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Table S1. Checklist Summarizing Compliance with PRISMA Guidelines

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Table S1. Checklist Summarizing Compliance with PRISMA Guidelines Supplementary Table S1. Checklist summarizing compliance with PRISMA guidelines. Reported Section/topic # Checklist item on page # TITLE Title 1 Identify the report as a systematic review, meta-analysis, or both. 1 ABSTRACT Structured summary 2 Provide a structured summary including, as applicable: background; objectives; data sources; study eligibility 2 criteria, participants, and interventions; study appraisal and synthesis methods; results; limitations; conclusions and implications of key findings; systematic review registration number. INTRODUCTION Rationale 3 Describe the rationale for the review in the context of what is already known. 4-5 Objectives 4 Provide an explicit statement of questions being addressed with reference to participants, interventions, comparisons, 4-5 outcomes, and study design (PICOS). METHODS Protocol and registration 5 Indicate if a review protocol exists, if and where it can be accessed (e.g., Web address), and, if available, provide N/A registration information including registration number. Eligibility criteria 6 Specify study characteristics (e.g., PICOS, length of follow-up) and report characteristics (e.g., years considered, 5-6 language, publication status) used as criteria for eligibility, giving rationale. Information sources 7 Describe all information sources (e.g., databases with dates of coverage, contact with study authors to identify 5-6 additional studies) in the search and date last searched. Search 8 Present full electronic search strategy for at least one database, including any limits used, such that it could be 5-6 repeated. Study selection 9 State the process for selecting studies (i.e., screening, eligibility, included in systematic review, and, if applicable, 5-6 included in the meta-analysis). Data collection process 10 Describe method of data extraction from reports (e.g., piloted forms, independently, in duplicate) and any processes 5-6 for obtaining and confirming data from investigators. 1 Data items 11 List and define all variables for which data were sought (e.g., PICOS, funding sources) and any assumptions and 5-6 simplifications made. Risk of bias in individual 12 Describe methods used for assessing risk of bias of individual studies (including specification of whether this was N/A studies done at the study or outcome level), and how this information is to be used in any data synthesis. Summary measures 13 State the principal summary measures (e.g., risk ratio, difference in means). 5-6 Synthesis of results 14 Describe the methods of handling data and combining results of studies, if done, including measures of consistency 5-6 2 (e.g., I ) for each meta-analysis. Reported Section/topic # Checklist item on page # Risk of bias across studies 15 Specify any assessment of risk of bias that may affect the cumulative evidence (e.g., publication bias, selective reporting N/A within studies). Additional analyses 16 Describe methods of additional analyses (e.g., sensitivity or subgroup analyses, meta-regression), if done, indicating which N/A were pre-specified. RESULTS Study selection 17 Give numbers of studies screened, assessed for eligibility, and included in the review, with reasons for exclusions at each 7-8 stage, ideally with a flow diagram. Study characteristics 18 For each study, present characteristics for which data were extracted (e.g., study size, PICOS, follow-up period) and provide Supplementa the citations. ry tables Risk of bias within studies 19 Present data on risk of bias of each study and, if available, any outcome level assessment (see item 12). N/A Results of individual studies 20 For all outcomes considered (benefits or harms), present, for each study: (a) simple summary data for each intervention Supplementa group (b) effect estimates and confidence intervals, ideally with a forest plot. ry tables Synthesis of results 21 Present results of each meta-analysis done, including confidence intervals and measures of consistency. N/A Risk of bias across studies 22 Present results of any assessment of risk of bias across studies (see Item 15). N/A Additional analysis 23 Give results of additional analyses, if done (e.g., sensitivity or subgroup analyses, meta-regression [see Item 16]). N/A DISCUSSION 2 Summary of evidence 24 Summarize the main findings including the strength of evidence for each main outcome; consider their relevance to key 11 groups (e.g., healthcare providers, users, and policy makers). Limitations 25 Discuss limitations at study and outcome level (e.g., risk of bias), and at review-level (e.g., incomplete retrieval of identified 11 research, reporting bias). Conclusions 26 Provide a general interpretation of the results in the context of other evidence, and implications for future research. 