Embodiment and Everyday Cyborgs INSCRIPTIONS
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Allotransplantation, from Dream to Realty
allotransplantation, froM dreaM to realtY DENYS MONTANDON, MD Switzerland In the vegetal world, grafting can be defined as the natural or deliberate fusion Later, St. John obtained by praying his cut hand, touched it to his wrist and of plant parts so that vascular continuity is established between them, and kneeled in front of the icon of the Virgin Mary. After a long prayer, he felt thus the resulting genetically composite organism functions as a single plant. asleep and dreamed of the Virgin Mary who Vegetal grafts have been performed since antiquity, particularly around the told him “Your hand is healed because you Mediterranean Basin. No wonder, the idea of grafting a portion of tissue, an wrote in defense of God.” When St. John organ or a limb from one individual to another has been a conscious or an awoke, he saw his cured hand and to express unconscious dream for centuries. We are speaking here not only of implanting his gratitude to the Virgin Mary he ordered a foreign body in a living creature, but to graft living material which will be to put on the icon a silver copy of the cut re-vascularized so as to become an integral part of the recipient host. hand. That’s why the icon is called the Three Handed Virgin. (Fig. 3) myThS ANd mIrACleS Hybrid monsters made of different ANeCdoTeS animal or human parts are not rare in During the Renaissance, the possibility of the myths of several civilizations. One reconstructing a nose with the person’s of the best known in Greek mythology own flesh, as initiated by the Branca family is the Centaur Chiron who had the in Catania (Sicily), and later described and Figure3 - Three Hands Icon of Virgin head and torso of a man and the illustrated in detail by Gaspare Tagliacozzi Mary body of a horse (Fig. -
DRUGS on Page 3 Ladder by VIMAL PATEL the Rocky Mountain Collegian
CONGRESS STRESSES OVER BUSH’S NEW BUDGET PLAN | PAGE 6 THE ROCKY MOUNTAIN Fort Collins, Colorado COLLEGIAN Volume 114 | No. 99 Tuesday, February 7, 2006 www.collegian.com THE STUDENT VOICE OF COLORADO STATE UNIVERSITY SINCE 1891 Police draw gun on man in library Women By VIMAL PATEL out of his arm, police said. stand being sober, according north bathroom. He could toilet stall toward the window, The Rocky Mountain Collegian The incident, which oc- to the police report. hear the commotion while he the report states. climb curred in a library bathroom Rosenblath, who does not was talking to other offi cers When the man turned The day before a man al- on the night of Jan. 26, ended attend CSU, said he bought near the fi rst fl oor entrance. toward Martinez, he was in legedly ejaculated in Morgan peacefully with the suspect’s $40 of the drug in Denver ear- After he entered the bath- a defensive stance and had a Library, a CSU Police De- compliance. lier that day, the report states. room and identifi ed himself hypodermic needle sticking partment offi cer in the same Fort Collins resident Chris CSUPD Cpl. Darren Mar- as a police offi cer, he saw the out of his right forearm, and business building drew his gun on a Rosenblath, 37, told police tinez responded to a distur- shirtless, 200-pound Rosenb- man with a needle sticking he’s a heroin addict who can’t bance in the second fl oor lath move from the side of a See DRUGS on Page 3 ladder By VIMAL PATEL The Rocky Mountain Collegian Female ownership of busi- nesses increased by 20 percent in fi ve years, twice the overall LET’S GET PHYSICAL national rate, according to a recent U.S. -
Actant Stories and the Australian Xenotransplantation Network
Constructing and Fracturing Alliances: Actant Stories and the Australian Xenotransplantation Network Copyright - Neil Leslie, Wellcome Images; reproduced with permission Peta S. Cook BPhoto; BSocSc (Sociol.) (hons.) Humanities Research Program Queensland University of Technology Submitted in full requirement for the degree of Doctor of Philosophy 2008 “The XWP [Xenotransplantation Working Party] agree that, in retrospect, a sociologist would have been a useful addition to the group to help understand these issues” (Xenotransplantation Working Party 2004: 14, emphasis added). - i - Keywords sociology; xenotransplantation; transplantation; allotransplantation; actor-network