Sensation and Perception
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Original Article the Acute E€Ects of Continuous and Conditional
Spinal Cord (2001) 39, 420 ± 428 ã 2001 International Medical Society of Paraplegia All rights reserved 1362 ± 4393/01 $15.00 www.nature.com/sc Original Article The acute eects of continuous and conditional neuromodulation on the bladder in spinal cord injury APS Kirkham*,1, NC Shah1, SL Knight1, PJR Shah1 and MD Craggs1 1Neuroprostheses Research Centre, Royal National Orthopaedic Hospital, Stanmore, Middlesex HA7 4LP, UK Study design: Laboratory investigation using serial slow-®ll cystometrograms. Objectives: To examine the acute eects of dierent modes of dorsal penile nerve stimulation on detrusor hyperre¯exia, bladder capacity and bladder compliance in spinal cord injury (SCI). Setting: Spinal Injuries Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK. Methods: Fourteen SCI patients were examined. Microtip transducer catheters enabled continuous measurement of anal sphincter, urethral sphincter and intravesical pressures. Control cystometrograms were followed by stimulation of the dorsal penile nerve at 15 Hz, 200 ms pulse width and amplitude equal to twice that which produced a pudendo-anal re¯ex. Stimulation was either continuous or in bursts of one minute triggered by a rise in detrusor pressure of 10 cm water (conditional). Further control cystometrograms were then performed to examine the residual eects of stimulation. Results: Bladder capacity increased signi®cantly during three initial control ®lls. Continuous stimulation (n=6) signi®cantly increased bladder capacity by a mean of 110% (+Standard Deviation 85%) or 173 ml (+146 ml), and bladder compliance by a mean of 53% (+31%). Conditional stimulation in a dierent group of patients (n=6) signi®cantly increased bladder capacity, by 144% (+127%) or 230 ml (+143 ml). -
BJCP Mead Exam Study Guide
BJCP Mead Exam Study Guide What you need to know to pass the Mead Exam September 2009 Initial release: September 22, 2009 Contributing Authors Gordon Strong Susan Ruud Kristen England Ken Schramm Curt Stock Petar Bakulić Michael Zapolski, Sr. (Hightest) Copyright © 2009 by the authors and the BJCP TABLE OF CONTENTS 1. Introduction............................................................................................................................. 1 1.1. Recommended Reading.................................................................................................. 1 1.2. Advanced Reading.......................................................................................................... 3 1.3. Important BJCP References............................................................................................ 3 2. The BJCP Mead Exam............................................................................................................ 4 2.1. Mead Exam Details......................................................................................................... 4 2.1.1. Written Section..................................................................................................... 4 2.1.2. Tasting Section..................................................................................................... 5 2.2. BJCP Mead Judge Question Pool ................................................................................... 5 2.2.1. Section 1.............................................................................................................. -
Taste and Smell Laboratory Experiments Activity 1
Name ___________________ Per._____________________ Taste and Smell Laboratory Experiments Activity 1 : Use a mirror to examine your tongue. Describe the location and structure of the three types of papillae. Papillae Location Observation of structure circumvallate filiform fungiform Activity 2: Stimulating your taste buds. 1. Dry the superior surface of your tongue with a paper towel. 2. Place a few sugar crystals on your dried tongue. Do not close your mouth. 3. Time how long it takes to taste the sugar. ____________ sec. 4. Why couldn’t you taste the sugar immediately? Activity 3: Plotting taste bud distribution. 