DOCSLIB.ORG

Colloidal Gold Nanoparticles: a Study of Their Drying-Mediated Assembly

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

UNIVERSITY OF HAUTE-ALSACE 2011 A Dissertation Submitted to the Graduate Faculty In Partial Fulfillment of the Requirements For the Degree Doctor of Philosophy in Physical Chemistry Colloidal Gold Nanoparticles: A study of their Drying-mediated Assembly in mesoscale aggregation patterns and of their AFM-assisted Nanomanipulation on model solid surfaces Samer DARWICH December 14, 2011 Examination committee: Prof. Serge STOLL (Principal Examiner) Dr. Hendrik HÖLSCHER (Principal Examiner) Prof. Claudine FILIATRE (Examiner) Dr. Enrico GNECCO (Examiner) Dr. Karine MOUGIN (Co-Advisor) Dr. Hamidou HAIDARA (Supervisor) University of Haute-Alsace A Dissertation Submitted to the Graduate Faculty in Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in Physical Chemistry Colloidal Gold Nanoparticles: A Study of their Drying-Mediated Assembly in Mesoscale Aggregation Patterns and of their AFM Assisted Nanomanipulation on Model Solid Surfaces Examination Committee: Prof. Serge STOLL Samer Darwich Dr. Hendrik HÖLSCHER 14 December 2011 Prof. Claudine FILIATRE Dr. Enrico GNECCO Dr. Karine MOUGIN Dr. Hamidou HAIDARA Institut de Science des Matériaux de Mulhouse “Anything which can be counted is finite and will come to an end” Ali Al-Mortadhâ (A) To those who had opened to me the door to live, to learn, to love and to be loved; my father Hassan and my mother Zahra My love for you is uncountable “Yestarday I was with you; today I have become the object of a lesson for you, and tomorrow I shall leave you...” Ali Al-Mortadhâ (A) First of all, I would like to thank Dr. Hamidou Haidara who gave me the opportunity to join his group (“PMA” of the Institut de Science des Matériaux de Mulhouse) and who opened to me the prospects of research world. I am grateful for every discussion we had together, and for every lesson that lights me the way to knowledge. I express my gratitude to his rich humility, his humanity and his great attitude... I am indebted to my co-adviser Dr. Karine Mougin for his help at every step on the road of experimental work. I am thankful for his optimism, his patience and his trust in me. I would also like to thank her because she gave me the opportunity to work in the FANAS project (ESF) which showed me research life in different European countries and which allowed me to meet marked researchers. I would like to thank all the European partners Dr. Enrico Gnecco, Dr. Hendrick Höshler, Dr. Akshata Rao, Dr. Rogerio Colaço, Dr. Mykhaylo Evstigneev, Dr. André Schirmeisen, Dr. Rynno Lohmus, Dr. Guido Paolicelli, Dr. Andrzej Kulik, Dr. Santiago Casado, Dr. Sergei Vlassov, Ms. Patrizia Paradiso and Mr. Tobias Meier to all their near or far contributions in this work especially in the subject of the FANAS project (AFM manipulation of nanoparticles). I am thankful to the examination committee members Dr. Serge Stoll, Prof. Claudine Filiatre, Dr. Enrico Gnecco and Dr. Hendrick Höshler for accepting to evaluate my PhD work. I would like to thank the Director of our institute Dr. Catie Vix for being supportive to each personnel of the institute. I am grateful to all the technical and administrative personnel of the laboratory to their technical support, in particular, Dr. Loïc Vidal (TEM), Mr. Hugues Bonnet and Dr. Ludovic Josien (SEM), Mr. Simon Grée (SERS and UV-VIS), Dr. Aissam Airoudj and Dr. Jean-luc Bubendorff (AFM), Mrs. Marie-Paule Hirn (Centrifugation), Mr. Philippe Kunemann (Contact angle measurements system), Mr. Eric Ehrhard (informatics), Mr. Patrick Lamielle (Plant), Mr. Stéphan Knopf (Store), Mrs. Fabienne Sorgato (Secreteria), Mrs. Natalina Muller, Mrs. Joëlle Dangy and Louisa Idiri (Accounting), Mrs. Nathalie Castelein (Library) and Mrs. Sylvie Forget (Reception). Many thanks to Sylvie to the special time and discussions we had in the hallways of the institute. Many thanks to all of them to the social time shared with them. I am also thankful to all the researchers of the institute to each social and scientific time and discussion shared with them. Particularly I would like to thank Dr. Laurent Vonna, Dr. Vincent Roucoules, Dr. Govindasamy Chandrasekar and Dr. Bassel Haidar... I would like to thank all Ph-D students with whom I shared great moments of a social, scientific and personal perspective. In particular, Enormous thanks to Jalal Bacharouche, Mathieu Wagner, Carine Diebold, Jean-Nicolas Munsch, Patrice Brender, Sébastien Schlinger, Emilien Buet, Judith Böhmler, Guillaume Colombe, Arnaud Bach, Philippe Bernardo, Alexandre Geissler, Marie Palmieri, Mohammad Rajab, Houssam Hamie, Ahmad Fahs, Emilia Kulaga, Nicolas Ducruet, Helena Marques Da Silva, Christine De Saint-Aubin, Alicia Henry and Dorris Moura Campus... I am thankful to my friend Abdallah Ghaddar and to my family, my father Hassan, my mother Zahra and my brothers Mohammad, Alaa’ and Waël. Contents General Introduction 1 Part 1: Presentation of the nanomaterials: Suspension of nanoparticles/ Self-Assembled Monolayers 5 Introduction 6 Chapter 1: Gold Colloidal NPs 11 1.1.0. Introduction 12 a.Methods