Scientific Days
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FéRI Scientific Days Hôtel Mercure – Tours Sud Allée Andrée Malraux 37300 Joué‐Lès‐Tours Thursday 17 & Friday 18 October 2019 FéRI 2019 – Journées d’Animation Scientifiique – 17 et 18 octobre 2019 – Tours – France Page 1 sur 63 FéRI Scientific Days ‐ programme Hôtel Mercure ‐ Tours Sud Thursday 17 october 2019 08h15 – 08h45 : Reception of participants 08h45 – 09h00 : Welcome opening – Daniel Alquier (VP Research – University of Tours) ‐ Nathalie Winter and Denys Brand (codirectors of the FéRI) 09h00 – 09h30 : Keynote lecture by William Couet (INSERM U1070 de Poitiers) : La modélisation PK/PD peut‐elle contribuer à lutter contre l’antibiorésistance ? Session 1 ‐ Virulence mechanisms and host‐pathogen adaptation Chairwoman/man : Elisabeth Herniou (University of Tours) and Karl Stefic (University of Tours) 09h30 – 10h00 : Keynote lecture 1 by Nolwenn Dheilly (University of New York, USA) : Characterizing the diversity of viruses in neodermata reveals the role of parasites with complex life‐cycles in virus evolution. 10h00 – 10h20 : Alexandra Cerqueira de Araujo (UMR 7261 University of Tours) : Functional and genomic approaches to study the evolution of recently domesticated viruses in Campopleginae parasitoid wasps. 10h20 – 10h40 : Vincent Foray (UMR 7261 University of Tours) : Wolbachia in filarial nematodes: a passenger holding the steering wheel in oogenesis through control of germline stem cell fate and differentiation. 10h40 – 11h10 : Coffee break 11h10 – 11h30 : Adeline Pastuszka (UMR 1282 University of Tours) : Functional study of type II‐A CRISPR‐Cas system of Streptococcus agalactiae hypervirulent strains. 11h30 – 11h50 : Thibaut Josse (UMR 7261 University of Tours) : Hybrid dysgenesis in the parasitoid wasp Cotesia congegata: a transposable element invasion ongoing in the field? 11h50 – 12h20 : Keynote lecture 2 by Heiri Wandeler (Andermatt, Grossdietwil, Switzerland) : Interactions between Baculoviruses and their Hosts – Implications for Biological Control. 12h40 – 13h30 : Lunch 13h30 – 14h00 : Poster Session 1 Session 2 ‐ Host‐pathogen interactions Chairwoman/man : Françoise Debierre (Inra‐University of Tours) et Nicolas Leveque (University of Poitiers) 14h00 – 14h30 : Keynote lecture 3 by Andrew Hemphill (University of Bern, Switzerland) : Novel drugs and drug targets for the treatment of toxoplasmosis and other diseases caused by apicomplexan parasites in farm animals. 14h30 – 14h50 : Adeline Ribeiro E Silva (UMR 1282 INRA‐University of Tours) : EtROP2 is an early expressed kinase localised in the rhoptry compartment of Eimeria tenella. 14h50 – 15h10 : Alexia Damour (EA 4331 University of Poitiers) Role of Staphyloccocus aureus in the physiopathology of atopic dermatitis lesions and eczema herpeticum 15h10 – 15h30 : Charline Herrscher (U1259 INSERM‐University of Tours) : Elucidation of Hepatitis B virus uptake mechanism. 15h30 – 16h00 : Coffee break 16h00 – 16h30 : Keynote lecture 4 by Dorian Kulifaj (BioMérieux, Velniolle, France) : Torque Teno Virus: potential biomarker of immune function in solid organ transplant recipient. 16h30 – 16h50 : Thibault Kervarrec (UMR 1282 INRA‐University of Tours) : Merkel cell carcinoma histogenesis. 16h50 – 17h10 : Jade Cochard (U1259 INSERM‐University of Tours) Impact of physiologically prolonged hypoxia on Zika virus infection and consequences on cellular disturbance. FéRI 2019 – Journées d’Animation Scientifiique – 17 et 18 octobre 2019 – Tours – France Page 2 sur 63 Friday 18 october 2019 Session 3 ‐ Inflammatory and immune responses Chairwoman/man : Valérie Quesniaux (University of Orléans) et Antoine Guillon (University of Tours) 09h00 – 09h30 : Keynote lecture 5 by Markus Maeurer (Champalimaud Foundation, Lisbon, Portugal) : Immunometabolism and pulmonary infections: how to shift the balance of dysfunctional immune responses to protective patterns? 09h30 – 10h50 : Ambre BAILLOU (UMR 1282 INRA‐University of Tours) : Importance of the intestinal cDC1 dendritic cells in the control of Cryptosporidiosis in the murine and lamb models. 09h50 – 10h10 : Aude Remot (UMR 1282 INRA‐University of Tours) : Immune metabolism programming in bovine innate cells. 10h10 – 10h30 : Oral communication by Danilo Guerini (Novartis Pharma, Basel, Switzerland) : cGAS or STING: Which is the most promising target? 10h30 – 11h00 : Coffee break 11h00 – 11h20 : Pierre Germon (UMR 1282 INRA‐University of Tours) : Role of the LPS O‐antigen in the recognition of Escherichia coli by the innate and adaptive immune system of cows. 11h20 – 11h40 : Mégane Nascimento (INEM CNRS‐University of Orléans) : Self‐DNA release and STING‐dependent sensing drives inflammation to cigarette smoke in mice. 11h40 – 12h10 : Keynote lecture 6 by David E Szymkowski (Vice President, Cell Biology of Xencor, Monrovia, USA) : Developing engineered antibodies and cytokines as therapeutics to modulate host immune responses. 