Spassova et al.: Supplementary materials and methods

Supplementary Table S3. Differentially expressed between responders and non-responders

# Function Classification 1 CCL5 Chemokine ligand 5, chemotactic GO:0010536 positive regulation of activation of Janus kinase for T-cells activity;GO:2000503 positive regulation of chemotaxis;GO:0010820 positive regulation of T cell chemotaxis 2 LAG3 Lymphocyte-activation gene 3, GO:0045085 negative regulation of interleukin-2 biosynthetic immune checkpoint process;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0002717 positive regulation of natural killer cell mediated immunity 3 PRF1 Perforin-1, pore forming cytolytic GO:0051712 positive regulation of killing of cells of other found in the granules of organism;GO:0002357 defense response to tumor cytotoxic T-cells and NK-cells cell;GO:0051709 regulation of killing of cells of other organism 4 CXCL9 Chemokine ligand 9, T-cell GO:0051281 positive regulation of release of sequestered chemoattractant calcium ion into cytosol;GO:0051279 regulation of release of sequestered calcium ion into cytosol;GO:0010524 positive regulation of calcium ion transport into cytosol 5 IRF4 Interferon regulatory factor 4, TF GO:0072540 T-helper 17 cell lineage commitment;GO:0002295 T-helper cell lineage commitment;GO:0072539 T-helper 17 cell differentiation 6 IL2RB IL2 receptor subunit beta, mediates GO:0038110 interleukin-2-mediated signaling proliferation of T-cells pathway;GO:0035723 interleukin-15-mediated signaling pathway;GO:0071350 cellular response to interleukin-15 7 GZMK Granzyme K, serine protease in the GO:0006508 proteolysis;GO:0019538 protein metabolic cytoplasmic granules of cytotoxic process;GO:1901564 organonitrogen compound metabolic lymphocytes process 8 CD3D T-cell surface glycoprotein CD3 GO:0045059 positive thymic T cell selection;GO:0045061 delta chain thymic T cell selection;GO:0043368 positive T cell selection 9 CD247 T-cell surface glycoprotein CD3 GO:0038096 Fc-gamma receptor signaling pathway involved in zeta chain phagocytosis;GO:0050690 regulation of defense response to virus by virus;GO:2000010 positive regulation of protein localization to cell surface 10 GZMA Granzyme A, serine protease in the GO:0032078 negative regulation of endodeoxyribonuclease cytoplasmic granules of cytotoxic activity;GO:0032076 negative regulation of deoxyribonuclease lymphocytes activity;GO:0032071 regulation of endodeoxyribonuclease activity 11 SIGLEC1 , cell adhesion GO:0007160 cell-matrix adhesion;GO:0031589 cell-substrate molecule, binding , adhesion;GO:0098609 cell-cell adhesion , NK-, B, T-cells 12 SOCS1 Suppressor of cytokine signaling 1, GO:0043377 negative regulation of CD8-positive, alpha-beta T negative regulator of cytokine cell differentiation;GO:0043376 regulation of CD8-positive, signaling alpha-beta T cell differentiation;GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation 13 ISG20 Interferon-stimulated gene 20 kDa GO:0045071 negative regulation of viral genome protein replication;GO:0000738 DNA catabolic process, exonucleolytic;GO:1903901 negative regulation of viral life cycle 14 PTPRC Protein tyrosine phosphatase, GO:0001915 negative regulation of T cell mediated receptor type C, essential regulator cytotoxicity;GO:2000473 positive regulation of hematopoietic of T- and B-cell antigen receptor stem cell migration;GO:0050857 positive regulation of antigen signaling receptor-mediated signaling pathway 15 CD38 cyclic ADP ribose hydrolase, GO:0014824 artery smooth muscle contraction;GO:0045907 functions in cell adhesion, signal positive regulation of vasoconstriction;GO:0014829 vascular transduction and calcium signaling smooth muscle contraction 16 IL10RA IL10 receptor alpha subunit, GO:0032496 response to lipopolysaccharide;GO:0002237 inhibits the synthesis of response to molecule of bacterial origin;GO:0050807 regulation proinflammatory cytokines of synapse organization