of preparation 13 b.Modes of stabilization 15 1.1.1. Gold nanospheres 16 a.Synthesis of gold colloidal nanospheres 20 b.Functionnalization of gold colloidal nanospheres 24 c.Characterization of Au NPs suspensions 26 1.1.2. Gold nanorods 29 a.Preparation of gold nanorods 32 b.Functionnalization of gold nanorods 33 c.Characterization of gold nanorods 34 1.1.3. Conclusion 39 Chapter 2: Self assembled monolayers 44 1.2.0. Introduction 45 1.2.1. Elaboration procedure 46 a.Cleaning and surface activation of the substrate 47 b.General preparation procedure of SAMs 47 1.2.2. Homogeneous molecular surfaces 49 a.Preparation of the molecular films 49 b.Characterizations 52 c.Conclusion 55 1.2.3. Heterogeneous molecular surfaces 56 1.2.4. Conclusion 59 Conclusion 61 Part 2: Drying-mediated assembly of gold NPs in mesoscale structures on model solid surfaces 63 Introduction 64 Chapter 1: Complex aggregation patterns issued for drying nanocolloidal suspensions 68 2.1.0. Introduction 69 2.1.1. Theoritical point of view vs. experimental 73 2.1.2. Complex drying patterns of “as-synthesized” Au NPs solution-Dependence of structure formation and aggregate stability on NPs 78 1.Experimental methods 78 2.Results and discussion 79 3.Conclusion 90 2.1.3. The role of salts in the formation of the complex NPs-based structures 91 1.Experimental methods 91 2.Results and discussion 93 3.Conclusion 103 2.1.4.General conclusion 104 Chapter 2: Nanobubbles and nanodroplets template growth of particles nanorings 106 2.2.0. Introduction 107 2.2.1. Experimental methods 111 2.2.2. Results and discussion 112 2.2.3. Conclusion 128 Chapter 3: Drying-mediated assembly structurs of binary solutions of (NPs/biopolymer) mixtures 130 2.3.0. Introduction 131 2.3.1. Experimental methods 137 2.3.2. Results and discussion 139 a.Structural characterization of samples 140 b.The surface microscopic complex aggregation patterns 141 c.Nanoscale aggregation structures 165 2.3.3. Conclusion 172 Conclusion 174 Part 3: Aging of the aggregation structures vs NPs mobility 177 Introduction 178 Chapter 1: Aging of complex NP-based structures 180 3.1.0. Introduction 181 3.1.1. Aging of the complex structures induced by drying of pure colloidal NPs 182 a.Experimental methods 182 b.Results and discussion 183 c.Conclusion 192 3.1.2. Aging of the complex structures induced by drying of mixed (alginate/NPs) solutions 193 3.1.3. Conclusion 198 Chapter 2: AFM Manipulation of NPs on Model Surfaces- a tentative account of the surface mobility and dislocation of aging NPs structures 199 3.2.0. Introduction 200 3.2.1. Experimental methods 203 3.2.2. Results and discussion 205 a.Influence of the size and the shape of NP 205 b.Influence of the chemistry of NP 210 c.Influence of the temperature 211 d.Organization effects 212 e.Influence of the relative humidity 213 f.Influence of the topography of the substrate 219 g.Influence of scan velocity 221 3.2.3. Conclusion 223 Conclusion 225 General conclusion 227 General Annexe: Combined electrostatic-covalent building of gold nanoparticles multilayers, and their size enhanced cohesive and SERS properties A1 General Introduction The development and the structuring of materials at the nanoscale can address new physics but also can perform features that are operating on original principles. This originality is determined by the unique properties of nanomaterials. These properties are used in particular for new technological applications in many fields: medicine, energy, electronics, optics, catalysis... The critical parameter in most of these properties is the small size of the material itself or of the unit object composing the nanomaterial (typically from 1 nm to 100 nm) that causes an increase in the (surface / volume) ratio. This work deals with the study of the drying-mediated assembly of colloidal gold nanoparticles (Au NPs) in mesoscale aggregation patterns and their manipulation by atomic force microscopy (AFM) on model surfaces. The objective of this work is twofold. First, it is aimed at understanding and controlling the genesis of original drying structures and patterns NPs based complex fluids. And secondly, we seek to understand and relate the stability of the NP-based structures (cohesion and dislocation/ desaggregation) to the intrinsic mobility of the constitutive unit NPs on various substrates. First, we will discuss the synthesis of two nanostructured materials. These materials are the basis of systems development at the mesoscopic scale, but also of the fundamental understanding of phenomena and physical parameters that are acting at the nanoscale. These materials are the Au NPs and the self-assembled molecular surfaces (SAMs) on rigid substrates, which are the supports for the assembly and the structuring of NPs. The morphology (size and shape) and the surface chemistry (functionality of grafted molecules) of NPs are adjusted during their chemical synthesis to control the physical and the chemical properties of the studied nano-objects.
Recommended publications
  • Zinc Oxide Nanorod Surface-Enhanced Raman Scattering Substrates Without and with Gold Nanoparticles Fabricated Through Pulsed-Laser-Induced Photolysis

