DOCSLIB.ORG

Drug Policy: Cometriq/Cabometyx ™ (Cabozantinib)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Drug Policy: Cometriq/Cabometyx ™ (Cabozantinib) Drug Policy: Cometriq/Cabometyx ™ (cabozantinib) POLICY NUMBER SUBJECT DEPT/PROGRAM PAGE 1 OF 3 UM ONC_1237 Cometriq/Cabometyx ™ (cabozantinib) UM Dept DATES COMMITTEE REVIEWED APPROVAL DATE EFFECTIVE DATE COMMITTEE APPROVAL DATES 01/09/13, 01/08/14, 06/10/15, February 10, 2021 February 26, 2021 (latest version listed last) 06/07/16, 05/10/17, 05/07/18, 01/09/13, 01/08/14, 06/10/15, 06/07/16, 05/10/17, 05/08/19, 12/11/19, 04/08/20, 05/07/18, 05/08/19, 12/11/19, 04/08/20, 02/10/21 02/10/21 PRIMARY BUSINESS OWNER: UM COMMITTEE/BOARD APPROVAL Utilization Management Committee URAC STANDARDS NCQA STANDARDS ADDITIONAL AREAS OF IMPACT HUM 1 UM 2 CMS REQUIREMENTS STATE/FEDERAL REQUIREMENTS APPLICABLE LINES OF BUSINESS Commercial, Exchange, Medicaid I. PURPOSE To define and describe the accepted indications for Cometriq/Cabometyx (cabozantinib) usage in the treatment of cancer, including FDA approved indications, and off-label indications. New Century Health (NCH) is responsible for processing all medication requests from network ordering providers. Medications not authorized by NCH may be deemed as not approvable and therefore not reimbursable. The use of this drug must be supported by one of the following: FDA approved product labeling, CMS-approved compendia, National Comprehensive Cancer Network (NCCN), American Society of Clinical Oncology (ASCO) clinical guidelines, or peer-reviewed literature that meets the requirements of the CMS Medicare Benefit Policy Manual Chapter 15. II. INDICATIONS FOR USE/INCLUSION CRITERIA A. PREFERRED MEDICATION GUIDANCE FOR INITIAL REQUEST: 1. When health plan Medicaid coverage provisions—including any applicable PDLs (Preferred Drug Lists)—conflict with the coverage provisions in this drug policy, health plan Medicaid coverage provisions take precedence per the Preferred Drug Guidelines OR 2. When health plan Exchange coverage provisions-including any applicable PDLs (Preferred Drug Lists)-conflict with the coverage provisions in this drug policy, health plan Exchange coverage provisions take precedence per the Preferred Drug Guidelines OR 3. For Health Plans that utilize NCH UM Oncology Clinical Policies as the initial clinical criteria, the Preferred Drug Guidelines shall follow NCH L1 Pathways when applicable, otherwise shall follow NCH drug policies AND 4. Continuation requests of previously approved, non-preferred medication are not subject to this provision AND 5. When available, generic alternatives are preferred over brand-name drugs. B. Thyroid Cancer 1. NOTE: The preferred oral tyrosine kinase inhibitor (TKI) for use in metastatic medullary thyroid cancer is Caprelsa (vendatinib) and the preferred TKI for differentiated thyroid cancers (e.g., papillary, follicular, or Hurthle cell thyroid cancer) is Lenvima (Lenvatinib) over Cometriq (cabozantinib). 