Satisfying Your Sweet Tooth
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The Impact of Saccharin on Saccharomyces Cerevisiae Yeast
Journal of Undergraduate Biology Laboratory Investigations 2018 The Impact of Saccharin on Saccharomyces Cerevisiae Yeast Fermentation Parker Brown, Megan Hanson, Edison Huo, Derica Smith, and Bianca Galletti * 1 University of Oklahoma, Department of Biology, 730 Van Vleet Oval, Room 314 Norman, OK 73019 _________________________________________________________________________________________ Previous research has shown that mammals struggle to metabolize sugar substitutes such as saccharin. But these results are less clear when it comes to microorganisms such as yeast. Because many animals cannot metabolize saccharin, we hypothesize that yeast growth will be less in saccharin dominate solutions as compared to glucose dominate solutions. To test this, differing solutions of glucose and saccharin were fed to Saccharomyces cerevisiae, a yeast type which uses the Crabtree Effect to carry out alcoholic fermentation in the presence of glucose. Like in animals, it was found that saccharin also negatively impacts the growth of yeast meaning that saccharin could not be used in industrial processes wishing to use yeast to make ethanol. _________________________________________________________________________________________ Introduction sugars in processes requiring yeast growth such as In the last several decades, sugar substitutes the alcoholic beverage industry. have become more common in the food and Because yeast is a commonly used organism beverage industry as they allow “healthier” low in the food industry, the process of yeast calorie foods to be produced and marketed to fermentation has been well established. In certain consumers. However, these sugar substitutes have types of yeast, such as Saccharomyces cerevisiae, not been introduced without controversy with past yeast can utilize glucose to undergo alcoholic research voicing their harmful impacts and others fermentation in what is called the Crabtree Effect revealing no deleterious impacts (Sharma et. -
MINI REVIEW Neotame: High Intensity Low Caloric Sweetener
Asian Journal of Chemistry Vol. 22, No. 7 (2010), 5792-5796 MINI REVIEW Neotame: High Intensity Low Caloric Sweetener K. SATYAVATHI*, P. BHOJA RAJU, K.V. BUPESH and T. NAGA RAVI KIRAN Chandigarh College of Pharmacy, Landran, Mohali-140 307, India E-mail: [email protected] Neotame is an artificial sugar substitute which is N-alkyl derivative of aspartame. It is non caloric and 7000-13,000 times sweeter than sucrose, 30-60 times sweeter than aspartame respectively. It has excellent shelf life in dry conditions. Neotame is more stable in aqueous form at neutral pH. It is heat stable and consequently used in cooking and baking. Unlike aspartame it is safe for people with phenylketonurea. It is compatible with wide range of food ingredients, so blended with other caloric sweeteners to enhance taste and flavour. It doesn't show any significant toxicity and is non-carcinogenic. Neotame is a highly potent sweetener that can be used to modify and enhance flavour of foods and beverages. Key Words: Neotame, Sweetner. INTRODUCTION Sweeteners are the agents added to foods to enhance the taste. Nowadays most of people use food and beverages with sugars which are less caloric sweeteners. Naturally occurring sweeteners such as sucrose, fructose and maltose are used, but because of their toxicity and high food value, artificial sweeteners are used like sucrose, fructose, aspartame, saccharin which are sweeter and low caloric value than table sugar. Neotame is an artificial sweetener manufactured by NutraSweet Company in 1991. Neotame is a non-nutritive, non-caloric sweetener and 7000-13000 times and 30-60 times sweeter than regular table sugar and aspartame, respectively. -
An Analysis of the Link Between Aspartame and Cancer and Its Public Health Implications