    Zinc Oxide Nanorod Surface-Enhanced Raman Scattering Substrates Without and with Gold Nanoparticles Fabricated Through Pulsed-Laser-Induced Photolysis

    applied sciences Article Zinc Oxide Nanorod Surface-Enhanced Raman Scattering Substrates without and with Gold Nanoparticles Fabricated through Pulsed-Laser-Induced Photolysis Chia-Man Chou 1,2 , Le Tran Thanh Thi 3,4, Nguyen Thi Quynh Nhu 3,4, Su-Yu Liao 5, Yu-Zhi Fu 3, Le Vu Tuan Hung 4,* and Vincent K. S. Hsiao 3,* 1 Division of Pediatric Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan; [email protected] 2 Department of Medicine, National Yang-Ming University, Taipei 112, Taiwan 3 Department of Applied Materials and Optoelectronic Engineering, National Chi Nan University, Nantou 54561, Taiwan; [email protected] (L.T.T.T.); [email protected] (N.T.Q.N.); [email protected] (Y.-Z.F.) 4 Department of Applied Physics, Faculty of Physics and Engineering Physics, University of Science, Ho Chiç Minh City, Vietnam 5 Department of Electrical Engineering, National Chi Nan University, Nantou 54561, Taiwan; [email protected] * Correspondence: [email protected] (L.V.T.H.); [email protected] (V.K.S.H.) Received: 18 June 2020; Accepted: 17 July 2020; Published: 21 July 2020 Abstract: We fabricated surface-enhanced Raman scattering (SERS) substrates using gold nanoparticle (AuNP)-decorated zinc oxide (ZnO) nanorods (NRs). Prior to decoration with AuNPs, ZnO NRs on the glass substrate fabricated using the sol–gel method could enhance the SERS signal for detecting 5 10− M rhodamine 6G (R6G). Microscopic analysis revealed that the thermal-annealing process for fabricating the seed layers of ZnO facilitated the growth of ZnO NRs with the highly preferred c-axis (002) orientation.
  • Solution Processed Zn1-X-Ysmxcuyo Nanorod Arrays for Dye Sensitized

