January 5, 2021 u vol. 118 u no. 1

From the Cover

e2019115118 Pink bollworm eradication e1917623117 Antimicrobial neuropeptide for host brain defense e2020205118 Inverse design of water purification membranes e2020551118 Biochemical action of endocrine disruptor mixture e2021446118 Deep learning and near-infrared imaging

Contents

THIS WEEK IN PNAS—This week’s research highlights eiti0121118 In This Issue Cover image: Pictured is a moth of the pink bollworm (Pectinophora gossypiella). Based on analysis of OPINION—Leading scientists discuss current issues computer simulations and 21 years of field data, Bruce E. Tabashnik et al. e2024143118 We need to improve the welfare of life science trainees found that synergy between planting Daniele Simoneschi genetically engineered cotton and the release of billions of sterile moths — helped to eradicate the devastating SCIENCE AND CULTURE How science intersects with culture cotton pest, pink bollworm, from the e2024280118 Astronomer-turned-filmmaker strives to ignite an interest in space continental United States and Mexico Stephen Ornes a century after it invaded both countries. Pink bollworm eradication has led to economic benefits for farmers and RETROSPECTIVE environmental benefits from reduced e2023954118 José Mario Molina: Life and legacy of a man who helped to save Earth’s insecticide use. See the article by ozone layer Tabashnik et al., e2019115118. Image Rodolfo Dirzo and Adria´n Ferna´ndez credit: Alexander Yelich (University of Arizona, Tucson, AZ). The cover image has been updated. COMMENTARIES e2022238118 Glycomic profiling and the mammalian brain Jennyfer Tena and Carlito B. Lebrilla See companion article on page 28743 in issue 46 of volume 117 e2023962118 A field theory for plant tropisms Oliver E. Jensen See companion article on page 32226 in issue 51 of volume 117 e2023895118 Mobility restrictions are more than transient reduction of travel activities Ruiyun Li See companion article on page 32883 in issue 52 of volume 117 e2024346118 Navigating the waters of membrane design Henry S. Ashbaugh See companion article, e2020205118, in vol. 118, issue 1

PERSPECTIVE e2015370118 Historical natural kinds and mineralogy: Systematizing contingency in the context of necessity Carol E. Cleland, Robert M. Hazen, and Shaunna M. Morrison

Free online through the PNAS open access option. PNAS u January 5, 2021 u vol. 118 u no. 1 u iii–viii Downloaded by guest on September 27, 2021 e1907856118 On the use of simulation in robotics: EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Opportunities, challenges, and suggestions e2013349118 Stochastic dynamics of barrier island elevation for moving forward Orencio Dura´n Vinent, Benjamin E. Schaffer, HeeSun Choi, Cindy Crump, Christian Duriez, Asher and Ignacio Rodriguez-Iturbe Elmquist, Gregory Hager, David Han, Frank Hearl, e2013254118 Probabilistic structure of events controlling Jessica Hodgins, Abhinandan Jain, Frederick Leve, Chen Li, Franziska Meier, Dan Negrut, Ludovic Righetti, Alberto the after-storm recovery of coastal dunes Rodriguez, Jie Tan, and Jeff Trinkle Tobia Rinaldo, Kiran Adhithya Ramakrishnan, Ignacio Rodriguez-Iturbe, and Orencio Dura´n Vinent e2016430118 Global silicate weathering flux overestimated LETTERS because of sediment–water cation exchange