theory; science and technology studies; public understanding of science (PUS); critical public understanding of science (critical PUS); scientific knowledge; public consultation; risk; animals - ii - Abstract Xenotransplantation (XTP; animal-to-human transplantation) is a controversial technology of contemporary scientific, medical, ethical and social debate in Australia and internationally. The complexities of XTP encompass immunology, immunosuppression, physiology, technology (genetic engineering and cloning), microbiology, and animal/human relations. As a result of these controversies, the National Health and Medical Research Council (NHMRC), Australia, formed the Xenotransplantation Working Party (XWP) in 2001. The XWP was designed to advise the NHMRC on XTP, if and how it should proceed in Australia, and to provide draft regulatory guidelines. During the period -
HARBIN. NOVEMBER 2017. Sergio
POWER OVER LIFE AND DEATH Natalie Köhle ARBIN. NOVEMBER 2017. Sergio NESS is NOT in the BRAIN, which seeks HCanavero and Ren Xiaoping 任晓 to prove the existence of an eternal 平 announced that the world’s first hu- soul on the basis of near death experi- man head transplant was ‘imminent’. ence, as well as two guides on seducing They had just completed an eight- women. He also drops flippant refer- een-hour rehearsal on two human ca- ences to Stalin or the Nazi doctor Josef davers, and now claimed to be ready Mengele. for the real deal: the transplant of a human head from a living person with a degenerative disease onto a healthy, but brain-dead, donor body.1 Ren — a US-educated Chinese orthopaedic surgeon, was part of the team that performed the first hand transplant in Louisville in 1999. Canavero, an Italian, and former neu- rosurgeon at the university of Turin, is the more controversial, maverick per- sona of the team. In addition to many respected scientific publications, he Frankenstein’s Monster from The Bride of Frankenstein (1935) published Immortal: Why CONSCIOUS- Source: Commons Wikimedia 276 tor function and sensation. It would 277 also depend on the unproven capacity of the human brain to adjust to — and gain control over — a new body and a new nervous system without suffering debilitating pain or going mad.2 So far, Ren and Canavero have Sergio Canavero transplanted the heads of numerous Source: 诗凯 陆, Flickr lab mice and one monkey, and they Ren and Canavero see the head have also severed and subsequently Power over Life and Death Natalie Köhle transplant, formally known as cepha- mended the spinal cords of several POWER losomatic anastomosis, as the logical dogs. -
The Interdisciplinary Journal of Health, Ethics, & Policy
TUFTSCOPE THE INTERDISCIPLINARY JOURNAL OF HEALTH, ETHICS, & POLICY A DISCUSSION WITH LYDIA X. Z. BROWN: DISABILITY JUSTICE POTENTIAL FOR WORLD’S FIRST HUMAN HEAD TRANSPLANT d 23AndMe: AT-HOME GENETIC Fall 2017 • Volume 17 Issue I TESTING JOURNAL HISTORY EDITORIAL BOARD INSIDE THIS ISSUE Since 2001, TuftScope: The Interdisciplinary Journal of Health, Ethics, & Policy has provided an academic forum for discus- Editor-in-Chief TuftScope | Fall 2017 • Volume 17, Issue I sion of pertinent healthcare and biosocial issues in today’s Neeki Parsa world. The journal addresses different aspects of health- LETTER FROM THE EDITOR care, bioethics, public health, policy, and active citizen- Managing Editor Moving Forward.....................................................................................5 ship. It is operated and edited by undergraduate students of Tufts University and is advised by an Editorial Board Michael Seleman Neeki Parsa composed of Tufts undergraduates and faculty. Today the journal is one of the few peer-reviewed, undergraduate- Senior Financial Officer Ursula Biba NEWS BRIEFS published journals in the country. Selections From Our News Analysis Blog.....................................6 Faculty Advisors TuftScope Staff PUBLISHER AND PRINTER Harry Bernheim, PhD TuftScope is published by the TuftScope Journal organiza- Alexander Queen, PhD FEATURE INTERVIEW tion at Tufts University. The journal is printed by Puritan A Discussion with Lydia X. Z. Brown ..............................................8 Press, NH (http://www.puritanpress.com). Junior Financial Officer Michael Seleman Akari Miki COPYRIGHT TUFTSCOPE 2016 News & Analysis Editor BOOK REVIEW TuftScope is an open-access journal distributed under the Ted Midthun A Book Review of Mark Wolynn’s It Didn’t Start with You......12 terms of the Creative Commons Attribution License, which Neeki Parsa permits use, distribution, and reproduction in any medium, Research Highlights Editor provided the original author and source are credited. -
