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Cellular Senescence and Inflammaging in Age-Related Diseases Mediators of Inflammation Cellular Senescence and Inflammaging in Age-Related Diseases Lead Guest Editor: Carmela R. Balistreri Guest Editors: Fabiola Olivieri, Johannes Grillari, and Francesco Prattichizzo Cellular Senescence and Inflammaging in Age-Related Diseases Mediators of Inflammation Cellular Senescence and Inflammaging in Age-Related Diseases Lead Guest Editor: Carmela R. Balistreri Guest Editors: Fabiola Olivieri, Johannes Grillari, and Francesco Prattichizzo Copyright © 2018 Hindawi. All rights reserved. This is a special issue published in “Mediators of Inflammation.” All articles are open access articles distributed under the Creative Com- mons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Anshu Agrawal, USA Antonella Fioravanti, Italy Kutty Selva Nandakumar, China Muzamil Ahmad, India Stefanie B. Flohé, Germany Hannes Neuwirt, Austria Maria Jose Alcaraz, Spain Jan Fric, Czech Republic Nadra Nilsen, Norway Simi Ali, UK Tânia Silvia Fröde, Brazil Daniela Novick, Israel Amedeo Amedei, Italy Julio Galvez, Spain Marja Ojaniemi, Finland Oleh Andrukhov, Germany Mirella Giovarelli, Italy Sandra Helena Penha Oliveira, Brazil Emiliano Antiga, Italy Denis Girard, Canada Olivia Osborn, USA Adone Baroni, Italy Ronald Gladue, USA Carla Pagliari, Brazil Jagadeesh Bayry, France Markus H. Gräler, Germany Martin Pelletier, Canada Jürgen Bernhagen, Germany Hermann Gram, Switzerland Vera L. Petricevich, Mexico Tomasz Brzozowski, Poland Francesca Granucci, Italy Sonja Pezelj-Ribarić, Croatia Philip Bufler, Germany Oreste Gualillo, Spain Phileno Pinge-Filho, Brazil Elisabetta Buommino, Italy Elaine Hatanaka, Brazil Michele T. Pritchard, USA Daniela Caccamo, Italy Nobuhiko Kamada, USA Michal A. Rahat, Israel Luca Cantarini, Italy Yoshihide Kanaoka, USA Zoltan Rakonczay Jr., Hungary Raffaele Capasso, Italy Yona Keisari, Israel Marcella Reale, Italy Calogero Caruso, Italy Alex Kleinjan, Netherlands Alexander Riad, Germany Maria Rosaria Catania, Italy Marije I. Koenders, Netherlands Carlos Rossa, Brazil Carlo Cervellati, Italy Elzbieta Kolaczkowska, Poland Settimio Rossi, Italy Cristina Contreras, Spain Vladimir A. Kostyuk, Italy Bernard Ryffel, France Robson Coutinho-Silva, Brazil Dmitri V. Krysko, Belgium Carla Sipert, Brazil Jose Crispin, Mexico Sergei Kusmartsev, USA HelenC.Steel,SouthAfrica Fulvio D’Acquisto, UK Martha Lappas, Australia Jacek Cezary Szepietowski, Poland Eduardo Dalmarco, Brazil Philipp M. Lepper, Germany Dennis D. Taub, USA Pham My-Chan Dang, France Eduardo López-Collazo, Spain Taina Tervahartiala, Finland Wilco de Jager, Netherlands Andreas Ludwig, Germany Kathy Triantafilou, UK Beatriz De las Heras, Spain Ariadne Malamitsi-Puchner, Greece Fumio Tsuji, Japan Chiara De Luca, Germany Francesco Marotta, Italy Giuseppe Valacchi, Italy Clara Di Filippo, Italy Joilson O. Martins, Brazil Luc Vallières, Canada Carlos Dieguez, Spain Donna-Marie McCafferty, Canada Elena Voronov, Israel Agnieszka Dobrzyn, Poland Barbro N. Melgert, Netherlands Kerstin Wolk, Germany Elena Dozio, Italy Paola Migliorini, Italy Soh Yamazaki, Japan Emmanuel Economou, Greece Vinod K. Mishra, USA Shin-ichi Yokota, Japan Ulrich Eisel, Netherlands Eeva Moilanen, Finland Teresa Zelante, Singapore Giacomo Emmi, Italy Alexandre Morrot, Brazil Fabíola B Filippin Monteiro, Brazil Jonas Mudter, Germany Contents Cellular Senescence and Inflammaging in Age-Related Diseases Fabiola Olivieri, Francesco Prattichizzo, Johannes Grillari, and Carmela R. Balistreri Volume 2018, Article ID 9076485, 6 pages The Role of Immunosenescence in Neurodegenerative Diseases Erica Costantini , Chiara D’Angelo, and Marcella Reale Volume 2018, Article ID 6039171, 12 pages Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring Federico Sizzano , Sebastiano Collino, Ornella Cominetti, Daniela Monti , Paolo Garagnani , Rita Ostan, Chiara Pirazzini , Maria Giulia Bacalini, Daniela Mari , Giuseppe Passarino , Claudio Franceschi, and Alessio Palini Volume 2018, Article ID 7109312, 14 pages Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy Marco Malavolta , Massimo Bracci ,LorySantarelli , Md Abu Sayeed, Elisa Pierpaoli, Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Maurizio Cardelli, and Mauro Provinciali Volume 2018, Article ID 4159013, 32 pages Anti-Inflamm-Ageing and/or Anti-Age-Related