e2018949118 Island species experience higher niche Edward T. Tipper, Emily I. Stevenson, Victoria Alcock, expansion and lower niche conservatism Alasdair C. G. Knight, J. Jotautas Baronas, Robert G. during invasion Hilton, Mike J. Bickle, Christina S. Larkin, Linshu Feng, James T. Stroud Katy E. Relph, and Genevieve Hughes e2020172118 Reply to Stroud: Invasive amphibians and e2015211118 Remnants of early Earth differentiation in the reptiles from islands indeed show higher deepest mantle-derived lavas niche expansion than mainland species Andrea Giuliani, Matthew G. Jackson, Angus Chunlong Liu, Christian Wolter, Weiwei Xian, Fitzpayne, and Hayden Dalton and Jonathan M. Jeschke e2016187118 Metabolites as frailty biomarkers in ENGINEERING older adults e2021096118 Adipose tissue is a critical regulator Yiming Pan, Yun Li, and Lina Ma of osteoarthritis Kelsey H. Collins, Kristin L. Lenz, Eleanor N. Pollitt, e2016640118 Reply to Pan et al.: Whole blood metabolome Daniel Ferguson, Irina Hutson, Luke E. Springer, Arin K. analysis combined with comprehensive Oestreich, Ruhang Tang, Yun-Rak Choi, Gretchen A. frailty assessment Meyer, Steven L. Teitelbaum, Christine T. N. Pham, Masahiro Kameda, Takayuki Teruya, Mitsuhiro Charles A. Harris, and Farshid Guilak Yanagida, and Hiroshi Kondoh PHYSICS INAUGURAL ARTICLE e2011709118 Tregs self-organize into a computing ecosystem and implement a sophisticated e2022112118 Ancient DNA from Guam and the peopling of optimization algorithm for mediating the Pacific immune response Irina Pugach, Alexander Hu¨bner, Hsiao-chun Hung, Robert Marsland III, Owen Howell, Andreas Mayer, Matthias Meyer, Mike T. Carson, and Mark Stoneking and Pankaj Mehta e1921529118 On conservation laws in quantum mechanics PHYSICAL SCIENCES Yakir Aharonov, Sandu Popescu, and Daniel Rohrlich

APPLIED PHYSICAL SCIENCES e1917623117 PACAP is a pathogen-inducible resident STATISTICS antimicrobial neuropeptide affording rapid e2016877118 A data-driven approach to identify risk profiles and contextual molecular host defense and protective drugs in COVID-19 of the brain Pietro E. Cippa`, Federica Cugnata, Paolo Ferrari, Ernest Y. Lee, Liana C. Chan, Huiyuan Wang, Juelline Chiara Brombin, Lorenzo Ruinelli, Giorgia Bianchi, Lieng, Mandy Hung, Yashes Srinivasan, Jennifer Wang, Nicola Beria, Lukas Schulz, Enos Bernasconi, Paolo James A. Waschek, Andrew L. Ferguson, Kuo-Fen Lee, Merlani, Alessandro Ceschi, and Clelia Di Serio Nannette Y. Yount, Michael R. Yeaman, and Gerard C. L. Wong SOCIAL SCIENCES e2018837118 Proton strings and rings in atypical nucleation of ferroelectricity in ice ANTHROPOLOGY J. Lasave, S. Koval, A. Laio, and E. Tosatti e2022112118 Ancient DNA from Guam and the peopling of e2021299118 Discovering multiscale and self-similar the Pacific structure with data-driven wavelets Irina Pugach, Alexander Hu¨bner, Hsiao-chun Hung, Daniel Floryan and Michael D. Graham Matthias Meyer, Mike T. Carson, and Mark Stoneking

