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Pathogenic Mutations Identified by a Multimodality Approach in 117 Japanese Fanconi Anemia Patients
ERRATA CORRIGE Bone Marrow Failure Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients Minako Mori, 1,2 Asuka Hira, 1 Kenichi Yoshida, 3 Hideki Muramatsu, 4 Yusuke Okuno, 4 Yuichi Shiraishi, 5 Michiko Anmae, 6 Jun Yasuda, 7Shu Tadaka, 7 Kengo Kinoshita, 7,8,9 Tomoo Osumi, 10 Yasushi Noguchi, 11 Souichi Adachi, 12 Ryoji Kobayashi, 13 Hiroshi Kawabata, 14 Kohsuke Imai, 15 Tomohiro Morio, 16 Kazuo Tamura, 6 Akifumi Takaori-Kondo, 2 Masayuki Yamamoto, 7,17 Satoru Miyano, 5 Seiji Kojima, 4 Etsuro Ito, 18 Seishi Ogawa, 3,19 Keitaro Matsuo, 20 Hiromasa Yabe, 21 Miharu Yabe 21 and Minoru Takata 1 1Laboratory of DNA Damage Signaling, Department of Late Effects Studies, Radiation Biology Center, Graduate School of Biostudies, Kyoto University, Kyoto, Japan; 2Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 3Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 4Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan; 5Laboratory of DNA Information Analysis, Human Genome Center, The Institute of Medical Science, University of Tokyo, Tokyo Japan; 6Medical Genetics Laboratory, Graduate School of Science and Engineering, Kindai University, Osaka, Japan; 7Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; 8Department of Applied Information Sciences, Graduate School of Information Sciences, Tohoku University, Sendai, Japan; 9Institute of Development, Aging, -
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Minamino et al. Arthritis Research & Therapy (2021) 23:96 https://doi.org/10.1186/s13075-021-02479-x RESEARCH ARTICLE Open Access Urinary sodium-to-potassium ratio associates with hypertension and current disease activity in patients with rheumatoid arthritis: a cross-sectional study Hiroto Minamino1,2*†, Masao Katsushima3†, Motomu Hashimoto4* , Yoshihito Fujita1*, Tamami Yoshida5, Kaori Ikeda1, Nozomi Isomura1, Yasuo Oguri1, Wataru Yamamoto6, Ryu Watanabe4, Kosaku Murakami3, Koichi Murata4,7, Kohei Nishitani4, Masao Tanaka4, Hiromu Ito4,7, Koichiro Ohmura3, Shuichi Matsuda7, Nobuya Inagaki1 and Akio Morinobu3 Abstract Background: Excessive salt intake is thought to exacerbate both development of hypertension and autoimmune diseases in animal models, but the clinical impact of excessive salt in rheumatoid arthritis (RA) patients is still unknown. We performed a cross-sectional study to clarify the associations between salt load index (urinary sodium- to-potassium ratio (Na/K ratio)), current disease activity, and hypertension in an RA population. Methods: Three hundred thirty-six participants from our cohort database (KURAMA) were enrolled. We used the spot urine Na/K ratio as a simplified index of salt loading and used the 28-Joint RA Disease Activity Score (DAS28- ESR) as an indicator of current RA disease activity. Using these indicators, we evaluated statistical associations between urinary Na/K ratio, DAS28-ESR, and prevalence of hypertension. Results: Urinary Na/K ratio was positively associated with measured systolic and diastolic blood pressure and also with prevalence of hypertension even after covariate adjustment (OR 1.34, p < 0.001). In addition, increased urinary Na/K ratio was significantly and positively correlated with DAS28-ESR in multiple regression analysis (estimate 0.12, p < 0.001), as was also the case in gender-separated and prednisolone-separated sub-analyses. -
Section 2 Contribution of Science and Technology to Global Issues
