Exploring the Brain

Total Page:16

File Type:pdf, Size:1020Kb

Exploring the Brain © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NEUROSCIENCENOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning,Exploring LLC ©the Jones & BartlettBrain Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning LLC, an Ascend Learning Company. NOT FOR SALE OR DISTRIBUTION. 9781284218817_FMxx_i_xlii.indd 1 21/02/20 3:27 PM © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning LLC, an Ascend Learning Company. NOT FOR SALE OR DISTRIBUTION. 9781284218817_FMxx_i_xlii.indd 2 21/02/20 3:27 PM © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NEUROSCIENCENOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning,Exploring LLC ©the Jones & BartlettBrain Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION Enhanced Fourth Edition © JonesMark & Bartlett F. Learning, BEAR, LLC PhD © Jones & Bartlett Learning, LLC NOT FORPicower SALE Professor OR DISTRIBUTION of Neuroscience NOT FOR SALE OR DISTRIBUTION The Picower Institute for Learning and Memory Department of Brain and Cognitive Sciences Massachusetts Institute of Technology © Jones & Bartlett Learning,Cambridge, LLC Massachusetts © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION Barry W. CONNORS, PhD L. Herbert Ballou University Professor Professor of Neuroscience and Chair © Jones & Bartlett Learning, LLCDepartment of Neuroscience© Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTIONBrown University NOT FOR SALE OR DISTRIBUTION Providence, Rhode Island Michael A. PARADISO, PhD © JonesSidney & Bartlett A. Fox Learning,and Dorothea LLC Doctors Fox Professor of © Jones & Bartlett Learning, LLC Opthamology and Visual Science NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION Department of Neuroscience Brown University Providence, Rhode Island © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning LLC, an Ascend Learning Company. NOT FOR SALE OR DISTRIBUTION. 9781284218817_FMxx_i_xlii.indd 3 21/02/20 3:27 PM © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION World Headquarters Jones & Bartlett Learning 5 Wall Street Burlington, MA 01803 978-443-5000 © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC [email protected] NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION www.jblearning.com Jones & Bartlett Learning books and products are available through most bookstores and online booksellers. To contact Jones & Bartlett Learning directly, call 800-832-0034, fax 978-443-8000, or visit our website, www.jblearning.com. © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC Substantial discounts on bulk quantities of Jones & Bartlett Learning publications are available to corporations, professional associations, and otherNOT qualified FOR organizations. SALE OR For DISTRIBUTIONdetails and specific discount information, contactNOT the FORspecial salesSALE department OR DISTRIBUTION at Jones & Bartlett Learning via the above contact information or send an email to [email protected]. Copyright © 2016 by Jones & Bartlett Learning, LLC, an Ascend Learning Company © JonesAll rights& Bartlett reserved. Learning,No part of the materialLLC protected by this copyright© mayJones be reproduced & Bartlett or utilized Learning, in any form, LLC electronic or mechanical, NOT FORincluding SALE photocopying, OR DISTRIBUTION recording, or by any information storage andNOT retrieval FOR system, SALE without OR written DISTRIBUTION permission from the copyright owner. The content, statements, views, and opinions herein are the sole expression of the respective authors and not that of Jones & Bartlett Learning, LLC. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or other- wise does not constitute or imply its endorsement or recommendation by Jones & Bartlett Learning, LLC and such reference shall not be used for advertising or product endorsement purposes. All trademarks displayed are the trademarks of the parties noted herein. Neuroscience: Exploring the Brain, Enhanced© Fourth Jones Edition & Bartlett is an independent Learning, publication LLC and has not been authorized, sponsored,© Jones or &otherwise Bartlett approved Learning, LLC by the owners of the trademarksNOT or service FOR marks SALE referenced OR DISTRIBUTION in this product. NOT FOR SALE OR DISTRIBUTION There may be images in this book that feature models; these models do not necessarily endorse, represent, or participate in the activities represented in the images. Any screenshots in this product are for educational and instructive purposes only. Any individuals and scenarios featured in the case studies throughout this product may be real or fictitious but are used for instructional purposes only. This publication© Jones is designed & Bartlett to provide Learning,accurate and authoritative LLC information in regard© to Jonesthe Subject & Matter Bartlett covered. Learning, It is sold with LLC the understanding that the publisher is not engaged in