1. Prepare to make a taste sensation map of your lab partner’s tongue by obtaining the following: cotton-tipped swabs, salt solution, bitter solution, sweet solution and sour solution. 2. Before each test, the subject should rinse his or her mouth thoroughly with water and lightly dry his or her mouth with paper towel. 3. Generously moisten a swab with the sweet solution and touch it to the center, back, tip, and sides of the dorsal surface of the subject’s tongue. 4. Map, with O’s on the tongue outline below, the location of the sweet receptors. 5. Using a fresh swab in each case, repeat the procedure with the other solutions. Use a “B” to map location the bitter receptors, a “+” to map the salt receptors and a “–“ to map the sour receptors. 6. What area of the tongue seems to lack receptors? _________________________________ Tongue Map Activity 4: Examining the combined effects of smell and texture on taste. 1. Ask the subject to sit with eyes closed and to pinch his or her nostrils shut. -
A Proposed Neural Pathway for Vocalization in South African Clawed Frogs, Xenopus Laevis
Journal of J Comp Physiol A (1985) 157:749-761 Sensory, Comparative and.ou~,, Physiology A Physiology~h.v,or* Springer-Verlag 1985 A proposed neural pathway for vocalization in South African clawed frogs, Xenopus laevis Daniel M. Wetzel*, Ursula L. Haerter*, and Darcy B. Kelley** Program in Neuroscience, Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA, and Department of Biological Sciences, Columbia University, New York, New York 10027, USA Accepted September 9, 1985 Summary. 1. Vocalizations of South African 3. Injection of HRP-WGA into DTAM re- clawed frogs are produced by contractions of la- sulted in labelled cells in the striatum, preoptic area ryngeal muscles innervated by motor neurons of and thalamus. Posterior to DTAM, labelled cells the caudal medulla (within cranial nerve nucleus were found in the rhombencephalic reticular nuclei IX-X). We have traced afferents to laryngeal mo- as well as n. IX-X of males. Results in females tor neurons in male and female frogs using retro- were similar with the exception that n. IX-X la- grade axonal transport of horseradish peroxidase belled cells were only seen after very large injec- conjugated to wheat germ agglutinin (HRP- tions of unconjugated HRP into DTAM and sur- WGA). rounding tegmentum. Thus, the projection of n. 2. After iontophoretic injection of HRP-WGA IX-X neurons to DTAM is not as robust in fe- into n. IX-X, retrogradely labelled neurons were males as males. seen in the contralateral n. IX-X, in rhombence- 4. These anatomical studies revealed candidate phalic reticular nuclei, and in the pre-trigeminal brain nuclei contributing to the generation of vocal nucleus of the dorsal tegmental area (DTAM) of behaviors and confirmed some features of a model both males and females. -
Selective Neural Pathway Targeting Reveals Key Roles of Thalamostriatal Projection in the Control of Visual Discrimination
The Journal of Neuroscience, November 23, 2011 • 31(47):17169–17179 • 17169 Behavioral/Systems/Cognitive Selective Neural Pathway Targeting Reveals Key Roles of Thalamostriatal Projection in the Control of Visual Discrimination Shigeki Kato,1 Masahito Kuramochi,1,2 Kenta Kobayashi,1 Ryoji Fukabori,1 Kana Okada,1,2 Motokazu Uchigashima,3 Masahiko Watanabe,3 Yuji Tsutsui,4 and Kazuto Kobayashi1,2 1Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan, 2Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan, 3Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060-8638, Japan, and 4Faculty of Symbiotic Systems Science, Fukushima University, Fukushima 960-1296, Japan The dorsal striatum receives converging excitatory inputs from diverse brain regions, including the cerebral cortex and the intralaminar/ midline thalamic nuclei, and mediates learning processes contributing to instrumental motor actions. However, the roles of each striatal input pathway in these learning processes remain uncertain. We developed a novel strategy to target specific neural pathways and applied this strategy for studying behavioral roles of the pathway originating from the parafascicular nucleus (PF) and projecting to the dorso- lateral striatum. A highly efficient retrograde gene transfer vector encoding the recombinant immunotoxin (IT) receptor was injected into the dorsolateral striatum in mice to express the receptor in neurons innervating the striatum. IT treatment into the PF of the vector-injected animals caused a selective elimination of neurons of the PF-derived thalamostriatal pathway. The elimination of this pathway impaired the response selection accuracy and delayed the motor response in the acquisition of a visual cue-dependent discrim- ination task. -
