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Science That Makes an Impact the Stories Behind Some of Our Innovations Science that makes an impact The stories behind some of our innovations EDITION 5 | JULY 2021 CONTENTS INTRODUCTION 2 THE FOREFATHERS OF 15 A PASSIVE REVOLUTION IN 27 20 MILLION TESTS A MONTH TO 36 PESTICIDE TESTING WATER SAMPLING HELP PROTECT THE WORLD AGAINST PROTECTING TRANSPLANT PATIENTS 3 First multi-pesticide detection From spot-checking to continuous COVID-19 AND SAVING LIVES method in Europe environmental monitoring Innovation and action during a Immunity at the heart of the matter global pandemic 30 YEARS OF DATA FOR LIFE 16 ALGAE, ALGAE, EVERYWHERE – 28 TACKLING GLOBAL 4 Building rich databases before Big Data TOXIC AND WHAT A STINK PROTECTING CROPS AND HUMAN 39 ANTIBIOTIC RESISTANCE First rapid test for cyanobacteria HEALTH AT THE SAME TIME Testing for multiple resistance genes FINDING ADULTERATION EVEN 18 toxins in water bodies Developing the first test kit to WHEN NOT LOOKING FOR IT detect glyphosate BUSTING THE IDENTICAL TWIN MYTH 5 Leading the way with non-targeted screening SOLVING OLD CRIMES 29 Milestone research proves genetic differences WITH NEW TECHNOLOGY WHAT DO PIZZA BOXES, 40 MODERN FARMING IS 20 NEW GENERATION OF NON-INVASIVE 6 Eurofins’ new DNA software heats up RAINCOATS AND FRYING PANS PRECISION FARMING cold cases HAVE IN COMMON? PRENATAL TESTING METHODS Farming and herd improvement Breakthrough genetic disorder determination Detecting PFAS in the everyday products testing – in six seconds LEADING THE WORLD IN 30 and our environment SNIF-NMR® – HOW IT ALL BEGAN 7 GM FISH DETECTION BEATING DRUG-ASSISTED 21 Fast, reliable testing for PROTECTING CANCER PATIENTS 42 Authenticity and origin testing to RAPE – FORENSICALLY protect our food and drink genetically modified fish Identifying high-risk patients Identifying knock-out drugs in hair following stem cell transplant THE FUTURE OF BEES 8 NOT WANTED! DEAD OR ALIVE! 31 HIGH-FLYING INNOVATION 22 MOULD AND BACTERIA SEEKING OUT A SILENT KILLER 43 THE FUTURE OF LIFE Unconventional inspiration for Breakthrough science for supporting Eurofins’ new molecular methods Developing the first test to identify Radon DNA synthesis enhance mould analysis better bee health ENSURING LIQUID GOLD IS THE 44 TESTING FOR TAILORED 23 FUELLING THE FIRST ASTRONAUTS 32 REAL DEAL HELPING TO STOP ZIKA IN ITS TRACKS 10 CANCER TREATMENT Rapid real-time Zika test results Fortifying food for space A unique method for fraud detection Empowering cancer research in honey A PIONEER IN DIOXINS DETECTION 11 through innovation TACKLING THE BIG PROBLEM OF 33 TINY PARTICLES DETECTING A SILENT THREAT – 46 Detecting one part out of 1,000 billion NURTURING CELLS TO GROW 24 is not the limit Making microplastic testing TRANSPLANT REJECTION Culture media monitoring commercially available Optimising outcomes for ACRYLAMIDE ON THE 12 with Spedia-NMR™ kidney transplant patients SAFEGUARDING THE HEALTH OF 34 TIP OF EVERYONE’S TONGUE OUT OF THE BOX PRODUCT TESTING 25 First to detect acrylamide in food THE WORLD’S MOST VULNERABLE BIBLIOGRAPHY 48 When nothing is available, CONSUMERS – INFANTS TESTING FOR TRACEABILITY OF 14 build your own robot Setting the new standard in MEAT FROM FARM TO FORK DOWN INVENTING THE MOST SENSITIVE 26 infant formula testing TO INDIVIDUAL ANIMALS HEAVY METALS DETECTION METHOD Clarity and confidence for the food chain Testing for safety in soil, water, food and pharmaceuticals EUROFINS | TESTING FOR LIFE 1 EUROFINS LABORATORIES HAVE REGULARLY BEEN THE FIRST IN THE WORLD TO DEVELOP NEW TESTING TECHNOLOGIES THAT HAVE HAD AN IMPACT ON LIFE OVER 30 YEARS 900 LABORATORIES 55,000 EMPLOYEES 33 MILLION TESTS PERFORMED EVERY MONTH. WE’RE HERE TO KEEP OUR WORLD SAFE. Since its foundation in 1987, Eurofins has The complexity of our analyses, often searching contributed significantly to the advancement of for the minutest traces of a substance, mean our science in testing for life. We are proud of the activities in these areas necessarily sometimes discoveries and advancements our specialists have take years of painstaking research and ongoing made in myriad sectors, ranging from food to improvements of our numerous methods. In other pharma to forensics testing. areas, we have responded overnight to global health crises. Our laboratories around the world are helping to improve cancer treatments, fight the growing Wherever we are and however long it may take, problem of antibiotic resistance, catch criminals, our work helps to make life safer. safeguard the health of bees, ensure our food and water is safe, determine paternity, and beat viruses This booklet presents a mere fraction of the like COVID-19. Underpinning our work in these areas hundreds of stories from across our activities about and more, Eurofins has one of the world’s largest our scientists’ great work to push the frontiers of and most varied databases, rich with fingerprints of Testing for Life. thousands upon thousands of foodstuffs and drugs. 