rendering legal, accounting, or other professional service. If legal advice or other expert assistanceNOT is required, FOR the SALE service ofOR a competent DISTRIBUTION professional person should be sought. NOT FOR SALE OR DISTRIBUTION 21881-7 Production Credits VP, Product Management: Amanda Martin Cover Image: Courtesy of Satrajit Ghosh and John Gabrieli, © JonesDirector & Bartlett of Product Learning,Management: Cathy LLC L. Esperti © JonesMcGovern & Bartlett Institute for Learning, Brain Research LLC and Department of Brain NOT FORProduct SALE Specialist: OR Ashley DISTRIBUTION Malone NOT andFOR Cognitive SALE Sciences, OR DISTRIBUTIONMassachusetts Institute of Technology. Product Coordinator: Elena Sorrentino Part I Chapter Opener: Courtesy of Sebastian Seung, Princeton Digital Project Specialist: Angela Dooley University, and Alex Norton, EyeWire. Director of Marketing: Andrea DeFronzo Part II Chapter Opener: Courtesy of Shane Crandall, Saundra Marketing Manager: Dani Burford Patrick, and Barry Connors, Department of Neuroscience, Brown Production Services Manager: Colleen Lamy University. VP, Manufacturing and Inventory© Jones Control: & Bartlett Learning,Part LLC III Chapter Opener: Courtesy of© Arthur Jones Toga & and Bartlett Paul Learning, LLC Therese Connell NOT FOR SALE OR DISTRIBUTIONThompson, Keck School of Medicine,NOT University FOR SALEof Southern OR DISTRIBUTION Product Fulfillment Manager: Wendy Kilborn California. Composition: S4Carlisle Publishing Services Part IV Chapter Opener: Courtesy of Miquel Bosch and Mark Bear, Project Management: S4Carlisle Publishing Services The Picower Institute for Learning and Memory and Department Cover & Text Design: Kristin E. Parker
Recommended publications
  • Unrestricted Immigration and the Foreign Dominance Of
    Unrestricted Immigration and the Foreign Dominance of United States Nobel Prize Winners in Science: Irrefutable Data and Exemplary Family Narratives—Backup Data and Information Andrew A. Beveridge, Queens and Graduate Center CUNY and Social Explorer, Inc. Lynn Caporale, Strategic Scientific Advisor and Author The following slides were presented at the recent meeting of the American Association for the Advancement of Science. This project and paper is an outgrowth of that session, and will combine qualitative data on Nobel Prize Winners family histories along with analyses of the pattern of Nobel Winners. The first set of slides show some of the patterns so far found, and will be augmented for the formal paper. The second set of slides shows some examples of the Nobel families. The authors a developing a systematic data base of Nobel Winners (mainly US), their careers and their family histories. This turned out to be much more challenging than expected, since many winners do not emphasize their family origins in their own biographies or autobiographies or other commentary. Dr. Caporale has reached out to some laureates or their families to elicit that information. We plan to systematically compare the laureates to the population in the US at large, including immigrants and non‐immigrants at various periods. Outline of Presentation • A preliminary examination of the 609 Nobel Prize Winners, 291 of whom were at an American Institution when they received the Nobel in physics, chemistry or physiology and medicine • Will look at patterns of
    [Show full text]
  • MED C-LIVE Transcript
    JUNE 2020 Mario Capecchi, Ph.D. NOT FOR PUBLIC DISTRIBUTION Michael Keel My name is Michael Keel from New Jersey. And it is my honor to introduce Dr. Mario Capecchi. Dr. Capecchi is the Distinguished Professor of Human Genetics at the University of Utah School of Medicine. He is best known for his groundbreaking work in gene targeting, in mass embryo derived stem cells. He was awarded the Nobel Prize in Physiology for Medicine, for his work in finding ways to manipulate the mammalian genome by changing mammals’ genes. His research interests include analysis of neural development in mammals, gene therapy, and production of murine models of human genetic diseases, from cancer to neuropsychiatric disorders. Dr. Capecchi, welcome to the Congress of Future Medical Leaders. Dr. Capecchi Thank you. First of all, welcome to the Medical Leaders’ Congress. It's a pleasure to be here. My name is Mario. I'm going to be talking about gene targeting. Next slide please. My laboratory has developed a technology called gene targeting that allows you to change any gene in any conceivable manner in a living creature, such as a mouse. Next slide. Why do we do gene targeting? Next slide. There are many reasons, but they boil down to two. One is basic research and the other is applied research. In basic research, you investigate the biology of an animal. For example, how do you make a limb or a heart or a brain? Those are basic research questions. The other is applied research. That is we can use gene targeting to generate mice with human diseases.