Loss of Taste Is Very Common After HCT: Taste in Wine Is Very Important
Bone Marrow Transplantation (2020) 55:995–996 https://doi.org/10.1038/s41409-019-0775-y EDITORIAL Loss of taste is very common after HCT: taste in wine is very important. Shaun R. McCann1 Received: 24 November 2019 / Revised: 26 November 2019 / Accepted: 3 December 2019 / Published online: 17 December 2019 © Springer Nature Limited 2019 ‘The first taste of a wine is like the first kiss; you look Of course, taste and smell are intimately related [4] forward to the second’. and smelling a wine cork or a small sample of wine, Andre Tcelistcheff. American winemaker. 1901–1994 without swilling, to detect contamination with TCA (2,4,6—Trichloroanisole) is paramount (Fig. 1). We are all Tchelistcheff’s words remind me of the lyrics ‘… a kiss is familiar with the tongue map wherein certain areas of the just a kiss…’ from the song ‘As Time Goes by’ written by tongue were believed to detect certain tastes, (sweetness, Herman Hupfeld in 1931 and made famous in the film sourness, bitterness and saltiness), with bitterness at the 1234567890();,: 1234567890();,: ‘Casablanca’ in 1942 sung by Sam (played by the American back, sourness and saltiness at the sides and sweetness at actor, singer and musician Arthur ‘Dooley’ Wilson) in the tip (Fig. 2). You can add ‘umami’ to this list a word Rick’s Café. derived from Japanese that refers to detection of a savoury Most physicians who look after patients who have taste (yes, I only learnt this word when researching this received a haematopoietic cell transplant (HCT) are not particularly concerned with dysgeusia (a distortion of the sense of taste). -
Central Neurocircuits Regulating Food Intake in Response to Gut Inputs—Preclinical Evidence
nutrients Review Central Neurocircuits Regulating Food Intake in Response to Gut Inputs—Preclinical Evidence Kirsteen N. Browning * and Kaitlin E. Carson Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA 17033, USA; [email protected] * Correspondence: [email protected]; Tel.: +1-717-531-8267 Abstract: The regulation of energy balance requires the complex integration of homeostatic and hedonic pathways, but sensory inputs from the gastrointestinal (GI) tract are increasingly recognized as playing critical roles. The stomach and small intestine relay sensory information to the central nervous system (CNS) via the sensory afferent vagus nerve. This vast volume of complex sensory information is received by neurons of the nucleus of the tractus solitarius (NTS) and is integrated with responses to circulating factors as well as descending inputs from the brainstem, midbrain, and forebrain nuclei involved in autonomic regulation. The integrated signal is relayed to the adjacent dorsal motor nucleus of the vagus (DMV), which supplies the motor output response via the efferent vagus nerve to regulate and modulate gastric motility, tone, secretion, and emptying, as well as intestinal motility and transit; the precise coordination of these responses is essential for the control of meal size, meal termination, and nutrient absorption. The interconnectivity of the NTS implies that many other CNS areas are capable of modulating vagal efferent output, emphasized by the many CNS disorders associated with dysregulated GI functions including feeding. This review will summarize the role of major CNS centers to gut-related inputs in the regulation of gastric function Citation: Browning, K.N.; Carson, with specific reference to the regulation of food intake. -
Oral Sensation