Review Article Annals of Short Reports Published: 05 Feb, 2019 An Analysis of the Link between Aspartame and Cancer and Its Public Health Implications Yen Dang* Department of Oncology, University of Maryland Eastern Shore School of Pharmacy, USA Abstract There have been conflicting reports that artificial sweeteners, including aspartame, increase the risk of malignancy despite their beneficial weight loss marketing. A literature review was conducted to determine the causality between aspartame and the incidences of cancer. Studies involving animals and humans were explored to determine the association and its impacts on the public health domain. Based on the current evidence, it appears that the link between aspartame and cancer is inconclusive at this time and that there seems to be no strong causality between the two factors. Future research should be directed at longer studies that are stronger in design to further explore the association between aspartame and cancer. Introduction America has a sweet tooth, and the sugar industry has generated billions of dollars in their contributions to baked goods, cooked items, desserts, and soft drinks. However, since the turn of the century, natural sugar products are slowly being replaced by artificial sweeteners as a more health conscientious option. Artificial sweeteners, or “sugar substitutes”, are a group of agents that are synthetic sugar products, and some items on the market have a higher level of sweetness compared to natural sugar [1]. Currently, there are over 6 different types of artificial sweeteners used in approximately 17 trademarked sugar substitute products including popular products such as Splenda, Sweet N’ Low, and Equal. -
Effects of Saccharin Consumption on Operant Responding for Sugar
foods Article Effects of Saccharin Consumption on Operant Responding for Sugar Reward and Incubation of Sugar Craving in Rats Kenjiro Aoyama * and Akane Nagano Department of Psychology, Doshisha University, Kyotanabe-shi, Kyoto 610-0394, Japan; [email protected] * Correspondence: [email protected] Received: 11 November 2020; Accepted: 5 December 2020; Published: 8 December 2020 Abstract: Repeated experience with artificial sweeteners increases food consumption and body weight gain in rats. Saccharin consumption may reduce the conditioned satiety response to sweet-tasting food. Rats were trained to press a lever to obtain sucrose for five days. A compound cue (tone + light) was presented with every sucrose delivery. On the following day, each lever press produced only the compound cue (cue-reactivity test). Subjects were then provided with yogurt for three weeks in their home cages. The rats were divided into two groups. Rats in the saccharin group received yogurt sweetened with saccharin on some days and unsweetened yogurt on others. For the plain group, only unsweetened plain yogurt was provided. Subsequently, the cue-reactivity test was conducted again. On the following day, the rats underwent a consumption test in which each lever press was reinforced with sucrose. Chow consumption and body weight gain were larger in the saccharin group than in the plain group. Lever responses increased from the first to the second cue-reactivity tests (incubation of craving) in both groups. During the consumption test, lever responses were higher in the saccharin group than in the plain group, suggesting that the conditioned satiety response was impaired in the saccharin group. -
Approved: Tre Specific Dynamic Action of Fat and P
TRE SPECIFIC DYNAMIC ACTION OF CARBOHYD.RATF, " FAT AND P.ROJ!EIN IN FIVE WOMEN by P.:l.tricia Jo ~~IG.n.'lley Thesis submitted to the Graduate faculty of the Virginie. Fblytechnic Institute in candidacy for the degree of MAmR OF SCIENCE in RUMAN NllfRITION AND FOODS APPROVED: "Ms.cy W. Korsliind • June, 1966 Blacksburg, Virginia -2- TABLE OF CONTENTS Page ·LIST OF TABLES • • • • • • • • • • • • • • • • • • • • • • 3 LIST OF FIGURES . " . 4 ACKNOWLEDGEMENT • • . .. 5 Chapter 1. INTRODUCTION . 6 II. REVIEW OF LITERATURE • . 9 Summary of Specific Dynamic Action Theories . 9 Specific Dynamic Action of Carbohydrate . • 10 Specific Dynamic Action of Fat , • . 14 Specific Dynamic Action of Protein . .. 15 III. METHODS AND PROCEDURES . 18 Subjects . 18 Adminilt~ation of Food and Measurements . .. 19 Collection and Analysis of Expired Air • . 20 Calculations . • • . • • • . .- . .. 20 IV. RESULTS AND DISCUSSION • • • • • • . .. 21 Changes in Respiratory Quotient Following the Ingestion of Carbohydrate, Fat and Protein •• . 21 V;irr-;iations in He11t Production After Ingestion of Carbohydrate, Fat and Protein • • • 28 V. SUMMARY •••••• . 37 BIBLIOGRAPHY • . 38 VITA •• . ... 44 APPENDIX . 45 TABLE NUMBlll PAGE 1. Time required, aft•l' the inge•tion of carbohydrate by f tve women, to reach highest re•piratory quotient and highest heat production. • • • • • • • • • • • • • • • • 31 2. Maximum increaee in heat production in. four women after ingestion of fat and time required for _.ximum increase to occur •••••••••••••••••• • • 31 3. Ma;xt... tacreaee in heat production in five women after ingeatioa of protein and time required for maximwll increaee to occur. • • • • • • • • • • • •. • • • • • • • 35 -4- LIST OF FIGURES FIGURE NUMBER PAGE 1~ Changes in reepiratory quotient in five women 22 after ingestion of sucrose. -
