JOURNAL OF VIROLOGY JOURNAL OF VIROLOGY

VOLUME 11 * NUMBER 3 * MARCH 1973

EDITORIAL BOARD

Robert R. Wagner, Editor-in-Chief (1977) University of Virginia School of Medicine, Charlottesville

Myron Levine, Editor (1976) Norman P. Salzman, Editor (1975) School of Medicine, National Institute of Allergy and University of Michigan, Infectious Diseases, Ann Arbor Bethesda, Md.

Dwight L. Anderson (1974) Angus Graham (1975) Bernard Moss (1974) David Baltimore (1975) D. MacDonald Green (1974) Elmer R. Pfefferkorn (1974) Marcel A. Baluda (1975) Klaus Hummeler (1973) Lennart Philipson (1973) Allan M. Campbell (1975) Paul J. Kaesberg (1973) Fred Rapp (1975) Purnell Choppin (1974) Albert S. Kaplan (1973) Bernard Roizman (1973) Eugene H. Cota-Robles (1973) Edwin D. Kilbourne (1973) Aaron J. Shatkin (1973) Vittorio Defendi (1973) David W. Kingsbury (1973) Robert W. Simpson (1973) Walter Doerfler (1974) Lloyd M. Kozloff (1976) Donald F. Summers (1973) Richard M. Franklin (1973) Margaret Lieb (1973) Howard M. Temin (1973) Robert M. Friedman (1973) Jean Lindenmann (1973) Peter Vogt (1973) Harold S. Ginsberg (1973) Royce Z. Lockart, Jr. (1975) John S. Wiberg (1973) Marc Girard (1974) Christopher K. Mathews (1973) Julius Youngner (1973)

Robert A. Day, Managing Editor, 1913 I St., N. W., Washington, D.C. 20006

EX OFFICIO

R. G. E. Murray, President (1972-1973) L. Leon Campbell, Vice-President (1972-1973) Donald E. Shay, Secretary T. J. Carski, Treasurer

