ESE NewsIssue 22 Autumn 2013 THE NEWSLETTER OF THE EUROPEAN SOCIETY OF ENDOCRINOLOGY – THE EUROPEAN SOCIETY ISSN 2045-1563 (print) ISSN 2045-1571 (online)

Communication and collaboration: Journals at the heart of endocrinology

Also in this issue: Perioperative Steroids: avoiding a crisis A Day in the Life of... an endocrine nurse Endo Explorer in Germany and Tunisia

Contents & Editorial

In this issue Editorial

03 Society News We work most effectively when ECE 2014, plus Nurses’ Network collaborating with our colleagues. Our meeting of the ESE Affiliated 04 Society News National Societies in Vienna on 13–14 September resulted in a Journal and committee news wonderful exchange of many exciting ideas for collaboration, as it was attended by the majority of the societies and the 05 ESE Committees ESE Executive Committee. During the meeting, we decided to EYES, plus new Club 30 in Poland create the ESE Council of Affiliated Societies (ECAS). ECAS will 06 ESE Committees be a collaborative global network enhancing the visibility of New Finance Committee plus endocrine research, development and education – essential Science Committee activities for our discipline. ECAS has ambitious objectives, but together we can become a real presence on the international stage, 07 Feature Article and discuss shared challenges and issues. Our next step Surgery, steroids and adrenal insufficiency is to carefully scope the projects that we agreed. Further information about these and ECAS itself will follow over the 08 Editor’s Selection coming months. The latest from ESE’s official journals On the subject of successful collaboration, cover in adrenal insufficiency. How can we 09 Feature Article we all recognise the burgeoning quantity ensure patients aren’t put at unnecessary of scientific data that results from our risk of adrenal crisis? Your favourite reads in EJE... research endeavours as we work together. This issue is also the first under the Crucial to our ability to learn what is 10 The Endo Explorer leadership of a new Editor for ESE News. relevant and important to our future We look at research in Munich I welcome Wouter de Herder of The studies is the art of scientific publication. and visit the Tunisian Society Netherlands, and thank Richard Ross for At ESE, we are proud and fortunate his huge contribution in the role, which 11 A Day in the Life of… to have a range of high quality official has overseen exciting times, including An endocrine nurse specialist journals: European Journal of development of the excellent new design. Endocrinology (EJE), Endocrine Connections, We also thank Leonie van Houten, who 12 Coffee Break & Diary Journal of Endocrinology, Journal of has stepped down from the Editorial Win with the Endo Prize Puzzle! Molecular Endocrinology (JME) and Board, and welcome Gesthimani Mintziori Plus future meeting dates Endocrine-Related Cancer. Their impact is (Greece) in her place. Richard Ross has enormous, and they enable us to publish of course moved to new challenges in our work where we know our peers will ESE, as Treasurer, and is already making read it, and give us a central location his mark with the development of a new where we can be certain that we will Finance Committee (see page 6). find the information we need Look out also for information about to know. This document is available on the ESE website, endocrine nurses, with ESE’s Endocrine www.ese-.org In this issue of ESE News, we celebrate the Nurses’ Working Group initiating an The address lists used to mail this issue of ESE News were supplied by the member societies of ESE and are publication of research, and look at how Endocrine Nurses’ Network (page 3), as stored in ’s database for future use. If you do not wish to receive further mailings, please advise its transition online and the availability of well as our feature on A Day in the Life of [email protected] make the information widely an Endocrine Nurse (page 11). We also ©2013 European Society of Endocrinology The views expressed by the contributors are not accessible, for the good of us all. On have the first information about ECE necessarily those of ESE page 9, Hans Romijn, Editor of EJE, takes 2014 in Wrocław, Poland (page 3), and, Editor: Wouter de Herder, The Netherlands a fascinating look at the most popular coincidentally, news of an exciting new Email: [email protected] Co-Editor: Philippe Bouchard, France articles in that journal. There is also a host group for young endocrinologists in that Email: [email protected] of journal-related news on page 4, with same country (page 5). Editorial Board: Justo Castaño, Spain Endocrine Connections now indexed on Gesthimani Mintziori, Greece I wish you happy reading – of all our Hans Romijn, The Netherlands PubMed Central, and JME celebrating 25 Dominik Schulte, Germany publications! years of publication. Website: www.ese-hormones.org Newsletter designed by Qube Design Associates Sometimes, publications are controversial. Philippe Bouchard ESE would like to thank its Corporate Members for their On page 7, Wiebke Arlt discusses one continued support: Bayer Pharma AG, Eli Lilly, Ipsen, ESE President Laboratoire HRA Pharma, Merck Serono, Novartis, such paper, the cause of much concern Co-Editor of ESE News Novo Nordisk, Otsuka Pharmaceuticals Europe Limited, Pfizer, Sandoz International GmbH, ViroPharma SPRL for many in our specialty: the latest Cochrane review on perioperative steroid

02 European Society of Endocrinology - the European hormone society EuropeanSocietyofEndocrinology Society News

New ESE nurse activities The new ESE Endocrine Nurses’ Working Group is set to provide a Nurses’ Network, giving support and resources to endocrine nurses based in Europe. It will develop and promote their role and raise the profile of endocrine nursing throughout Europe and Submit your abstracts online by: internationally, to enable nurses to 13 January 2014 share experience, and to benchmark Early bird registration by: against and learn from one another. 10 March 2014 A new section for nurses is now available on the ESE website See www.ece2014.org (www.ese-hormones.org/nurse). ECE 2014: Here, you can become part of the Nurses’ Network by signing up to Get ready for Wrocław receive updates from the Endocrine Nurses’ Working Group (alternatively, 16th European Congress of Endocrinology email [email protected]). Wrocław, Poland 3–7 May 2014 Endocrine nurses recognise the value of meeting and networking, and ECE 2014 will welcome a truly John Wass (Oxford, UK) and Dr Albert ECE 2013 (27 April–1 May 2013, international delegation from across Beckers (Liège, Belgium), among others. Copenhagen, Denmark) saw a the entire spectrum of endocrinology, formalised nurse programme at the The congress will also feature oral including scientists, clinicians, ECE meeting for the second time. communications, poster presentations nurses – and not forgetting the next The sessions were very well received, and a European Young Endocrine generation of endocrinologists! with over 100 attendees from various Scientists’ (EYES) symposium, as well as We are delighted to be holding multi-disciplinary areas. To continue endocrine nurses’ sessions and pre- this year’s event at the prestigious this success, we ask all our colleagues congress courses on proper medical Centennial Hall in Wrocław, Poland. to participate in future nurse sessions, writing and thyroid ultrasound. not just as attendees, but also as You will have the chance to hear from You can find out more and read the speakers and chairs. some of the leading figures in our programme at www.ece2014.org. field, in a comprehensive programme To become a nurse member of ESE of plenary lectures, symposia, meet- We look forward to welcoming for just €35 per year, apply online at the-expert sessions and debates. The you to Wrocław for ECE 2014. www.ese-hormones.org/membership. carefully selected speakers include Paolo Beck-Peccoz and Anna Spada You can read more about ‘A Day in a Geoffrey Harris Prize Lecturer Professor Joint Chairs, Life of an Endocrine Nurse’ on page Ashley Grossman (Oxford, UK), European Programme Organising Committee 11 of this issue, which features Sofia Journal of Endocrinology Prize Lecturer Llahana (London, UK), Chair of the ESE Andrzej Milewicz Professor Martin Fassnacht (Munich, Nurses’ Working Group, which oversees Chair, Local Organising Committee Germany), Professor Martin Reincke all of ESE’s nurse activities. Sofia is now (Munich, Germany), Professor Sophie the ex-officio Nurse Representative on Christin-Maître (Paris, France), Professor the ESE Executive Committee.