2 EUROFINS | TESTING FOR LIFE CLINICAL DIAGNOSTICS | TRANSPLANTATION Surgeons worldwide perform more than 100,000 solid organ transplants annually, with successful transplantation of hearts, lungs, livers and kidneys, saving and changing PROTECTING TRANSPLANT PATIENTS AND thousands of lives. After complex surgery, the risks of infection and organ rejection mean the patient’s fight for recovery starts immediately; even anti-rejection medication SAVING can lead to serious adverse effects. Eurofins’ work in immunity is helping to change patient recovery outcomes. LIVES Immunity at the heart of the matter the science behind Adverse reactions that can hamper patients helped decrease bacterial and ImmuKnow® is an immune cell patient recovery are managed by fungal infections, particularly in the function assay that detects understanding the exact state of a critical two-week post-surgery period. cell-mediated immunity in an patient’s immune cell function and It also reduced immunosuppressant immunosuppressed population using that knowledge to balance the drug use and improved patient by measuring the concentration immune system. Experts at Eurofins survival by 13% in the first year post- of adenosine triphosphate (ATP) Viracor developed ImmuKnow® assay, transplant. ImmuKnow® is cleared synthesis from CD4 cells following a test that provides a biomarker to for use by the US Food and Drug stimulation. The technology help doctors to evaluate a patient’s Administration. combines cell stimulation, cell existing immunity levels and to selection, and quantification of optimise treatment. Eurofins Viracor has developed metabolic markers (ATP) to measure additional, innovative tests with fast, cell-mediated immunity. Since In 2015, a study published in accurate results to help surgeons care the CD4 lymphocytes orchestrate Transplantation showed that Viracor’s for their transplant patients. It now cell-mediated immunity responses assay improves outcomes in solid organ works with approximately 60% of US through immunoregulatory transplant patients. The study showed transplant programmes and has earned signalling, the measurement of CD4 that not only was ImmuKnow® able to its leading position in the field. activation reflects the degree of detect the level of immunity provided immune function. by cells in immunosuppressed patients, Eurofins is deeply committed to but it ultimately improved patient contributing positively to global For references, please see bibliography survival rates by helping to optimise health. With technological and medical immunosuppression. This benefit is advances leading to continual increases critical when balancing the risk of in the number of transplant operations organ rejection caused by insufficient occurring worldwide, Eurofins is Disclaimer: ImmuKnow® is FDA suppression and the risk of infection focused on the development of further cleared for the following Intended Use: caused by excessive suppression. specialised and fast-turnaround tests Detection of cell-mediated immune response in populations undergoing that will play an important role in immunosuppressive therapy for organ The study also showed that using patient outcomes. transplant. Product Insert 2015. Eurofins ImmuKnow® in solid organ transplant Viracor, Inc., Lee’s Summit, MO. EUROFINS | TESTING FOR LIFE 3 CLINICAL DIAGNOSTICS | ANTIBIOTIC RESISTANCE SCREENING TACKLING GLOBAL ANTIBIOTIC RESISTANCE Testing for multiple resistance genes the science behind The ABRx™ Antibiotic Resistance Panel allows the molecular identification of antibiotic- resistant genes in patient samples. It is focused on the detection of 17 gene types, within seven gene Since the accidental discovery of penicillin by The CDC (Centres for Disease Control) of the most commonly prescribed classes which are associated with reports that each year, more than antibiotics. resistance to three major groups Alexander Fleming in 1928, the world’s reliance two million people in the US alone of antibiotics (ß-lactams like on antibiotics has increased dramatically. become infected with bacteria that With specimens taken directly from penicillins, cephalosporins and are resistant to many antibiotics, the patient, the ABRx™ Antibiotic carbapenems, fluoroquinolones, Yet overuse and misuse across the world has and attributes at least 23,000 deaths Resistance Panel provides rapid- and macrolides). Offering the seen antibiotics become ineffective against to these infections. Even the World response results within one day. direct detection of clinical samples, Health Organization has warned that It also offers doctors and pharmacists without the requirement
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