Poison or Antibiotic? A Guide to “Class” Entries Preface Most entries in the Poisons List and the First, Second and Third Schedules to the Pharmacy and Poisons Regulations are in the form of individual drugs and their salts, e.g. “Abacavir; its salts”. However, some entries are in the form of a “class”, e.g. “Barbituric acid; its salts; its derivatives …”. In such cases, it is not always clear which drugs are members of the class (e.g. amobarbital, barbital, pentobarbital, phenobarbital, etc. are poisons, being derivatives of barbituric acid). Likewise, the Antibiotics Ordinance applies to the substances specified in Schedule 1 to the Antibiotics Regulations, to their salts and derivatives, and to the salts of such derivatives. Again, it is not always clear which drugs are derivatives of an antibiotic named in the Schedule (e.g. demeclocycline, doxycycline, tigecycline, etc. are antibiotics, being derivatives of “Tetracycline” named in the Schedule). This Guide provides a list of such drugs which are available as registered pharmaceutical products in Hong Kong. Drugs which are not available as registered pharmaceutical products in Hong Kong are also included in this Guide as far as possible. It should be noted that it is not possible to compile a complete list of all these drugs, simply because there is no limit to the number of “derivatives” a parent chemical can have. This Guide should be read in conjunction with the Poisons List, the First, Second and Third Schedules to the Pharmacy and Poisons Regulations, and Schedule 1 to the Antibiotics Regulations, if the poison/antibiotic classification of a particular pharmaceutical product is to be determined. Pharmaceutical Service Department of Health September 2007 Step-by-step guidance on determining the poison/antibiotic classification of a pharmaceutical product 1. Identify the (first) drug contained in the pharmaceutical product. 2. If this drug is found in the Poisons List, continue to look for it in the First and Third Schedules to the Pharmacy and Poisons Regulations to determine the “poison” classification of the pharmaceutical product containing this drug. Then look for it in the Second Schedule to determine if the product is exempted from control as poison under that Schedule. 3. If the drug is not found in the Poisons List, look for it in Schedule 1 to the Antibiotics Regulations. 4. If the drug is found in Schedule 1, the pharmaceutical product will be an antibiotic. 5. If the drug is found neither in the Poisons List nor in Schedule 1 to the Antibiotics Regulations, look for it in the Index to the Guide. 6. If the drug is found in the Index to the Guide, note the Item Number against it, then turn to the Guide itself to identify the Item number and the corresponding Entry in the Poisons List or Antibiotics Schedule of the drug. 7. Repeat steps 2 to 5 with respect to this entry, to determine the classification of the pharmaceutical product containing this drug. 8. If the drug is not found in the Index to the Guide, look for its synonyms (in “Martindale”, the Merck Index, etc), and repeat steps 2 to 7 with respect to each synonym. 