CHEMISTRY ECONOMIC SCIENCES e2019265118 Strong metal–metal Pauli repulsion leads to e2015455118 Nursing home staff networks and COVID-19 8 repulsive metallophilicity in closed-shell d M. Keith Chen, Judith A. Chevalier, and Elisa F. Long and d10 organometallic complexes Qingyun Wan, Jun Yang, Wai-Pong To, e2008740118 Incorporating ethics and welfare into and Chi-Ming Che randomized experiments e2020205118 Affinity of small-molecule solutes Yusuke Narita to hydrophobic, hydrophilic, and chemically patterned interfaces ENVIRONMENTAL SCIENCES in aqueous solution e2012370118 Global evidence for ultraviolet radiation Jacob I. Monroe, Sally Jiao, R. Justin Davis, decreasing COVID-19 growth rates Dennis Robinson Brown, Lynn E. Katz, Tamma Carleton, Jules Cornetet, Peter Huybers, and M. Scott Shell Kyle C. Meng, and Jonathan Proctor

iv u www.pnas.org Contents Downloaded by guest on September 27, 2021 PSYCHOLOGICAL AND COGNITIVE SCIENCES BIOPHYSICS AND COMPUTATIONAL BIOLOGY e2014271118 Transfer of information across repeated e2021456118 A phosphorylation-dependent switch in the decisions in general and in obsessive– disordered p53 transactivation domain compulsive disorder regulates DNA binding Alec Solway, Zhen Lin, and Ekansh Vinaik Xun Sun, H. Jane Dyson, and Peter E. Wright e2007538118 Concerns for others increases the likelihood of e2021446118 Deep learning for in vivo near- vaccination against influenza and COVID-19 infrared imaging more in sparsely rather than densely Zhuoran Ma, Feifei Wang, Weizhi Wang, Yeteng populated areas Zhong, and Hongjie Dai Haesung Jung and Dolores Albarracı´n e2014085118 Structural and molecular basis of cross-seeding barriers in amyloids SOCIAL SCIENCES Asen Daskalov, Denis Martinez, Virginie Coustou, e2019378118 Impacts of the COVID-19 pandemic on Nadia El Mammeri, Me´lanie Berbon, Loren B. rural America Andreas, Benjamin Bardiaux, Jan Stanek, Abdelmajid J. Tom Mueller, Kathryn McConnell, Paul Berne Burow, Noubhani, Brice Kauffmann, Joseph S. Wall, Guido Katie Pofahl, Alexis A. Merdjanoff, and Justin Farrell Pintacuda, Sven J. Saupe, Birgit Habenstein, and Antoine Loquet e2016385118 Enforcement may crowd out voluntary support for COVID-19 policies, especially CELL BIOLOGY where trust in government is weak and in a liberal society e1904338118 Extrasynaptic acetylcholine signaling through Katrin Schmelz a muscarinic receptor regulates cell migration e2013515118 Filling the gaps in the global prevalence map Mihoko Kato, Irina Kolotuev, Alexandre Cunha, Shahla of clinical antimicrobial resistance Gharib, and Paul W. Sternberg Rik Oldenkamp, Constance Schultsz, Emiliano Mancini, and Antonio Cappuccio e2010054118 In vitro reconstitution reveals phosphoinositides as cargo-release factors and activators of the ARF6 GAP ADAP1 BIOLOGICAL SCIENCES Christian Duellberg, Albert Auer, Nikola Canigova, Katrin Loibl, and Martin Loose AGRICULTURAL SCIENCES e2005539118 Downregulation of autophagy by Met30- e2019115118 Transgenic cotton and sterile insect releases mediated Atg9 ubiquitination synergize eradication of pink bollworm Yuchen Feng, Aileen R. Ariosa, Ying Yang, Zehan Hu, a century after it invaded the Jo¨rn Dengjel, and Daniel J. Klionsky United States e2015887118 The Ligand of Ate1 is intrinsically disordered Bruce E. Tabashnik, Leighton R. Liesner, Peter C. and participates in nucleolar phase Ellsworth, Gopalan C. Unnithan, Jeffrey A. Fabrick, Steven E. Naranjo, Xianchun Li, Timothy J. Dennehy, separation regulated by Jumonji Domain Larry Antilla, Robert T. Staten, and Yves Carrie`re Containing 6 Akshaya Arva, Yasar Arfat T. Kasu, Jennifer Duncan, Mosleh A. Alkhatatbeh, and Christopher