12h10 – 13h00 : Lunch 13h00 – 13h30 : Poster Session 2 Session 4 ‐ Thérapies and résistances Chairwoman/man : Marie‐Cécile Ploy (Universiy of Limoges) et Luigi Agrofoglio (University of Orléans) 13h30 – 14h00 : Keynote lecture 7 by Michaël Mourez (Evotec, Marcy l’Etoile, France) : Antibacterials R&D: Trends, Challenges and Opportunities. 14h00 – 14h20 : Amokrane Reghal (Atlangram – Nantes) : Lipid Nanoparticles for Reviving Antibiotics: Efficacy of a Gel of Daptomycin in a Methicillin‐Resistant Staphylococcus aureus Rabbit Osteomyelitis Model. 14h20 – 14h40 : Catherine Dupuy‐Papin (UMR 1282 INRA‐University of Tours) : Molecular and Functional Characterization of ligand‐gated Ion Channels of the Human Louse (Pediculus humanus) to Develop New Treatment Strategies 14h40 – 15h00 : Julien Marlet (U1259 INSERM‐University of Tours) : Toward A Better Understanding Of Entecavir Resistance Using Phenotypic Assays. 15h00 – 15h15 : Stéphane Abrioux (UE 1277 PFIE – INRA Nouzilly) : Presentation of the INRA Infectiology Platform 15h15 – 15h45 : Coffee break 15h45 – 16h15 : Keynote lecture 8 by Bruno Canard (AFMB ‐ UMR7257 CNRS ‐ Aix‐Marseille Univ., France): Challenges in drug‐ design against Nidoviruses of medical and veterinary importance. 16h15 – 16h35 : Lucie Laval (UMR 1092 INSERM‐University of Limoges) : The CALYPSO project: analysis of the integron “cassettome” from hospital effluents. 16h35 – 16h55 : Thomas Jové (UMR 1092 INSERM‐University of Limoges) : Functional Characterization of Novel Mobile Integrons Gene Cassettes. 16h55 ‐ 17h15 : FéRI awards for the best oral communication and poster ‐ Closing of the JAS FéRI 2019 FéRI 2019 – Journées d’Animation Scientifiique – 17 et 18 octobre 2019 – Tours – France Page 3 sur 63 Selected abstracts Session 1 Virulence mechanisms and host‐pathogen adaptation .................................... 7 Alexandra Cerqueira de Araujo ................................................................................................................................... 8 Functional and genomic approaches to study the evolution of recently domesticated viruses in Campopleginae parasitoid wasps. Vincent Foray ...........................................................................................................................................................................10 Wolbachia in filarial nematodes: a passenger holding the steering wheel in oogenesis through control of germline stem cell fate and differentiation. Adeline Pastuszka .....................................................................................................................................................................11 Functional study of type II‐A CRISPR‐Cas system of Streptococcus agalactiae hypervirulent strains. Thibaut Josse ...........................................................................................................................................................................12 Hybrid dysgenesis in the parasitoid wasp Cotesia congegata: a transposable element invasion ongoing in the field? Session 2 Host‐pathogen interactions ........................................................................... 13 Adeline Ribeiro E Silva .............................................................................................................................................. 14 EtROP2 is an early expressed kinase localised in the rhoptry compartment of Eimeria tenella. Alexia Damour ......................................................................................................................................................................... 15 Role of Staphyloccocus aureus in the physiopathology of atopic dermatitis lesions and eczema herpeticum Charline Herrscher .................................................................................................................................................................. 16 Elucidation of Hepatitis B virus uptake mechanism. Thibault Kervarrec .................................................................................................................................................................. 17 Merkel cell carcinoma histogenesis. Jade Cochard ........................................................................................................................................................................... 18 Impact of physiologically prolonged hypoxia on Zika virus infection and consequences on cellular disturbance. Session 3 Inflammatory and immune responses ........................................................... 19 Ambre Baillou .........................................................................................................................................................................