    Solution Processed Zn1-X-Ysmxcuyo Nanorod Arrays for Dye Sensitized

    nanomaterials Article Solution Processed Zn1−x−ySmxCuyO Nanorod Arrays for Dye Sensitized Solar Cells Muhammad Saleem 1,*, Ali Algahtani 2,3 , Saif Ur Rehman 4, Muhammad Sufyan Javed 4,5,*, Kashif Irshad 6 , Hafiz Muhammad Ali 6,7 , Muhammad Zeeshan Malik 8, Amjad Ali 6 , Vineet Tirth 2,3 and Saiful Islam 9 1 Institute of Physics, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan 2 Mechanical Engineering Department, College of Engineering, King Khalid University, Abha 61411, Asir, Saudi Arabia; [email protected] (A.A.); [email protected] (V.T.) 3 Research Center for Advanced Materials Science (RCAMS), King Khalid University, Guraiger, Abha 61413, Asir, Saudi Arabia 4 Department of Physics, COMSATS University Islamabad Lahore Campus, Lahore 54000, Pakistan; [email protected] 5 School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China 6 Interdisciplinary Research Center in Renewable Energy and Power Systems (IRC-REPS), King Fahd University of Petroleum & Minerals, Dhahran 31261, Eastern Province, Saudi Arabia; [email protected] (K.I.); hafi[email protected] (H.M.A.); [email protected] (A.A.) 7 Mechanical Engineering Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Eastern Province, Saudi Arabia 8 School of Electronics and Information Engineering, Taizhou University, Taizhou 318000, China; [email protected] 9 Civil Engineering Department, College of Engineering, King Khalid University, Abha 61413, Asir, Saudi Arabia; [email protected] * Correspondence: [email protected] (M.S.); [email protected] (M.S.J.); Tel.: +92-3063645433 (M.S.) Citation: Saleem, M.; Algahtani, A.; Rehman, S.U.; Javed, M.S.; Irshad, K.; Abstract: Ali, H.M.; Malik, M.Z.; Ali, A.; Tirth, Cu- and Sm-doped ZnO nanorod arrays were grown with 1 wt% of Sm and different V.; Islam, S.
  • Differentiating Gold Nanorod Samples Using Particle Size and Shape Distributions from Transmission Electron Microscope Images

    Differentiating Gold Nanorod Samples Using Particle Size and Shape Distributions from Transmission Electron Microscope Images

    HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Metrologia Manuscript Author . Author manuscript; Manuscript Author available in PMC 2020 May 14. Published in final edited form as: Metrologia. 2018 February 28; 55(2): 254–267. doi:10.1088/1681-7575/aaa368. Differentiating gold nanorod samples using particle size and shape distributions from transmission electron microscope images Eric A Grulke1, Xiaochun Wu2, Yinglu Ji2, Egbert Buhr3, Kazuhiro Yamamoto4, Nam Woong Song5, Aleksandr B Stefaniak6, Diane Schwegler-Berry6, Woodrow W Burchett7, Joshua Lambert7, Arnold J Stromberg7 1Chemical and Materials Engineering, University of Kentucky, Lexington, KY, United States of America 2CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 1001901, People’s Republic of China 3Physikalisch-Technische Bundesanstalt (PTB), Braunschweig, Germany 4National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan 5Korea Research Institute of Standards and Science (KRISS), Daejeon, Republic of Korea 6US National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, United States of America 7Applied Statistics Laboratory, University of Kentucky, Lexington, KY, United States of America Abstract Size and shape distributions of gold nanorod samples are critical to their physico-chemical properties, especially their longitudinal surface plasmon resonance. This interlaboratory comparison study developed methods for measuring and evaluating size and shape distributions for gold nanorod samples using transmission electron microscopy (TEM) images. The objective was to determine whether two different samples, which had different performance attributes in their application, were different with respect to their size and/or shape descriptor distributions. Touching particles in the captured images were identified using a ruggedness shape descriptor.
  • First-Principles and Molecular Dynamics Simulation Studies of Functionalization of Au32 Golden Fullerene with Amino Acids

