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Negative Symptoms in Schizophrenia
Reward Processing Mechanisms of Negative Symptoms in Schizophrenia Gregory P. Strauss, Ph.D. Assistant Professor Department of Psychology University of Georgia Disclosures ACKNOWLEDGMENTS & DISCLOSURES ▪ Receive royalties and consultation fees from ProPhase LLC in connection with commercial use of the BNSS and other professional activities; these fees are donated to the Brain and Behavior Research Foundation. ▪ Last 12 Months: Speaking/consultation with Minerva, Lundbeck, Acadia What are negative symptoms and why are they important? Domains of psychopathology in schizophrenia Negative Symptoms ▪ Negative symptoms - reductions in goal-directed activity, social behavior, pleasure, and the outward expression of emotion or speech Cognitive Positive ▪ Long considered a core feature of psychotic disorders1,2 Deficits Symptoms ▪ Distinct from other domains of psychopathology (e.g., psychosis, disorganization) 3 ▪ Associated with a range of poor clinical outcomes (e.g., Disorganized Affective disease liability, quality of life, subjective well-being, Symptoms Symptoms recovery) 4-7 1. Bleuler E. [Dementia praecox or the group of schizophrenias]. Vertex Sep-Oct 2010;21(93):394-400. 2. Kraepelin E. Dementia praecox and paraphrenia (R. M. Barclay, Trans.). New York, NY: Krieger. 1919. 3. Peralta V, Cuesta MJ. How many and which are the psychopathological dimensions in schizophrenia? Issues influencing their ascertainment. Schizophrenia research Apr 30 2001;49(3):269-285. 4. Fervaha G, Remington G. Validation of an abbreviated quality of life scale for schizophrenia. Eur Neuropsychopharmacol Sep 2013;23(9):1072-1077. 5. Piskulic D, Addington J, Cadenhead KS, et al. Negative symptoms in individuals at clinical high risk of psychosis. Psychiatry research Apr 30 2012;196(2-3):220-224. -
Identity & In-Group Critique in James Mason's Siege
A Paler Shade of White: Identity & In-group Critique in James Mason’s Siege J.M. Berger RESOLVE NETWORK | April 2021 Racially and Ethnically Motivated Violent Extremism Series https://doi.org/10.37805/remve2021.1 The views expressed in this publication are those of the author. They do not necessarily reflect the views of the RESOLVE Network, the U.S. Institute of Peace, or any entity of the U.S. government. CONTENTS EXECUTIVE SUMMARY ......................................................................................... 1 INTRODUCTION ...................................................................................................... 2 HISTORY AND CONTEXT ...................................................................................... 4 METHODOLOGY: LINKAGEBASED ANALYSIS ............................................... 6 OVERVIEW OF CONTENT ..................................................................................... 7 INGROUP CRISIS: A PALER SHADE OF WHITE .............................................13 INGROUPS IN CRISIS ........................................................................................20 THE OUTGROUP IN THE INGROUP ...............................................................23 CONCLUSION: INSIGHTS & RECOMMENDATIONS .....................................25 BIBLIOGRAPHY .....................................................................................................28 EXECUTIVE SUMMARY Discussions of extremist ideologies naturally focus on how in-groups criticize and attack out-groups. But -
A Critical Assessment of Robert Chambers' Work on Participatory
Third World Quarterly, Vol 23, No 1, pp 101–117, 2002 The devil’s in the theory: a critical assessment of Robert Chambers’ work on participatory development ILAN KAPOOR ABSTRACT The practice orientation of Robert Chambers’ work on Participatory Rural Appraisal ( PRA), which aims at enabling local people and communities to take control over their own development, has received much attention in develop- ment circles. This article attempts to shift the emphasis away from PRA’s practice towards its theoretical underpinnings. The article argues that PRA’s practice/ empiricist orientation causes it to be insufficiently theorised and politicised. As a result, questions about inclusiveness, the role of PRA facilitators, and the personal behaviour of elites overshadow, or sometimes ignore, questions of legitimacy, justice, power and the politics of gender and difference. The article draws on arguments and debates involving