    [Show full text]
  • Advertising (PDF)
    Neuroscience 2013 SEE YOU IN San Diego November 9 – 13, 2013 Join the Society for Neuroscience Are you an SfN member? Join now and save on annual meeting registration. You’ll also enjoy these member-only benefits: • Abstract submission — only SfN members can submit abstracts for the annual meeting • Lower registration rates and more housing choices for the annual meeting • The Journal of Neuroscience — access The Journal online and receive a discounted subscription on the print version • Free essential color charges for The Journal of Neuroscience manuscripts, when first and last authors are members • Free online access to the European Journal of Neuroscience • Premium services on NeuroJobs, SfN’s online career resource • Member newsletters, including Neuroscience Quarterly and Nexus If you are not a member or let your membership lapse, there’s never been a better time to join or renew. Visit www.sfn.org/joinnow and start receiving your member benefits today. www.sfn.org/joinnow membership_full_page_ad.indd 1 1/25/10 2:27:58 PM The #1 Cited Journal in Neuroscience* Read The Journal of Neuroscience every week to keep up on what’s happening in the field. s4HENUMBERONECITEDJOURNAL INNEUROSCIENCE s4HEMOSTNEUROSCIENCEARTICLES PUBLISHEDEACHYEARNEARLY in 2011 s )MPACTFACTOR s 0UBLISHEDTIMESAYEAR ,EARNMOREABOUTMEMBERAND INSTITUTIONALSUBSCRIPTIONSAT *.EUROSCIORGSUBSCRIPTIONS *ISI Journal Citation Reports, 2011 The Journal of Neuroscience 4HE/FlCIAL*OURNALOFTHE3OCIETYFOR.EUROSCIENCE THE HISTORY OF NEUROSCIENCE IN AUTOBIOGRAPHY THE LIVES AND DISCOVERIES OF EMINENT SENIOR NEUROSCIENTISTS CAPTURED IN AUTOBIOGRAPHICAL BOOKS AND VIDEOS The History of Neuroscience in Autobiography Series Edited by Larry R. Squire Outstanding neuroscientists tell the stories of their scientific work in this fascinating series of autobiographical essays.
    [Show full text]
  • Eric Kandel Form in Which This Information Is Stored
    RESEARCH I NEWS pendent, this system would be expected to [2] HEEsch and J E Bums. Distance estimation work quite well, since the new recruit bees by foraging honeybees, The Journal ofExperi­ mental Biology, Vo1.199, pp. 155-162, 1996. tend to take the same route as the experi­ [3] M V Srinivasan, S W Zhang, M Lehrer, and T enced scout bee. What dOJhe ants do when S Collett, Honeybee Navigation en route to they cover similarly several kilometres on the goal: Visual flight control and odometry, foot to look for food? Preliminary evidence The Journal ofExperimental Biology, Vol. 199, pp. 237-244, 1996. indicates that they don't use an odometer but [4] M V Srinivasan, S W Zhang, M Altwein, and instead might count steps! J Tautz, Honeybee Navigation: Nature and Calibration of the Odometer, Science, Vol. Suggested Reading 287, pp. 851-853, 1996. [1] Karl von Frisch, The dance language and OT­ Moushumi Sen Sarma, Centre for Ecological Sci­ ientation of bees, Harvard Univ. Press, Cam­ ences, Indian Institute of Science, Bangalore 560012, bridge, MA, USA, 1993. India. Email: [email protected] Learning from a Sea Snail: modify future behaviour, then memory is the Eric Kandel form in which this information is stored. Together, they represent one of the most valuable and powerful adaptations ever to Rohini Balakrishnan have evolved in nervous systems, for they In the year 2000, Eric Kandel shared the allow the future to access the past, conferring Nobel Prize in Physiology and Medicinel flexibility to behaviour and improving the with two other neurobiologists: Arvid chances of survival in unpredictable, rapidly Carlsson and Paul Greengard.