2,3 2. COMETRIQ (cabozantinib) is being used for members with any of the following: a. Unresectable or metastatic medullary thyroid cancer OR b. Unresectable or metastatic papillary, follicular, or Hurthle cell thyroid cancer and the member is refractory to or is not a candidate for radioactive iodine treatment. C. Kidney Cancer 1. NOTE: The preferred tyrosine kinase inhibitor, per NCH Policy & NCH Pathway for advanced/metastatic RCC, is CABOMETYX (cabozantinib) in the first line setting for Intermediate/Poor Risk disease, and for subsequent therapy for any risk disease. 2. IMDC criteria: Please see table below. RISK CATEGORIES= RISK SCORE CRITERIA= Assign 1 point for each Time to systemic treatment less than 1 year Favorable Risk = 0 from diagnosis Performance Status < 80% Karnofsky Scale Intermediate Risk = 1-2 Hemoglobin < LLN; <12 g/dL Poor Risk= 3-6 Calcium > ULN; > 12 mg/dL Neutrophils > ULN Platelets > ULN 3. CABOMETYX (cabozantinib) may be used as monotherapy in metastatic/inoperable renal cell carcinoma in the first line setting for Intermediate/Poor Risk disease (IMDC Criteria) OR 4. As monotherapy in subsequent line therapy regardless of IMDC Risk. D. Hepatocellular Carcinoma (HCC) 1. NOTE: The preferred tyrosine kinase inhibitor, per NCH Policy & NCH Pathway, for subsequent line therapy of unresectable or metastatic HCC is Stivarga (regorafenib). This recommendation is based on lack of Level 1 evidence supporting the superior efficacy of Cabometyx (cabozantinib) over Stivarga (regorafenib). 2. The member has HCC and CABOMETYX (cabozantinib) is being used as a single agent for unresectable or metastatic disease in members with Child-Pugh Class A only and who have been previously treated with 2 prior systemic therapies including Nexavar (sorafenib). III. EXCLUSION CRITERIA A. Disease progression while taking Cometriq/Cabometyx (cabozantinib). B. Dosing exceeds single dose limit of Cometriq 140 mg and Cabometyx 60 mg. PROPRIETARY AND CONFIDENTIAL UM ONC_1237 Cometriq or Cabometyx (cabozantinib)_02262021 © 2020 New Century Health C. Treatment exceeds the maximum limit of Cometriq 90 (20 mg) capsules or 30 (80 mg) capsules per month; Cabometyx 90 (20 mg) or 30 (60 mg) tablets per month. D. Indications not supported by CMS recognized compendia or acceptable peer reviewed literature. IV. MEDICATION MANAGEMENT A. Please refer to the FDA label/package insert for details regarding these topics. V. APPROVAL AUTHORITY A. Review – Utilization Management Department B. Final Approval – Utilization Management Committee VI. ATTACHMENTS A. None VII. REFERENCES A. Cometriq/Cabometyx prescribing information. Exelixis, Inc. South San Francisco, CA 2020. B. Koehler VF, et al. Real-World Efficacy and Safety of Cabozantinib and Vandetanib in Advanced Medullary Thyroid Cancer. Thyroid. 2020 Sep 23. C. G Tremblay, et al. Cost-Effectiveness Analysis of Lenvatinib as a Treatment for Radioactive Iodine Refractory Differentiated Thyroid Cancer in the United States. Value in Health, ISSN:098- 3015, Vol: 19, Issue: 3, Page: A151. D. Abou-Alfa et al, CELESTIAL trial, N Engl J Med 2018; 379:54-63 E. DOI: 10.1056/NEJMoa1717002 F. Choueiri et al, METEOR trial, N Engl J Med; 373:1814-1823. DOI: 10.1056/NEJMoa1510016 G. Choueiri TK, et al. Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial. J Clin Oncol. 2017 Feb 20;35(6):591-597. PROPRIETARY AND CONFIDENTIAL UM ONC_1237 Cometriq or Cabometyx (cabozantinib)_02262021 © 2020 New Century Health .
