Isolation of Blastomyces Dermatitidis Yeast from Lung Tissue During Murine Infection for in Vivo Transcriptional Profiling
Fungal Genetics and Biology 56 (2013) 1–8 Contents lists available at SciVerse ScienceDirect Fungal Genetics and Biology journal homepage: www.elsevier.com/locate/yfgbi Technological Advancement Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling Amber J. Marty a, Marcel Wüthrich b, John C. Carmen c, Thomas D. Sullivan d, Bruce S. Klein d, ⇑ Christina A. Cuomo e, Gregory M. Gauthier f, a Department of Medicine, School of Medicine and Public Health, University of Wisconsin – Madison, 1550 Linden Drive, Microbial Sciences Building, Room 4335A, Madison, WI 53706, USA b Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin – Madison, 1550 Linden Drive, Microbial Sciences Building, Room 4301, Madison, WI 53706, USA c Department of Biology, Aurora University, Stephens Hall, Room 126, Aurora, IL 60506, USA d Departments of Pediatrics and Medicine, School of Medicine and Public Health, University of Wisconsin – Madison, 1550 Linden Drive, Microbial Sciences Building, Room 4303, Madison, WI 53706, USA e Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA f Department of Medicine, Section of Infectious Diseases, School of Medicine and Public Health, University of Wisconsin – Madison, 1550 Linden Drive, Microbial Sciences Building, Room 6301, Madison, WI 53706, USA article info abstract Article history: Blastomyces dermatitidis belongs to a group of thermally dimorphic fungi that grow as sporulating mold in Received 19 November 2012 the soil and convert to pathogenic yeast in the lung following inhalation of spores. Knowledge about the Accepted 3 March 2013 molecular events important for fungal adaptation and survival in the host remains limited.
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