Journal of Clinical Medicine Article T Helper Cell Infiltration in Osteoarthritis-Related Knee Pain and Disability 1, 1, 1 1 Timo Albert Nees y , Nils Rosshirt y , Jiji Alexander Zhang , Hadrian Platzer , Reza Sorbi 1, Elena Tripel 1, Tobias Reiner 1, Tilman Walker 1, Marcus Schiltenwolf 1 , 2 2 1, 1, , Hanns-Martin Lorenz , Theresa Tretter , Babak Moradi z and Sébastien Hagmann * z 1 Clinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Schlierbacher Landstr. 200a, 69118 Heidelberg, Germany;
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[email protected] (B.M.) 2 Department of Internal Medicine V, Division of Rheumatology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany;
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[email protected]; Tel.: +49-622-1562-6289; Fax: +49-622-1562-6348 These authors contributed equally to this study. y These authors share senior authorship. z Received: 16 June 2020; Accepted: 23 July 2020; Published: 29 July 2020 Abstract: Despite the growing body of literature demonstrating a crucial role of T helper cell (Th) responses in the pathogenesis of osteoarthritis (OA), only few clinical studies have assessed interactions between Th cells and OA—related symptoms.