    [Show full text]
  • 2004 Albert Lasker Nomination Form
    albert and mary lasker foundation 110 East 42nd Street Suite 1300 New York, ny 10017 November 3, 2003 tel 212 286-0222 fax 212 286-0924 Greetings: www.laskerfoundation.org james w. fordyce On behalf of the Albert and Mary Lasker Foundation, I invite you to submit a nomination Chairman neen hunt, ed.d. for the 2004 Albert Lasker Medical Research Awards. President mrs. anne b. fordyce The Awards will be offered in three categories: Basic Medical Research, Clinical Medical Vice President Research, and Special Achievement in Medical Science. This is the 59th year of these christopher w. brody Treasurer awards. Since the program was first established in 1944, 68 Lasker Laureates have later w. michael brown Secretary won Nobel Prizes. Additional information on previous Lasker Laureates can be found jordan u. gutterman, m.d. online at our web site http://www.laskerfoundation.org. Representative Albert Lasker Medical Research Awards Program Nominations that have been made in previous years may be updated and resubmitted in purnell w. choppin, m.d. accordance with the instructions on page 2 of this nomination booklet. daniel e. koshland, jr., ph.d. mrs. william mccormick blair, jr. the honorable mark o. hatfied Nominations should be received by the Foundation no later than February 2, 2004. Directors Emeritus A distinguished panel of jurors will select the scientists to be honored. The 2004 Albert Lasker Medical Research Awards will be presented at a luncheon ceremony given by the Foundation in New York City on Friday, October 1, 2004. Sincerely, Joseph L. Goldstein, M.D. Chairman, Awards Jury Albert Lasker Medical Research Awards ALBERT LASKER MEDICAL2004 RESEARCH AWARDS PURPOSE AND DESCRIPTION OF THE AWARDS The major purpose of these Awards is to recognize and honor individuals who have made signifi- cant contributions in basic or clinical research in diseases that are the main cause of death and disability.
    [Show full text]
  • Eighty Years of Fighting Against Cancer in Serbia Ovarian Cancer Vaccine
    News Eighty years of fighting against cancer Recent study by Kunle Odunsi et al., Roswell Park Cancer Institute, Buffalo, in Serbia New York, USA, showed an effects of vaccine based on NY-ESO-1, a „cancer This year on December 10th, Serbian society for the fight against cancer has testis“ antigen in preventing the recurrence of ovarian cancer. NY-ESO-1 is a ovarian celebrated the great jubilee - 80 years of its foundation. The celebration took „cancer-testis“ antigen expressed in epithelial cancer (EOC) and is place in Crystal Room of Belgrade’s Hyatt hotel, gathering many distinguished among the most immunogenic tumor antigens defined to date. presence + guests from the country and abroad. This remarkable event has been held Author’s previous study point to the role of of intraepithelial CD8 - under the auspices of the President of Republic of Serbia, Mr. Boris Tadić. infiltrating T lymphocytes in tumors that was associated with improved survival of The whole ceremony was presided by Prof. Dr. Slobodan Čikarić, actual presi- patients with the disease. The NY-ESO-1 peptide epitope, ESO157–170, is recog- + + dent of Society, who greeted guests and wished them a warm welcome. Than nized by HLA-DP4-restricted CD4 T cells and HLA-A2- and A24-restricted CD8 + followed the speech of Serbian health minister, Prof. Dr. Tomica Milosavljević T cells. To test whether providing cognate helper CD4 T cells would enhance who pointed out the importance of preventive measures and public education the antitumor immune response, Odunsi et al., conducted a phase I clinical trial along with timely diagnosis and multidisciplinary treatment in global fight of immunization with ESO157–170 mixed with incomplete Freund's adjuvant + against cancer in Serbia.
    [Show full text]
  • I. Hox Genes 2
    School ofMedicine Oregon Health Sciences University CERTIFICATE OF APPROVAL This is certify that the Ph.D. thesis of WendyKnosp has been approved Mentor/ Advisor ~ Member Member QUANTITATIVE ANALYSIS OF HOXA13 FUNCTION IN THE DEVELOPING LIMB By Wendy M. lt<nosp A DISSERTATION Presented to the Department of Molecular and Medical Genetics and the Oregon Health & Science University School of Medicine in partial fulfillment of the requirements for the degree of Doctor of Philosophy August 2006 TABLE OF CONTENTS LIST OF FIGURES iv LIST OF ABBREVIATIONS vii ACKNOWLEDGEMENTS X ABSTRACT xii CHAPTER 1: Introduction 1 I. Hox genes 2 A. Discovery of Hox genes in Drosophila melanogaster 2 B. Hox cluster colinearity and conservation 7 C. Human Hox mutations 9 D. Hoxa13: HFGS and Guttmacher syndromes 10 II. The Homeodomain 12 A. Homeodomain structure 12 B. DNA binding 14 Ill. Limb development 16 A. Patterning of the limb axes 16 B. Digit formation 20 C. lnterdigital programmed cell death 21 IV. BMPs and limb development 23 A. BMP signaling in the limb 23 B. BMP target genes 27 V. Hoxa13 and embryonic development 30 A. The Hoxa13-GFP mouse model 30 B. Hoxa13 mutant phenotypes 34 C. HOXA 13 homeodomain 35 D. HOXA 13 protein-protein interactions 36 E. HOXA 13 target genes 37 VI. Hypothesis and Rationale 39 CHAPTER 2: HOXA13 regulates Bmp2 and Bmp7 40 I. Abstract 42 II. Introduction 43 Ill. Results 46 IV. Discussion 69 v. Materials and Methods 75 VI. Acknowledgements 83 11 CHAPTER 3: Quantitative analysis of HOXA13 function 84 HOXA 13 regulation of Sostdc1 I.