Artificial Sweeteners: a Review Kranthi Kumar Poshala School of Health and Life Sciences, Teesside University, England
ISSN 2321 3361 © 2020 IJESC Research Article Volume 10 Issue No.10 Artificial Sweeteners: A Review Kranthi Kumar Poshala School of Health and Life Sciences, Teesside University, England Abstract: Sugar gained a bitter name regards to health. Consumption of more sugars involves risk of more calories which leads to diseases like obesity, diabetes and cardiovascular problems in human body. These days food which is sugar free acquired much more reputation because of their low or no calorie content. So as a result many food industries use different low calorie artificial sweeteners instead of sugars. Food and Drug Administration (FDA or USFDA) accepted the use of six sugar substitutes (aspartame, saccharine, sucralose, neotame, acesulfame-k and stevia) safe human consumption. Advantame and extract from swingle fruit have recently discovered and added to the list of nonnutritive sweeteners. These artificial sweeteners or sugar substitutes are extensively applied in the fields of processed foods, dairy and therapeutic industries. The main aim of this review is to discuss the different types of artificial sweeteners, their history, synthesis, metabolism, uses, toxicity, therapeutic use, nontherapeutic use, health benefits and toxic effects. Keywords: Artificial sweeteners, diabetes, nonnutritive sweeteners, obesity, sugar substitutes. I. INTRODUCTION Many of Non-nutritive sweeteners (NSSs) have been manufactured, but intense research and development in natural In the recent and current years people are very much conscious NSSs is expanding (Toews et al., 2019). about their health and showing a great concern on quality of life. Imbalanced consumption of excess calories and saturated fats is Non-nutritive sweeteners (NSSs) vary from sugars not only in leading most of the population to obesity. -
UC Berkeley Berkeley Scientific Journal
UC Berkeley Berkeley Scientific Journal Title Aspartame: History of the Artificial Sweetener Permalink https://escholarship.org/uc/item/8r30s9hf Journal Berkeley Scientific Journal, 14(2) ISSN 1097-0967 Author Sawant, Manali Publication Date 2011 DOI 10.5070/BS3142011713 Undergraduate eScholarship.org Powered by the California Digital Library University of California aSpartame: HISTORY OF THE ARTIFICIAL SWEETNER Manali Sawant Do you ever wonder how some of the processed of the pencil to his lips and was amazed by the incred- foods you eat taste so sweet and yet claim to have less ible sweetness. He rushed back to his lecture hall and sugar than one would imagine? And sometimes you skip systematically tasted all the chemicals until he found the real sugar, thinking that the substance in the pink packet one prepared by Fahlberg (article 7). Another story, told is a much better substitute that will help you keep your by Fahlberg at a 1904 chemical congress in Berlin, goes diet on track. Regardless of where you get your sweet that Constantine Falhlberg discovered saccharin while taste from, humans have been attracted to sweetness working in Ira Remsen’s laboratory at Johns Hopkins Uni- throughout history. Furthermore, a study of newborns versity. He spilled a chemical on his hand when he was clearly showed a strong liking for sweet-tasting stimuli, signifying that the attraction is innate, rather than a learned one. Such importance has prompted chem- ists to discover the structures naturally occurring and artificial sweeteners to replace sugar. While sugary and starchy foods are dangerous to dental enamel, sugars do BSJ not contain carbohydrates and thus prevent teeth from attack (article 1). -
Food Laboratory Services Guide