S. Brower ANTHROPOLOGY e2022112118 Ancient DNA from Guam and the peopling of e2007526118 Evolutionarily related small viral fusogens the Pacific hijack distinct but modular actin nucleation Irina Pugach, Alexander Hu¨bner, Hsiao-chun Hung, pathways to drive cell-cell fusion Matthias Meyer, Mike T. Carson, and Mark Stoneking Ka Man Carmen Chan, Ashley L. Arthur, Johannes Morstein, Meiyan Jin, Abrar Bhat, Do¨rte Schlesinger, e2015317118 Maternal death and offspring fitness in Sungmin Son, Donte´ A. Stevens, David G. Drubin, multiple wild primates and Daniel A. Fletcher Matthew N. Zipple, Jeanne Altmann, Fernando A. Campos, Marina Cords, Linda M. Fedigan, Richard R. DEVELOPMENTAL BIOLOGY Lawler, Elizabeth V. Lonsdorf, Susan Perry, Anne E. e2020028118 Pusey, Tara S. Stoinski, Karen B. Strier, Maternal GABAergic and GnRH/corazonin and Susan C. Alberts pathway modulates egg diapause phenotype of the silkworm Bombyx mori BIOCHEMISTRY Ryoma Tsuchiya, Aino Kaneshima, Masakazu + + Kobayashi, Maki Yamazaki, Yoko Takasu, Hideki e2020438118 Binding of cardiotonic steroids to Na ,K - Sezutsu, Yoshiaki Tanaka, Akira Mizoguchi, ATPase in the E2P state and Kunihiro Shiomi Ryuta Kanai (金井隆太), Flemming Cornelius, Haruo e2007322118 GATA6 is a regulator of sinus node Ogawa (小川治夫), Kanna Motoyama (元山かん奈), Bente Vilsen, and Chikashi Toyoshima (豊島近) development and heart rhythm Lara Gharibeh, Abir Yamak, Jamieson e2020551118 Mechanistic insights into the synergistic Whitcomb, Aizhu Lu, Mathieu Joyal, Hiba activation of the RXR–PXR heterodimer Komati, Wenbin Liang, Ce´line Fiset, and Mona Nemer by endocrine disruptor mixtures Vanessa Delfosse, Tiphaine Huet, Deborah Harrus, ECOLOGY Meritxell Granell, Maxime Bourguet, Caroline Gardia- Pare`ge, Barbara Chiavarina, Marina Grimaldi, e2011389118 Microrheology reveals microscale viscosity Se´bastien Le Me´vel, Pauline Blanc, David Huang, gradients in planktonic systems Jakub Gruszczyk, Barbara Demeneix, Sarah Cianfe´rani, O` scar Guadayol, Tania Mendonca, Mariona Segura- Jean-Baptiste Fini, Patrick Balaguer, Noguera, Amanda J. Wright, Manlio Tassieri, and William Bourguet and Stuart Humphries

Contents PNAS u January 5, 2021 u vol. 118 u no. 1 u v Downloaded by guest on September 27, 2021 ENVIRONMENTAL SCIENCES e2011763118 UFMylation inhibits the proinflammatory e2012370118 Global evidence for ultraviolet radiation capacity of interferon-γ–activated decreasing COVID-19 growth rates macrophages Tamma Carleton, Jules Cornetet, Peter Huybers, Dale R. Balce, Ya-Ting Wang, Michael R. McAllaster, Kyle C. Meng, and Jonathan Proctor Bria F. Dunlap, Anthony Orvedahl, Barry L. Hykes Jr, Lindsay Droit, Scott A. Handley, Craig B. Wilen, John G. Doench, Robert C. Orchard, Christina L. EVOLUTION Stallings, and Herbert W. Virgin e2021958118 Single-molecule nanopore sequencing reveals e2017120118 Cigarette smoke induces miR-132 in Th17 cells extreme target copy number heterogeneity that enhance osteoclastogenesis in in arylomycin-resistant mutants inflammatory arthritis Hany S. Girgis, Cory D. DuPai, Jessica Lund, Janina Paula B. Donate, Kalil Alves de Lima, Raphael S. Peres, Reeder, Joseph Guillory, Steffen Durinck, Yuxin Liang, Fausto Almeida, Sandra Y. Fukada, Tarcilia A. Silva, Joshua Kaminker, Peter A. Smith, Daniele C. Nascimento, Nerry T. Cecilio, Jhimmy