    [Show full text]
  • October 2, 2001, NIH Record, Vol. LIII, No. 20
    R Still The Second Best Thing About Payday Translating the Histone Code: A H G H L 1,G H T, S Tale of Tails at Stetten Talk Attacks on U.S. Change Life at NIH By Rich McManus By Alison Davis Security Beefed Up News stories appearing over the last year he transition from peacetime's reliable routine to wartime On Campus would have everyone believe that scientists anxiety took place in only minutes as NTH employees came have-once and for all~racked the human Tto work on an otherwise spectacular late summer morning genetic code. Indeed, two teams of 50th Anniversary Sept. 11 and scientists have already published a draft For NINOS, NIMH discovered by 9:45- sequence of our 3-billion-unit jumble of via office televisions, DNA "letters." But t he task of thoroughly radio, the web, deciphering the code's protein-making phone calls and Grantees Win hallway conversa­ instructions-something our bodies do Lasker Award SEE STETTEN LECTURE, PAGE 2 tions-that terror­ ism on an almost unimaginable scale Kolb To Give was taking place in Pittman Lecture New York City and in the heart of Washington, D.C. Fall Computer The workday froze Courses Offered as workers tuned in to the news-the World Trade Center towers in flames, Flag flies at half-mast in tragedy's wake. Outdoor Film and smoke rising from behind the Old Executive Office buiJding Dr. C. David Allis to give Stetten Lecture. Festival a Big Hit near the White House. Summer Jobs into Permanent Posts In the OD Office of Communications and Public Liaison in Bldg.
    [Show full text]
  • The Brain That Changes Itself
    The Brain That Changes Itself Stories of Personal Triumph from the Frontiers of Brain Science NORMAN DOIDGE, M.D. For Eugene L. Goldberg, M.D., because you said you might like to read it Contents 1 A Woman Perpetually Falling . Rescued by the Man Who Discovered the Plasticity of Our Senses 2 Building Herself a Better Brain A Woman Labeled "Retarded" Discovers How to Heal Herself 3 Redesigning the Brain A Scientist Changes Brains to Sharpen Perception and Memory, Increase Speed of Thought, and Heal Learning Problems 4 Acquiring Tastes and Loves What Neuroplasticity Teaches Us About Sexual Attraction and Love 5 Midnight Resurrections Stroke Victims Learn to Move and Speak Again 6 Brain Lock Unlocked Using Plasticity to Stop Worries, OPsessions, Compulsions, and Bad Habits 7 Pain The Dark Side of Plasticity 8 Imagination How Thinking Makes It So 9 Turning Our Ghosts into Ancestors Psychoanalysis as a Neuroplastic Therapy 10 Rejuvenation The Discovery of the Neuronal Stem Cell and Lessons for Preserving Our Brains 11 More than the Sum of Her Parts A Woman Shows Us How Radically Plastic the Brain Can Be Appendix 1 The Culturally Modified Brain Appendix 2 Plasticity and the Idea of Progress Note to the Reader All the names of people who have undergone neuroplastic transformations are real, except in the few places indicated, and in the cases of children and their families. The Notes and References section at the end of the book includes comments on both the chapters and the appendices. Preface This book is about the revolutionary discovery that the human brain can change itself, as told through the stories of the scientists, doctors, and patients who have together brought about these astonishing transformations.