Endocrine Proper Thyroid nurses’ sessions medical writing ultrasound The popular dedicated endocrine This specially designed pre-congress Attend this postgraduate course nurses’ strand will include clinical workshop has been developed for for a review of the latest advances sessions with presentations and scientists and medical professionals in thyroid ultrasound techniques case studies from physicians and in the healthcare system, academia through presentations, interactive nurses, as well as a session focused and clinical departments of the discussions and practical sessions on professional development. pharmaceutical industry. working with thyroid patients.

ESEndocrinology European Society of Endocrinology - the European hormone society 03 Society News

Endocrine Publishing and Connections Communications The ESE journal Endocrine Committee Connections is now indexed and The ESE Publications Committee, live in PubMed Central. You can which is chaired by Vera Popovic- find the content at www.ncbi.nlm. Brkic, has recently been revamped nih.gov/pmc/journals/2122. and renamed as the Publishing and Communications Committee. Consequently, all articles published in Endocrine Connections will now be freely The move follows a review which available in PubMed Central, increasing highlighted that the Committee’s the reach and discoverability of authors’ remit should encompass ESE’s work. This is a major achievement in communications strategy, in addition the establishment of a new journal, to the Society’s publications. and a crucial consideration for authors To submit your article to Membership of the Committee will when deciding where to publish Endocrine Connections, visit therefore not be limited to individuals their work. www.endocrineconnections.com. with involvement in ESE’s publications.

NEW Finance 25 years of description of the newly developed Committee technique of real-time PCR – the gold standard of RNA quantitation – in 2000. A new ESE Finance Committee has Journal of been formed, chaired by ESE Treasurer Molecular After publishing over 1700 papers, Richard Ross. the journal is celebrating with a series Endocrinology of articles from major contributors to It will serve to:

JOURNAL OF MOLECULAR ENDOCRINOLOGY the field, guest edited by Ron Evans. • support the Treasurer

OCTOBER 2013 • make the approval process clearer VOLUME 51 So, is the need for a specialist molecular NUMBER 2

ISSN 0952-5041 (PRINT) for the Executive and other ISSN 1479-6813 (ONLINE) endocrinology journal now coming to committees an end? As Editor-in-Chief Adrian Clark CONTENTS ISSN 0952-5041 (PRINT) • increaseVOLUME transparency 51 NUMBER 2 ISSN 1479-6813 (ONLINE) reflects, ‘New molecular techniques

REVIEWS Infl uence of chronic hyperglycemia on the 225–232 loss of the unfolded protein response in • ensure Thefinancial regulation and function of the controlR15–R22 transplanted and islets effective are constantly emerging, and will need NUAK family Stacey N Walters, Jude Luzuriaga, PAGES R15–R64, 213–276 Xianglan Sun, Ling Gao, Hung-Yu Chien, Jeng Yie Chan, Shane T Grey & D Ross Laybutt Wan-Chun Li & Jiajun Zhao Estradiol and tamoxifen regulate NRF-1 and 233–246 forecastingStructural determinants regulating cell R23–R32 mitochondrial function in mouse mammary publishing in a dedicated journal. surface targeting of melanocortin receptors gland and uterus A R Rodrigues, D Sousa, H Almeida & Margarita M Ivanova, Brandie N Radde, A M Gouveia Jieun Son, Fabiola F Mehta, Sang-Hyuk Chung & Astrocytes: new targets of melanocortin 4 R33–R50 Carolyn M Klinge Furthermore, a molecular torrent is receptor actions Aromatase activity induction in human 247–260 Carla Caruso, Lila Carniglia, Daniela Durand, adipose fi broblasts by retinoic acids via You can readTeresa N Scimonelli more & Mercedes Lasaga on page 6. retinoic acid receptor α Metabolic endotoxemia: a molecular link R51–R64 Jan Wilde, Maria Erdmann, Michael Mertens, Gabriele Eiselt & Martin Schmidt building in endocrinology as a result between obesity and cardiovascular risk Ana Luísa Neves, João Coelho, Characterization of the novel duplicated 261–276 Luciana Couto, Adelino Leite-Moreira & PRLR gene at the late-feathering K locus Roberto Roncon-Albuquerque Jr in Lohmann chickens Guixian Bu, Guian Huang, Hao Fu, Juan Li, VOL of the incredible technology to collect RESEARCH Simiao Huang & Yajun Wang JOURNAL OF 51 NO. Are youPKC and ERK mediate GH-stimulatedin lipolysis training? 213–224 Heather E Bergan, Jeff rey D Kittilson & Mark A Sheridan 2 MOLECULAR huge amounts of molecular data An in-training membership fee of just ENDOCRINOLOGY MOLECULES, CELLS AND MECHANISMS from tiny samples, even single cells, €20 per year is available for those at low cost. The massive challenge wishing to join ESE who are studying is to be able to make sense of this