Habermasian ‘deliberative democracy’ and post-structuralist notions of power. Most of those who have innovated in developing PRA have been practitioners, concerned with what works, and what will work better, not academic theorists concerned with why it works. They have been searching not for new theories or principles but for new and better ways of learning and doing. For them, the power and utility of … PRA, undertaken with rapport and self-critical rigor, are empirical facts of common experience: they know that they work, and that done well they can lead to better development. (Chambers, 1994b: 1262) Robert Chambers’ work on Participatory Rural Appraisal ( PRA) has become remarkably influential in NGO circles and among national and international development agencies. PRA champions local knowledge and puts forth a method- ology aimed at enabling local people to take control over their own development. -
Neurophysiological Correlates of Avolition-Apathy in Schizophrenia: a Resting-EEG Microstates Study T ⁎ Giulia M
NeuroImage: Clinical 20 (2018) 627–636 Contents lists available at ScienceDirect NeuroImage: Clinical journal homepage: www.elsevier.com/locate/ynicl Neurophysiological correlates of Avolition-apathy in schizophrenia: A resting-EEG microstates study T ⁎ Giulia M. Giordanoa,1, Thomas Koenigb,1, Armida Muccia, , Annarita Vignapianoa, Antonella Amodioa, Giorgio Di Lorenzoc, Alberto Siracusanoc, Antonello Bellomod, Mario Altamurad, Palmiero Monteleonee, Maurizio Pompilif, Silvana Galderisia, Mario Maja, The add-on EEG study of the Italian Network for Research on Psychoses2 a Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy b Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland c Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy d Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Foggia, Foggia, Italy e Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Section of Neurosciences, University of Salerno, Salerno, Italy f Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant' Andrea Hospital, Sapienza University of Rome, Rome ARTICLE INFO ABSTRACT Keywords: Background: The “Avolition-apathy” domain of the negative symptoms was found to include different symptoms Schizophrenia by factor analytic studies on ratings derived by different scales. In particular, the relationship of anhedonia with Avolition-apathy this domain is controversial. Recently introduced negative symptom rating scales provide a better assessment of Anhedonia anhedonia, allowing the distinction of anticipatory and consummatory aspects, which might be related to dif- Resting-EEG ferent psychopathological dimensions. The study of associations with external validators, such as electro- Brain electrical microstates physiological, brain imaging or cognitive indices, might shed further light on the status of anhedonia within the Avolition-apathy domain. -
Sex Differences in Symptom Presentation of Schizotypal
Philadelphia College of Osteopathic Medicine DigitalCommons@PCOM PCOM Psychology Dissertations Student Dissertations, Theses and Papers 2009 Sex Differences in Symptom Presentation of Schizotypal Personality Disorder in First-Degree Family Members of Individuals with Schizophrenia Alexandra Duncan-Ramos Philadelphia College of Osteopathic Medicine, [email protected] Follow this and additional works at: http://digitalcommons.pcom.edu/psychology_dissertations Part of the Clinical Psychology Commons Recommended Citation Duncan-Ramos, Alexandra, "Sex Differences in Symptom Presentation of Schizotypal Personality Disorder in First-Degree Family Members of Individuals with Schizophrenia" (2009). PCOM Psychology Dissertations. Paper 40. This Dissertation is brought to you for free and open access by the Student Dissertations, Theses and Papers at DigitalCommons@PCOM. It has been accepted for inclusion in PCOM Psychology Dissertations by an authorized administrator of DigitalCommons@PCOM. For more information, please contact [email protected]. Philadelphia College of Osteopathic Medicine Department of Psychology SEX DIFFERENCES IN SYMPTOM PRESENTATION OF SCHIZOTYPAL PERSONALITY DISORDER IN FIRST-DEGREE FAMILY MEMBERS OF INDIVIDUALS WITH SCHIZOPHRENIA By Alexandra Duncan-Ramos, M.S., M.S. Submitted in Partial Fulfillment of the Requirements of the Degree of Doctor of Psychology July 2009 PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE DEPARTMENT OF PSYCHOLOGY Dissertation Approval This is to certify that the thesis presented to us by Alexandra Duncan-Ramos on the 23rd day of July, 2009 in partial fulfillment of the requirements for the degree of Doctor of Psychology, has been examined and is acceptable in both scholarship and literary quality. Committee Members' Signatures: Barbara Golden, Psy.D., ABPP, Chairperson Brad Rosenfield, Psy.D. Monica E. Calkins, Ph.D. -