and Elizabeth Skippington Talbot, Rene D. Oliveira, Geraldo A. Passos, Jose´ e2008850118 Mammalian molar complexity follows simple, Carlos Alves-Filho, Thiago M. Cunha, Paulo Louzada- predictable patterns Junior, Foo Y. Liew, and Fernando Q. Cunha Keegan R. Selig, Waqqas Khalid, e2015632118 Recruitment of pro-IL-1α to mitochondrial and Mary T. Silcox cardiolipin, via shared LC3 binding domain, e2009227118 The evolution of skin pigmentation-associated inhibits mitophagy and drives maximal variation in West Eurasia NLRP3 activation Dan Ju and Iain Mathieson Jargalsaikhan Dagvadorj, Karolina Mikulska-Ruminska, Gantsetseg Tumurkhuu, Rojo A. Ratsimandresy, Jessica Carriere, Allen M. Andres, Stefanie Marek- GENETICS Iannucci, Yang Song, Shuang Chen, Malcolm Lane, e2021996118 Precise genome engineering in Drosophila Andrea Dorfleutner, Roberta A. Gottlieb, Christian using prime editing Stehlik, Suzanne Cassel, Fayyaz S. Sutterwala, Ivet Bahar, Timothy R. Crother, and Moshe Arditi Justin A. Bosch, Gabriel Birchak, and Norbert Perrimon e2009837118 Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis e2004077118 Genome-wide surveillance of transcription errors in response to genotoxic stress through bacterial-mediated prothrombin activation C. Fritsch, J.-F. Gout, S. Haroon, A. Towheed, C. Chung, J. LaGosh, E. McGann, X. Zhang, Joni M. Prasad, Oscar Negro´n, Xinli Du, Y. Song, S. Simpson, P. S. Danthi, B. A. Eric S. Mullins, Joseph S. Palumbo, Jessica M. Benayoun, D. Wallace, K. Thomas, M. Lynch, Gilbertie, Magnus Ho¨o¨k, Steven P. Grover, Rafal and M. Vermulst Pawlinski, Nigel Mackman, Jay L. Degen, and Matthew J. Flick e2008498118 Mfd regulates RNA polymerase association with hard-to-transcribe e2013686117 Two populations of self-maintaining regions in vivo, especially those with monocyte-independent macrophages structured RNAs exist in adult epididymis and testis Ming Wang, Yalong Yang, Dilay Cansever, Mark N. Ragheb, Christopher Merrikh, Kaitlyn Yiming Wang, Crystal Kantores, Se´bastien Messiaen, Browning, and Houra Merrikh Delphine Moison, Gabriel Livera, Svetoslav Chakarov, Tobias Weinberger, Christopher Stremmel, Monika IMMUNOLOGY AND INFLAMMATION Fijak, Britta Klein, Christiane Pleuger, Zhexiong e1917623117 PACAP is a pathogen-inducible resident Lian, Wentao Ma, Qingzhi Liu, Kathrin Klee, antimicrobial neuropeptide affording rapid Kristian Ha¨ndler, Thomas Ulas, Andreas Schlitzer, Joachim L. Schultze, Burkhard Becher, Melanie and contextual molecular host defense Greter, Zhaoyuan Liu, Florent Ginhoux, Slava of the brain Epelman, Christian Schulz, Andreas Meinhardt, Ernest Y. Lee, Liana C. Chan, Huiyuan Wang, Juelline and Sudhanshu Bhushan Lieng, Mandy Hung, Yashes Srinivasan, Jennifer Wang, James A. Waschek, Andrew L. Ferguson, Kuo-Fen Lee, e2018457118 Sunlight exposure exerts immunomodulatory Nannette Y. Yount, Michael R. Yeaman, effects to reduce multiple sclerosis severity and Gerard C. L. Wong Patrick Ostkamp, Anke Salmen, Be´atrice Pignolet, Dennis Go¨rlich, Till F. M. Andlauer, Andreas Schulte- e2011709118 Tregs self-organize into a computing Mecklenbeck, Gabriel Gonzalez-Escamilla, Florence ecosystem and implement a sophisticated Bucciarelli, Isabelle Gennero, Johanna Breuer, Gisela optimization algorithm for mediating Antony, Tilman Schneider-Hohendorf, Nadine