full-time for an academic qualification. published by www.bioscientifica.com bioscientifi ca deluge of “big data” far more This does0952-5041(201310)51:2;1-R not include those studying JME_51_2_Cover.indd 1 9/17/13 7:57:16 PM effectively, so that we can integrate part-time whilst working in another Journal of Molecular Endocrinology was genetic, epigenetic, transcriptomic, role (e.g. MD students). Applicants first published in 1988, to support the proteomic and metabolomic must provide written proof of their burgeoning discipline of molecular data in a constructive manner. student status. You can apply online at endocrinology. Now, 25 years on, we Journal of Molecular Endocrinology www.ese-hormones.org/membership. can look back on the great number certainly has a role to play!’ ESE collaboration of important and well-cited papers You can view a selection of the journal’s that have since appeared in the seminal papers at www.try-jme.org. in Tunisia journal, including Bustin’s authoritative ESE has enjoyed a recent collaboration with the Tunisian Endocrine Society, to organise a postgraduate meeting 2012 impact factors at the 10th Maghreb Meeting of ESE is delighted to announce the latest Molecular Endocrinology have increased Endocrinology in Hammamet, Tunisia, impact factors for its official journals. to 5.261, 4.058 and 3.577 respectively. on 31 October–2 November 2013. To European Journal of Endocrinology Endocrine Connections, your new learn more about your colleagues in continues to stand strong with an open access journal, has a focus on the Tunisian Society, read the article of 3.136, giving it an publishing high quality papers, which on page 10, or visit their website at underlying 5-year figure of 3.575. we hope will stand it in good stead www.endocrinologie.org.tn. Values for Endocrine-Related Cancer, when the time comes for it to receive Journal of Endocrinology and Journal of its first impact factor.

04 European Society of Endocrinology - the European hormone society EuropeanSocietyofEndocrinology Society News

For further information, contact [email protected] or see www.ese-hormones.org

EYES wide awake at ECE 2013! A new tradition has been born: the about his innovative research, ‘Making a invited all young members of ESE to European Young Endocrine Scientists’ functional thyroid in a dish’, after which become part of the EYES initiative. (EYES) symposium at ECE. This we will never again think of the thyroid The evening social event was jointly symposium, organised by the members of in the same way. ‘Dissecting androgen organised by EYES and the Danish Young EYES, provides a platform for young and action: new clues from conditional Endocrine Society (FYEN). It gave a great experienced scientists to discuss cutting knockout mice’ was a truly inspirational opportunity for informal discussions edge endocrine topics. look at the research of Lee Smith (UK). and networking, leaving us with nice The 2013 EYES symposium was entitled Novel studies presented by Anneke memories and new friends. ‘Novel technologies and inspiring ideas: van den Beukel (The Netherlands) and The next EYES symposium will take place from basic endocrine research to clinical Thomas Kvist (Denmark), both young at ECE 2014 in Wrocław, Poland. Watch practice’, and was chaired by Gefsi endocrinologists, led to interesting this space for more information. We look Mintziori (Greece) and Filip Gabalec discussions, thoughts and new ideas. forward to seeing you there. (Czech Republic). Finally, Wiebke Arlt, as the ESE Executive Committee Member in liaison with EYES, Gefsi Mintziori & Max Bielohuby Francesco Antonica (Belgium) talked EYES Committee

1st Central European Symposium of Young Endocrinologists Organised by the new Club 30 of the Peccoz (former ESE Vice-President) and Polish Society of Endocrinology (PSE; see Barbara Jarzab (ESE Secretary). It was a New Club 30 takes right), this event took place on 10 May in great pleasure to see the Presidents and shape in Poland Wrocław, Poland, and was the group’s first Vice-Presidents of ESE and PSE actively Club 30 is a new venture of the Polish international initiative. supporting the next generation of Society of Endocrinology (PSE). It aims to endocrinologists. Representatives of all Congratulations are due to Ewelina enhance scientific collaboration between endocrine societies from Central Europe Szczepanek-Parulska, Club 30 President, members of PSE who are under 35, came along to show their enthusiasm, and her team for providing young by organising scientific meetings and politically and scientifically. I was delighted endocrinologists in Central European co-operation with other organisations to lead a session looking at how EYES and countries with a platform to exchange supporting young endocrinologists Club 30 can work together. ideas and, most importantly, feel at home. (including EYES), as well as subsidising As well as lectures by invited speakers scientific projects and participation in This brilliant kick-off meeting saw Philippe Bouchard and Andrea Genazzani congresses. young endocrinologists from across (President of the International Society of Central Europe, along with their Club 30 was founded in September Gynecological Endocrinology), there were mentors, presenting their own work and 2012, during PSE’s 20th Jubilee Congress seven scientific oral and poster sessions ´ networking with their peers in front of in Poznan. The ‘godfather’ of the idea covering all major fields of endocrinology, an international audience. Participation was PSE President Andrzej Milewicz, who enabling young endocrinologists from and accommodation were free for active has always supported initiatives to aid the Central Europe to present their original participants and their tutors. development of young endocrinologists. research, and to receive awards for the Honorary guests included Philippe best oral and poster presentations. For more information about Club30, Bouchard (ESE President), Vera Popovic- contact [email protected]. Dominik M Schulte Brkic (ESE Vice-President), Paolo Beck- EYES Committee

ESEndocrinology European Society of Endocrinology - the European hormone society 05 Society News

New Finance Committee: From strength to strength

ESE has been exponentially successful the start, and is already leading change since its inception in 2006, running which will allow us to fulfil our ambitions a major annual congress and clinical and deliver on our strategy. and basic science courses, as well as Richard Ross One of the major changes is the providing grants, developing guidelines, introduction of a Finance Committee to and supporting young endocrinologists, share the burden of the Treasurer. The basic scientists and nurses. Finance Committee is chaired by the These activities are supported by the Treasurer and includes the President, Vice- work of 12 committees, including the President, Chair of the Corporate Liaison governing Executive Committee. The Committee and up to four members. budgetary implications are significant, The Committee’s role is to increase and the organisation now has revenue transparency and ensure financial control and expenses of over €3 million per and effective forecasting for the Society. annum. An immediate task is to revise budget The Society’s success has been a great reporting, such that each ESE committee Helen Gregson credit to its officers – particularly can clearly see its spend and commitments, outgoing Treasurer, AJ van der and give flexibility to develop new projects. Lely. Between 2008 and 2013 he The financial world is changing and the Finance Committee Members conscientiously maintained the Society’s Society’s income from sponsors and its Richard Ross (Chair; ESE Treasurer, UK) healthy positive balance, allowing it to meeting is always under threat, so a key Philippe Bouchard (ESE President, France) develop its international profile. role for the new Finance Committee is to Jens Christiansen (ESE Corporate Liaison review our financial strategy and ensure our Our success has allowed us to grow Committee Chair, Denmark) future remains secure. our infrastructure and very significantly AJ van der Lely (The Netherlands) to appoint a General Manager, Helen Richard Ross Massimo Mannelli (Italy) Gregson. Helen has a great background Treasurer and Finance Committee Chair Vera Popovic-Brkic (ESE Vice-President, knowledge, having been with us since Serbia)

Science Committee news: More support, more courses! We hope you will benefit from two exciting new initiatives from your Science Committee