    First-Principles and Molecular Dynamics Simulation Studies of Functionalization of Au32 Golden Fullerene with Amino Acids

    www.nature.com/scientificreports OPEN First-principles and Molecular Dynamics simulation studies of functionalization of Au32 golden Received: 4 August 2017 Accepted: 18 July 2018 fullerene with amino acids Published: xx xx xxxx M. Darvish Ganji1, H. Tavassoli Larijani2, R. Alamol-hoda1 & M. Mehdizadeh1 With the growing potential applications of nanoparticles in biomedicine especially the increasing concerns of nanotoxicity of gold nanoparticles, the interaction between protein and nanoparticles is proving to be of fundamental interest for bio-functionalization of materials. The interaction of glycine (Gly) amino acid with Au32 fullerene was frst investigated with B3LYP-D3/TZVP model. Several forms of glycine were selected to better understand the trends in binding nature of glycine interacting with the nanocage. We have evaluated various stable confgurations of the Gly/Au32 complexes and the calculated adsorption energies and AIM analysis indicate that non-Gly, z-Gly and also tripeptide glycine can form stable bindings with Au32 at aqueous solution via their amino nitrogen (N) and/or carbonyl/carboxyl oxygen (O) active sites. Furthermore, cysteine, tyrosine, histidine and phenylalanine amino acids bound also strongly to the Au32 nanocage. Electronic structures and quantum molecular descriptors calculations also demonstrate the signifcant changes in the electronic properties of the nanocage due to the attachment of selected amino acids. DFT based MD simulation for the most stable complex demonstrate that Gly/Au32 complex is quite stable at ambient condition. Our frst-principles fndings ofer fundamental insights into the functionalization of Au32 nanocage and envisage its applicability as novel carrier of the drugs. Drug delivery has gained a lot of attention as it can minimize the side efects of various drugs.
  • Grown and Characterization of Zno Aligned Nanorod Arrays for Sensor Applications

    Grown and Characterization of Zno Aligned Nanorod Arrays for Sensor Applications

    energies Article Grown and Characterization of ZnO Aligned Nanorod Arrays for Sensor Applications Arkady N. Redkin, Eugene E. Yakimov, Maria V. Evstafieva and Eugene B. Yakimov * Institute of Microelectronics Technology RAS, 6 Academician Ossipyan str., 142432 Chernogolovka, Russia; [email protected] (A.N.R.); [email protected] (E.E.Y.); [email protected] (M.V.E.) * Correspondence: [email protected] Abstract: ZnO nanorods are promising materials for many applications, in particular for UV de- tectors. In the present paper, the properties of high crystal quality individual ZnO nanorods and nanorod arrays grown by the self-catalytic CVD method have been investigated to assess their possible applicationsfor UV photodetectors. X-ray diffraction, Raman spectroscopy and cathodolu- minescence investigations demonstrate the high quality of nanorods. The nanorod resistivity and carrier concentration in dark is estimated. The transient photocurrent response of both as grown and annealed at 550 ◦C nanorod array under UV illumination pulses is studied. It is shown that annealing increases the sensitivity and decreases the responsivity that is explained by oxygen out-diffusion and the formation of near surface layer enriched with oxygen vacancies. Oxygen vacancy formation due to annealing is confirmed by an increase of green emission band intensity. Keywords: ZnO nanorod; self-catalytic CVD method; photoresponse; cathodoluminescence Citation: Redkin, A.N.; Yakimov, E.E.; Evstafieva, M.V.; Yakimov, E.B. Grown and Characterization of ZnO 1. Introduction Aligned Nanorod Arrays for Sensor Zinc oxide, a well-known direct bandgap II–VI semiconductor, is a material with Applications. Energies 2021, 14, 3750. large exciton binding energy (60 meV) and a wide bandgap (Eg ~ 3.37 eV) [1], suitable for https://doi.org/10.3390/en14133750 short wavelength optoelectronic applications [2].
  • Internal Structure of Polyelectrolyte Multilayers on Nanometer Scale