9. If none of the synonyms is found in the Index to the Guide after repeating steps 2 to 7, the pharmaceutical product containing the drug will be neither a poison nor an antibiotic. 10. For a multi-component product, repeat the above steps with respect to each component. The “poison” classification of the product itself will be that of the most stringently classified component. In addition, if one component is classified as antibiotic, the product itself will also be classified as an antibiotic. Index to the Guide Drug Name Item Amoxicillin 105 No. Ampicillin 105 Acepromazine 108 Amylobarbitone 36 Acetarsol 33 Amylocaine 24 Acetophenazine 108 Androstenediol 29 Acetoxypregnenolone 126 Androstenedione 29 Acetyl sulfamethoxypyrazine 25 Antihaemophilic factor 41 Acetyldigitoxin 63 Antimony potassium tartrate 32 Acetyldigoxin 63 Antimony sodium gluconate 32 Acetyldihydrocodeinone 65 Aprobarbital 36 Acetylkitasamycin 48 Arbekacin 87 Aconitine 5 Arbutamine 126 Adefovir dipivoxil 2 Arsanilic acid 33 Adiphenine 24 Arsenamide 33 Adrenaline 126 Arsenic Trioxide 33 Ajmaline 19 Arsthinol 33 Alatrofloxacin 131 L-Asparaginase 58 Alclofenac monoethanolamine 4 Atropine methobromide 6 Alclometasone 126 Atropine methonitrate 6 Aldosterone 126 Azaribine 34 Algestone 126 Azatadine 31 Algestone acetophenide 29 Azathioprine 90 Allobarbital 36 Azidamphenicol 51 Allyloestrenol 29 Azithromycin 69 Alphadolone acetate 23 Azosemide 55 Alprazolam 61 Aztreonam 105 Althiazide 53 Bacampicillin 105 Altrenogest 29 Bamipine 31 Altretamine 77 Barbital 36 Ambucaine 24 Barbitone 36 Amcinonide 126 Beclomethasone 126 Amethocaine 24 Bekanamycin 87 Amfepramone 96 Bendamustine 99 Amikacin 87 Bendrofluazide 53 Aminosalicylate 28 Bendroflumethiazide 53 p-Aminosalicylic acid hydrazide 28 Benfluorex 96 Amitriptylinoxide 119 Benmoxine 78 Amobarbital 36 Benoxinate 24 Amodiaquin 52 Benperidol 76 Benzathine Benzylpenicillin 105 Carbarsone 33 Benzestrol 29 Carbenicillin 105 Benzocaine 26 Carbetocin 104 Benzodepa 35 Carbinoxamine 31 Benzoylpas 28 Carbocloral 50 Benzphetamine 96 Carboprost 118 Benzthiazide 53 Carboquone 35 Benzylhydrochlorothiazide 53 Carfecillin 105 Benzylpenicillin 105 Cargutocin 104 Benzylsulfamide 25 Carindacillin 105 Bepotastine 31 Carmofur 71 Betamethasone 126 Carphenazine 108 Boldenone 29 Cathine 11 Brallobarbital 36 Cefaclor 49 Bromazepam 61 Cefadroxil 49 Bromperidol 76 Cefalexin 49 Brompheniramine 31 Cefaloridine 49 Bromvalerylurea 42 Cefalotin 49 Broparestrol 29 Cefamandole 49 Budesonide 126 Cefapirin 49 Bufotenine 81 Cefatrizine 49 Butabarbital 36 Cefazedone 49 Butacaine 26 Cefcapene 49 Butalbital 36 Cefdinir 49 Butamben 26 Cefditoren 49 Butaperazine 108 Cefepime 49 Butethamate 24 Cefetamet 49 Butethamine 26 Cefixime 49 Buthiazide 53 Cefmenoxime 49 Butobarbital 36 Cefminox 49 Butoxycaine 24 Cefodizime 49 Butriptyline 119 Cefonicid 49 Butropium 15 Cefoperazone 49 Butyl aminobenzoate 26 Ceforanide 49 Cacodylate 33 Cefoselis 49 Cafedrine 96 Cefotaxime 49 Calcitonin 129 Cefotiam 49 Camazepam 61 Cefpimizole 49 Candesartan cilexetil 45 Cefpiramide 49 Canfosfamide 99 Cefpirome 49 Cannabidiol 47 Cefpodoxime 49 Cefprozil 49 Clopenthixol 54 Cefradine 49 Cloprednol 126 Cefroxadine 49 Cloprostenol 118 Cefsulodin 49 Clorazepate 61 