ESE Short-Term Fellowships proposed start date. The application located within Europe and easy to are available to fund research must be supported by a research plan, reach for most, but we considered it visits of between 1 week and 3 and only genuine ad-hoc visits to important to extend further. months for early career members perform scientific experiments will be (basic or clinical scientists), to supported. The first course in the series, on promote collaboration within neuroendocrinology, will take place the ESE community. They will be You can find further information in Amsterdam, The Netherlands, awarded for exchanges between at www.ese-hormones.org/prizes/ on 15–17 January 2014, organised two laboratories in different ESE ESEShortTermFellowship.aspx. We in collaboration with the Dutch member countries, and will cover hope this will fill a gap in the available Endocrine Society. More information the fellow’s economy class travel funding schemes and promote can be found at www.ese-hormones. plus subsistence, but not research collaboration between ESE members. org/education/basicscience.aspx. costs or dependents. So, if your The course is specifically aimed at study depends on a technique Circulating Basic Science Courses early career basic and translational not available in your locality, this aim to expand the geographic scientists, and funding is available could allow you to visit another boundaries of ESE’s basic science from ESE to support participation. laboratory to run the critical events, to include a series of courses We expect to arrange an event like experiments. at a changing venue. The annual ESE this every year, each in a different Summer School in Endocrinology in location. Applications may be made Bregenz, Austria, and ESE Symposium electronically at any time, but on Hormones and Cell Regulation in Ilpo Huhtaniemi at least 2 months before the Mt Ste Odile, France, are centrally Science Committee Chair

06 European Society of Endocrinology - the European hormone society EuropeanSocietyofEndocrinology Feature Article The need for perioperative steroid cover (or how to avoid early administration of the last rites) Yong and colleagues recently published a Cochrane review (an update of their previous report in 2009) asking ‘whether it is necessary to administer supplemental perioperative steroids in adult patients on maintenance doses of glucocorticoids because of adrenal insufficiency’.1 Is this a question we need to ask?

are required at the time of surgery for patients with adrenal insufficiency’. I think most of us will strongly disagree with this conclusion, and worry that such a statement will put patients at serious risk. Just yesterday, I was called to review a patient with Addison’s disease who survived emergency surgery for a ruptured abdominal aortic aneurysm. He had stress dose steroid cover during and immediately after surgery, but had been switched back to his routine dose of 20mg hydrocortisone on the first postoperative day. The surgical In 1955, John Fitzgerald Kennedy was with adrenal insufficiency. Hahner and colleagues were worried as he had famously described by Nicholas and colleagues described that, amongst the developed severe hypotension, nausea, colleagues as ‘Case 3, a 37-year-old 42% of 442 patients who reported at least vomiting and abdominal pain. This has man who has had Addison’s disease for one adrenal crisis, it had occurred during now quickly resolved after immediate 7 years’ and who ‘had managed well the perioperative period in 7% of the initiation of appropriately increased on deoxycorticosterone acetate pellets patients with primary and in 16% of those intravenous hydrocortisone cover. implanted every 3 months and cortisone with secondary adrenal insufficiency.3 in doses of 25mg daily’ but now required A similar study surveying 823 patients As my colleague John Wass and I recently spine surgery for disabling pain due with adrenal insufficiency showed that put it, diabetes is treated with insulin to a previous back injury.2 This paper a surgical procedure with insufficient and adrenal insufficiency is treated with was one of the first to document how steroid cover caused more adrenal cortisol.7 There will not be any studies on increasing glucocorticoid dose during emergencies than accidental injury.4 how type 1 diabetes patients do without the perioperative period of planned insulin, and we do not need studies on Yong et al. identified two double blind surgery can help to reduce mortality. how adrenal insufficiency patients fare studies that compared placebo with in major surgical stress whilst receiving At that time, death appeared close to increased steroid dose during the treatment with placebo only. It would be certain in patients with Addison’s disease perioperative period.1 One study looked in the interest of all patients with adrenal undergoing elective major surgery. JFK at 18 patients with secondary adrenal insufficiency if Cochrane were to remove underwent a 3-hour surgery with ‘two insufficiency due to chronic exogenous the Yong paper from the public domain. bone fusions and insertion of a metal steroid treatment with doses ≥7.5mg plate’, but survived on the new regimen prednisolone. Of these, 6 underwent Wiebke Arlt of increased perioperative steroid surgery on increased steroids, whereas Centre for Endocrinology, administration. However, doctors did 12 received placebo, with postoperative Diabetes and , not realise that the early postoperative hypotension episodes in both groups.5 School of Clinical & Experimental Medicine, period also required increased steroid The other study considered 20 organ University of Birmingham, UK cover. Consequently, JFK received the transplant patients on chronic treatment last rites ‘after falling into a coma due with 5–10mg prednisone, comparing References to a urinary tract infection’ only a few hydrocortisone 100mg i.v. with placebo 1. Yong et al. 2012 Cochrane Database of Systematic days after his surgery. Fortunately, he for gingival surgery carried out under Reviews 12 CD005367. 2. Nicholas et al. 1955 AMA Archives of Surgery recovered and went on to take office as local anaesthesia, with no adverse 71 737–742. the 35th President of the USA in 1961. events observed in either group.6 3. Hahner et al. 2010 European Journal of Endocrinology 162 597–602. Sadly, even nowadays, failure to increase From these two studies in patients on 4. White & Arlt 2010 European Journal of Endocrinology 162 115–120. glucocorticoid dose during and shortly chronic high dose steroids undergoing 5. Glowniak & Loriaux 1997 Surgery 121 123–129. after surgical intervention is still a mostly minor procedures, Yong et al. 6. Thomason et al. 1999 Journal of Clinical cause for serious clinical deterioration concluded that ‘there is insufficient Periodontology 26 577–582. 7. Wass & Arlt 2012 British Medical Journal in a significant number of patients evidence on whether additional steroids 345 e6333.