Chapter 1 Progress in Science and Technology and Socioeconomic Changes Section 2 Contribution of Science and Technology to Global Issues From the end of the 19th century to the 20th century, science and technology has rapidly advanced. Chemical industry, electrical industry and heavy industry and so on emerged and we have advanced forward to ages of mass production and mass consumption, when goods could be transported in bulk to distant locations for a short period, as physical distribution, including railways, cars and airplanes, developed. This accompanied the mass disposal of goods and mass consumption of energy, highlighting the Chapter 1 risk of depletion of limited resources, global warming, the destruction of ecosystems and the crisis in the global environment. Science and technology that changed our lives were explained in Section 1 of this chapter, but as well as changing our lives in terms of key daily lifestyle elements, science and technology are also crucial to solve global issues such as climate change, natural resource depletion and energy. There are significant expectations as to how science and technology can contribute to solve global issues. This section addresses the social contribution of science and technology in Japan domestically and internationally. 1 Contribution to Global Warming Countermeasures ○ Global warming state Climate changes caused by global warming are Average global surface temperature (land + sea) anomaly one of the most urgent problems which the world faces. The Intergovernmental Panel on Climate Change (IPCC)1, awarded the Nobel Peace Prize Year in 2007, published the Synthesis Report of Fifth Changes in average global sea level Assessment Report in 2014. -
Kyoto University Contents Mission Statement
2019–2020 2019 – 2020 www.kyoto-u.ac.jp/en Kyoto University Contents Mission Statement Mission Statement 2 Message from the President 3 Kyoto University Basic Concept for Internationalization 4 Kyoto University states its mission to sustain and develop its historical commitment to academic freedom and to pursue harmonious coexistence within the human and ecological community on this planet. History of Kyoto University 5 Award-Winning Research 6 Kyoto University at a Glance 7 Kyoto University will generate world-class knowledge through freedom and 2019 Topics 9 autonomy in research that conforms with high ethical standards. Developing the KyotoU Model of Industry-Government-Academia Collaboration 9 Research As a university that comprehends many graduate schools, faculties, research Promoting Innovation through Industry-Academia Collaboration 10 institutes and centers, Kyoto University will strive for diverse development in pure and applied research in the humanities, sciences and technology, while Global Engagement 11 seeking to integrate these various perspectives. International Partners / Overseas Offices and Facilities 11 On-site Laboratory Initiative 12 International Consortia and Networks 12 Within its broad and varied educational structure, Kyoto University will Alumni Associations 12 transmit high-quality knowledge and promote independent and interactive General Information 13 learning. Statement Mission Education Undergraduate Faculties / Graduate Schools 13 Kyoto University will educate outstanding and humane researchers and Kyoto -
Osaka City University 2021
Take a break with fun activities throughout the year University events & Award-Winning Research Facilities extracurricular activities Dance Award-Winning Research Facilities Boat race Center of Education and Research for Osaka City University Disaster Management (CERD) Advanced Mathematical Institute (OCAMI) Social Implementation of Disaster Knowledge. Wide Angle Mathematical Basis Focused on OCU Botanical Gardens Disaster-Resilient Communities. Knots and International Research Center in Rakugo ichiro Namb Mathematics & Mathematical Physics. Yo u Instagram Account @osakacityuniversity OSAKA CITY UNIVERSITY OCU distinguished professor emeritus and Why Osaka? Nobel Laureate in 2008 for his discovery of a Yama the mechanism of spontaneous broken Shiny naka Osaka offers you all you could want from a modern city: excellent food, convenient public 2021 transport, mountains nearby and a 35 minute commute to the city from the airport. Also, cost of symmetry in subatomic physics. ©京都大学iPS細胞研究所 living is relatively low, commuting times short and being in the middle of the culturally rich Kansai Director of the Center for iPS Cell Research and area with cities such as Kyoto and Nara means you will never run out of places to explore. Center for Health Science Innovation (CHSI) Application, Kyoto University and Nobel Laureate Research Center for Fatigue and Active Health. in 2012 for his discovery of iPS cells. Urban Health and Sports (RCUHS) Sightseeing Received his PhD at OCU in 1993. Promote a Healthy and Active Lifestyle in Modern Society. Spots Kiyomizu-dera Temple, Kyoto Shisendo Temple, Kyoto CENTRAL WESTERN HONSHU HONSHU HYOGO KYOTO Nambu Yoichiro Institute of Theoretical Pref. Pref. Kyoto SHIGA and Experimental Physics (NITEP) Nobuo Kamiya Urban Research Plaza (URP) Pref. -