Human Organ Transplant Authority (Guidelines)
HUMAN ORGAN TRANSPLANT AUTHORITY Protocol/Guidelines for Stem Cell Research/Regulation in Pakistan In Collaboration with the National Bioethics committee, Pakistan INTRODUCTION The ability to cultivate a special class of cells known as stem cells and the possibility to use them as therapeutic tools has ushered in the era of what is known as regenerative medicine. All across the world research and clinical applications of stem cells involving human subjects are regulated by well established international guidelines with country specific details mandated by religious and social mores. Origin and Properties of Stem Cells: During the development of multi-cellular organisms a fertilized egg undergoes repeated cellular divisions to produce a mass of unspecialized cells known as embryonic stem cells. They are uncommitted primordial cells which ultimately give rise to adult stem cells most of which differentiate into characteristic cells of organs and tissues. Stem cells are defined by their ability to keep dividing and renewing their population and thus are not exhausted. In contrast some of the differentiated specialized cells often do not divide and once damaged are depleted. Potential of stem cells to renew and differentiate offers exciting possibilities to reverse tissue and organ damages caused by metabolic and degenerative diseases and aging. Where are Stem Cells found? Gametes/ blastocysts/ fetal tissues/ placenta/umbilical cord cells/ adult tissues serve as sources of stem cells. Classification of Stem Cells according to their Differentiation Potential Totipotent stem cells: These are stem cells with absolute developmental plasticity which can give rise to all cell types that are found in an embryo, fetus or developed organism including the trophoblast and the placenta. -
The Morality of Head Transplant: Frankenstein’S Allegory
5 THE MORALITY OF HEAD TRANSPLANT: FRANKENSTEIN’S ALLEGORY Aníbal Monasterio Astobiza1 Abstract: In 1970 Robert J. White (1926-2010) tried to transplant the head of a Rhesus monkey into another monkey’s body. He was in- spired by the work of a Russian scientist, Vladimir Demikhov (1916- 1998), who had conducted similar experiments in dogs. Both Demikhov and White have been successful pioneers of organ transplantation, but their scientific attempts to transplant heads of mammals are often remem- bered as infamous. Both scientists encountered important difficulties in such experiments, including their incapacity to link the spinal cord, which ended up by creating quadriplegic animals. In 2013, neurosurgeon Sergio Canavero claimed his capacity and plan to carry out the first human head 1 I am grateful to the Basque Government sponsorship for carrying out a posdoc- toral research fellowship at the Uehiro Centre for Practical Ethics of the University of Oxford, and to the latter institution for its warm welcome. Also, I would like to thank David Rodríguez-Arias for his invaluable comments and suggestions for the improvement of this paper. As usual, any error is solely the author’s responsibility. This work was carried out within the framework of the following research projects: KONTUZ!: “Responsabilidad causal de la comisión por omisión: Una dilucidadión ético-jurídica de los problemas de la acción indebida” (MINECO FFI2014-53926-R); “La constitución del sujeto en la interacción social: identidad, normas y sentido de la acción desde la perspectiva de la filosofía de la acción, la epistemología y la filosofía experimental” (FFI2015-67569-C2-2-P), and “Artificial Intelligence and Biotechnol- ogy of Moral Enhancement Ethical Aspects” (FFI2016-79000-P). -
From Immunology to Peripheral Nerve Fusion Sergio Canavero, Xiaoping Ren HEAVEN-GEMINI International Collaborative Group, Turin, Italy and Nanning, China