Mykicki, immune response Antonios Bayas, Florian Then Bergh, Stefan Bittner, Robert Marsland III, Owen Howell, Andreas Mayer, Hans-Peter Hartung, Manuel A. Friese, Ralf A. Linker, and Pankaj Mehta Felix Luessi, Klaus Lehmann-Horn, Mark Mu¨hlau, Friedemann Paul, Martin Stangel, Bjorn Tackenberg, e2022343118 HMGB1-mediated chromatin remodeling ¨ Hayrettin Tumani, Clemens Warnke, Frank Weber, attenuates Il24 gene expression for Brigitte Wildemann, Uwe K. Zettl, Ulf Ziemann, Bertram the protection from allergic Mu¨ller-Myhsok, Tania Ku¨mpfel, Luisa Klotz, Sven G. contact dermatitis Meuth, Frauke Zipp, Bernhard Hemmer, Reinhard Naoyuki Senda, Hideyuki Yanai, Sana Hibino, Hohlfeld, David Brassat, Ralf Gold, Catharina C. Gross, Lei Li, Yu Mizushima, Tomomitsu Miyagaki, Carsten Lukas, Sergiu Groppa, Karin Loser, Heinz Mai Saeki, Yusuke Kishi, Sho Hangai, Junko Wiendl, Nicholas Schwab, and on behalf of the German Nishio, Makoto Sugaya, Tadatsugu Taniguchi, Competence Network Multiple Sclerosis (KKNMS) and Shinichi Sato and the BIONAT Network

vi u www.pnas.org Contents Downloaded by guest on September 27, 2021 MEDICAL SCIENCES e2014444118 Staphylococcus aureus binds to the N- e2016877118 A data-driven approach to identify risk profiles terminal region of corneodesmosin to and protective drugs in COVID-19 adhere to the stratum corneum in Pietro E. Cippa`, Federica Cugnata, Paolo Ferrari, atopic dermatitis Chiara Brombin, Lorenzo Ruinelli, Giorgia Bianchi, Aisling M. Towell, Ce´cile Feuillie, Pauline Vitry, Nicola Beria, Lukas Schulz, Enos Bernasconi, Paolo Thaina M. Da Costa, Marion Mathelie´-Guinlet, Merlani, Alessandro Ceschi, and Clelia Di Serio Sanja Kezic, Orla M. Fleury, Maeve A. e2021450118 Targeting transcriptional regulation of McAleer, Yves F. Dufreˆne, Alan D. Irvine, and Joan A. Geoghegan SARS-CoV-2 entry factors ACE2 and TMPRSS2 Yuanyuan Qiao, Xiao-Ming Wang, Rahul Mannan, e2016144118 Cryo-EM structure of the full-length WzmWzt Sethuramasundaram Pitchiaya, Yuping Zhang, ABC transporter required for lipid-linked O Jesse W. Wotring, Lanbo Xiao, Dan R. Robinson, Yi-Mi antigen transport Wu, Jean Ching-Yi Tien, Xuhong Cao, Stephanie A. Christopher A. Caffalette and Jochen Zimmer Simko, Ingrid J. Apel, Pushpinder Bawa, Steven Kregel, e2015794118 E3 ubiquitin ligase Mindbomb 1 facilitates Sathiya P. Narayanan, Gregory Raskind, Stephanie J. Ellison, Abhijit Parolia, Sylvia Zelenka-Wang, Lisa nuclear delivery of adenovirus genomes McMurry, Fengyun Su, Rui Wang, Yunhui Cheng, Stephanie L. Sarbanes, Vincent A. Blomen, Andrew D. Delekta, Zejie Mei, Carla D. Pretto, Eric Lam, Søren Heissel, Joseph M. Luna, Thijn R. Shaomeng Wang, Rohit Mehra, Jonathan Z. Sexton, Brummelkamp, Erik Falck-Pedersen, H.-Heinrich and Arul M. Chinnaiyan Hoffmann, and Charles M. Rice e2020868118 Oral administration of PEGylated TLR7 ligand e2016066118 The retromer is co-opted to deliver ameliorates alcohol-associated liver disease via lipid enzymes for the biogenesis the induction of IL-22 of lipid-enriched tombusviral Qinglan Wang, So Yeon Kim, Hiroshi Matsushita, replication organelles Zhijun Wang, Vijay Pandyarajan, Michitaka Matsuda, Zhike Feng, Jun-ichi Inaba, and Peter D. Nagy Koichiro Ohashi, Takashi Tsuchiya, Yoon Seok Roh, Calvin Kiani, Yutong Zhao, Michael Chan, Suzanne