Spassova et al.: Supplementary materials and methods

17 ISG15 Interferon-stimulated gene 15, GO:0045648 positive regulation of erythrocyte secreted by monocytes and differentiation;GO:0045071 negative regulation of viral genome lymphpcytes and functions as replication;GO:0032020 ISG15-protein conjugation cytokine 18 SLAMF7 Self-ligand receptor of the GO:0042267 natural killer cell mediated signaling lymphocytic activation cytotoxicity;GO:0002228 natural killer cell mediated molecule family immunity;GO:0030101 natural killer cell activation 19 CD8A Cell surface GO:0045065 differentiation;GO:0030217 T cell glycoprotein/coreceptor, found on differentiation;GO:0002456 T cell mediated immunity most cytotoxic T-cells 20 IL16 Pro-interleukin-16, functions as GO:0050930 induction of positive chemotaxis;GO:0050927 chemoattractant, modulator of T- positive regulation of positive chemotaxis;GO:0050926 cell activation regulation of positive chemotaxis 21 HLA-DMB HLA class II histocompatibility GO:2001190 positive regulation of T cell activation via T cell antigen, DM beta chain receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:2001188 regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0002503 peptide antigen assembly with MHC class II protein complex 22 IFI16 Interferon-inducible myeloid GO:0097202 activation of cysteine-type endopeptidase differentiation transcriptional activity;GO:0045071 negative regulation of viral genome activator replication;GO:0030224 differentiation 23 CYFIP2 Cytoplasmic FMR1 interacting GO:0051388 positive regulation of neurotrophin TRK receptor protein 2, involved in T-cell signaling pathway;GO:0097202 activation of cysteine-type adhesion endopeptidase activity;GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 24 CXCL11 Chemokine 11, chemotactic for GO:0051281 positive regulation of release of sequestered activated T-cells calcium ion into cytosol;GO:0051279 regulation of release of sequestered calcium ion into cytosol;GO:0010524 positive regulation of calcium ion transport into cytosol 25 JAK3 Tyrosine-protein kinase, associated GO:0045626 negative regulation of T-helper 1 cell with cytokine receptors differentiation;GO:0045625 regulation of T-helper 1 cell differentiation;GO:0045623 negative regulation of T-helper cell differentiation 26 CMKLR1 Chemokine like receptro 1, GO:0010759 positive regulation of attraction of dendritic cells and chemotaxis;GO:1905523 positive regulation of macrophage migration;GO:0010758 regulation of macrophage chemotaxis 27 CCL3 Chemokine ligand 3, attracts GO:0014808 release of sequestered calcium ion into cytosol by macrophages, monocytes and sarcoplasmic reticulum;GO:1903514 release of sequestered neutrophils calcium ion into cytosol by endoplasmic reticulum;GO:2000503 positive regulation of natural killer cell chemotaxis 28 CD74 HLA class II histocompatibility GO:0002906 negative regulation of mature apoptotic antigen, gamma chain process;GO:0046598 positive regulation of viral entry into host cell;GO:0002905 regulation of mature B cell apoptotic process 29 PLAUR , involved in GO:2001268 negative regulation of cysteine-type endopeptidase tissue reorganization activity involved in apoptotic signaling pathway;GO:0042730 fibrinolysis;GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 30 FCER1A Fc fragment of IgE, high affinity I, GO:0001798 positive regulation of type IIa receptro for; alpha polypeptide - hypersensitivity;GO:0001805 positive regulation of type III plays a central role in allergic hypersensitivity;GO:0002894 positive regulation of type II disease hypersensitivity 31 IDO1 Indoleamine-pyrrole 2,3- GO:0019441 tryptophan catabolic process to dioxygenase - immune modulation kynurenine;GO:0034276 kynurenic acid biosynthetic by limiting T-cell function process;GO:0002666 positive regulation of T cell tolerance induction 32 CXCL10 Chemokine 10, attraction of GO:0051281 positive regulation of release of sequestered monocytes, dendritic cells, T-, calcium ion into cytosol;GO:1901740 negative regulation of NK-cells myoblast fusion;GO:0051279 regulation of release of sequestered calcium ion into cytosol