Living with Serious Mental Illness: the Role of Personal Loss in Recovery and Quality of Life
LIVING WITH SERIOUS MENTAL ILLNESS: THE ROLE OF PERSONAL LOSS IN RECOVERY AND QUALITY OF LIFE Danielle Nicole Potokar A Dissertation Submitted to the Graduate College of Bowling Green State University in partial fulfillment of the requirements for the degree of: DOCTOR OF PHILOSOPHY December 2008 Committee: Catherine Stein, Ph.D., Advisor Alexander Goberman, Ph.D., Graduate Faculty Representative Dryw Dworsky, Ph.D. Jennifer Gillespie, Ph.D. © 2008 Danielle Nicole Potokar All Rights Reserved iii ABSTRACT Catherine Stein, Ph.D., Advisor As the mental health field is moving towards a recovery based model of serious mental illness for both conceptualization and treatment, further research into the factors which may impact recovery and quality of life are needed. Currently, there are no studies which examine how personal loss due to mental illness or cognitive insight relate to factors such as quality of life and recovery. The purpose of the present study was to investigate the relative contribution of demographic factors, self-reports of psychiatric symptoms, and individual factors of cognitive insight and personal loss in describing variation in reports of quality of life and recovery from mental illness. It was hypothesized that cognitive insight and personal loss would each predict a significant portion of the variance in scores of quality of life and recovery from mental illness. A sample of 65 veterans with serious mental illness from the Minneapolis Veterans Affairs Medical Center completed structured interviews regarding psychiatric symptomotology and quality of life and completed questionnaires related to demographics, cognitive insight, personal loss due to mental illness, and recovery. Thirteen significant hierarchical regression models emerged. -
Cognitive Behavioural Therapy (CBT) for Schizophrenia: a Meta-Analysis
Running head: COGNITIVE BEHAVIOURAL THERAPY (CBT) FOR SCHIZOPRENIA Cognitive Behavioural Therapy (CBT) for Schizophrenia: A Meta-Analysis Gemma Holton BA (Hons) A report submitted in partial requirement for the degree of Master of Psychology (Clinical) at the University of Tasmania October 2015 COGNITIVE BEHAVIOURAL THERAPY (CBT) FOR SCHIZOPHRENIA I declare that this research report is my own work, and that, to the best of my knowledge and belief, it does not contain material from published sources without acknowledgement, nor does it contain material which has been accepted for the award for any other higher degree or graduate diploma in any university. Gemma Holton ii COGNITIVE BEHAVIOURAL THERAPY (CBT) FOR SCHIZOPHRENIA Acknowledgements I wish to express my thanks to my supervisor Dr Bethany Wootton for her considerate support throughout this project. I am extremely grateful for all the practical advice and continual support and encouragement she gave. Dr Wootton encouraged me to complete my thesis in an area of my interest and never expressed any doubt in my ability. Her methodical and consistent approach, patience and valuable advice are truly appreciated. I thank the staff of RFT who understood my vision when I informed them I was returning to university to complete my Masters in clinical psychology. RFT have been immensely supportive throughout this degree, encouraging me to achieve and share my knowledge, and share my valuable time. To my family and friends, I would like to say a big thank you for encouraging me to return to university and finish what I began. Thank you for supporting me and understanding how much time was dedicated to completing my studies. -
A Treatment Approach Informed by Cognitive Behavioral Therapy for Psychosis
