. Pearson (Editor), 1999 Metalloproteinases as Targets for Anti-Inflammatory Drugs, K.M.K. Bottomley, D. Bradshaw, J.S. Nixon (Editors), 1999 Free Radicals and Inflammation, P.G. Winyard, D.R. Blake, C.H. Evans (Editors), 1999 Gene Therapy in Inflammatory Diseases, C.H. Evans, P. Robbins (Editors), 2000 New Cytokines as Potential Drugs, S. K. Narula, R. Coffmann (Editors), 2000 High Throughput Screening for Novel Anti-inflammatories, M. Kahn (Editor), 2000 Immunology and Drug Therapy of Atopic Skin Diseases, C.A.F. Bruijnzeel-Komen, E.F. Knol (Editors), 2000 Novel Cytokine Inhibitors, G.A. Higgs, B. Henderson (Editors), 2000 Inflammatory Processes. Molecular Mechanisms and Therapeutic Opportunities, L.G. Letts, D.W. Morgan (Editors), 2000 Backlist

Cellular Mechanisms in Airways Inflammation, C. Page, K. Banner, D. Spina (Editors), 2000 Inflammatory and Infectious Basis of Atherosclerosis, J.L. Mehta (Editor), 2001 Muscarinic Receptors in Airways Diseases, J. Zaagsma, H. Meurs, A.F. Roffel (Editors), 2001 TGF-β and Related Cytokines in Inflammation, S.N. Breit, S. Wahl (Editors), 2001 Nitric Oxide and Inflammation, D. Salvemini, T.R. Billiar, Y. Vodovotz (Editors), 2001 Neuroinflammatory Mechanisms in Alzheimer’s Disease. Basic and Clinical Research, J. Rogers (Editor), 2001 Disease-modifying Therapy in Vasculitides, C.G.M. Kallenberg, J.W. Cohen Tervaert (Editors), 2001 Inflammation and Stroke, G.Z. Feuerstein (Editor), 2001 NMDA Antagonists as Potential Analgesic Drugs, D.J.S. Sirinathsinghji, R.G. Hill (Editors), 2002 Migraine: A Neuroinflammatory Disease? E.L.H. Spierings, M. Sanchez del Rio (Editors), 2002 Mechanisms and Mediators of Neuropathic pain, A.B. Malmberg, S.R. Chaplan (Editors), 2002 Bone Morphogenetic Proteins. From Laboratory to Clinical Practice, S. Vukicevic, K.T. Sampath (Editors), 2002 The Hereditary Basis of Allergic Diseases, J. Holloway, S. Holgate (Editors), 2002 Inflammation and Cardiac Diseases, G.Z. Feuerstein, P. Libby, D.L. Mann (Editors), 2003 Mind over Matter – Regulation of Peripheral Inflammation by the CNS, M. Schäfer, C. Stein (Editors), 2003 Heat Shock Proteins and Inflammation, W. van Eden (Editor), 2003 Pharmacotherapy of Gastrointestinal Inflammation, A. Guglietta (Editor), 2004 Arachidonate Remodeling and Inflammation, A.N. Fonteh, R.L. Wykle (Editors), 2004 Recent Advances in Pathophysiology of COPD, P.J. Barnes, T.T. Hansel (Editors), 2004 Cytokines and Joint Injury, W.B. van den Berg, P. Miossec (Editors), 2004 Cancer and Inflammation, D.W. Morgan, U. Forssmann, M.T. Nakada (Editors), 2004 Bone Morphogenetic Proteins: Bone Regeneration and Beyond, S. Vukicevic, K.T. Sampath (Editors), 2004 Antibiotics as Anti-Inflammatory and Immunomodulatory Agents, B.K. Rubin, J. Tamaoki (Editors), 2005 Antirheumatic Therapy: Actions and Outcomes, R.O. Day, D.E. Furst, P.L.C.M. van Riel, B. Bresnihan (Editors), 2005 Regulatory T-Cells in Inflammation, L. Taams, A.N. Akbar, M.H.M Wauben (Editors), 2005 Sodium Channels, Pain, and Analgesia, K. Coward, M. Baker (Editors), 2005