Spassova et al.: Supplementary materials and methods

33 ITGAL , cellular adhesion GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0043312 degranulation;GO:0002286 T cell activation involved in immune response 34 CD53 Leukocyte surface antigen , growth GO:1901741 positive regulation of myoblast regulation in T- and NK-cells fusion;GO:1901739 regulation of myoblast fusion;GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 35 MX1 Interferon-induced GTP-binding GO:0003374 dynamin family protein polymerization involved protein in mitochondrial fission;GO:0045071 negative regulation of viral genome replication;GO:0003373 dynamin family protein polymerization involved in membrane fission 36 Lymphocyte-specific protein GO:0050862 positive regulation of T cell receptor signaling tyrosine kinase, assists signaling pathway;GO:0050857 positive regulation of antigen receptor- from the TCR into the T-cells mediated signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol 37 ITGB4 , receptor for GO:0031581 hemidesmosome assembly;GO:0035878 nail laminins development;GO:0097186 amelogenesis 38 RUNX1 Runt-related transcription factor 1, GO:0043378 positive regulation of CD8-positive, alpha-beta T regulates the differentiation of cell differentiation;GO:0043376 regulation of CD8-positive, hematopoietic cells alpha-beta T cell differentiation;GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 39 CD97 promortes adhesion and migration GO:0043312 neutrophil degranulation;GO:0002283 neutrophil to sides of inflammation activation involved in immune response;GO:0042119 neutrophil activation 40 HLA-DMA HLA class II histocompatibility GO:0002503 peptide antigen assembly with MHC class II antigen, DM alpha chain protein complex;GO:0002399 MHC class II protein complex assembly;GO:0002501 peptide antigen assembly with MHC protein complex 41 ITGB2 , cellular/immune GO:0043315 positive regulation of neutrophil cell adhesion and cell surface degranulation;GO:0045963 negative regulation of dopamine signaling metabolic process;GO:1903980 positive regulation of microglial cell activation 42 NFATC2 Nuclear factor of activated T-cells, GO:1905064 negative regulation of vascular smooth muscle cell cytoplasmic 2 differentiation;GO:0045589 regulation of regulatory T cell differentiation;GO:1901741 positive regulation of myoblast fusion 43 ALCAM Cd166 antigen, mediating adhesion GO:0031290 retinal ganglion cell axon guidance;GO:0048846 interactions axon extension involved in axon guidance;GO:0008045 motor neuron axon guidance 44 INPP5D negative regulator of BCR GO:0045659 negative regulation of neutrophil signaling in B-cells differentiation;GO:0045658 regulation of neutrophil differentiation;GO:0045656 negative regulation of monocyte differentiation 45 C1QA Complement C1q subcomponent GO:0006958 complement activation, classical subunit A pathway;GO:0030449 regulation of complement activation;GO:0002455 humoral immune response mediated by circulating immunoglobulin 46 IL2RG IL2 receptor subunit gamma, GO:0038113 interleukin-9-mediated signaling directs the growth and maturation pathway;GO:0038114 interleukin-21-mediated signaling of T-, B-, NK-cells pathway;GO:0071355 cellular response to interleukin-9 47 GZMB Granzyme B, serine protease in the GO:1900740 positive regulation of protein insertion into cytoplasmic granules of cytotoxic mitochondrial membrane involved in apoptotic signaling lymphocytes pathway;GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 48 NLRC5 NOD-like receptor, regulating GO:0060335 positive regulation of interferon-gamma-mediated interferon activity signaling pathway;GO:0060339 negative regulation of type I