1 2 Recovery Enhancement Practices for Psychosis (REP): A treatment approach informed by Cognitive Behavioral Therapy for Psychosis A Mental Health Provider’s Guide to Working with Psychosis Developed by Harry Sivec and Val Kreider Best Practices in Schizophrenia Treatment (BeST) Center Cognitive Behavioral Therapy for Psychosis Program 3 4 Recovery Enhancement Practices for Psychosis (REP): A treatment approach informed by Cognitive Behavioral Therapy for Psychosis Table of Contents Section 1: Introduction to Recovery Enhancement Practices for Psychosis (REP) Part 1: Understanding Care for Psychosis 7 Part 2: Schizophrenia and Recovery Mindset 19 Section 2: Relationship Building/Engagement Part 1: Developing a Collaborative Relationship 33 Part 2: Listening and Responding to Psychosis 39 Part 3: Recovery Goals and Structuring Sessions 47 Section 3: Teaching and Learning Together Part 1: Normalization 65 Part 2: Stress-Vulnerability-Resilience Model 75 Part 3: The Cognitive Model 85 References 95 5 6 Section 1 Introduction to Recovery Enhancement Practices for Psychosis (REP) Part 1: Psychosis and an Approach to Care Objectives: 1. To describe psychosis and schizophrenia 2. To provide an overview for an approach to care 7 Introduction: What is Psychosis? Psychosis refers to a state of mind in which reality testing is impaired. The root meaning of the word “psychosis” is psyche (soul or mind) and “osis” (unusual or abnormal state). So, we might say psychosis reflects an unusual or altered state of mind. For a variety of reasons, our brains are prone to misperceive information and when this happens to the extent that it causes serious distress and/or impairment, we refer to the experience as a psychotic symptom. -
Introduction
Introduction Ewa Mazierska and Lars Kristensen It is widely assumed that one of the main diff erences between Marxism and other types of philosophy is its practical orientation, most clearly revealed in Marx’s ‘Theses on Feuerbach’ and The Communist Manifesto. Thesis 8 of ‘The- ses on Feuerbach’ states: ‘All social life is essentially practical. All the mysteries which urge theory into mysticism fi nd their rational solution in human prac- tice and in the comprehension of this practice’ (Marx and Engels 1947: 199). This thesis suggests that practice tests the usefulness of theories, but equally theories refl ect on practice. Theories and practices are thus dependent on each other, although the precise character of their connection is diffi cult to assess. Thesis 11, the best known of Marx’s ‘Theses on Feuerbach’, states: ‘The philosophers have only interpreted the world diff erently, the point is to change it’ (ibid.: 199). This thesis represents Marx as diverting from a Hegelian version of history as a sequence of events, emerging as if on its own accord, or shaped solely by material forces. Instead, it evokes the idea of history as an arena, in which objective and subjective factors come together, producing results that cannot be predicted on the basis of what happened previously. This means that people striving for a specifi c state of aff airs should not wait in a comfort- able armchair for this state to occur, or resign in the conviction that it would not happen during their lifetime, but work towards its fulfi lment. Among these people a privileged place is occupied by those, who thanks to their intellec- tual resources, are able to better understand the world in which they operate than the bulk of the population. -
God in the Brain: Experiencing Psychosis in the Postsecular United States
Transcultural Psychiatry 0(0) 1–18 ! The Author(s) 2016 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/1363461516660902 tps.sagepub.com Article God in the brain: Experiencing psychosis in the postsecular United States Nev Jones Felton Institute Timothy Kelly University of Iowa Mona Shattell Rush University Abstract There is a growing literature on what contemporary cultural theorists have broadly termed the “postsecular”: the abandonment of clear-cut boundaries between the secu- lar and nonsecular in the industrialized West and an embrace of a complex understand- ing of what is real that neither accepts nor rejects the supernatural. These new cultural currents may affect not only philosophers and theologians, but also the ways in which individuals with psychosis make sense of their experiences. This paper reports on the key findings of an in-depth qualitative analysis of 19 interviews of individuals diagnosed with psychotic disorders. The majority of participants described ongoing and self- conscious struggles to demarcate their experiences as the products of the real world or a “crazy” mind. With equal frequency, participants weighed and debated competing secular and supernatural explanations, often juxtaposing and blending different explana- tory frameworks. We found that this syncretic process affected not only the content of psychotic experiences—what delusions or hallucinations are about—but also the type of arguments or logics used to justify particular interpretations. We discuss the implications of these observations with respect to clinical practice and the broader phenomenology of psychosis, challenging often oversimplified discourse on “insight” and suggesting that polarization(s) between “biomedical” and “psychosocial” explan- ations may be of less relevance to patients’ real-world experiences than is often assumed. -