Japan Various Activities of UNESCO Have Been Implemented Under The
NATIONAL REPORT ON IHP RELATED ACTIVITIES Japan Various activities of UNESCO have been implemented under the support of the Japanese National Commission for UNESCO with financial contribution in the form of Fund-in-Trust (JFIT) for the Promotion of Science for the Sustainable Development. Japanese National Committee for IHP of UNESCO is expected to solve complex global challenges through following activities with a cross- cutting approach in collaboration with all the studies including social and human sciences, in addition to changing value. The following summary includes the activities of Japanese National Committee for IHP of UNESCO undertaken during June 2014 to May 2016. 1. ACTIVITIES UNDERTAKEN IN THE PERIOD JUNE 2014 – MAY 2016 1.1 Meetings of the IHP National Committee 1.1.1 Decisions regarding the composition of the IHP National Committee The composition of the Japanese IHP National Committee is as follows: Members of the IHP National Committee as of May 2016. Name Position E-mail Chair* TACHIKAWA Yasuto Prof., Kyoto Univ. [email protected] * UEMATSU Mitsuo Director and Prof., CICAORI, The Univ. of [email protected] Tokyo. * KURODA Reiko Prof. The Tokyo Univ. of Science [email protected] OKI Taikan Prof., IIS, The Univ. of Tokyo [email protected] KAZAMA Futaba Prof., Univ. of Yamanashi [email protected] KAWAMURA Akira Prof., Tokyo Metropolitan Univ. [email protected] TANIGUCHI Makoto Prof., RIHN [email protected] CHIKAMORI Hidetaka Prof.,Okayama Univ [email protected] TSUJIMURA Maki Prof., Univ. of Tsukuba [email protected] NAKAYAMA Mikiyasu Prof., The Univ. -
Facilities Are Enhancing Research Quality
University Establishments Facilities are Enhancing Research Quality One of the key elements of the internationally lauded accomplishments of our researchers is 智the university’s state-of-the-art laboratories and research facilities. Meteorology MU Radar Observations Atmospheric Turbulence In collaboration with a French research group, we conducted an extensive study on the small-scale dynamics of the lower atmosphere. The study aims to characterize atmospheric turbulence, its sources and its interactions with large- scale dynamics and clouds by means of remote sensing and in situ observations. The Middle and Upper atmosphere (MU) radar of the Research Institute for Sustainable Humanosphere (RISH) is one of the most suitable instruments for detecting turbulence and stable interfaces throughout the entire MU Radar troposphere at any time, irrespective of clear or cloudy conditions. In turbulence observations, excellent spatial and temporal resolutions can be achieved through a range-imaging technique using frequency diversity. In recent years, all the measurement campaigns have involved the MU radar in range-imaging mode with complementary instruments (e.g. radiosondes, Rayleigh-Mie lidars, ultra high frequency [UHF] and meteorological radars) for validating the technique in turbulence studies. The bottom figure shows an example of a time-height cross section of echo power obtained using the MU radar in range-imaging mode on 8 October 2008. We found Kelvin-Helmholtz (KH) braided-like structures along the slope of a cloud base gradually rising with time at an altitude of approximately 5 km, and vertical air motion oscillations exceeding ±3 m/s with a period of approximately 3 min above and below the cloud base. -
0Saka City University