Load more

Recommended publications
  • PD-L1 Expression and Clinical Outcomes to Cabozantinib
    Author Manuscript Published OnlineFirst on August 1, 2019; DOI: 10.1158/1078-0432.CCR-19-1135 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. PD-L1 expression and clinical outcomes to cabozantinib, everolimus and sunitinib in patients with metastatic renal cell carcinoma: analysis of the randomized clinical trials METEOR and CABOSUN Abdallah Flaifel1, Wanling Xie2, David A. Braun3, Miriam Ficial1, Ziad Bakouny3, Amin H. Nassar3, Rebecca B. Jennings1, Bernard Escudier4, Daniel J. George5, Robert J. Motzer6, Michael J. Morris6, Thomas Powles7, Evelyn Wang8, Ying Huang9, Gordon J. Freeman3, Toni K. Choueiri*3, Sabina Signoretti*1,9 1Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA 2Department of Data Sciences, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA 3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA 4Department of Medical Oncology, Gustave Roussy Cancer Campus, Villejuif, France 5Department Medical Oncology, Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA 6Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA 7Department of Experimental Cancer Medicine, Barts Cancer Institute, London, UK 8Exelixis Inc., South San Francisco, CA, USA 9Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA *equal contribution Correspondence: Toni K. Choueiri, M.D., Department of Medical Oncology, Dana-Farber Cancer Institute, Dana 1230, 450 Brookline Ave, Boston, MA 02115; Phone: 617-632-5456; Fax: 617-632-2165 E-mail: [email protected] Or Sabina Signoretti, M.D., Department of Pathology, Brigham and Women's Hospital, Thorn Building 504A, 75 Francis Street, Boston, MA 02115; Phone: 617-525-7437; Fax: 617-264-5169 Email: [email protected] Downloaded from clincancerres.aacrjournals.org on September 29, 2021.
    [Show full text]
  • Management of Brain and Leptomeningeal Metastases from Breast Cancer
    International Journal of Molecular Sciences Review Management of Brain and Leptomeningeal Metastases from Breast Cancer Alessia Pellerino 1,* , Valeria Internò 2 , Francesca Mo 1, Federica Franchino 1, Riccardo Soffietti 1 and Roberta Rudà 1,3 1 Department of Neuro-Oncology, University and City of Health and Science Hospital, 10126 Turin, Italy; [email protected] (F.M.); [email protected] (F.F.); riccardo.soffi[email protected] (R.S.); [email protected] (R.R.) 2 Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70121 Bari, Italy; [email protected] 3 Department of Neurology, Castelfranco Veneto and Treviso Hospital, 31100 Treviso, Italy * Correspondence: [email protected]; Tel.: +39-011-6334904 Received: 11 September 2020; Accepted: 10 November 2020; Published: 12 November 2020 Abstract: The management of breast cancer (BC) has rapidly evolved in the last 20 years. The improvement of systemic therapy allows a remarkable control of extracranial disease. However, brain (BM) and leptomeningeal metastases (LM) are frequent complications of advanced BC and represent a challenging issue for clinicians. Some prognostic scales designed for metastatic BC have been employed to select fit patients for adequate therapy and enrollment in clinical trials. Different systemic drugs, such as targeted therapies with either monoclonal antibodies or small tyrosine kinase molecules, or modified chemotherapeutic agents are under investigation. Major aims are to improve the penetration of active drugs through the blood–brain barrier (BBB) or brain–tumor barrier (BTB), and establish the best sequence and timing of radiotherapy and systemic therapy to avoid neurocognitive impairment. Moreover, pharmacologic prevention is a new concept driven by the efficacy of targeted agents on macrometastases from specific molecular subgroups.
    [Show full text]
  • Lenvatinib in Advanced, Radioactive Iodine– Refractory, Differentiated Thyroid Carcinoma Kay T
    Published OnlineFirst October 20, 2015; DOI: 10.1158/1078-0432.CCR-15-0923 CCR Drug Updates Clinical Cancer Research Lenvatinib in Advanced, Radioactive Iodine– Refractory, Differentiated Thyroid Carcinoma Kay T. Yeung1 and Ezra E.W. Cohen2 Abstract Management options are limited for patients with radioactive therapy for these patients. Median PFS of 18.3 months in the iodine refractory, locally advanced, or metastatic differentiated lenvatinib group was significantly improved from 3.6 months in thyroid carcinoma. Prior to 2015, sorafenib, a multitargeted the placebo group, with an HR of 0.21 (95% confidence interval, tyrosine kinase inhibitor, was the only approved treatment and 0.4–0.31; P < 0.0001). ORR was also significantly increased in the was associated with a median progression-free survival (PFS) of lenvatinib arm (64.7%) compared with placebo (1.5%). In this 11 months and overall response rate (ORR) of 12% in a phase III article, we will review the molecular mechanisms of lenvatinib, trial. Lenvatinib, a multikinase inhibitor with high potency the data from preclinical studies to the recent phase III clinical against VEGFR and FGFR demonstrated encouraging results in trial, and the biomarkers being studied to further guide patient phase II trials. Recently, the pivotal SELECT trial provided the selection and predict treatment response. Clin Cancer Res; 21(24); basis for the FDA approval of lenvatinib as a second targeted 5420–6. Ó2015 AACR. Introduction PI3K–mTOR pathways (reviewed in ref. 3). The signals ultimately converge in the nucleus, influencing transcription of oncogenic Thyroid carcinoma is the most common endocrine malignan- proteins including, but not limited to, NF-kB), hypoxia-induced cy, with an estimated incidence rate of 13.5 per 100,000 people factor 1 alpha unit (HIF1a), TGFb, VEGF, and FGF.