    Internal Structure of Polyelectrolyte Multilayers on Nanometer Scale

    INTERNAL STRUCTURE OF POLYELECTROLYTE MULTILAYERS ON NANOMETER SCALE Inauguraldissertation zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften der Mathematisch-Naturwissenschaftlichen Fakult¨at der Ernst-Moritz-Arndt-Universit¨atGreifswald vorgelegt von Oxana Ivanova geboren am 06. April 1980 in Sankt-Petersburg (Russland) - Greifswald, 2010 - Dekan: Prof. Dr. Dr. Klaus Fesser 1. Gutachter: Prof. Dr. Christiane A. Helm 2. Gutachter: Prof. Dr. Monika Sch¨onhoff Tag der Promotion: 15. Oktober 2010 Ich m¨ochte mich ganz herzlich bei allen Mitarbeitern des Instituts f¨urPhysik f¨urzahllose fachverwandte sowie fachfremde Unterst¨utzungbedanken. Contents I Introduction to the Field of Research 7 1 Introduction 9 1.1 Polyelectrolytes and their Properties . 9 1.2 Layer-by-Layer Assembly of Polyelectrolytes . 10 1.3 Polyelectrolyte Multilayers . 13 1.4 Objectives . 15 2 Physical Background 17 2.1 Electrostatic and Secondary Interactions . 17 2.1.1 Electrostatic Interactions: Electric Double Layer . 18 2.1.2 Effect of Salt on Formation of PEMs . 21 2.1.3 Classification and Range of Intermolecular Forces . 22 2.1.4 Temperature Effect: Hydrophobic Interactions . 23 II Materials and Methods 25 3 Materials and Sample Preparation 27 3.1 Chemicals . 27 3.2 Fabrication of Multilayered Nanofilms . 29 4 Characterization Methods 33 4.1 X-ray and Neutron Reflectivity . 33 4.1.1 Basic Principles of X{ray and Neutron Reflection . 35 4.1.2 Reflection from Ideally Smooth & Rough Interfaces . 37 4.1.3 Refractivity Set{up . 41 4.2 UV-Vis Absorption Spectroscopy . 43 4.2.1 Interaction of Light with Matter . 43 4.2.2 Beer-Lambert Law .
  • Size and Zeta Potential of Colloidal Gold Particles

    Size and Zeta Potential of Colloidal Gold Particles

    Size and Zeta Potential of Colloidal Gold Particles Mark Bumiller [email protected] © 2012 HORIBA, Ltd. All rights reserved. Colloid Definition Two phases: •Dispersed phase (particles) •Continuous phase (dispersion medium, solvent) May be solid, liquid, or gaseous Size range 1 nm – 1 micron High surface area creates unique properties (suspension) © 2012 HORIBA, Ltd. All rights reserved. Nanoparticle Definition Nanoparticle: size below 100 nm SSA = 6/D ultrasound 50 nm D from SEM ~50 nm Used ultrasound to disperse D from SSA ~60-70 nm to primary particles or use D from DLS ~250 nm weak acid to break bonds So: is this a nanoparticle? D from DLS ~50 nm © 2012 HORIBA, Ltd. All rights reserved. SZ-100: Nanoparticle Analyzer Size: .3 nm - 8 µm 90° and 173° Zeta potential: -200 - +200 mV Patented carbon coated electrodes Molecular weight: 1x103 - 2x107 g/mol Optional titrator •Nanoparticles •Colloids •Proteins •Emulsions •Disperison stability © 2012 HORIBA, Ltd. All rights reserved. Dynamic Light Scattering Particles in suspension undergo Brownian motion due to solvent molecule bombardment in random thermal motion. ~ 1 nm to 1 µm Particle moves due to interaction with liquid molecules Small – faster Large - slower © 2012 HORIBA, Ltd. All rights reserved. SZ-100 Optics 90° for size and MW, A2 Backscatter (173°) (High conc.) Particles Laser PD Attenuator 532nm, 10mW For T% Particles moving due to Brownian motion Zeta potential Attenuator Modulator © 2012 HORIBA, Ltd. All rights reserved. SZ100 Measurement Principle 1 lngq,r lim 0 ts R n(i) Relaxation time n(1)=2 n(3)=1 n(5)=2 2 n(2)=1 n(4)=3 t t 6D Particle’s moving distance <n(i)n(i+j)> Diffusion constant j 0 4 5 1 k T 1 2 3 D B <n2(i)> 2 Autocorrelation Function q R 6a g(q、r) Relaxation time <n(i)>2 Particle radius j 0 1 2 3 4 5 q: Scattering vector η: Viscosity 0 t 2t 3t 4t 5t k : Boltzmann constant s s s s s τ B © 2012 HORIBA, Ltd.
  • Characterization and Functionalization of Iron-Oxide Nanoparticles for Use As Potential Agents for Cancer Thermotherapy at the U

    Characterization and Functionalization of Iron-Oxide Nanoparticles for Use As Potential Agents for Cancer Thermotherapy at the U