ESEndocrinology European Society of Endocrinology - the European hormone society 07 Editor's Selection

Congenital isolated GH Predicting sensitivity to DPP-4 inhibitors improve deficiency and diabetes mTOR inhibitors in bronchial cognition in insulin-resistant ENDOCRINE-RELATED CANCER Growth hormone carcinoids JOURNAL OF ENDOCRINOLOGY rats OCTOBER 2013 NOVEMBER 2013 VOLUME 20 VOLUME 219 NUMBER 5 NUMBER 2

ISSN 1351-0088 (PRINT) ISSN 0022-0795 (PRINT) (GH) regulates beta- ISSN 1479-6821 (ONLINE) Bronchial ISSN 1479-6805 (ONLINE) Vildagliptin

cell CONTENTSfunction and CONTENTS ISSN 1351–0088 (PRINT) carcinoids ISSN 0022-0795 (PRINT) and sitagliptin VOLUME 20 NUMBER 5 ISSN 1479–6821 (ONLINE) VOLUME 219 NUMBER 2 ISSN 1479-6805 (ONLINE)

COMMENTARY RESEARCH REVIEW Evidence for a role of sterol 27-hydroxylase 119–129 PAGES R37–R57, 89–182, X1 PAGES C19–C21, R215–R305, 621–766, L11–L21 in glucocorticoid metabolism in vivo IGF2 revs the steroidogenesis engine C19–C21 Endurance training improves insulin 621–632 Growth hormone and Klotho R37–R57 Isabelle Vögeli, Hans H Jung, Bernhard Dick, insulinClay E S Comstock &sensitivity Karen E Knudsen sensitivity and body composition in Christoph Schmid, Marian C Neidert, Sandra K Erickson, Robert Escher, prostate cancer patients treated with Oliver Tschopp,are Lisa Sze rare John W Funder, Felix J Frey & Geneviève Escher are dipeptidyl- REVIEWS androgen deprivation therapy & René L Bernays Thine Hvid, Kamilla Winding, Anders Rinnov, Neonatal overnutrition in mice exacerbates 131–143 Common gene pathways and families R215–R232 Thomas Dejgaard, Carsten Thomsen, RESEARCH high-fat diet-induced metabolic perturbations altered by DNA methylation in breast Peter Iversen, Klaus Brasso, Kari J Mikines, Zhiguo Liu, Chun Yan Lim, Michelle Yu-Fah Su, and prostate cancers Gerrit van Hall, Birgitte Lindegaard, Blunted HPA axis response in lactating, 89–100 Stephanie Li Ying Soh, Guanghou Shui, Tanya K Day & Tina Bianco-Miotto Thomas P J Solomon & Bente K Pedersen vasopressin-defi cient Brattleboro rats Markus R Wenk, Kevin L Grove, George K Radda, both directly Anna Fodor, Ottó Pintér, Ágnes Domokos, Weiping Han & Xiaoqiu Xiao Thyroid dysfunction and tyrosine R233–R245 Ionizing radiation enhances 633–647 kinase inhibitors in renal cell carcinoma Kristina Langnaese,neuroendocrine István Barna, peptidase-4 dl922–947-mediated cell death of Alendronate promotes bone formation by 145–158 Mario Engelmann & Dóra Zelena Loredana Bianchi, Luigi Rossi, anaplastic thyroid carcinoma cells inhibiting protein prenylation in osteoblasts Federica Tomao, Anselmo Papa, Carmela Passaro, Antonella Abagnale, Metformin increases the novel adipokine in rat tooth replantation model Federica Zoratto & Silverio Tomao Silvana Libertini, Massimiliano Volpe, adipolin/CTRP12: role of the 101–108 Koichiro Komatsu, Akemi Shimada, The optimal use of cardiac imaging in the R247–R255 Ginevra Botta, Laura Cella, Roberto Pacelli, AMPK pathway Tatsuya Shibata, Satoshi Wada, Hisashi Ideno, quantifi cation of carcinoid heart disease Gunnel Halldèn, David Gillespie & Bee K Tan, Jing Chen, Raghu Adya, Kazuhisa Nakashima, Norio Amizuka, andRebecca via Dobson, Daniel Jcomplex Cuthbertson & Giuseppe Portella Manjunath Ramanjaneya, Masaki Noda & Akira Nifuji VOL Malcolm I Burgess Vanlata Patel & Harpal S Randeva Are G3 ENETS neuroendocrine neoplasms 649–657 tumours,Pre- and postnatal nutrition in sheep aff ects 159–171 VOL. 219 NO. inhibitors, drugs MicroRNAs in the tumour R257–R267 heterogeneous? 20 NUMBER 5 ENDOCRINE- Pioglitazone does not improve insulin β−cell secretion and hypothalamic control JOURNAL OF microenvironment: big role for Fritz-Line Vélayoudom-Céphise, signaling in mice with GH 109–117 Anna H Kongsted, Sanne V Husted, small players Pierre Duvillard, Lydia Foucan, Julien Hadoux, over-expression Malin P Thygesen, Vibeke G Christensen, Patsy Soon & Hippokratis Kiaris Cecile N Chougnet, Sophie Leboulleux, Adam Gesing, Andrzej Bartke & Dominique Blache, Anders Tolver, Torben Larsen, David Malka, Joël Guigay, Diane Goere, RELATED Michal M Masternak Bjørn Quistorff & Mette O Nielsen 2 ENDOCRINOLOGY interactionsMesenchymal stem cells as a vector R269–R290 withThierry Debaere, Carolineits Caramella, for the infl ammatory prostate Martin Schlumberger, David Planchard, PHYSIOLOGY, METABOLISM microenvironment the medical used in type 2 Dominique Elias, Michel Ducreux, AND TRANSLATION W Nathaniel Brennen, Samuel R Denmeade & CANCER Jean-Yves Scoazec & Eric Baudin John T Isaacs Targeting mTOR in RET mutant medullary 659–667 HORMONES AND CANCER: The management of head-and-neck R291–R305 and diff erentiated thyroid cancer cells FROM RESEARCH TO THERAPIES paragangliomas Matti L Gild, Iñigo Landa, Mabel Ryder, principalCristina Capatina, Georgia Ntali, mediator,Ronald A Ghossein, Jeff rey A Knauf & Niki Karavitaki & Ashley B Grossman James A Fagin treatment of diabetes mellitus. insulin-like growth published by which has published by Pintana et al., 1351-0088(201310)20:5;1-D www.bioscientifica.com bioscientifi ca www.bioscientifica.com bioscientifi ca 0022-0795(201311)219:2;1-4

ERC_20_5_ Cover.indd 1 9/18/13 11:31:18 AM factor-1. Vicente et al. JOE_219_2_Cover.indd 1 limitations. 10/3/13 5:37 PM using rats with document that subjects with lifetime GH They have a relative lack of sensitivity to insulin resistance induced by high fat deficiency due to homozygous GHRH currently employed mTOR inhibitors. feeding, have shown that vildagliptin and receptor gene mutations have increased Gagliano et al. have documented that sitagliptin not only attenuate peripheral insulin sensitivity but decreased beta-cell the novel dual PI3K/mTOR inhibitor insulin resistance, but also decrease function compared with heterozygous NVP-BEZ235 is more potent than oxidative stress parameters in the brain subjects matched for body mass index. everolimus in reducing the proliferation and restore brain and hippocampal The prevalence of impaired glucose of human bronchial carcinoid cells. mitochondrial function. A high fat tolerance and type 2 diabetes was not Moreover, cells resistant to mTOR diet induced learning and memory reduced in these subjects, compared inhibitors display lower levels of mTOR, impairment in rats, which was attenuated with the general population. The p70S6K, AKT and ERK1/2, indicating by vildagliptin and sitagliptin. It appears authors conclude that lifetime untreated that these may be useful as predictive that the effects of high fat feeding isolated GH deficiency does not protect markers of resistance to mTOR and extend to cognitive dysfunction, and that from diabetes. PI3K/mTOR inhibitors. The suitability dipeptidyl-peptidase-4 inhibitors are more Read the full article in Endocrine of such markers, however, needs to be pleiotropic than hitherto appreciated. confirmed in clinical trials. Connections 2 112–117 Read the full article in Journal of Read the full article in Endocrine-Related Endocrinology 218 1–11 Cancer 20 463–475