NEUROSCIENCE Devkota, Shelly C. Lu, Tomoko Hayashi, Dennis A. e2014271118 Transfer of information across repeated Carson, and Ekihiro Seki decisions in general and in obsessive– e2016605118 Pharmacokinetic modeling reveals parameters compulsive disorder that govern tumor targeting and delivery by Alec Solway, Zhen Lin, and Ekansh Vinaik a pH-Low Insertion Peptide (pHLIP) e2017841118 Environmental noise degrades hippocampus- Alexander A. Svoronos and Donald M. Engelman related learning and memory e2008072118 A protease-activated, near-infrared fluorescent Yifan Zhang, Min Zhu, Yutian Sun, Binliang probe for early endoscopic detection of Tang, Guimin Zhang, Pengying An, Yuan premalignant gastrointestinal lesions Cheng, Ye Shan, Michael M. Merzenich, Joshua J. Yim, Stefan Harmsen, Krzysztof Flisikowski, and Xiaoming Zhou Tatiana Flisikowska, Hong Namkoong, Megan e2020810118 Astrocyte-secreted IL-33 mediates Garland, Nynke S. van den Berg, Jose´ G. Vilches- homeostatic synaptic plasticity in the Moure, Angelika Schnieke, Dieter Saur, Sarah Glasl, Dimitris Gorpas, Aida Habtezion, Vasilis Ntziachristos, adult hippocampus Christopher H. Contag, Sanjiv S. Gambhir, Matthew Ye Wang, Wing-Yu Fu, Kit Cheung, Kwok-Wang Hung, Bogyo, and Stephan Rogalla Congping Chen, Hongyan Geng, Wing-Ho Yung, Jianan Y. Qu, Amy K. Y. Fu, e2020102118 Adaptive responses to mTOR gene and Nancy Y. Ip targeting in hematopoietic stem cells e2018078118 Social isolation uncovers a circuit underlying reveal a proliferative mechanism evasive context-dependent territory- to mTOR inhibition covering micturition Cuiqing Fan, Chuntao Zhao, Feng Zhang, Meenu Kesarwani, Zhaowei Tu, Xiongwei Cai, Ashley Kuenzi Minsuk Hyun, Julian Taranda, Gianna Radeljic, Davis, Lingli Xu, Cindy L. Hochstetler, Xiaoyi Chen, Lauren Miner, Wengang Wang, Nicole Fukun Guo, Gang Huang, Mohammad Azam, Ochandarena, Kee Wui Huang, Pavel Osten, Weidong Tian, Q. Richard Lu, and Yi Zheng and Bernardo L. Sabatini e2012482118 Primary cilia safeguard cortical neurons in MICROBIOLOGY neonatal mouse forebrain from environmental e2013515118 Filling the gaps in the global prevalence map stress-induced dendritic degeneration of clinical antimicrobial resistance Seiji Ishii, Toru Sasaki, Shahid Mohammad, Hye Rik Oldenkamp, Constance Schultsz, Emiliano Mancini, Hwang, Edwin Tomy, Fahad Somaa, Nobuyuki and Antonio Cappuccio Ishibashi, Hideyuki Okano, Pasko Rakic, Kazue Hashimoto-Torii, and Masaaki Torii e2018365118 Endogenous membrane stress induces T6SS activity in Pseudomonas aeruginosa e2020454118 A genome-wide microRNA screen identifies Anne-Sophie Stolle, Bradley Thomas Meader, Jonida the microRNA-183/96/182 cluster as Toska, and John J. Mekalanos a modulator of circadian rhythms Lili Zhou, Caitlyn Miller, Loren J. Miraglia, Angelica e2020216118 Cross-species recognition of SARS-CoV-2 to Romero, Ludovic S. Mure, Satchidananda Panda, bat ACE2 and Steve A. Kay Kefang Liu, Shuguang Tan, Sheng Niu, Jia Wang, Lili Wu, Huan Sun, Yanfang Zhang, Xiaoqian Pan, Xiao Qu, e2011266118 Prioritized experience replays on Pei Du, Yumin Meng, Yunfei Jia, Qian Chen, Chuxia a hippocampal predictive map Deng, Jinghua Yan, Hong-Wei Wang, Qihui Wang, for learning Jianxun Qi, and George Fu Gao Hideyoshi Igata, Yuji Ikegaya, and Takuya Sasaki