    [Show full text]
  • BC Cancer Benefit Drug List September 2021
    Page 1 of 65 BC Cancer Benefit Drug List September 2021 DEFINITIONS Class I Reimbursed for active cancer or approved treatment or approved indication only. Reimbursed for approved indications only. Completion of the BC Cancer Compassionate Access Program Application (formerly Undesignated Indication Form) is necessary to Restricted Funding (R) provide the appropriate clinical information for each patient. NOTES 1. BC Cancer will reimburse, to the Communities Oncology Network hospital pharmacy, the actual acquisition cost of a Benefit Drug, up to the maximum price as determined by BC Cancer, based on the current brand and contract price. Please contact the OSCAR Hotline at 1-888-355-0355 if more information is required. 2. Not Otherwise Specified (NOS) code only applicable to Class I drugs where indicated. 3. Intrahepatic use of chemotherapy drugs is not reimbursable unless specified. 4. For queries regarding other indications not specified, please contact the BC Cancer Compassionate Access Program Office at 604.877.6000 x 6277 or [email protected] DOSAGE TUMOUR PROTOCOL DRUG APPROVED INDICATIONS CLASS NOTES FORM SITE CODES Therapy for Metastatic Castration-Sensitive Prostate Cancer using abiraterone tablet Genitourinary UGUMCSPABI* R Abiraterone and Prednisone Palliative Therapy for Metastatic Castration Resistant Prostate Cancer abiraterone tablet Genitourinary UGUPABI R Using Abiraterone and prednisone acitretin capsule Lymphoma reversal of early dysplastic and neoplastic stem changes LYNOS I first-line treatment of epidermal
    [Show full text]
  • Dual Inhibition Using Cabozantinib Overcomes HGF/MET Signaling Mediated Resistance to Pan-VEGFR Inhibition in Orthotopic and Metastatic Neuroblastoma Tumors
    INTERNATIONAL JOURNAL OF ONCOLOGY 50: 203-211, 2017 Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors ESTELLE DAUDIGEOS-DUBUS1, LUDIVINE LE DRET1, OLIVIA Bawa2, PAULE OPOLON2, ALBANE Vievard3, IRÈNE VILLA4, JACQUES BOSQ4, GILLES VASSAL1 and BIRGIT GEOERGER1 1Vectorology and Anticancer Therapies, UMR 8203, CNRS, Univ. Paris-Sud, Gustave Roussy, Université Paris-Saclay, Villejuif; 2Preclinical Evaluation Platform, Gustave Roussy, Villejuif; 3Tribvn, Châtillon; 4Pathology Laboratory, Gustave Roussy, Villejuif, France Received August 8, 2016; Accepted October 6, 2016 DOI: 10.3892/ijo.2016.3792 Abstract. MET is expressed on neuroblastoma cells and Introduction may trigger tumor growth, neoangiogenesis and metastasis. MET upregulation further represents an escape mechanism The tyrosine kinase receptor c-MET, also called MET or to various anticancer treatments including VEGF signaling hepatocyte growth factor receptor (HGFR), is the only known inhibitors. We developed in vitro a resistance model to pan- receptor for hepatocyte growth factor (HGF) (1). Aberrant VEGFR inhibition and explored the simultaneous inhibition MET signaling plays a pivotal role in angiogenesis as well as in of VEGFR and MET in neuroblastoma models in vitro and tumor cell proliferation, survival and migration (2-4). Several in vivo using cabozantinib, an inhibitor of the tyrosine kinases studies suggest that HGF/c-MET signaling promotes angio- including VEGFR2, MET, AXL and RET. Resistance in genesis directly by stimulating endothelial cells in response to IGR-N91-Luc neuroblastoma cells under continuous in vitro VEGF in various tumor types (5-8). Moreover, MET has been exposure pressure to VEGFR1-3 inhibition using axitinib was described as an oncogene in different pathologies such as liver associated with HGF and p-ERK overexpression.