    [Show full text]
  • Message from the Chairman
    Abstract1 6/01/09 8:36 Page 1 Abstract1 6/01/09 8:36 Page 2 MESSAGE FROM THE CHAIRMAN Recent years have been marked by unprecedented growth and development in the life sciences in areas such as gene sequencing, protein interactions and molecular biology. Research conducted during the last decade has resulted in important technological and conceptual advances, along with the development of treatments and early stage cures for diseases like cancer or neurodegenerative diseases. The full sequencing of the human genome, and of a growing number of other living organisms, has heralded a new era in molecular biology and genetics for human medicine. Although these discoveries have opened an unprecedented path toward medical advances, they have also revealed that organic, physiological and genetic mechanisms are far more complex than initially believed. I am therefore particularly honoured that such an impressive panel of scientists agreed to gather together at Ipsen’s new corporate headquarters to lecture on the challenging and exciting perspectives of medical innovation. Jean-Luc Bélingard, Chairman and CEO of the Ipsen Group Abstract1 6/01/09 8:36 Page 3 Professor at the Collège de France and the Institut Pasteur, he is a member of the French Académie des Sciences, the National Academy of Sciences US, the Institute of Medicine of the NAS. He discovered the allostery of proteins and isolated the nicotinic receptor of acetylcholine. Past president of the Comité National d’Ethique, he is the president of the Commission des dations, and the Jean-Pierre Changeux laureate of many scientific prizes: Chairperson médaille d’or du CNRS, Balzan prize, Louis-Jeantet Prize, Biotechnology Study Center of the New York University school of Medicine award, Jean-Louis Signoret Prize of la Fondation Ipsen, the National Academy of Sciences award in neurociences (2007).
    [Show full text]
  • Download Ps Nobel Prizes for Site BEE 11.18.16 Revised 11.30.17.Pdf
    Nobel Laureates at the College of Physicians and Surgeons For years, College of Physicians and Surgeons alumni, faculty, and researchers have led groundbreaking clinical and basic scientific studies that have transformed our understanding of human biology and advanced the practice of medicine. On many occasions, this work has been honored with the Nobel Prize. The scope of research led by P&S Nobel laureates is tremendous. Although most of our prizewinners were honored for work in physiology or medicine, a few also received the prize for chemistry. Their research has fundamentally shaped the course of numerous fields, including cardiology, neuroscience, genetics, pharmaceutical development, and more. Our Nobel laureates include: André Cournand and Dickinson Richards (P&S’23), whose work at P&S on cardiac catheterization—a method of inserting a tiny tube into the heart—provided the basis for open-heart surgery and interventional cardiology Baruch Blumberg (P&S’51), who discovered the hepatitis B virus and helped develop a test and a vaccine for the virus Joshua Lederberg, a Columbia College and P&S graduate student who showed that bacteria can exchange genes when they reproduce, creating a way to model and study genetics in higher organisms Harold Varmus (P&S’66), who demonstrated how genes in normal human and animal cells can mutate to cause cancer, leading to a new generation of research on the genetic origins of cancer Eric Kandel, current University Professor, who showed how memories are stored in nerve cells, greatly enhancing
    [Show full text]
  • Making Your Mind: Molecules, Motion, and Memory Lecture One – Mapping Memory in the Brain Eric R
    Making Your Mind: Molecules, Motion, and Memory Lecture One – Mapping Memory in the Brain Eric R. Kandel, M.D. 1. Start of Lecture I (0:15) [ANNOUNCER:] From the Howard Hughes Medical Institute. The 2008 Holiday Lectures on Science. This year's lectures, "Making Your Mind: Molecules, Motion, and Memory," will be given by Dr. Eric Kandel, Howard Hughes Medical Institute investigator at Columbia University, and Dr. Thomas Jessell, Howard Hughes Medical Institute investigator also at Columbia University. The first lecture is titled "Mapping Memory in the Brain." And now to introduce our program, the President of the Howard Hughes Medical Institute, Dr. Thomas Cech. 2. Welcome by HHMI President Dr. Thomas Cech (1:08) [DR. CECH] Welcome to the Howard Hughes Medical Institute and the 2008 Holiday Lectures on Science. The Institute initiated this series in 1993. In 1995 I had the pleasure of coming here and delivering the lectures on catalytic RNA, and since I've been President of the Institute it's been a great pleasure to be involved in choosing 18 terrific scientists to talk to students here in the auditorium. The Holiday Lectures are one of more than 30 research and education programs of the Institute and please visit our website www.hhmi.org to learn more about all of our activities. This lecture series focuses on the most complex organ in our body and arguably the one that most is responsible for making us human. Clearly without this organ you wouldn't be able to find this auditorium, and even if you got here you wouldn't understand a word that was being said.
    [Show full text]