Oral sensation Beata Keremi DMD, PhD Department of Oral Biology General sensation in the oral cavity Protopathic: – touch A beta and A delta fibers – pressure (II and III types sensory neurons) – temperature – pain Epicritic: – stereognosia: detect the shape of objects General sensation in the oral cavity http://joecicinelli.com/homunculus-training/ Temperature sensation mucous membranes – very sensitive protective mechanism receptors are bare nerve endings – cold receptor - below a threshold – hot receptor - above a threshold – skin temperature receptor - around 25ºC - same on the lips – maximum tolerable temperature: 70-80 ºC A delta and C fibers – relatively slow (III or IV types sensory neurons) Pressure sensation teeth are sensitive – axially and laterally applied pressure – receptors in the periodontal ligaments end-organs of the Ruffini type - A beta nerve fibers – slow adaptation http://faculty.washington.edu/chudler/receptor.html http://people.usd.edu/~cliff/Courses/Behavioral%20Neuroscience/Lordosis/Lordosisfigs/lorsenspics.html excitability depend on the position Proprioception Proprioceptive impulses from: – muscles of the tongue Muscle spindle – masticatory muscles • elevator • depressor - few – temporomandibular joint http://medical-dictionary.thefreedictionary.com/muscle+spindle Neuropeptide - suggesting the presence of nerve endings – joint capsules – synovial discs Taste and smell Nose and mouth are sentinels of chemical world In dysfunction can be an early indicator of serious diseases – Alzheimer’s; Parkinson’s diseases -
The Five Neural Pathways of Memory HU Jian-Feng
5th International Conference on Education, Management, Information and Medicine (EMIM 2015) The five neural pathways of memory HU Jian-feng Institute of Information Technology, Jiangxi University of Technology, Nanchang 330098, China Keywords: Memory; Neuron; Learning; Brain Abstract: All the acquisition of knowledge is a memory, the memory is the foundation of all intellectual activities. Memory is also the basis of education. This paper presents five neural pathways of memory, respectively, based on information, rules, concepts, expectations and integration. These pathways has important significance on the formation and maintain of memory. Understanding these is very helpful to improve education. Introduction Memory is the results of modified synaptic transmission. The most prominent bottleneck to understand the mechanisms of memory is the connection structure of fine synapses. However, we still don't know how to connect the brain nerve, how synaptic connection work between what the specific types of neurons, and how synaptic connections modify. The lack of effective research method is important to explore the mechanism of memory, such as brain imaging device resolution and coverage is a contradiction, high resolution is often limited coverage, large coverage often insufficient resolution. Based on combining the various models of learning and memory, combined with some cases of pathological or genius, this paper proposes five neural pathway of memory. Pathway one: Memory based on information (the basis of information transmission) The input data are some sophisticated audio-visual information, following cognitive learning mechanism, then through neural pathway of audio-visual information processing, finally to realize the access of cognitive information by the area of cortex. -
Pathway-Specific Control of Reward Learning and Its Flexibility Via Selective Dopamine Receptors in the Nucleus Accumbens
Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbens Satoshi Yawata, Takashi Yamaguchi, Teruko Danjo, Takatoshi Hikida1, and Shigetada Nakanishi2 Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan Contributed by Shigetada Nakanishi, June 26, 2012 (sent for review June 6, 2012) In the basal ganglia, inputs from the nucleus accumbens (NAc) are is reversibly blocked in a doxycycline-regulated manner (13–15). transmitted through both direct and indirect pathways and control In this technique, the transmission-blocking tetanus toxin is reward-based learning. In the NAc, dopamine (DA) serves as a key expressed in a pathway-specific and doxycycline-regulated man- neurotransmitter, modulating these two parallel pathways. This ner, thus allowing separate and reversible blockade of neuro- study explored how reward learning and its flexibility are controlled transmission in the direct pathway (D-RNB mice) or the indirect in a pathway-specific and DA receptor-dependent manner. We used pathway (I-RNB mice) in vivo (15, 16). The function of the