    [Show full text]
  • CELEBRATING 25 YEARS of PROGRESS for PATIENTS for PROGRESS of YEARS 25 CELEBRATING Annual Report 2019 Report Annual
    CELEBRATING 25 YEARS OF PROGRESS FOR PATIENTS FOR PROGRESS YEARS OF 25 CELEBRATING Annual Report 2019 Annual Report Exelixis, Inc. Annual Report 2019 2019 HIGHLIGHTS In 2019, Exelixis marked its 25th anniversary. Our progress during the year highlights how far we’ve come since our early days. More than that, though, it underscores our commitment to pushing scientific and technological boundaries to advance our mission to help cancer patients recover stronger and live longer. As we move through 2020, our team has the same drive and passion for the work as we did when we first opened our doors back in 1994. 610+ employees committed to our mission at year-end 2019, an increase of 27% year over year 12 ongoing or planned trials with label-enabling potential, including four announced in 2019 $1 billion in annual global net revenues for the cabozantinib franchise1 20 ongoingon preclinical programs across ExelixisExxelixis internal disdiscovery and our partners, includingincludi three that ccocouldould reach the clinic this year 4 Commerciallyommerciallymmerciallymerciallyerciallyrciallyciallyiallyallyllyy availablavailablea pprproproduprodproductproducts benefittingttingtingingngg patientsatientstientsientsentsntstlblbi ono a ggloglobal basis 1 Including revenues generated by Ipsen Pharma SAS, our partner in cabozantinib’s global development and commercialization outside of the United States and Japan TO OUR STOCKHOLDERS Before I reflect on our progress in 2019, I want to take a moment to acknowledge the obvious: the coronavirus pandemic is making 2020 a markedly different year for the world, our industry, and for Exelixis. Despite this, I’m confident in our ability to navigate these difficult times and the significant challenges posed by COVID-19. For patients with cancer, continuity of treatment is paramount.
    [Show full text]
  • Free PDF Download
    Microb Health Dis 2021; 3: e531 REVIEW – RECENT NEWS ON PREVENTION AND TREATMENT OF GASTRIC CANCER G. Pasi, T. Matysiak-Budnik IMAD, Hepato-Gastroenterology & Digestive Oncology, University Hospital of Nantes, Nantes, France Corresponding Author: Tamara Matysiak-Budnik, MD; email: [email protected] Abstract: Despite its decreasing incidence, gastric cancer (GC) is still the third leading cause of cancer death in the world. Eradication of Helicobacter pylori has been shown to decrease the risk of GC, without evidence of adverse consequences. Operable GC is treated with surgery, and laparoscopic gastrectomy has proven to be a valid alternative to open gastrectomy. For advanced GC, the available therapies show limited benefit in extending survival, but some new approaches are emerging, like immunotherapy using immune checkpoint inhibitors which, in combination with chemotherapy, has been shown to increase survival. In this article, we review the most relevant articles concerning GC prevention and treatment published between April 2020 and March 2021. Keywords: Helicobacter pylori, Screening, Prevention, Immunotherapy, Laparoscopy. INTRODUCTION Gastric cancer (GC) is the third leading cause of cancer death in the world, and despite a decline in its incidence, it remains a major public health problem on a global scale. The impact of massive H. pylori eradication on GC prevention has been debated, and recent data further confirm the efficacy of this approach. In the treatment of advanced GC, promising results have been obtained with new targeted therapies and immunotherapies using checkpoint inhibitors. The safety of laparoscopic gastrectomy has been further supported. An innovative molecular approach for the detection of residual disease after surgery based on liquid biopsy has been proposed.