11 FUNDING Funding 27 Describe sources of funding for the systematic review and other support (e.g., supply of data); role of funders for the 12 systematic review. From: Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 6(6): e1000097. doi:10.1371/journal.pmed1000097 3 Supplementary Table S2. Summary profiles of cancer patients with systemic capillary leak syndrome Ref. Author, year Age/ Sex Presenting symptoms Etiology of SCLS Cancer diagnosis Blood Albumin Treatment Outcome Cause of No. pressure (g/dL) Death (mmHg) Pothen, et al., Hypotension, leg edema, anasarca, renal Theophylline treatment (200 1 75/F Cancer Diffuse large B-cell lymphoma 90/60 2.9 Alive - 2014 failure, hypoalbuminemia mg/day) High-dose diuretics Casadei Alive Drug (gemcitabine, nab- Ductal carcinoma (pT3 N0 M0, (furosemide 250 mg daily) 2 Gardini, et al., 65/F Pulmonary hypertension - 0.6 paclitaxel) stage IIa), ovarian cancer combined with cortisone 2013 (Relapse) (40 mg methylprednisolone) Radiosone, diuretics, Zhang, et al., 3 59/F Generalized edema, severe hypotension Drug (trastuzumab) Invasive carcinoma of the breast - 3 continuous thoracocentesis Alive - 2013 & pericardiocentesis Lourdes et al., Lower extremity and facial swelling, ALK-negative anaplastic large cell Methylprednisolone 90 mg Cancer 4 71/F Cancer 70/- 3 Died 2012 nausea, vomiting, diarrhea lymphoma twice daily relapse Fever, progressive abdominal Ahn et al., Crystalloid, colloid, and 5 50/F distention, nausea, bilious emesis, Cancer Stage IV rectal cancer 69/17 < 1 Alive - 2012 vasopressors malaise, weakness Pericardial and pleural effusion, severe Fluid resuscitation, Maroz et al., Drug (pemetrexed 6 74/M edema of the face, abdominal wall, and Non–small cell lung cancer - 2.0 discontinuation of Alive - 2012 therapy) lower and upper extremities pemetrexed Fluid resuscitation, Kai-Feng et transfusion, infusion of 7 46/M Hypotension, hypoproteinemia Drug (Interleukin-11) Hepatic carcinoma 102/61 1.8 Alive - al., 2011 hydroxyethyl starch and albumin Kai-Feng et Dyspnea with bilateral edema of the 7 66/M Drug (Interleukin-11) Hepatic carcinoma 93/59 - Fluid resuscitation Alive - al., 2011 hands 8 43/F Hypotension, unexplained shock Cancer Lobular carcinoma of the breast - Terbutaline and Alive - Bencsath et Hypotens theophylline, albumin 4 Ref. Author, year Age/ Sex Presenting symptoms Etiology of SCLS Cancer diagnosis Blood Albumin Treatment Outcome Cause of No. pressure (g/dL) Death (mmHg) al., 2011 ion infusion, montelukast Umemoto et High fever, dyspnea, hypoxemia, ALK+ anaplastic large cell High dose 9 13/M Cancer - - Alive - al., 2011 pulmonary edema lymphoma methylprednisolone Methylprednisolone therapy Krzesiński et General weakening, decreased exercise 10 71/M Drug (doxorubicin) Myeloma multiplex IgA (stage III) 100/80 2.9 (Solu-medrol) at high doses Alive - al., 2010 tolerance, symmetric crural edema (initially 1.5mg/kg /day) Hsiao et al., Cardiac 11 65/F Ascites, general anasarca Drug (bortezomib) Relapsed multiple myeloma - - Dexamethasone Died 2010 amyloidosis Died Baytan et al., Hypotension, periorbital edema, Refractory acute lymphoblastic 12 10/F Drug (clofarabine) 70/50 - Albumin, immunoglobulin SCLS 2010 oliguria, dyspnea leukemia (Relapse) High-dose prednisone (60 Rapidly progressing shortness of breath, Ingegnoli et mg/day, subsequently 13 61/M profuse sweating, leg edema, severe Cancer Nasopharyngeal carcinoma - - Alive - al., 2009 gradually tapered), fatigue, otalgia furosemide (25mg/day) Zhang et al., 14 49/M Abdomen distention, hypotension Cancer Metastatic liver sarcoma 90/60 3 Hydroxyethyl starch Alive - 2009 Dizziness and brief syncope episode, Avarbock et Drug (denileukin Albumin, vancomycin, 15 53/M generalized muscle aches, respiratory Cutaneous T-cell lymphoma - 2.1 Died SCLS al., 2008 diftitox) cefepime, vasopressors distress Baron et al., Loop diuretics and high- 16 55/M Generalized edema, dyspnea Cancer Adenocarcinoma of the pancreas - 2.0 Alive 2006 dose IV steroids 17 66/F Drug (G-CSF) 98/45 2.1 Corticosteroids, dialysis Died SCLS Deeren et al., Weight gain, urine output decreased, Stage IIIB diffuse large B-cell 5 Ref. Author, year Age/ Sex Presenting symptoms Etiology of SCLS Cancer diagnosis Blood Albumin Treatment Outcome Cause of No. pressure (g/dL) Death (mmHg) 2005 lower limb edema lymphoma (Relapse) High-dose diuretic therapy, Biswas et al., Adenocarcinoma of the pancreatic 18 58/M Dyspnea, generalized edema Cancer - - hydrocortisone 100 mg four Alive - 2004 uncinate times a day IV furosemide and oral Pulkkanen et Mild dyspnea during exercise, pleural prednisolone (starting with 19 50/M Drug (gemcitabine) Renal cell carcinoma - 2.2 Alive - al.,
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