    Characterization and Functionalization of Iron-Oxide Nanoparticles for Use as Potential Agents for Cancer Thermotherapy By Nora O’Reilly A dissertation submitted in partial fulfillment of the requirement for the degree of Doctor of Philosophy (Animal Science) At the University of Wisconsin-Madison 2013 Date of final oral examination: April 18th, 2013 The dissertation is approved by the following members of the Final Oral Committee: Professor Ralph Albrecht, Animal Science, Pediatrics, Pharmaceutical Sciences Professor Mark Cook, Animal Science Professor Amin Fadl, Animal Science Professor Manish Patankar, Obstetrics and Gynecology Professor Chris Brace, Radiology, Biomedical Engineering i Abstract This thesis presents experimental studies of iron oxide nanoparticle synthesis, functionalization, and intracellular hyperthermal effects on murine macrophages as a model in vitro system. Colloidal suspensions of magnetic nanoparticles (MNPs) are of particular interest in Magnetic Fluid Hyperthermia (MFH). Iron oxide nanoparticles (IONPs) have garnered great interest as economical, biocompatible hyperthermia agents due to their superparamagnetic activity. Here we seek to optimize the synthetic reproducibility and in vitro utilization of IONPs for application in MFH. We compared aqueous synthetic protocols and various protective coating techniques using various analytical techniques and in vitro assays to assess the biocompatibility and feasibility of the various preparations of nanoparticles. Using a co-precipitation of iron salts methodology,
  • Gold Nanoparticles and Quantum Dots: Their Optical Interaction and Application in a Hydrogel Modified Lateral Flow Sensing Device Julie A

    Gold Nanoparticles and Quantum Dots: Their Optical Interaction and Application in a Hydrogel Modified Lateral Flow Sensing Device Julie A

    University of Connecticut OpenCommons@UConn Doctoral Dissertations University of Connecticut Graduate School 6-8-2017 Gold Nanoparticles and Quantum Dots: Their Optical Interaction and Application in A Hydrogel Modified Lateral Flow Sensing Device Julie A. Jenkins University of Connecticut - Storrs, [email protected] Follow this and additional works at: https://opencommons.uconn.edu/dissertations Recommended Citation Jenkins, Julie A., "Gold Nanoparticles and Quantum Dots: Their Optical Interaction and Application in A Hydrogel Modified Lateral Flow Sensing Device" (2017). Doctoral Dissertations. 1521. https://opencommons.uconn.edu/dissertations/1521 Gold Nanoparticles and Quantum Dots: Their Optical Interaction and Application in A Hydrogel Modified Lateral Flow Sensing Device Julie Ann Jenkins, Ph.D. University of Connecticut, 2017 The goal of this dissertation was to study the optical properties of gold nanoparticles (Au NP) and quantum dots (QD) and to use their unique properties in sensing applications. The first part of this dissertation focuses on studying the dipole coupling in a gold nanoparticle random array. A blue shift and narrowing of the extinction peak, when compared to the single particle and solution spectra, was observed when 120 nm Au NPs were randomly immobilized on a glass substrate. This was determined to be due to the long-range dipole coupling of the Au NPs in the array. The motivation behind the second project was to study the temperature dependent change in decay kinetics of aqueous phase quantum dots when in close proximity to 120 nm Au NP, using α-carboxy-ω-Thiol terminated Poly(N-isopropyl acrylamide) (PNIPAM) as a spacer. The structure of PNIPAM will expand or collapse based with a change in temperature, thus varying the interparticle distance between the QD and the Au NP.
  • THE OPTIMIZATION of GOLD COATED IRON NANOPARTICLE SYNTHESIS METHODS by Mark Riggs, B.S., B.S. a Thesis Submitted to the Gradua

    THE OPTIMIZATION of GOLD COATED IRON NANOPARTICLE SYNTHESIS METHODS by Mark Riggs, B.S., B.S. a Thesis Submitted to the Gradua