    [Show full text]
  • Your Pharmacy Benefits Welcome to Your Pharmacy Plan
    Your Pharmacy Benefits Welcome to Your Pharmacy Plan OptumRx manages your pharmacy benefits for your health plan sponsor. We look forward to helping you make informed decisions about medicines for you and your family. Please review this information to better understand your pharmacy benefit plan. Using Your Member ID Card You can use your pharmacy benefit ID card at any pharmacy participating in your plan’s pharmacy network. Show your ID card each time you fill a prescription at a network pharmacy. They will enter your card information and automatically file it with OptumRx. Your pharmacy will then collect your share of the payment. Your Pharmacy Network Your plan’s pharmacy network includes more than 67,000 independent and chain retail pharmacies nationwide. To find a network pharmacy near you, use the Locate a Pharmacy tool at www.optumrx.com. Or call Customer Service at 1-877-559-2955. Using Non -Network Pharmacies If you do not show the pharmacy your member ID card, or you fill a prescription at a non-network pharmacy, you must pay 100 percent of the pharmacy’s price for the drug. If the drug is covered by your plan, you can be reimbursed. To be reimbursed for eligible prescriptions, simply fill out and send a Direct Member Reimbursement Form with the pharmacy receipt(s) to OptumRx. Reimbursement amounts are based on contracted pharmacy rates minus your copayment or coinsurance. For a copy of the form, go to www.optumrx.com. Or call the Customer Service number above. The number is also on the back of your ID card.
    [Show full text]
  • Lenvatinib with Everolimus for Previously Treated Advanced Renal Cell Carcinoma
    Lenvatinib with everolimus for previously treated advanced renal cell carcinoma Technology appraisal guidance Published: 24 January 2018 www.nice.org.uk/guidance/ta498 © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights). Lenvatinib with everolimus for previously treated advanced renal cell carcinoma (TA498) Your responsibility The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take this guidance fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this guidance are at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian. Commissioners and/or providers have a responsibility to provide the funding required to enable the guidance to be applied when individual health professionals and their patients wish to use it, in accordance with the NHS Constitution. They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- Page 2 of conditions#notice-of-rights).
    [Show full text]
  • A Review on Newer Tyrosine Kinase Inhibitors and Their Uses Oncology Section Oncology
    DOI: 10.7860/JCDR/2018/31031.11957 Review Article A Review on Newer Tyrosine Kinase Inhibitors and their Uses Oncology Section Oncology NITHU M KUMAR1, MEENU MATHEW2, KN ANILA3, S PRIYANKA4 ABSTRACT Tyrosine Kinase Inhibitors (TKI) can reversibly or irreversibly block the signaling pathway occurring in the extracellular part of the receptor by inhibiting Tyrosine Kinase (TK) phosphorylation. This review included the drugs that were newly marketed or drugs with newer approved uses after 2015, such as Gefitinib, Osimertinib, Crizotinib, Alectinib, Ibrutinib, Cabozantinib. Brigatinib and Lorlatinib are investigational drugs that have not been approved and have shown promising results in trials for the treatment of Anaplastic Lymphoma Kinase (ALK) positive metastatic Non Small Cell Lung Carcinoma (NSCLC). Gefitinib, Osimertinib, Crizotinib, Alectinib were approved for treating NSCLC. Cabozantinib and Lenvatinib were approved for treating renal cell carcinoma and thyroid carcinoma. Ibrutinib was approved for treatment of Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Waldenström macroglobulinemia, previously treated Mantle cell lymphoma and relapsed or refractory Marginal zone lymphoma. TKI have promising efficacy in treating a wide range of oncologic diseases. Hand-foot-skin reaction are the most common side effect of drugs in this category, however, TKI are found to have relatively fewer side effects compared to other anti cancer drugs. Keywords: Anaplastic lymphoma kinase, Bruton's tyrosine kinase inhibitor, Epidermal growth factor receptor inhibitor, Non small cell lung carcinoma, Vascular endothelial growth factor INTRODUCTION In this review we have given a generalized insight into the anti Cancer kinome is now recognized as potential target for treating cancer activity, mechanism of action, and adverse drug reaction of cancer and comprise of more than 500 members where only few TK whose clinical activity have been fairly understood.