Aldosterone directly affects apelin in adipocytes

JOURNAL OF MOLECULAR ENDOCRINOLOGY Hyperaldosteronism OCTOBER 2013 VOLUME 51 NUMBER 2

ISSN 0952-5041 (PRINT) ISSN 1479-6813 (ONLINE) is associated with Metformin inhibits goitrogenous CONTENTS altered adipokine ISSN 0952-5041 (PRINT) VOLUME 51 NUMBER 2 ISSN 1479-6813 (ONLINE)

REVIEWS Infl uence of chronic hyperglycemia on the 225–232 loss of the unfolded protein response in The regulation and function of the R15–R22 transplanted islets

NUAK family Stacey N Walters, Jude Luzuriaga, PAGES R15–R64, 213–276 profiles. Apelin, the Xianglan Sun, Ling Gao, Hung-Yu Chien, Jeng Yie Chan, Shane T Grey & D Ross Laybutt Wan-Chun Li & Jiajun Zhao Estradiol and tamoxifen regulate NRF-1 and 233–246 effects of type 2 diabetes Structural determinants regulating cell R23–R32 mitochondrial function in mouse mammary surface targeting of melanocortin receptors gland and uterus A R Rodrigues, D Sousa, H Almeida & Margarita M Ivanova, Brandie N Radde, A M Gouveia Jieun Son, Fabiola F Mehta, Sang-Hyuk Chung & Astrocytes: new targets of melanocortin 4 R33–R50 Carolyn M Klinge endogenous ligand receptor actions Aromatase activity induction in human 247–260 Carla Caruso, Lila Carniglia, Daniela Durand, adipose fi broblasts by retinoic acids via Teresa N Scimonelli & Mercedes Lasaga retinoic acid receptor α Metabolic endotoxemia: a molecular link R51–R64 Jan Wilde, Maria Erdmann, Michael Mertens, between obesity and cardiovascular risk Gabriele Eiselt & Martin Schmidt In a cross-sectional study in 2570 Ana Luísa Neves, João Coelho, Characterization of the novel duplicated 261–276 Luciana Couto, Adelino Leite-Moreira & PRLR gene at the late-feathering K locus of the G-protein- Roberto Roncon-Albuquerque Jr in Lohmann chickens Guixian Bu, Guian Huang, Hao Fu, Juan Li, VOL RESEARCH Simiao Huang & Yajun Wang JOURNAL OF 51 NO. PKC and ERK mediate GH-stimulated lipolysis 213–224 Heather E Bergan, Jeff rey D Kittilson & subjects, Ittermann et al. showed that Mark A Sheridan 2 MOLECULAR coupled receptor ENDOCRINOLOGY MOLECULES, CELLS AND MECHANISMS (APJ), has multiple females with type 2 diabetes mellitus protective functions (T2DM) receiving anti-diabetic published by www.bioscientifica.com bioscientifi ca 0952-5041(201310)51:2;1-R medication other than metformin had JME_51_2_Cover.indd 1 9/17/13 7:57:16 PM in cardiovascular homeostasis and metabolism. a larger thyroid volume than females Here, Jiang et al. have found that without T2DM, whereas no such aldosterone is a negative regulator association was detected in males. of apelin production in vivo and in In females or males treated with adipocytes. This effect was reversed by metformin, T2DM was not associated glucocorticoid receptor (GR) antagonists with thyroid volume or goitre. or GR knockdown. Moreover, both In longitudinal analyses in 1088 glucocorticoids and mineralocorticoids subjects, they found that incident regulated apelin expression through GR T2DM not treated with metformin activation. This supports the existence was significantly associated with of crosstalk between adipose tissue and a higher risk for incident goitre in the adrenal cortex. These mechanisms the total population. This inhibitory effect of metformin on prevalent and may be involved in the pathophysiology J A Romijn incident goitre add to the benefits of of hyperaldosteronism and/or the Editor-in-Chief of European Journal of its use in T2DM. cardiometabolic syndrome associated Endocrinology, Department of Medicine, with hyperaldosteronism. Read the full article in European Journal Academic Medical Center, of Endocrinology 169 9–15 Read the full article in Journal of Molecular University of Amsterdam, The Netherlands Endocrinology 51 37–48 [email protected]

08 European Society of Endocrinology - the European hormone society EuropeanSocietyofEndocrinology Feature Article So, what have YOU been reading? Statistics regarding the medical literature are astonishing, with more than 22 million citations of publications in Medline. A conservative estimate is that 6% of these are related to endocrinology. The romantic notion that knowledge might be gained passively by attending some seminars and incidental journal subscriptions has thus dissipated.