Disease Emerging Treatments: A Historical Alchemy or Revolutionary Effective Procedures? Carmela Rita Balistreri Volume 2018, Article ID 3705389, 13 pages Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells? Angelica Giuliani, Francesco Prattichizzo, Luigina Micolucci, Antonio Ceriello, Antonio Domenico Procopio, and Maria Rita Rippo Volume 2017, Article ID 2309034, 11 pages Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals Costarelli Laura, Giacconi Robertina, Francesco Piacenza, Andrea Basso, Deborah Pacetti, Michele Balzano, Riccardo Gagliardi, Natale Giuseppe Frega, Eugenio Mocchegiani, Mauro Provinciali, and Marco Malavolta Volume 2017, Article ID 3868545, 12 pages Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase Giovanna Traina, Samuela Cataldi, Paola Siccu, Elisabetta Loreti, Ivana Ferri, Angelo Sidoni, Michela Codini, Chiara Gizzi, Marzia Sichetti, Francesco Saverio Ambesi-Impiombato, Tommaso Beccari, Francesco Curcio, and Elisabetta Albi Volume 2017, Article ID 8102170, 5 pages HIV as a Cause of Immune Activation and Immunosenescence T.Sokoya,H.C.Steel,M.Nieuwoudt,andT.M.Rossouw Volume 2017, Article ID 6825493, 16 pages The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine Laura Iop, Eleonora Dal Sasso, Leonardo Schirone, Maurizio Forte, Mariangela Peruzzi, Elena Cavarretta, Silvia Palmerio, Gino Gerosa, Sebastiano Sciarretta, and Giacomo Frati Volume 2017, Article ID 7953486, 13 pages Increased Levels of sRAGE in Diabetic CKD-G5D Patients: A Potential Protective Mechanism against AGE-Related Upregulation of Fibroblast Growth Factor 23 and Inflammation Elena Dozio, Valentina Corradi, Elena Vianello, Elisa Scalzotto, Massimo de Cal, Massimiliano Marco Corsi Romanelli, and Claudio Ronco Volume 2017, Article ID 9845175, 9 pages Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults Leticia Elizondo-Montemayor, Elena C. Castillo, Carlos Rodríguez-López, José R. Villarreal-Calderón, Merit Gómez-Carmona, Sofia Tenorio-Martínez, Bianca Nieblas, and Gerardo García-Rivas Volume 2017, Article ID 5719461, 14 pages Vitamin D Deficiency Is Associated with Increased Osteocalcin Levels in Acute Aortic Dissection: A Pilot Study on Elderly Patients Elena Vianello, Elena Dozio, Alessandra Barassi, Lorenza Tacchini, John Lamont, Santi Trimarchi, Massimiliano M. Marrocco-Trischitta, and Massimiliano M. Corsi Romanelli Volume 2017, Article ID 6412531, 8 pages Hindawi Mediators of Inflammation Volume 2018, Article ID 9076485, 6 pages https://doi.org/10.1155/2018/9076485 Editorial Cellular Senescence and Inflammaging in Age-Related Diseases 1,2 3 4 5 Fabiola Olivieri, Francesco Prattichizzo, Johannes Grillari, and Carmela R. Balistreri 1Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy 2Center of Clinical Pathology and Innovative Therapy, INRCA-IRCCS National Institute, Ancona, Italy 3IRCCS MultiMedica, Milan, Italy 4University of Natural Resources and Life Sciences Vienna, Vienna, Austria 5Department of Pathobiology and Medical Biotechnologies, University of Palermo, Corso Tukory 211, 90134 Palermo, Italy Correspondence should be addressed to Carmela R. Balistreri; [email protected] Received 15 February 2018; Accepted 15 February 2018; Published 17 April 2018 Copyright © 2018 Fabiola Olivieri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The term cellular senescence was used in 1961 for the first wound closure by inducing myofibroblast differentiation time by Hayflick and Moorhead [1], to define the mechanism through the secretion of platelet-derived growth factor AA determining the irreversible loss of the proliferative activity (PDGF-AA). In addition, it has been also demonstrated that of human somatic cells [1]. In this respect, cellular senes- forced cellular reprogramming induces senescence, and senes- cence has been usually viewed as one of the regulatory mech- cent cells (SCs) create a permissive environment for repro- anisms able to stop the eventual uncontrolled proliferation of gramming itself [9]. This evidence leads to an interesting old and injured cells, mediating an activity likely similar to a hypothesis based on the concept that SCs act as a trigger of tumour suppressor gatekeeper [2]. Accordingly, oncogene tissue remodeling, following a precise regulated succession overexpression (i.e., H-ras) in primary cells is sufficient to of events, characterized
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