    [Show full text]
  • Effect of Kinase Inhibitors on the Technetium-99M Uptake Into Thyroid Carcinoma Cells in Vitro ANNA ANSCHLAG 1, BRANDON H
    in vivo 35 : 721-729 (2021) doi:10.21873/invivo.12313 Effect of Kinase Inhibitors on the Technetium-99m Uptake into Thyroid Carcinoma Cells In Vitro ANNA ANSCHLAG 1, BRANDON H. GREENE 2, LORIANNA KÖNNEKER 3, MARKUS LUSTER 4, JAMES NAGARAJAH 5, SABINE WÄCHTER 6, ANNETTE WUNDERLICH 6 and ANDREAS PFESTROFF 4 1Department of Child and Adolescent Psychiatry, University Hospital of Marburg, Marburg, Germany; 2Bio 21 Institute, CSL Limited Melbourne, Parkville, VIC, Australia; 3Department of Virology, Hospital Nordwest Frankfurt, Frankfurt, Germany; 4Department of Nuclear Medicine, University Hospital of Marburg, Marburg, Germany; 5Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany; 6Department of Visceral, Thoracic and Vascular Surgery, University Hospital of Marburg, Marburg, Germany Abstract. Background/Aim: We evaluated the potential of the distribution between the genders, and above 45,000 deaths kinase inhibitors sorafenib, lenvatinib and selumetinib on were recorded globally due to malignant thyroid disease (2). increasing the uptake of technetium-99m into thyroid cancer Its manifestations can be subdivided into different categories. cells. Materials and Methods: Four established cell lines and Differentiated thyroid carcinomas (DTC), accounting for about three patient’s cell cultures were treated with 0.1, 1 and 5μM 85% of all thyroid cancers, derive from the follicular of sorafenib, lenvatinib and selumetinib for 72 hours. After epithelium and include papillary (PTC) as well as follicular incubation with 1 MBq of technetium-99m, the radioactivity thyroid carcinoma (FTC), and a couple of rare subtypes. uptake was measured. Results: The experiments showed Medullary thyroid cancers (MTC) are developed from heterogeneous results. Maximum technetium-99m uptake calcitonin producing C-cells, whereas the highly aggressive increases of 312% (sorafenib), 326% (lenvatinib) and 759% anaplastic thyroid carcinomas (ATC) are composed of (selumetinib) were obtained using the highest applied dedifferentiated tissue.
    [Show full text]
  • (FDA) Approved Bristol Myers Squibb's (Bms.Com) Br
    tools Approved Drugs (cemiplimab-rwlc) for patients with • On Dec. 18, 2020, the FDA approved locally advanced basal cell carcinoma Tagrisso® (osimertinib) (AstraZeneca, • On Feb. 5, 2021, the U.S. Food and Drug previously treated with a hedgehog astrazeneca.com) for adjuvant therapy Administration (FDA) approved Bristol pathway inhibitor (HHI) or for whom an after tumor resection in patients with ® Myers Squibb’s (bms.com) Breyanzi HHI is not appropriate and accelerated non-small cell lung cancer (NSCLC) whose (lisocabtagene maraleucel), a CD19- approval to Libtayo for patients with tumors have epidermal growth factor directed chimeric antigen receptor T-cell metastatic basal cell carcinoma previ- receptor exon 19 deletions or exon 21 therapy for the treatment of adult ously treated with an HHI or for whom an L858R mutations, as detected by an patients with relapsed or refractory large HHI is not appropriate. FDA-approved test. B-cell lymphoma after two or more lines • On Dec. 16, 2020, the FDA approved On Feb. 3, 2021, the FDA granted of systemic therapy, including diffuse ™ • Margenza (margetuximab-cmkb) ® large B-cell lymphoma not otherwise accelerated approval to Tepmetko (MacroGenics, macrogenics.com) in specified (including diffuse large B-cell (tepotinib) (EMD Serono, combination with chemotherapy for the lymphoma arising from indolent emdserono.com/us-en) for adult patients treatment of adult patients with with metastatic NSCLC harboring lymphoma), high-grade B-cell lymphoma, metastatic HER2-positive breast cancer primary mediastinal large B-cell mesenchymal-epithelial transition exon who have received two or more prior 14 skipping alterations. lymphoma, and follicular lymphoma anti-HER2 regimens, at least one of which grade 3B.
    [Show full text]