The Journal of Virology, a publication of the American to the ASM Publications Office, 1913 I St., N.W., Wash- Society for Microbiology, 1913 I St., N.W., Washington, D.C. ington, D.C. 20006 (area 202 833-9416). Correspondence from 20006, is devoted to the dissemination of fundamental ASM members relating to membership dues, member knowledge concerning viruses of bacteria, plants, and ani- subscriptions, changes of address, incorrect address, mals. Investigators are invited to submit reports of original incorrect journals, etc., should be directed to the Executive research in all areas of basic virology, including biochemis- Secretary, American Society for Microbiology, 1913 I St., try, biophysics, genetics, immunology, morphology, and N.W., Washington, D.C. 20006. Published monthly bv the physiology. The Journal is issued monthly, two volumes per ASM at 428 E. Preston St., Baltimore, Md. 21202. year. The subscription price is $40 (foreign, $41.) per year; single copies are $4.00 (foreign, $4.25). Members of the American Society for Microbiology may receive the Journal Second-class postage paid at Baltimore, Md. 21202, and as part of their dues. Correspondence relating to sub- at additional mailing offices scriptions, reprints, defective copies, availability of back Made in the U.S.A. issues, lost or late proofs, disposition of submitted manu- Copyright ( 1973, American Society for Microbiology. scripts and general editorial matters should be directed All Rights Reserved. JOURNAL OF VIROLOGY INSTRUCTIONS TO AUTHORS Correspondence. Submit manuscripts in dupli- cussion, Acknowledgments, and Literature Cited. cate (original and one carbon) to ASM Publica- Only one weight of heading (paragraph lead-in) tions office, 1913 I St., N.W., Washington, D.C. should be used within each section. 20006. Abstract. An Abstract appears at the beginning General policy. Any manuscript submitted must of each paper in the Journal. The abstract should be a report of unpublished original research, which not exceed 250 words. is not being considered for publication elsewhere. Literature Cited. In the text references are cited A manuscript accepted and published by the by number. The Literature cited section should Journal must not be published again in any form be typed in alphabetical order, by first author, and without the consent of ASM. numbered. Names of journals are abbreviated ac- A charge of $25 per printed page is assessed for cording to Chemical Abstracts Service Source In- publication in the Journal. Most institutions and dex (American Chemical Society, 1970). Litera- granting agencies in the United States permit the ture citations should be restricted to closely payment of publication charges as part of their pertinent papers. Citations of abstracts, theses, general research support. It is recognized, how- "unpublished data," "personal communication, " ever, that such funds are not always available to and "in press" will not be accepted in the Litera- laboratories outside the United States. In such ture Cited, but may be used parenthetically in cases, the cost of publication will be borne by the the text. American Society for Microbiology. Ability or in- Tables. Each table should be typed on a sepa- ability to pay the publication charge is not a factor rate page. The data should be arranged so that in the selection of manuscripts for publication. columns of like material read down, not across. The "editorial style" of the Journal essentially The headings should be sufficiently clear so that follows the CBE Style Manual (3rd ed., AIBS, the meaning of the data will be understandable 1972). "Instructions" published in the Journal without reference to the text. Explanatory foot- of Bacteriology apply also to the Journal of Vi- notes are permitted, but detailed descriptions of rology. Biochemical abbreviations and nomen- the experiments are not. The materials and meth- clature should essentially follow "Biochemical ods used to gain the data should properly remain Nomenclature" in Handbook of Biochemistry in the section of that name. (2nd ed., 1970 H. A. Sober, ed., The Chemical Figures. A complete set of figures, preferably Rubber Co., Cleveland, p. A4-A24). Normally, glossy photographs, should accompany each of the abbreviations (except those of standard units of two copies of the manuscript. Each figure should measurement and symbols of the elements) should be numbered and should include the name of the be defined and introduced parenthetically at first author, either in the margin or on the back (marked use in the text. Certain abbreviations will be ac- lightly with a soft pencil). Graphs (submit as cepted without definition in the title, abstract, and photographs) should be finished drawings not text. Among these abbreviations are: DNA (de- needing further artwork or type-setting. Ab- oxyribonucleic acid); RNA (ribonucleic acid); solutely no part of a graph should be typewritten rRNA (ribosomal RNA); mRNA (messenger (except the legend, which should be typed on a RNA); tRNA (transfer RNA); AMP, ADP, ATP, separate page). All lettering should be done with dAMP, dADP, dATP (for the respective 5' phos- a lettering set. Most graphs will be reduced to one- phates of adenosine or the other nucleosides, using column width, and all elements in the drawing appropriate letter symbols); 2'-AMP, 3'-AMP, should be prepared to withstand this reduction. 5'-AMP (the 2'-, 3'-, and 5'-, where needed for con- The legend of- the figure should provide enough trast, phosphates of the nucleosides); DNase information so that the figure is understandable (deoxyribonuclease); RNase (ribonuclease); P without reference to the text. Experimental de- (orthophosphate); PPi (pyrophosphate); mol wt tails from Materials and Methods should not be (molecular weight); UV (ultraviolet); PFU repeated in figure legends. (plaque-forming units); Tris (tris (hydroxy- Notes. The accepted form for Notes is somewhat methyl)aminomethane); DEAE- (diethylamino- different from the foregoing. Contributors should ethyl-); and EDTA (ethylenediaminetetraace- consult a recent issue of the Journal for style. tate). Genetic symbols should essentially follow Notes should not exceed 500 words. The Abstract the recommendations of Demerec et al. (Genetics should not exceed 25 words. 54:61, 1966). Enzyme activity should be expressed Nomenclature of viruses. Viruses named after a in terms of international units (Enzyme Nomen- disease should be written as separate words in clature, Elsevier Publishing Co., 1965), and the EC lower-case roman, except when the name of the number should be given parenthetically at first use disease is derived from a proper noun: herpes in the text. In expressing lengths, weights, and simplex virus, measles virus, Newcastle disease volumes, the prefixes nano (n) and pico (p) should virus, poliomyelitis virus, varicella-zoster virus, be used instead of millimicro (m,u) and micromicro vaccinia virus. (pu). Express lengths in nanometers (nm; 10-9 m) Most other viruses should be written as a single or in micrometers Cum; 10 m) instead of milli- word in lower case: adenovirus, coxsackievirus, microns (m,u; 10'9 m), microns (u; 10 m), or cytomegalovirus, echovirus, herpesvirus, mengo- Angstroms (A; 10-10 m). Express parts per million virus, picornavirus, poliovirus, poxvirus. (ppm) as micrograms per milliliter (.ug/ml), micro- Copyright. Once a paper has been published in grams per gram (ug/g), or microliters per liter the Journal, which is a copyrighted publication, (uliters/liter), as appropriate. In general, measure- the legal ownership of all parts of the paper, ini- ments should be expressed in terms of standard cluding the illustrations, has passed from the international metric units. The Journal reserves author to the Journal. If the same author, or any the privilege of editing manuscripts to make them author, wishes to republish material previously conform with the adopted style. published in the Journal, he must first receive Form of manuscript. All parts of the manuscript written permission from ASM. should be typed double-space or, preferably, Reprints. Reprints (in multiples of 100) will be triple-space. Most manuscripts can and should be furnished contributors when ordered in advance. divided into the following sections: Abstract, In- A table showing the cost of reprints, and an order troduction, Materials and Methods, Results, Dis- form, will be sent with the proof. YOU ARE INVITED to attend THE 73RD ANNUAL MEETING AMERICAN SOCIETY FOR MICROBIOLOGY Over 200 Scientific Sessions Symposia Special Lectures Seminars Round Tables Workshops Contributed Papers Over 250 Exhibits Technical-Scientific-Educational 6-11 May 1973 Miami Beach, Florida Registration Open to All Interested Persons

For Additional Information: The Executive Secretary, ASM, 1913 Eye St., NW, Washington, DC 20006