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In addition to the safety findings, the research on xero- gitudinal study. Head Neck 2015;10.1002/hed.24286. stomia yielded an unexpected outcome. There was a signifi- 4. Bassim CW, Fassil H, Mays JW, Edwards D, Baird K, Steinberg SM, Cowen EW, Naik H, Datiles M, Stratton P, Gress RE, Pavletic SZ. Oral cant (P< 0.05) increase in daytime unstimulated salivary flow disease profiles in chronic graft versus host disease. J Dent Res in the two-step oral hygiene group. While the amount was 2015;94:547-554. relatively small (+0.06 mL/5 minute), this represented 5. Singh ML, Papas A. Oral implications of polypharmacy in the elderly. Dent Clin North Am 2014;58:783-796. approximately a 72% increase above the baseline level. The 6. Singh M, Papas AS, Papas AN, Barker ML, Biesbrock A. Prevalence of xerostomia in the study was medication-associated, and in dental carious lesions with different classes of medications. J Gerontol contrast to Sjögren’s syndrome or similar conditions, it may Geriatr Med 2015;1:004 http://www.heraldopenaccess.us/fulltext/Geron be reversible with stimulation.1 The mechanism remains un- tology-&-Geriatric-Medicine/Prevalence-of-Dental-Carious-Lesions-with- Different-Classes-of-Medications.php#tab2 known, and of course, further research is needed to ascertain 7. Villa A, Nordio F, Gohel A. A risk prediction model for xerostomia: A whether this favorable effect on salivation is real and repro- retrospective cohort study. Gerodontology 201;33(4):562-568. ducible, and whether it contributes to other positive health or 8. Pajukoski H, Meurman JH, Halonen P, Sulkava R. Prevalence of subjective dry mouth and burning mouth in hospitalized elderly patients experiential outcomes. What is clear, however, is that use of and outpatients in relation to saliva, medication, and systemic diseases. stannous fluoride followed by hydrogen peroxide did not limit Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92:641-649. salivary flow relative to baseline or control in this vulnerable 9. Aliko A, Wolff A, Dawes C, Aframian D, Proctor G, Ekström J, Narayana population study. N, Villa A, Sia YW, Joshi RK, McGowan R, Beier Jensen S, Kerr AR, Lynge Pedersen AM, Vissink A. World Workshop on Oral Medicine VI: Overall, this research showed a significant and consistent clinical implications of medication-induced salivary gland dysfunction. reduction in daytime plaque following use of a stannous Oral Surg Oral Med Oral Pathol Oral Radiol 2015;120:185-206. fluoride plus hydrogen peroxide oral hygiene sequence. The 10. Plemons JM, Al-Hashimi I, Marek CL, American Dental Association study was conducted among individuals with hyposalivation, Council on Scientific Affairs. Managing xerostomia and salivary gland 23 hypofunction: Executive summary of a report from the American Dental as this population may have an added risk for oral irritation. Association Council on Scientific Affairs. J Am Dent Assoc 2014;145: Safety outcomes in the new study were consistent with other 867-873. general clinical research using this novel sequential oral 11. Najera MP, al-Hashimi I, Plemons JM, Rivera-Hidalgo F, Rees TD, 17 Haghighat N, Wright JM. Prevalence of periodontal disease in patients hygiene technology. To date, clinical testing in vulnerable with Sjögren's syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol populations remains uncommon, but research such as this Endod 1997;83:453-457. may provide important evidence on the overall safety and 12. Antoniazzi RP, Miranda LA, Zanatta FB, Islabão AG, Gustafsson A, tolerability with broader use. Chiapinotto GA, Oppermann RV. Periodontal conditions of individuals with Sjögren's syndrome. J Periodontol 2009;80:429-435. 13. Furness S, Worthington HV, Bryan G, Birchenough S, McMillan R. a. Marketed as Crest Pro-Health [HD] and Oral-B [HD] depending on the region; Interventions for the management of dry mouth: Topical therapies. The Procter & Gamble Company, Cincinnati, Ohio, USA. Cochrane Database Syst Rev 2011;Dec 7:CD008934. b. Colgate Cavity Protection, Colgate-Palmolive, New York, New York, 14. Furness S, Bryan G, McMillan R, Birchenough S, Worthington HV. USA. Interventions for the management of dry mouth: non-pharmacological interventions. Cochrane Database Syst Rev 2013;9:CD009603. Acknowledgements: Elizabeth Tzavaras, Britta Magnuson (Tufts University 15. Lynge Pedersen AM, Nauntofte B, Smidt D, Torpet LA. Oral mucosal School of Dental Medicine), Mary Kay Anastasia, Matthew Barker and Amy lesions in older people: relation to salivary secretion, systemic diseases Walanski (The Procter & Gamble Company) provided important and medications. Oral Dis 2015;21:721-729. contributions to the clinical study. 16. Janket SJ, Jones J, Rich S, Miller D, Wehler CJ, Van Dyke TE, Garcia R, Disclosure statement: Dr. Singh and Dr. Papas declared no conflict of Meurman JH. The effects of xerogenic medications on oral mucosa interest. Dr. Gerlach is an employee of the Procter & Gamble Company, among the Veterans Dental Study participants. Oral Surg Oral Med Oral which sponsored the project. Pathol Oral Radiol Endod 2007;103:223-230. 17. Amini P, Gerlach RW. Randomized controlled trial evaluating Dr. Singh is Associate Professor, Department of Diagnostic Sciences; Dr. concurrent gingivitis and stain effects of a two-step paste/gel sequence. Papas is Johansen Professor of Dental Research and Head of the Division of Am J Dent 2018;31:13A-17A. Oral Medicine, Department of Diagnostic Sciences. Dr. Gerlach is a Research 18. Sagel PA, Lapujade PG, Miller JM, Sundberg RJ. 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