ACCESS Sugimoto Campus Abiko sta. JR Sugimotocho sta. Osaka City University Sugimoto Campus 0SAKA CITY N UNIVERSITY Sugimoto Campus 3-3-138 Sugimoto Sumiyoshi-ku, Osaka 558-8585 JAPAN Access by Public Transport: 5 min. walk from Sugimoto-cho Station (JR Hanwa Line) 2020 From Kansai Airport: Take the Kansai-Airport Rapid Service, change at Sakai-shi to a local train for Tennoji and get off at Sugimoto-cho Station Abeno Campus Umeda Satellite Faculty of Medicine (Graduate School of Urban Management, Graduate School for Creative Cities and Academic Extension Center) MIO Hankyu JR Osaka Sta. Tennoji Sta. Daimaru Hanshin Kintetsu Umeda Sta. Higashi Umeda Osaka Sta. Osaka City University Abenobashi Sta. Abeno Campus Nishi Umeda N Sta. Osaka eki mae No.2bldg Abeno Campus Osaka City University 1-4-3 Asahimachi, Abeno-ku, Osaka Umeda Satellite 545-8585 JAPAN (Faculty of Medicine) 1-5-17 Asahimachi, Abeno-ku, Osaka Umeda Satellite 545-0051 JAPAN (School of Nursing) 1-2-2-600 Umeda, Kita-ku, Osaka 530-0001 JAPAN Access by Public Transport: Access by Public Transport: 10 min. walk from Tennoji Station 1 min. walk from Kitashinchi Station (JR Hanwa Line and Subway Midosuji Line) (JR Tozai Line) 10 min. walk from Osaka Abenobashi Station 3 min. walk from Umeda/Nishi Umeda/ (Kintetsu Minami Osaka Line) Higashi Umeda Station (Subway), From Kansai Airport: Umeda Station (Hanshin Line), Take the Kansai-Airport Rapid Service or Osaka Station (JR Line) Haruka Ltd. Express and get off at Tennoji Station From Kansai Airport: Take the Kansai-Airport Rapid Service for Kyobashi and get off at Osaka Station 2019.7 OSAKA CITY UNIVERSITY Message from the President History Osaka City University Osaka City University Osaka City University is one of the largest public universities in Japan, and the only multidisciplinary university in “The university is here for the city, and the city is here for the university.” Osaka City. -
Program (2013)
Poster and Flash Presentations Convention Hall, Makuhari-Messe, Chiba, Japan, September 5-6, 2013. A101 OPTIMIZATION OF MICROFLUIDIC-BASED IN SITU PADLOCK ROLLING CIRCLE AMPLIFICATION FOR MITOCHONDRIAL DNA ANALYSIS. Arisa Kuroda1, Naoki Sasaki1, Mats Nilsson2, Kae Sato1 1Japan Women’s University, 2Uppsala University A102 IMMUNOELECTROHORESIS OF EXTRACELLULAR NANOVESICLES ON A MICROCAPILLARY CHIP Takanori Akagi1, Nami Hanamura1, Masashi Kobayashi1, Kei Kato1, Takanori Ichiki1 1 Univ. Tokyo A103 CHARACTERIZATION OF NANOPARTICLE PERMEABILITY ON MEMBRANE-INTEGRATED MICROFLUIDIC DEVICES Naoki Sasaki,1 Mariko Tatanou,2 Yasutaka Anraku,3 Akihiro Kishimura,4 Kazunori Kataoka,3 and Kae Sato2 1Toyo University, 2Japan Women’s University, 3The University of Tokyo, 4Kyushu University, JAPAN A104 DIRECTED EVOLUTION OF PROTEINS USING A NOVEL MICROARRAY DEVICE Shingo Ueno1, Shusuke Sato1, Tatsunori Hirai1, Takumi Fukuda1, Hiromi Kuramochi1, Manish Biyani1, Takanori Ichiki1 1 Univ. Tokyo A105 HIGH EFFICIENCY SEPARATION OF PROTEIN BY MICROCHIP ELECTROHORESIS USING PDMS MICROCHANNEL MODIFIED WITH CHARGED PHOSPHOLIPID POLYMER Madoka Takai1, Kyosuke Nii1, Kenji Sueyoshi2, Koji Otsuka3 1 Univ. of Tokyo, 2 Osaka Prefecture University,3 Kyoto University A106 LUMAZINE-PEPTIDE CONJUGATES DISPLAY ENHANCED AFFINITY FOR RNA TARGETS Hiroki Saito1, Yusuke Sato1, Norio Teramae1, and Seiichi Nishiziawa1 1 Department of Chemistry, Graduate School of Science, Tohoku University A107 THIAZOLE ORANGE AS A FLUORESCENT LIGAND TO TARGET TAR RNA Yoshiko Ito 1, Yusuke Sato1, Norio -
College of Information Science and Engineering
Image of students studying in the Master’s Program Japan English-medium Undergraduate Program College of Information Science and Engineering Information Systems Science and Engineering Course (ISSE) About Ritsumeikan University The history of Ritsumeikan dates back to 1869 when a private academy of the same name was founded in Kyoto. The academy has become a comprehensive institution consisting of two universities, including Ritsumeikan University (RU), four junior and senior high schools and a primary school. RU, which boasts 14 colleges and 20 graduate schools across 4 campuses, has actively promoted research collaboration with industry and has made significant contributions to society both nationally and globally through various academic projects. The RU alumni network extends throughout Japan and