Spassova et al.: Supplementary materials and methods

interferon-mediated signaling pathway;GO:0060340 positive regulation of type I interferon-mediated signaling pathway 49 IL7R Interleukin 7 receptor, importent GO:0001915 negative regulation of T cell mediated for V(D)J recombination cytotoxicity;GO:0033089 positive regulation of T cell differentiation in thymus;GO:0033081 regulation of T cell differentiation in thymus 50 HLA-B major histocompatibility complex, GO:0002480 antigen processing and presentation of exogenous class I, B peptide antigen via MHC class I, TAP- independent;GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP- dependent;GO:0001916 positive regulation of T cell mediated cytotoxicity 51 IFI27 Interferon alpha-inducible protein GO:0006919 activation of cysteine-type endopeptidase activity 27, mediates INF-induced involved in apoptotic process;GO:0046825 regulation of protein apoptosis export from nucleus;GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 52 CCL4 Chemokine ligand 4, GO:2000503 positive regulation of natural killer cell chemoattractant for NK-cells, chemotaxis;GO:0043922 negative regulation by host of viral monocytes transcription;GO:2000501 regulation of natural killer cell chemotaxis 53 TAP1 Transporter associated with GO:1990668 vesicle fusion with endoplasmic reticulum-Golgi Antigen Processing 1 intermediate compartment (ERGIC) membrane;GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 54 HLA-DRB3 HLA class II histocompatibility GO:0050852 T cell receptor signaling pathway;GO:0019886 antigen, DRB3-1 beta chain antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0060333 interferon-gamma- mediated signaling pathway 55 PIK3CG play a pivotal role in the regulation GO:0010897 negative regulation of triglyceride catabolic of cytotoxicity in NK-cells process;GO:0055118 negative regulation of cardiac muscle contraction;GO:0035747 natural killer cell chemotaxis 56 ITGA4 , part of GO:1903238 positive regulation of leukocyte tethering or lymphocyte homing receptor rolling;GO:1990771 clathrin-dependent extracellular exosome endocytosis;GO:1903236 regulation of leukocyte tethering or rolling 57 CYBB NADPH oxidase 2, forms reactive GO:1904845 cellular response to L-glutamine;GO:0042535 oxygen species positive regulation of tumor necrosis factor biosynthetic process;GO:1904044 response to aldosterone 58 TGFB1 Transforming growth factor beta 1, GO:0048298 positive regulation of isotype switching to IgA controlles the isotypes;GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis;GO:0048296 regulation of isotype switching to IgA isotypes 59 C1QB Complement component 1q, beta GO:0006958 complement activation, classical chain pathway;GO:0030449 regulation of complement activation;GO:0002455 humoral immune response mediated by circulating immunoglobulin 60 HLA-DRA HLA class II histocompatibility GO:0002506 polysaccharide assembly with MHC class II antigen, DR alpha chain protein complex;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002505 antigen processing and presentation of polysaccharide antigen via MHC class II 61 CSF2RB colony stimulating factor 2 GO:0038043 interleukin-5-mediated signaling receptor beta for IL-3 and IL-5 pathway;GO:0038156 interleukin-3-mediated signaling pathway;GO:0036016 cellular response to interleukin-3 62 CD79B component of B-cell antigen GO:0050853 B cell receptor signaling pathway;GO:0030183 B receptor cell differentiation;GO:0050851 antigen receptor-mediated signaling pathway

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63 COL3A1 Collagen alpha-1(III) chain, GO:0060414 aorta smooth muscle tissue precursor to collagen III morphogenesis;GO:2001223 negative regulation of neuron migration;GO:0035909 aorta morphogenesis 64 TNFSF13B B-cell activating factor, cytokine GO:0031296 B cell costimulation;GO:0002636 positive regulation of germinal center formation;GO:0002634 regulation of germinal center formation 65 ICAM1 Intercellular adhesion molecule 1, GO:0097368 establishment of Sertoli cell barrier;GO:0046813 leukocyte migration receptor-mediated virion attachment to host cell;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 66 PIK3CD phosphoinositide 3-kinase, GO:0033031 positive regulation of neutrophil apoptotic important for the function of T-, B- process;GO:0033029 regulation of neutrophil apoptotic cells, mast cells and neutrophils process;GO:0060374 mast cell differentiation 67 CXCL14 Chemokine ligand 14, attracts GO:2000503 positive regulation of natural killer cell monocytes chemotaxis;GO:2000501 regulation of natural killer cell chemotaxis;GO:0140131 positive regulation of lymphocyte chemotaxis 68 HCK Tyrosine-protein kinase, migration GO:0045728 respiratory burst after phagocytosis;GO:0002522 and degranulation of neutrophils leukocyte migration involved in immune response;GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 69 AMICA1 Junctional Adhesion Molecule- GO:0035696 monocyte extravasation;GO:0072672 neutrophil Like, neutrophil extravasation extravasation;GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing 70 CD63 play a role in the regulation of cell GO:0035646 endosome to melanosome transport;GO:0043485 development, activation, growth, endosome to pigment granule transport;GO:0048757 pigment and motility granule maturation 71 PECAM1 Platelet endothelial cell adhesion GO:0072011 glomerular endothelium molecule, leukocyte development;GO:0072672 neutrophil transmigration, angiogenesis and extravasation;GO:0050904 diapedesis integrin activation 72 CD68 marker for monocytes and GO:0043312 neutrophil degranulation;GO:0002283 neutrophil macrophages, important for activation involved in immune response;GO:0042119 macrophages homing neutrophil activation 73 CCL21 Chemokine ligand 21, inhibits GO:2000529 positive regulation of myeloid dendritic cell hemopoiesos and stimulates chemotaxis;GO:2000527 regulation of myeloid dendritic cell chemotaxis chemotaxis;GO:2000548 negative regulation of dendritic cell dendrite assembly 74 CXCR4 Chemokine receptro type 4, GO:0019064 fusion of virus membrane with host plasma chemotaxis of lymphocytes membrane;GO:0039663 membrane fusion involved in viral entry into host cell;GO:0048714 positive regulation of oligodendrocyte differentiation 75 IRF8 Interferon regulatory factor 8, TF GO:0044130 negative regulation of growth of symbiont in critical for lineage commitment host;GO:0044126 regulation of growth of symbiont in regulation and myeloid cell host;GO:0044146 negative regulation of growth of symbiont maturation involved in interaction with host 76 CLEC4A C-type domain family 4 GO:0002470 plasmacytoid dendritic cell antigen processing and member A, plays a role in presentation;GO:0002223 stimulatory C-type lectin receptor inflammatory and immune signaling pathway;GO:0002220 innate immune response response activating cell surface receptor signaling pathway 77 LCP1 Plastin-2, plays a role in T-cell GO:0044319 wound healing, spreading of cells;GO:0071803 activation positive regulation of podosome assembly;GO:0035722 interleukin-12-mediated signaling pathway 78 TNFRSF1B Tumor necrosis factor receptor 2, GO:0003332 negative regulation of extracellular matrix regulates TNF-alpha function constituent secretion;GO:1902339 positive regulation of apoptotic process involved in morphogenesis;GO:0003330 regulation of extracellular matrix constituent secretion 79 IKBKE I-kappa-B kinase epsilon, GO:0035666 TRIF-dependent toll-like receptor signaling regulating inflammatory response pathway;GO:0002756 MyD88-independent toll-like receptor to viral infection signaling pathway;GO:0002224 toll-like receptor signaling pathway