The modern clinician and scientist have clinical and translational endocrinology. insulin aspart (IDegAsp), a soluble co- to navigate this gruesome avalanche to Reviews are accessed much more often formulation of insulin degludec (70%) collect and apply up-to-date knowledge than original studies. Apparently, there is a and insulin aspart (IAsp; 30%), with an in patient care and research. Nonetheless, high need for accumulation of integrated alternative IDegAsp formulation (AF; irrespective of the available literature, knowledge, which enables the readership containing 45% IAsp) and biphasic IAsp major questions remain in many areas of to put the contributions of many 30 (BIAsp 30). IDegAsp provided overall clinical endocrinology. individual original studies into perspective glycaemic control which was comparable in a cohesive way. with BIAsp 30, with a significantly lower The way we are reading has changed. rate of hypoglycaemia. Instead of using hard copies of journals Similarly, Table 2 shows the top and going to the library, we now downloaded clinical studies published in The study by Jakob et al. documents the download manuscripts, browse journals EJE in the same period. These manuscripts prolonged beneficial effects of 18 months and/or use PubMed. Consequently, provide important information on subjects of teriparatide treatment on incidences the number of downloads of articles that are clinically very relevant. of fractures, back pain and quality of life has far exceeded the number of formal in postmenopausal women with prior The study by Jejum et al. compared the subscriptions to journals. These high bisphosphonate therapy. new criteria for diagnosing gestational download scores may reflect a different, diabetes mellitus (GDM) proposed by the So, we encourage you to submit your best unappreciated, parameter from the International Association of Diabetes and clinical research and reviews to EJE. This citation scores, because the profile of the Pregnancy Study Groups (IADPSG) with will further inspire the global readers of readership who downloads manuscripts those of WHO. The new criteria identified ESE’s official clinical journal. must be quite different from that of 2.4 times more subjects with GDM, scientists who cite publications. Johannes (Hans) A Romijn especially of South Asian origin. Editor-in-Chief, These comments all hold true for European The study by Niskanen et al. compared European Journal of Endocrinology Journal of Endocrinology (EJE). With its truly the efficacy and safety of insulin degludec/ global readership, we have observed an upward trend in article downloads over the past few years. All articles are posted TABLE 1: Top review articles Author(s) and citation Downloads online within 24 hours of acceptance, and Heart failure and thyroid dysfunction Biondi (167 609-618) 1993 are accessible by ESE members and journal Insulin initiation in patients with type 2 diabetes mellitus: Vaag & Lund 1846 treatment guidelines, clinical evidence and patterns of use of basal (166 159-170) subscribers. Reviews are freely available vs premixed insulin analogues online to all immediately; original articles Insulin and type 1 diabetes: immune connections Culina et al. 1794 are freely available to all after 12 months, (168 R19-R31) or immediately if the authors choose the Vitamin D and fertility: a systematic review Lerchbaum & Obermayer- 1740 open access option. Pietsch (166 765-778) Approach to the patient with advanced differentiated thyroid Schlumberger & Sherman 1609 EJE’s growing influence as a global cancer (166 5-11) publication is reflected by the increase in submitted and published manuscripts TABLE 2: Top research papers Author(s) and citation Downloads from countries outside Europe. In line Impact of ethnicity on gestational diabetes identified with the Jenum et al. 591 with this, we have recently welcomed WHO and the modified International Association of Diabetes and (166 317-324) experts from these regions to the Editorial Pregnancy Study Groups criteria: a population-based cohort study Board: Cesar Bogusewski (Brazil), Ken Ho Comparison of a soluble co-formulation of insulin degludec/ Niskanen et al. 441 insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: a (167 287-294) (Australia), Andre Lacroix (Canada) and randomised trial Zhengpei Zeng (China). Effects of teriparatide in postmenopausal women with Jakob et al. 409 osteoporosis pre-treated with bisphosphonates: 36-month results (166 87-97) Table 1 shows the most frequently from the European Forsteo Observational Study downloaded review articles published Proteomic profiling of follicular and papillary thyroid tumors Sofiadiset al. 349 in EJE since January 2012 (based on (166 657-667) downloads in the first 3 months after Confirmatory testing in primary aldosteronism: extensive Solar et al. 344 publication). They cover many topics from medication switching is not needed in all patients (166 679-686)

ESEndocrinology European Society of Endocrinology - the European hormone society 09 The Endo Explorer

roughly 30 000 clinical annotations and more than 6500 biosamples. This platform serves as a hub for a number of associated clinical and biomarker studies which have received national and European funding. In one translational research approach, surgical tumour samples were used to establish individualised tumour models to study therapeutic efficacy of liposomal therapies in adrenocortical cancer. In the study of primary aldosteronism, The the European network recently enabled my group to identify, by exome analysis, Endo genes involved in the pathogenesis of aldosterone-producing adenomas. In future, these investigations might lead Explorer to personalised treatment decisions and identification of biomarkers with diagnostic or therapeutic relevance. Munich, known for its festivities, beer and beauty, is also As endocrinologists and clinicians, we aim renowned for biomedical studies, pursued at two universities to gain insights into mechanisms relevant and several large research facilities. Within this unique to disease, which in the long term should environment, endocrine research continues to flourish. translate into improvement of clinical care after testing in clinical studies. My group is located at the University expression profiling and genetic studies Clinic of the Ludwig Maximilian are performed on a variety of patients’ Felix Beuschlein University. One of the Endocrine Research tumour samples, and correlated with Klinikum der Universität München Department’s main areas of scientific clinical data and outcome measures. [email protected] study is unravelling the mechanisms Of particular importance for these involved in regulating growth and translational approaches have been differentiation of the adrenal cortex: clinical registries and associated biobanks. during development, during adaptation In addition to national initiatives, in the adult and in relation to European networks are instrumental adrenal tumorigenesis and endocrine when it comes to rare disorders that are autonomy. General concepts of relevance not encountered in single institutions. to adrenal tumours are further assessed in other endocrine tumour entities using One prime example of European appropriate in vitro and in vivo models. A collaboration is the European Network further focus of research is investigation for the Study of Adrenal Tumours of the relationship between adipocyte (ENSAT; www.ensat.org) which tissue and endocrine systems, which are focuses on adrenocortical cancer, explored in cellular and animal models. phaeochromocytomas, primary aldosteronism and adrenal Cushing’s Complementary to this model-based syndrome. The registry currently research, molecular characterisation, combines more than 4500 cases,

Tunisian We recently became affiliated to the to organise a postgraduate course Endocrine Society International and European Societies of during the 10th Maghreb Meeting of Endocrinology, and are also a member of Endocrinology in Hammamet, Tunisia, The Société Tunisienne d’Endocrinologie, the Maghreb Federation, which includes in November 2013. Diabète et Maladies Metaboliques the Algerian and Moroccan endocrine Our areas of greatest current interest (STEDIAM) has promoted endocrinology and diabetology societies. Since 2003, include diabetes, metabolic syndrome in Tunisia since 1991. It has 159 clinician the Federation has organised the Annual and thyroid, adrenal, gonadal, pituitary endocrinologist members (researchers, Maghreb Meeting of Endocrinology. and parathyroid diseases. teachers and clinical practitioners) and The Society also publishes the Maghreb associate members from other related For more information, see Journal of Endocrinology, Diabetes and disciplines. www.endocrinologie.org.tn. Reproduction. STEDIAM organises three annual events: Insaf Hadj Ali STEDIAM is involved in postgraduate the National Congress in Tunis each April, Vice-President courses and national guidelines. We and meetings in the Kerkennah Islands have recently collaborated with ESE each June, and Sousse each December.

10 European Society of Endocrinology - the European hormone society EuropeanSocietyofEndocrinology A Day in the Life of...