Ceftazidime 49 Clostebol 29 Ceftibuten 49 Cloxacillin 105 Ceftiofur 49 Cloxazolam 61 Ceftizoxime 49 Cloxotestosterone 29 Ceftriaxone 49 Clozapine 61 Chloral betaine 50 Cocaethylene 10 Chloral hydrate 50 Codoxime 64 Alpha-Chloralose 50 Colchicine 8 Chlorambucil 99 Colistimethate sodium 59 Chloraminophenamide 55 Colpormon 29 Chlormadinone acetate 29 Combelen 108 Chlornaphazine 99 Cortisone 126 Chloroprednisone 126 Cortivazol 126 Chloroprocaine 24 Crotarbital 36 Chloropyramine 30 Cyacetacide 79 Chlorothen 30 Cyamemazine 108 Chlorotrianisene 29 Cyclobarbital 36 Chlorphenamide 55 Cyclodrine 24 Chlorpheniramine 31 Cyclomethycaine 24 Chlorpromazine 108 Cyclopenthiazide 53 Choline theophyllinate 128 Cyclopentobarbital 36 Ciclesonide 126 Cyclopentolate 24 Cimetropium bromide 14 Cyclophosphamide 99 Cinchocaine 80 Cyclothiazide 53 Cinchophen 110 Cymarin 124 Cinnarizine 31 Cyproheptadine 31 Clarithromycin 69 Cyproterone 29 Clemastine 31 Dalfopristin 115 Clemizole 31 Danazol 29 Clindamycin 88 Deanol Benzilate 24 Clobetasol 126 Decamethonium bromide 114 Clobetasone 126 Deflazacort 126 Clocapramine 57 Defosfamide 99 Clocinizine 31 Delorazepam 61 Clocortolone 126 Demeclocycline 127 Clonazepam 61 Demegestone 29 Clopamide 55 Demoxytocin 104 Denopterin 27 Dimethylaminoethyl 19 Deoxycorticosterone 126 Reserpilinate Deprenyl 96 Dimethylthiambutene 68 Deptropine 31 Dimetindene 31 Deserpidine 19 Dimetofrine 126 Deslanoside 63 Diphenylpyraline 31 Desmopressin 135 Dipivefrin 126 Desogestrel 29 Dipyrone 101 Desonide 126 Dirithromycin 69 Desoxymethasone 126 Divalproex sodium 133 Dexamethasone 126 Dixyrazine 108 Dexbrompheniramine 31 Doxifluridine 71 Dexchlorpheniramine 31 Doxorubicin 3 Dextromethorphan 92 Doxycycline 127 Dextropropoxyphene 116 Drosprienone 29 Dextrorphan 82 Drostanolone 29 Diacetyldihydromorphine 66 Dydrogesterone 29 Diacetylmorphine 17 Eburnamonine 21 Diaziquone 35 Elcatonin 129 Dibekacin 87 Embramine 31 Dichloralphenazone 50 Emedastine 31 Dichlorisone 126 Enprostil 118 Dichlorphenamide 55 Ephedrine 11 Dicloxacillin 105 Epicillin 105 Dienoestrol 29 Epimestrol 29 Dienogest 29 Epinastine 31 Diethylpropion 96 Epinephrine 126 Diethylstilbestrol 29 Epirubicin 3 Diethylthiambutene 68 Epitiostanol 29 Diflorasone 126 Epoetin alfa 120 Diflucortolone 126 Eptacog alfa (activated) 41 Difluprednate 126 Equilin 29 Digitalin 63 Ergocornine 12 Digitoxin 63 Ergocristine 12 Digoxin 63 Ergocryptine 12 Dihydrostreptomycin 123 Ergometrine 12 Diisopropanolamine felbinac 38 Ergotamine 12 Dimenhydrinate 30 Ergotoxine 12 Dimethisterone 29 Ertapenem 105 Dimethocaine 26 Escitalopram 56 Eseridine salicylate 7 Estazolam 61 Flunitrazepam 61 Estradiol 29 Fluocortin butyl 126 Estramustine 99 Fluocortolone 126 Estrapronicate 29 Fluorometholone 126 Estriol 29 Fluoxymesterone 29 Estrone 29 Fluperolone acetate 126 Estropipate 29 Fluphenazine 108 Ethinyloestradiol 29 Fluprednidene acetate 126 Ethisterone 29 Fluprednisolone 126 Ethotoin 111 Flurandrenolide 126 Ethybenztropine 37 Flurazepam 61 Ethyl loflazepate 61 Flurogestone acetate 29 Ethylamphetamine 96 Fluticasone 126 Ethylmethylthiambutene 68 Flutoprazepam 61 Ethyloestrenol 29 Fluzacort 126 Ethynodiol 29 Follicle-stimulating hormone 112