www.surgicalneurologyint.com Surgical Neurology International Editor-in-Chief: Nancy E. Epstein, MD, NYU Winthrop Hospital, Mineola, NY, USA. SNI: Head and Spinal Cord Transplantation Editor Sergio Canavero, MD; XiaoPing Ren, MD HEAVEN/GEMINI International Collaborative Group, Turin, Italy Open Access Editorial Advancing the technology for head transplants: From immunology to peripheral nerve fusion Sergio Canavero, Xiaoping Ren HEAVEN-GEMINI International Collaborative Group, Turin, Italy and Nanning, China. E-mail: *Sergio Canavero - [email protected]; Xiaoping Ren - [email protected] In this editorial, we hash out the details of two major aspects of the technology behind head transplants (HEAVEN), one having to do with immunosuppression (IS), the other on the reconnection of peripheral nerves at neck level. IMMUNOTOLERANCE [5] *Corresponding author: In the context of HEAVEN, the donor body would reject the head (although it cannot Prof. Sergio Canavero, be excluded that resident head immune cells in the head can mount a reaction against the HEAVEN-GEMINI body), with rejection of tissues not protected by the blood–brain barrier (i.e., the brain) such International Collaborative as the pituitary gland or the spinal cord (and of course the face skin and muscles) especially Group, Turin, Italy and critical. This necessitates IS with a protocol similar to facial and limb transplants. Sirolimus, Nanning, China. with its minimal neurotoxicity and pro-neuroregenerative properties (despite its interference [email protected] with wound healing), is especially indicated. However, long-term administration of these medications results – as is well known – in significant morbidity and mortality, including Received : 24 September 19 nephrotoxicity, infections, neoplasm, and cardiovascular diseases. -
To-Head Transplant; a "Caputal" Crime? Examining the Corpus of Ethical and Legal Issues Zaev D
Suskin and Giordano Philosophy, Ethics, and Humanities in Medicine (2018) 13:10 https://doi.org/10.1186/s13010-018-0063-2 EDITORIAL Open Access Body –to-head transplant; a "caputal" crime? Examining the corpus of ethical and legal issues Zaev D. Suskin1,2,3* and James J. Giordano2,3,4 Abstract Neurosurgeon Sergio Canavero proposed the HEAVEN procedure – i.e. head anastomosis venture – several years ago, and has recently received approval from the relevant regulatory bodies to perform this body-head transplant (BHT) in China. The BHT procedure involves attaching the donor body (D) to the head of the recipient (R), and discarding the body of R and head of D. Canavero’s proposed procedure will be incredibly difficult from a medical standpoint. Aside from medical doubt, the BHT has been met with great resistance from many, if not most bio- and neuroethicists. Given both the known challenges and unknown outcomes of HEAVEN, several important neuroethical and legal questions have emerged should Canavero be successful, including: (1) What are the implications for transplantology in the U.S., inclusive of issues of expense, distributive justice, organizational procedures, and the cost(s) of novel insight(s)? (2) How do bioethical and neuroethical principles, and legal regulations of human subject research apply? (3) What are the legal consequences for Canavero (or any other surgeon) performing a BHT? (4) What are the tentative implications for the metaphysical and legal identity of R should they survive post-BHT? These questions are analyzed, issues are identified, and several solutions are proposed in an attempt to re-configure HEAVEN into a safe, clinically effective, and thus (more) realistically viable procedure. -
Head Transplant - the Newest Reports and Concerns on Planned Procedure
Available online at www.worldscientificnews.com WSN 105 (2018) 212-217 EISSN 2392-2192 SHORT COMMUNICATION Head transplant - the newest reports and concerns on planned procedure Maria Gołębiowska1,*, Beata Gołębiowska2 1 Student, I Faculty of Medicine, Medical University of Lublin, Al. Raclawickie 1, 20-059 Lublin, Poland 2 Pediatric Neurology Department, III Chair of Pediatrics, Medical University of Lublin, 6 Prof. A. Gebali Str., 20-093 Lublin, Poland *E-mail address: [email protected] ABSTRACT Transplantation, one of the most intensively developing fields of medicine, is giving patients hope for the chance of "second life" and health. The 21st century medical achievements heralded to achieve more difficult challenges, such as face transplant or lower extremity transplant. Among the futuristic