A Day in the life of... An endocrine nurse 05.45 Our 11-month-old daughter wakes us up; I walk to her room half-asleep and receive a big smile and lots of clapping. I leave the house at 06.45 and run to catch the train to London (this will probably be all my exercise today).

07.45 13.00 I arrive in the office and have some time for a coffee and to go It is our monthly departmental meeting where we discuss through my emails before clinic. internal affairs, service development and clinical governance issues (lunch included – yes!). 08.30 14.30 It’s a general endocrine nurse-led clinic today, with a mixture of pituitary, fertility and hypogonadism cases. The first patient is a Now I’m back at my desk to deal with admin tasks and to 25-year-old man who was seen recently by our consultant and answer several patient calls/queries. I am also reviewing the his karyotype revealed Klinefelter’s syndrome. So, I am to break nursing abstracts for ECE 2013 and am impressed by the the news and initiate his treatment. He was in tears when he standard of work submitted; I cannot wait to see the posters. heard the results, but says it is a relief to finally find out what is wrong. I give him time to digest the diagnosis before we plan 16.30 his treatment and follow-up. On the train home, I’m fast asleep; a 40-minute snooze is great to recharge my batteries. I knew this would be a long consultation and allowed extra time, something I did not anticipate for my next patient, who 18.00 was referred for growth hormone (GH) adjustment following I dress Elise in her new outfit (she is so pretty!) and we pick up a low IGF1 measurement. I soon realise that adherence to GH my husband from the station to go to our favourite restaurant – is the least of her worries; she has recently lost her job and her a great ending to a busy week. partner has left her. Alarm bells start ringing when she says she ‘...didn’t see a point in carrying on!’ and the 20-minute slot 20.30 becomes a 1-hour consultation. Nursing is about providing While I watch Elise sleeping like an angel, I take a moment to holistic care after all. remind myself how fortunate I am; I have the perfect family and job. There is nothing more I would ever want from life! Unfortunately, that means my next patient is 45 minutes late Well, actually yes! I want world peace, no poverty and health and my apology is met by a lengthy complaint. I decide it is and happiness for every child on earth, but this is another story, best to wait for him to finish (I don’t have much choice!) before perhaps for another newsletter... we proceed. He is starting gonadotrophins for spermatogenesis. I give him a prescription, and explain what the treatment Sofia Llahana entails and how to take his injections. The student nurse Consultant Nurse in Endocrinology shadowing me says that I handled the situation well; I must Independent Nurse Prescriber have done as the patient later emails me to thank me for the University College Hospital, detailed information and to apologise for losing his temper. London, UK [email protected] With a patient not attending and the other five being straightforward consultations, I manage to finish clinic just in Sofia Llahana is the Chair of time, albeit severely dehydrated! the newly formed ESE Endocrine Nurses’ Working Group. For 12.30 more information and to I grab a glass of water and a biscuit to keep me going and head participate in the ESE Endocrine off to meet Professor Baillie to discuss a grant application for a Nurses’ Network visit nursing project; let’s hope we will be successful this time. We www.ese-hormones.org/nurse. failed another bid in the last round – so close!

ESEndocrinology European Society of Endocrinology - the European hormone society 11 Coffee Break

Send us your solutions to this topical puzzle for your chance WIN! to win one of three €20 Amazon vouchers! Let us have your Save the Dates! answers, along with your name and email address, by emailing WIN! them to [email protected] or faxing them to 0044 1454 For more information about any ESE event 642222. The first three correctly completed puzzles that we see www.ese-hormones.org/meetings. receive will win the prizes! WIN! 5th ESE Clinical Update 1 2 3 4 Congratulations to 10–11 January 2014 Margherita Baccini Abu Dhabi, UAE (Italy), Daniel Kelly 5 6 7 (UK) and Milena ESE Basic Endocrinology 8 Lackovic (Serbia), last Course

9 10 issue’s winners. 15–17 January 2014 Amsterdam, The Netherlands

11 14th ESE Postgraduate Training Course in Clinical Answers to the puzzle Endocrinology 12 13 14 in issue 21 ACROSS 1. Salt-wasting, 10–12 April 2014 15 6. Pepsin, 7. Eat, Vilnius, Lithuania 8. Drug, 9. Inherit, 16 10. Melatonin, 11. Bile, 17 12. Systole DOWN 1. Sleep, 2. Leptin, 3. Resveratrol, 18 19 4. Vandetanib, 5. Nodule, 10. MODY

16th European Congress Endo Prize Puzzle of Endocrinology Extra challenge: The letters in the yellow squares must be rearranged to give the 3–7 May 2014 answer to the following clue: An author needs to declare this! (8,2,8) Wrocław, Poland Across Down 1 Research summary (8) 2 Heading – what’s it all about? (5) 17th European Congress of 3 Pictorial representation of results (5) 4 Unedited version of paper published Endocrinology (ECE 2015) 6 Intellectual ______– yours or the immediately on acceptance (8) 16–20 May 2015 journal’s? (8) 5 Journal ‘score’ (6,6) Dublin, Ireland 7 A colleague, your equal (4) 6 Similar gap (anagram) – copy! (10) 9 Store for past documents (7) 8 Correspondence – the first journals were 11 Background information – follows 1 across collections of these (6) in most papers (12) 10 Recognition of published work (8) Deadlines: 12 He/she to whom research correspondence 13 Punctuation mark: # (4) 13 Jan 2014 is often addressed (5,6) 14 Decline to publish – 12 across will be ECE 2014 – Abstract submission deadline 17 Publishing ____ – e.g. Bioscientifica, Wiley, disappointed (6) Macmillan (5) 15 A scientific report, and the material it’s 28 Feb 2014 18 An expert who checks submissions for printed on... (5) Geoffrey Harris Prize 2015 and accuracy (8) 16 The price charged to view Open Access European Journal of Endocrinology 19 A journal’s decision-maker (6) articles (4) Prize 2015 – Nominations 10 Mar 2014 Did you know? ECE 2014 – Early bird registration

Where art meets osteoporosis Follow ESE online for What is the relationship between the French art the latest news and world and new drugs against osteoporosis? developments: Henri Marie Raymond de Toulouse-Lautrec-Monfa (1864–1901), also known as ‘Toulouse Lautrec’, Follow ESE on Facebook: probably suffered from pycnodysostosis. This inborn www.facebook.com/ error of bone matrix degradation results from the EuropeanSocietyofEndocrinology deficient activity of a protease, cathepsin K, in the osteoclasts. Cathpepsin K plays an important role in Follow ESE on Twitter: mediating bone resorption by degrading collagen www.twitter.com/ESEndocrinology types I and II. Cathepsin K inhibitors, such as odanacatib, show great potential in the treatment www.ese-hormones.org of osteoporosis.