Contents PNAS u January 5, 2021 u vol. 118 u no. 1 u vii Downloaded by guest on September 27, 2021 e2012339118 Nitric oxide resets kisspeptin-excited GnRH e2022788118 MdERDL6-mediated glucose efflux to the neurons via PIP2 replenishment cytosol promotes sugar accumulation in the Stephanie Constantin, Daniel Reynolds, Andrew Oh, vacuole through up-regulating TSTs in apple Katherine Pizano, and Susan Wray and tomato e2013232118 Association of aerobic glycolysis with Lingcheng Zhu, Baiyun Li, Limin Wu, Huixia Li, the structural connectome reveals a Zhengyang Wang, Xiaoyu Wei, Baiquan Ma, Yanfeng benefit–risk balancing mechanism in Zhang, Fengwang Ma, Yong-Ling Ruan, and Mingjun Li the human brain e1919402118 Cellular transduction of mechanical oscillations Yuhan Chen, Qixiang Lin, Xuhong Liao, Changsong in plants by the plasma-membrane Zhou, and Yong He mechanosensitive channel MSL10 e2006476118 The Parkinson’s disease-associated gene Daniel Tran, Tiffanie Girault, Marjorie Guichard, ITPKB protects against α-synuclein Se´bastien Thomine, Nathalie Leblanc-Fournier, Bruno Moulia, Emmanuel de Langre, Jean-Marc Allain, aggregation by regulating ER-to- and Jean-Marie Frachisse mitochondria calcium release Daniel J. Apicco, Evgeny Shlevkov, Catherine L. Nezich, e2020857118 Naphthylphthalamic acid associates with and David T. Tran, Edward Guilmette, Justin W. Nicholatos, inhibits PIN auxin transporters Collin M. Bantle, Yi Chen, Kelly E. Glajch, Neeta A. Lindy Abas, Martina Kolb, Johannes Stadlmann, Abraham, Lan T. Dang, G. Campbell Kaynor, Ellen A. Dorina P. Janacek, Kristina Lukic, Claus Tsai, Khanh-Dung H. Nguyen, Joost Groot, YuTing Liu, Schwechheimer, Leonid A. Sazanov, Lukas Mach, Jirı´ Andreas Weihofen, Jessica A. Hurt, Heiko Runz, Friml, and Ulrich Z. Hammes and Warren D. Hirst e2017636118 Endoplasmic reticulum membrane receptors of the GET pathway are conserved PHYSIOLOGY throughout eukaryotes e2017603118 ROS and hypoxia signaling regulate periodic Lisa Yasmin Asseck, Dietmar Gerald Mehlhorn, Jhon metabolic arousal during insect dormancy Rivera Monroy, Martiniano Maria Ricardi, Holger Breuninger, Niklas Wallmeroth, Kenneth Wayne to coordinate glucose, amino acid, and Berendzen, Minou Nowrousian, Shuping Xing, Blanche lipid metabolism Schwappach, Martin Bayer, and Christopher Grefen Chao Chen, Rohit Mahar, Matthew E. Merritt, David L. Denlinger, and Daniel A. Hahn PSYCHOLOGICAL AND COGNITIVE SCIENCES e2018112118 Drosophila melanogaster sex peptide e2017224118 Discrimination and anxiety: Using multiple regulates mated female midgut polygenic scores to control for genetic liability morphology and physiology Adolfo G. Cuevas, Frank D. Mann, David R. Williams, Melissa A. White, Alessandro Bonfini, Mariana F. and Robert F. Krueger Wolfner, and Nicolas Buchon SI CORRECTION PLANT BIOLOGY e2012892118 Evidence for root adaptation to a spatially GENETICS discontinuous water availability in e2024687118 Prediction of inherited genomic susceptibility to the absence of external water 20 common cancer types by a supervised potential gradients machine-learning method Kara R. Lind, Oskar Siemianowski, Bin Yuan, Tom Byung-Ju Kim and Sung-Hou Kim Sizmur, Hannah VanEvery, Souvik Banerjee, and Ludovico Cademartiri ix Information for Authors

viii u www.pnas.org Contents Downloaded by guest on September 27, 2021