    THE OPTIMIZATION OF GOLD COATED IRON NANOPARTICLE SYNTHESIS METHODS by Mark Riggs, B.S., B.S. A thesis submitted to the Graduate Council of Texas State University in partial fulfillment of the requirements for the degree of Master of Science with a Major in Chemistry August 2014 Committee Members: Gary Beall Shannon Weigum Clois Powell COPYRIGHT by Mark Riggs 2014 FAIR USE AND AUTHOR’S PERMISSION STATEMENT Fair Use This work is protected by the Copyright Laws of the United States (Public Law 94-553, section 107). Consistent with fair use as defined in the Copyright Laws, brief quotations from this material are allowed with proper acknowledgment. Use of this material for financial gain without the author’s express written permission is not allowed. Duplication Permission As the copyright holder of this work I, Mark Riggs, authorize duplication of this work, in whole or in part, for educational or scholarly purposes only. DEDICATION I dedicate this to my wife, Melissa. Her constant support and encouragement were nothing short of heroic. Careful and delicate allocation of my focus became ever- increasing in importance throughout the progression of this research, primarily due to the birth of my beautiful daughter, Olivia Marie, on February 4th of 2014. My daughter’s arrival impacted my perception in ways I couldn’t have fully understood prior to that wonderful moment. I will be forever indebted to Melissa for showing me how blessed I am, enabling me to live a better life than I could have conceived, and providing never- ending assistance with caring for our daughter.
  • Nanotechnology and Drug Delivery Part 1: Background and Applications

    Nanotechnology and Drug Delivery Part 1: Background and Applications

    Ochekpe et al Tropical Journal of Pharmaceutical Research, June 2009; 8 (3): 265-274 © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved . Available online at http://www.tjpr.org Review Article Nanotechnology and Drug Delivery Part 1: Background and Applications Nelson A Ochekpe 1*, Patrick O Olorunfemi 2 and Ndidi C Ngwuluka 2 1Department of Pharmaceutical Chemistry and 2Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Jos, PMB 2084, Jos, Nigeria Abstract Nanotechnology in general and as it relates to drug delivery in humans has been reviewed in a two-part article, the first part of which is this paper. In this paper, nanotechnology in nature, history of nanotechnology and methods of synthesis are discussed, while also outlining its applications, benefits and risks. Nanotechnology is an industrial revolution, based on integration of disciplines that could change every facet of human life. Some examples of changes brought about by reduction in particle sizes to the physical, chemical and biological properties of substances, compounds and drug products have been cited. The benefits of nanotechnology are enormous and so these benefits should be maximized while efforts are made to reduce the risks. Keywords: Nanotechnology, Nanobiotechnology, Nanostructures, Nanomaterials, Nanocarriers, Drug delivery. Received: 4 Nov 2008 Revised accepted: 13 Jan 2009 *Corresponding author: E-mail: [email protected]; Tel: +234-(0)8037006372 Trop J Pharm Res, June 2009; 8 (3): 265 Ochekpe et al INTRODUCTION Definition Nanotechnology can simply be defined as the Nanotechnology in nature technology at the scale of one-billionth of a metre.
  • Functionalization of Gold Nanoparticles by Inorganic Entities

    Functionalization of Gold Nanoparticles by Inorganic Entities

    nanomaterials Review Functionalization of Gold Nanoparticles by Inorganic Entities Frédéric Dumur 1,* , Eddy Dumas 2 and Cédric R. Mayer 3,4,* 1 Aix Marseille Univ, CNRS, ICR, UMR 7273, F-13397 Marseille, France 2 Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles Saint-Quentin-en-Yvelines, F-78035 Versailles, France; [email protected] 3 Laboratoire LuMin, FRE CNRS 2036, CNRS, Université Paris-Sud, ENS Paris-Saclay, Université Paris-Saclay, F-91405 Orsay CEDEX, France 4 Département de Chimie, UFR des Sciences, Université de Versailles Saint-Quentin-en-Yvelines, F-78035 Versailles, France * Correspondence: [email protected] (F.D.); [email protected] (C.R.M.); Tel.: +33-0491289059 (F.D.) Received: 25 February 2020; Accepted: 13 March 2020; Published: 18 March 2020 Abstract: The great affinity of gold surface for numerous electron-donating groups has largely contributed to the rapid development of functionalized gold nanoparticles (Au-NPs). In the last years, a new subclass of nanocomposite has emerged, based on the association of inorganic molecular entities (IME) with Au-NPs. This highly extended and diversified subclass was promoted by the synergy between the intrinsic properties of the shell and the gold core. This review—divided into four main parts—focuses on an introductory section of the basic notions related to the stabilization of gold nanoparticles and defines in a second part the key role played by the functionalizing agent. Then, we present a wide range of inorganic molecular entities used to prepare these nanocomposites (NCs). In particular, we focus on four different types of inorganic systems, their topologies, and their current applications.