to all corners of the globe, promising students a wide range of contacts and career opportunities. Ritsumeikan University was selected in 2014 as one of 37 universities for the highly competitive “Top Global University Project” by Japan’s Ministry of Education, Culture, Sports, Science and Technology (MEXT). Acknowledged as one of the leading global universities in Japan, RU is committed to further promote its global profile and offer a world-class education to students worldwide. Academic Calendar Ritsumeikan University by Numbers All figures are as of 2015 March New Student Orientation starts (April Enrollment) FoundedFounded in in SelectedSelected by by degree-seekingdegree-seeking April + + thethe Japanese Japanese ofof the the universities -
An Analysis of Elliptical Phenomena Based on Non-Constituent Deletion
An Analysis of Elliptical Phenomena Based on Non-Constituent Deletion by Daisuke Hirai B. A., Kyoto University of Foreign Studies, 1997 M. S., University of Wisconsin-River Falls, 1999 A Dissertation Submitted for the Degree of Doctor of Philosophy to Kansai Gaidai University 2018 Acknowledgements It is hardly a trivial task to properly acknowledge everyone who has helped me during my research and reach this point. Without their help, this dissertation would never have come into existence or taken shape as it is. First and foremost, I would like to thank Yukio Oba, my thesis supervisor. He has given me a lot of advice and constant encouragement since I was a graduate student at Nagoya University. I am very fortunate that he invited me to study at Kansai Gaidai University and work on this topic to complete this dissertation. It has been a great pleasure to study under his guidance. I cannot thank him enough for reading my rough draft and giving me a lot of comments on it. I would also like to thank the other members of the committee, Nobuo Okada, Kansai Gaidai University, and Sadayuki Okada, Osaka University for reading my paper and giving me a lot of valuable comments. Their comments helped me look into more ellipsis-related examples. This will lead me to work on another topic as a next step. I would also like to acknowledge the past and present members of the graduate school of Kansai Gaidai University, Jun Omune and Shota Tanaka for reading my first version of this dissertation and their comments on it. -
Future of Electrochemistry in Light of History and the Present Conditions
Journal of Solid State Electrochemistry (2020) 24:2089–2092 https://doi.org/10.1007/s10008-020-04585-3 FEATURE ARTICLE Future of electrochemistry in light of history and the present conditions György Inzelt1 Received: 26 March 2020 /Revised: 26 March 2020 /Accepted: 29 March 2020 / Published online: 15 April 2020 # The Author(s) 2020 General thoughts would not be financed or financed properly, the development of science and consequently that of the technology will stop or We may agree with the saying which is attributable to Niels at least will slow down. The decision makers want an imme- Bohr who said: “It is difficult to make predictions, especially diate success for the money of the taxpayers. The applied about the future.” Nevertheless, the past can give ideas in this research and especially the innovation phase needing the cap- respect and the present circumstances set the course. ital also for buildings and machines want orders of magnitude However, the great breakthroughs cannot be predicted. higher money than the grant for some thousand researchers at Without any exaggeration, we may declare that electro- the universities and institutes. chemistry has played, plays, and will play an important role The support of the basic research is not a wasted money, in the scientific and technological advancement, and conse- and it underlies the future. I would like to draw the attention to quently the quality of life of the people. We cannot imagine another important point: it is the proper education. The well- the everyday life without electricity. We have had electric prepared and competent researchers are essential for the prog- current for 220 years since Volta constructed his pile.