basal two techniques (i) reversible neurotransmission blocking (RNB), in ganglia circuitry becomes defective only when both sides of the which transmission of the direct (D-RNB) or the indirect pathway basal ganglia circuit are simultaneously impaired in the brain (I-RNB) in the NAc on both sides of the hemispheres was selectively hemispheres (17, 18). We thus extended the RNB technique to blocked by transmission-blocking tetanus toxin; and (ii) asymmetric an asymmetric RNB (aRNB) technique, in which one side of the RNB, in which transmission of the direct (D-aRNB) or the indirect path- basal ganglia circuit is blocked by the RNB technique, and the way (I-aRNB) was unilaterally blocked by RNB techniques and the other intact side is treated with an agonist or antagonist specific intact side of the NAc was infused with DA agonists or antagonists. -
Anatomy and Physiology of the Vestibular System
1/28/2013 Overview Anatomy and Physiology of the Vestibular System J. Douglas Green, Jr, MD Input Central Processing Output Anatomy Vestibular Anatomy • Angular movements stimulate semicircular canals and are primarily important for visual stabilization • Semicircular canals paired with a contralateral semicircular canal (i.e. R Lat SCC with L Lat SCC) • Movement in any plane stimulates on SCC and inhibits corresponding SCC on opposite side • Otolithic labyrinth (utricle and saccule) respond to linear movement and primarily orient with regard to gravity • Static tilt results in continued stimulation 1 1/28/2013 Vestibular Hair Cells Anatomy Semicircular Canals • Stereocilia • Orientation • Kinocilium • Ampulla • Resting firing rate of 90 spikes/sec • Increased firing rate when deflection towards kinocilium Physiology Central Vestibular System Semicircular Canals • Push pull interaction • Sup SCC, Lat SCC, utricle and ant/sup portion • VOR of saccule innervated by Superior Vestibular Nerve • Post SCC and majority of saccule innervated by Inferior Vestibular Nerve • VIII consists of bipolar neurons with cell bodies in Scarpa’s Ganglion in IAC • Vestibular Nuclei in brainstem 2 1/28/2013 Vestibulo‐Ocular Reflex Physiology Otolithic Organs • Stabilizes gaze during active head movements • Otoconia • Absent VOR results in bouncing environment • Resting neural discharge while walking, riding in car or other activities • Linear acceleration (oscillopsia) • Superior Vestibular Nerve synapses in medial and superior vestibular nuclei then on to -
Molecular Gastronomy and Sensory Science
Sensory Science – myth busting Jannie Vestergaard Michael Bom Frøst, PhD Project manager Associate Professor, Director of Studies Taste Skåne Department of Food Science Skåne food Innovation Sensory Science Group Network [email protected] jannie.vestergaard@ livsmedelsakademin.se OVERVIEW • An envelope with unusual content • The senses at work in real life • Matching coffee with foods • Complexity enters the equation – Is really good coffee complex? • Learning to taste – train and be challenged – Tricks of the sensory trade The envelope Taste kit for the lecture 1. Take a piece of chewing gum (the white rectangular piece) Nordic Barista Cup, August 25 2011, Jannie Vestergaard & Michael Bom Frøst 3 THE SENSES AT WORK IN REAL LIFE Three basic properties by sense perception The quality (Qualitas) • Identification • What is the property? • Recognition of objects (= a number of properties) Intensity (magnitude = the size) • How much is there of it? Affective dimension • Affect: The experience of emotion • Is it something I like/don’t like Nordic Barista Cup, August 25 2011, Jannie Vestergaard & Michael Bom Frøst 5 The senses – 5 classic + some less known The remote senses Vision The higher senses Audition Olfaction The lower The near senses senses Gustation The chemical Somesthesis ( ~ sense of touch) senses Pressure Temperature Pain / irritation / chemesthesis Balance Body and joint position Nordic Barista Cup, August 25 2011, Jannie Vestergaard & Michael Bom Frøst 6 Taste – Myth busting : The tongue map The different basic tastes are experienced at different locations in the mouth: Bitter only in the back Tongues on scientific evidence: Take out the chewing gum Apply the filter paper to the tip of your tongue Taste-receptor cells, buds and papillae.