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80 CD84 function in adhesion interactions GO:0043305 negative regulation of mast cell between T lymphocytes and degranulation;GO:0032685 negative regulation of granulocyte accessory cells macrophage colony-stimulating factor production;GO:0033007 negative regulation of mast cell activation involved in immune response 81 TNFSF13 tumor necrosis factor ligand GO:0048298 positive regulation of isotype switching to IgA superfamily member 13, isotypes;GO:0048296 regulation of isotype switching to IgA important for B cell development isotypes;GO:0048290 isotype switching to IgA isotypes 82 HLA-DPB1 HLA class II histocompatibility GO:0042102 positive regulation of T cell antigen, DP beta chain proliferation;GO:0050852 T cell receptor signaling pathway;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 83 STAT1 Signal transducer and activator of GO:0072308 negative regulation of metanephric nephron tubule transcription 1, important for epithelial cell differentiation;GO:0003340 negative regulation survival of the cell, viability or of mesenchymal to epithelial transition involved in metanephros pathogen response morphogenesis;GO:0072183 negative regulation of nephron tubule epithelial cell differentiation 84 IL15RA Interleukin 15 receptor alpha GO:0035723 interleukin-15-mediated signaling subunit, enhances cell proliferation pathway;GO:0071350 cellular response to interleukin- and expression of apoptosis 15;GO:0070672 response to interleukin-15 inhibitors 85 IFNAR2 Interferon-alpha/beta receptor beta GO:0060338 regulation of type I interferon-mediated signaling chain, activates STAT1, STAT2 pathway;GO:0060337 type I interferon signaling and STAT3 pathway;GO:0035455 response to interferon-alpha 86 EP300 Histone acetyltransferase p300, GO:0006977 DNA damage response, signal transduction by p53 important in the processes of cell class mediator resulting in cell cycle arrest;GO:0043969 histone proliferation and differentiation H2B acetylation;GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint 87 PRKCD Protein kinase C delta type, GO:2000753 positive regulation of glucosylceramide catabolic involved in B cell signaling; process;GO:2000752 regulation of glucosylceramide catabolic regulation of growth, apoptosis, process;GO:2000755 positive regulation of sphingomyelin differentiation of a variety of cell catabolic process types 88 HLA-C HLA class I histocompatibility GO:0002480 antigen processing and presentation of exogenous antigen peptide antigen via MHC class I, TAP- independent;GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP- dependent;GO:0001916 positive regulation of T cell mediated cytotoxicity 89 CYLD Cylindromatosis, for regulation of GO:0050862 positive regulation of T cell receptor signaling pathways leading to NF-kappa-B pathway;GO:0070423 nucleotide-binding oligomerization activation domain containing signaling pathway;GO:0043369 CD4- positive or CD8-positive, alpha-beta T cell lineage commitment 90 SYK Spleen tyrosine kinase, regulates GO:0090237 regulation of arachidonic acid innate and adaptive immunity secretion;GO:0045588 positive regulation of gamma-delta T cell differentiation;GO:0002554 serotonin secretion by platelet 91 IFITM1 Interferon-induced transmembrane GO:0046597 negative regulation of viral entry into host protein 1, involved in mmune cell;GO:0046596 regulation of viral entry into host response signaling, germ cell cell;GO:0045071 negative regulation of viral genome maturation and development replication 92 TNFRSF13C B-cell activating factor receptor GO:0031296 B cell costimulation;GO:0002636 positive regulation of germinal center formation;GO:0045078 positive regulation of interferon-gamma biosynthetic process 93 C3AR1 Complement component 3a GO:0090023 positive regulation of neutrophil receptor 1 chemotaxis;GO:0010759 positive regulation of macrophage chemotaxis;GO:0071624 positive regulation of granulocyte chemotaxis 94 RUNX3 Runt-related transcription factor 3, GO:0043378 positive regulation of CD8-positive, alpha-beta T T-cell receptor enhancer cell differentiation;GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation;GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation

Spassova et al.: Supplementary materials and methods

95 CASP1 Caspase-1, initiator of GO:0050717 positive regulation of interleukin-1 alpha inflammatory response secretion;GO:0050705 regulation of interleukin-1 alpha secretion;GO:0050718 positive regulation of interleukin-1 beta secretion 96 EWSR1 Ewing Sarcoma Breakpoint GO:0006355 regulation of transcription, DNA- Region 1, transcriptional repressor templated;GO:1903506 regulation of nucleic acid-templated transcription;GO:0006351 transcription, DNA-templated 97 PSMB10 Proteasome subunit beta type-10, GO:0010499 proteasomal ubiquitin-independent protein part of an immunoproteasome catabolic process;GO:0043161 proteasome-mediated ubiquitin- dependent protein catabolic process;GO:0016579 protein deubiquitination 98 THBD , reduces blood GO:0051918 negative regulation of fibrinolysis;GO:0051917 coagulation regulation of fibrinolysis;GO:0010544 negative regulation of platelet activation 99 FUT7 Alpha-(1,3)-fucosyltransferase, GO:0002361 CD4-positive, CD25-positive, alpha-beta mediates adhesion of leukocytes regulatory T cell differentiation;GO:0042355 L-fucose catabolic process;GO:0019317 fucose catabolic process 100 ANXA1 Annexon A1, regulator of the GO:0045629 negative regulation of T-helper 2 cell inflammatory process differentiation;GO:0045627 positive regulation of T-helper 1 cell differentiation;GO:0045625 regulation of T-helper 1 cell differentiation 101 TAP2 Transporter associated with GO:0002489 antigen processing and presentation of Antigen Processing 2 endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent;GO:0002488 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway;GO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane 102 C5* Complement component 5, GO:0010760 negative regulation of macrophage important role in inflammatory and chemotaxis;GO:0090197 positive regulation of chemokine cell killing processes secretion;GO:1905522 negative regulation of macrophage migration 103 CDK1* Cyclin-dependent kinase 1, key GO:1905448 positive regulation of mitochondrial ATP player in cell cycle regulation synthesis coupled electron transport;GO:1905446 regulation of mitochondrial ATP synthesis coupled electron transport;GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 104 ITGAE* Integrin alpha E, important for T GO:0007229 integrin-mediated signaling pathway;GO:0030198 cell homing extracellular matrix organization;GO:0043062 extracellular structure organization 105 ITCH* Itchy E3 Ubiquitin Protein Ligase GO:0002669 positive regulation of T cell anergy;GO:0046642 negative regulation of alpha-beta T cell proliferation;GO:0002913 positive regulation of lymphocyte anergy 106 BCL2* B-cell lymphoma 2, regulator of GO:0032848 negative regulation of cellular pH apoptoses reduction;GO:0043375 CD8-positive, alpha-beta T cell lineage commitment;GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 107 NOS2A* Nitric oxide synthase, inducible, GO:0031284 positive regulation of guanylate cyclase synthesase reactive free radicals activity;GO:0032310 prostaglandin secretion;GO:0031282 regulation of guanylate cyclase activity 108 ITGA2B* Integrin alpha-IIb, induces rapid GO:0045652 regulation of megakaryocyte platelet aggregation differentiation;GO:0070527 platelet aggregation;GO:0002576 platelet degranulation * downregulated genes in responders, compared to non-responders.