SCARB1 (CD36 AND LIMPII ANALOGOUS 1, CD36, CD36 Antigen like 1, CD36 Antigen-like 1, CD36L1, CLA 1, CLA-1, CLA1, Collagen Type I Receptor, MGC138242, SCARB1, Scavebger Receptor Class B Member 1, Scavenger Receptor class B Member 1, Scavenger Receptor Class B Type 1, SCRB1, SR BI, SR-BI, SRB1, SRBI, Thrombospondin Receptor like 1, thrombospondin Receptor-like 1)

Catalog number 225689 Supplier United States Biological

The macrophage class A scavenger receptors (SR-A) type I and II mediate the uptake of modified low density (LDL), while the scavenger receptor class B type 1 (SR-B1) mediates the selective uptake of and cholesterol esters (CE) from HDLs into cells. SREC, Ox-LDL-R1, SR-A and SR- B1 may all be involved in the early development of . SR-B1, an integral membrane , acts as a receptor for various ligands, including apoptotic cells, cholesterol ester, phospholipids, and phosphatidyl-serine. SR-B1, which may be involved in phagocytosis of apoptotic cells, enables the movement of cholesterol between the cell surface and extracellular donors and acceptors. Although it is widely expressed, SR-B1 localizes primarily to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. Applications Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested. Recommended Dilution Western Blot: 1:500-1:2000 Immunohistochemistry: 1:50-1:200 Optimal dilutions to be determined by the researcher. Storage and Stability May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Immunogen Recombinant full length Human SCARB1. Formulation Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol. Purity Purified by immunoaffinity chromatography. Specificity Recognizes endogenous levels of SCARB1. Species Crossreactivity: Human, mouse, rat Product Type Pab Source human Isotype IgG Grade Affinity Purified Applications IHC WB Crossreactivity Hu Mo Rt Storage -20°C MW 61

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