Negative Symptoms- an Update
Galore International Journal of Health Sciences and Research Vol.4; Issue: 1; Jan.-March 2019 Website: www.gijhsr.com Review Article P-ISSN: 2456-9321 Negative Symptoms- an Update Dr Pavithra P. Rao1, Dr Preethi Rebello2, Dr P. John Mathai3 1Assistant Professor, Department of Psychiatry. Father Muller Medical College, Mangalore, Karnataka, India. 2Senior Resident, Department of Psychiatry, Father Muller Medical College, Mangalore, Karnataka, India. 3Professor. Department of Psychiatry, Jubilee Mission Medical College, East Fort Thrissur. Kerala. India. Corresponding Author: Dr P. John Mathai ABSTRACT INTRODUCTION Negative symptoms (NS) are Negative Symptoms in psychiatry are deficits in abnormal absence of normal behaviour and experience and behavior that are attributed to experience, attributed to the loss of normal loss of functions of brain. Negative symptoms functions of the brain. The NS are defined have been conceptualized as the core aspect of as absence of experience/behaviour that schizophrenia and have been recognized as [1] important ever since the days of Griesinger, should have been present. They are Kraepelin and Bleuler. But over the years the general descriptive terms used for the significance of the negative symptoms was various clinical manifestations of the deleted and emphasis was placed almost diminished capacity for ordinary exclusively on positive symptoms. The return of behavioural functioning (behavioural negative symptoms in schizophrenia was deficits). [2] Though there are differences in inevitable. The five general categories of the language used to refer to NS such as, negative symptoms include avolition, deficits symptoms, defect state symptoms, anhedonia, affective blunting, alogia and type II symptoms, core symptoms, asociality. The subdomains of negative fundamental symptoms, primary symptoms symptoms are experience domain (avolition and and basic symptoms, there are definite anhedonia) and expressivity domain (affective [3-7] blunting and alogia). -
Negative Symptoms and Behavioral Alterations Associated with Dorsolateral Prefrontal Syndrome in Patients with Schizophrenia
Journal of Clinical Medicine Article Negative Symptoms and Behavioral Alterations Associated with Dorsolateral Prefrontal Syndrome in Patients with Schizophrenia Pamela Ruiz-Castañeda 1,2, María Teresa Daza-González 1,2,* and Encarnación Santiago-Molina 3 1 Neuropsychological Evaluation and Rehabilitation Center (CERNEP), University of Almeria, Carretera de Sacramento, s/n, La Cañada de San Urbano, 04120 Almeria, Spain; [email protected] 2 Department of Psychology, University of Almeria, Carretera de Sacramento, s/n, La Cañada de San Urbano, 04120 Almeria, Spain 3 Mental Health Hospitalization Unit of Torrecárdenas Hospital, Calle Hermandad de Donantes de Sangre, s/n, 04009 Almería, Spain; [email protected] * Correspondence: [email protected]; Tel.: +34-950214623 Abstract: The present study had three main aims: (1) to explore the possible relationships between the two dimensions of negative symptoms (NS) with the three frontal behavioral syndromes (dorsolateral, orbitofrontal and the anterior or mesial cingulate circuit) in patients with schizophrenia; (2) to determine the influence of sociodemographic and clinical variables on the severity of the two dimensions of NS (expressive deficits and disordered relationships/avolition); and (3) to explore the possible relationships between the two dimensions of NS and social functioning. We evaluated a group of 33 patients with schizophrenia with a predominance of NS using the self-reported version Citation: Ruiz-Castañeda, P.; of the Frontal System Behavior scale. To quantify the severity of NS, the Assessment of Negative Daza-González, M.T.; Symptoms (SANS) scale was used. The results revealed that the two dimensions of NS correlate Santiago-Molina, E. Negative positively with the behavioral syndrome of dorsolateral prefrontal origin.