dreams of the scientists, one of the projects - the Head to Body Transplant, stands out as one of the most controversial surgeries of the century. The aim of this study was to present the current state of art in medical aspect on cephalic anastomosis, as well as ethical implications. Among articles in PubMed Medline database related to human cephalic anastomosis, head transplant, head to body transplant keywords, 15 articles were selected for further analysis. Reviewed research presents significant development in conduction of the human cephalic anastomosis project. Most of the crucial parts of the surgery, such as deep profound hypothermia, spinal cord anastomosis - the detachment and fusion with the fusiogenes particles, have been practiced on animal models. The more newest revelations are revealed to the public, the more ethical and technical concerns are raised, primarily in terms of one-center study aprroach, infavourable benefit-cost ratio and futuristic apprehensions of infertility, transsexual or even unnatural life prolongation reasons for performing this type of surgery. -
Frenchwoman Who Received First Face Transplant Dies 6 September 2016
Frenchwoman who received first face transplant dies 6 September 2016 The world's first face transplant recipient, He added that in addition to the risk of rejection a Frenchwoman Isabelle Dinoire, died in April "after number of other problems can crop up including a long illness", a hospital said Tuesday. "grafts that age a little faster than (the patient), problems of (skin) colour, high blood pressure (and) In 2005, at the age of 38, Dinoire received a graft mood." comprising the nose, lips and chin of a brain-dead donor to replace parts of her face that had been Meningaud said that with Dinoire's death, "we mauled by her dog. should put these transplants on hold pending advances in immunology". The hospital in Amiens, northern France, confirmed the death of "Mrs D., the first patient in Dinoire gave a remarkable news conference in the world to receive a face transplant". February 2006, just three months after the operation, when the blonde, blue-eyed mother of The hospital said her death had been kept quiet to two appeared before a scrum of TV cameras. protect her family's privacy. She appeared to be wearing thick makeup to The ground-breaking operation had raised hopes disguise the scars of the procedure and lips that around the world for victims with faces disfigured in were heavy and inflexible. accidents or assaults, with surgeons in the United States, Spain, China, Belgium, Poland and Turkey She spoke with a pronounced lisp but was performing partial or full transplants since the otherwise comprehensible as she recounted how ground-breaking surgery on Dinoire. -
Manchester Transplantation 50 Years
MANCHESTER TRANSPLANTATION 50 YEARS Titus Augustine Clinical Director WELCOME TO THE NORTH OF ENGLAND WELCOME TO MANCHESTER (It exists !) A REBORN CITY MANCHESTER UNIVERSITY FOUNDATION TRUST THE ISLAND SITE OF THE UNIVERSITY HOSPITALS FIRST SUCCESSFUL KIDNEY TRANSPLANTATION • I had worked on dogs for a couple of years developing a renal transplant operation. We had dogs running around with kidneys we had transplanted back into themselves. • Joe Murray GLOBAL TRANSPLANTATION LAST 50 YEARS • FROM PIONEERING SURGERY TO WELL ESTABLISHED TECHNIQUE FOR ORGAN FAILURE • EXCELLENT OUTCOMES FOR KIDNEY, LIVER, PANCREAS, HEART, LUNG AND ISLETS • SPECTRUM OF PROBLEMS HAVE SHIFTED FROM SURGICAL AND IMMEDIATE TO IMMUNOLOGICAL AND LONG TERM GRAFT SURVIVAL • INCREASING SPECTRUM OF POTENTIAL ORGANS THAT CAN BE TRANSPLANTED LIMB TRANSPLANTS UTERINE TRANSPLANTS HEAD TRANSPLANTS • IMMORTALITY POSSIBLE? World's first human head transplant 'successfully' carried out • THE world's first human head transplant has been "successfully" carried out after an 18-hour procedure in China, it was today claimed. • By JON AUSTIN • PUBLISHED: 16:35, Fri, Nov 17, 2017 | UPDATED: 16:56, Fri, Nov 17, 2017 A TRIBUTE TO PATIENTS • “The success of transplantation is largely due to the bravery of those who undergo it.” • Sir Peter Medawar A tribute to the 6500 transplant patients who have passed through our department THE MYRAID STRANDS OF TRANSPLANTATION • PERHAPS THE FINEST EXAMPLE OF THE DEVELOPMENT OF MEDICAL SCIENCE • SURGICAL TECHNIQUES CLOSELY INTERLINKED WITH IMMUNOLOGY