Food Laboratory Services Guide FDA Import Detention Services Food Adulteration, GMO & Quality Control Food Allergens Food Chemistry Food Microbiology Natural Toxins Nutritional Analysis Packaging Analysis Shelf Life Studies Specialty Chemistry Analysis Vitamins & Minerals The EMSL Diamond Standard EMSL Analytical, Inc., (EMSL) is a national network of laboratories located in key cities and regions nationwide and Canada. Established in 1981, the company has expanded its analytical services and ca- pabilities and now operates more than thirty-one locations all striving for excellence in providing quality laboratory services in a timely and cost competitive manner. Our diverse staff of over 585 employees includes a wide range of expertise, educational background and capabilities. These dedicated and capable employees follow the lead and standard of care demon- strated by the owner and founder of the company, Dr. Peter Frasca, who, as a hands on owner maintains daily involvement in our laboratory operations, and dictates that our work is consistent with his EMSL Diamond Standard. This “Diamond Standard” includes the following: u Quality Data - Strict Adherence to our Quality programs and regulatory requirements which comply with the ISO 17025 guidelines so that our data is tracked, managed, reported, and verified to be accurate and reliable. u Customer Dedication - We strive to create lasting, mutually beneficial relationships with all clients. We solicit feedback from our clients and we are committed to responding quickly to any questions or concerns that may arise before, during, or after an assignment. u Analytical Expertise - We employ highly qualified and experienced chemists, geologists, physicists, mycologists, microbiologists, biologists, materials scientists and industrial hygienists to enhance our analytical abilities and expertise. -
School Menu Allergy List
SCHOOL MENU All items are analyzed using the most accurate information as of: 10-Dec-15 ALLERGY LIST Items denoted with an X contain the allergen in the corresponding column. If your child has an approved form on file with the cafeteria, items with an X* Mary Andreae, MS, RD, LDN can be prepared without that allergen, upon request. Email: [email protected] Phone: 423-209-5679 Wh- Pea- Tree Snflwr Glu- Carra- Red Coc Milk Egg Soy Fish Oats Corn eat nut Nut Oil ten geenan Dye onut Notes: BEVERAGES Milk, Skim, Plain X Milk, 1%, Plain X Milk, Chocolate X X X Milk, Vanilla X X Juice, Apple Juice, Fruit Punch Juice, Grape Juice, Orange BREAKFAST ITEMS Bagel, Mini, Cinnamon X X X X X Cinnamon Bagel, Mini, Strawberry X X X X X Biscuit, Plain X X X X Biscuit w/ Chicken X X X X X Biscuit w/ Gravy X X X X X X Biscuit w/ Sausage X X X X Breadstick, Apple-Filled X X X X Breakfast Bar (Apple or Choc) X X X X X X X Cinnamon (Apple) Breakfast Pizza, Gravy Based X X X X X Artificial Color Breakfast Pizza, Red Sauce X X X X X Artificial Color Chicken Patty, Breakfast X X X X Egg, Scrambled X X X French Toast Sticks, Cinnamon X X X X X X Cinnamon Graham Crackers, Choc Bear X X Graham Crackers, Elves X X X Honey Graham Crackers, Squares X X X X Produced in a nut-free/peanut-free facility; Honey, Cinn. -
Review on Artificial Sweeteners Used in Formulation of Sugar Free Syrups
International Journal of Advances in Pharmaceutics ISSN: 2320–4923; DOI: 10.7439/ijap Volume 4 Issue 2 [2015] Journal home page: http://ssjournals.com/index.php/ijap Review Article Review on artificial sweeteners used in formulation of sugar free syrups Afaque Raza Mehboob Ansari*, Saddamhusen Jahangir Mulla and Gosavi Jairam Pramod Department of Quality Assurance, D.S.T.S. Mandal’s College of Pharmacy, Jule Solapur-1, Bijapur Road, Solapur- 413004, Maharashtra, India. *Correspondence Info: Abstract Prof. Afaque Raza Mehboob Ansari Sweetening agents are employed in liquid formulations designed for oral Department of Quality Assurance, administration specifically to increase the palatability of the therapeutic agent. The D.S.T.S. Mandal’s College of main sweetening agents employed in oral preparations are sucrose, liquid glucose, Pharmacy, Jule Solapur-1, Bijapur glycerol, Sorbitol, saccharin sodium and aspartame. The use of artificial Road, Solapur- 413004, Maharashtra, sweetening agents in formulations is increasing and, in many formulations, India saccharin sodium is used either as the sole sweetening agent or in combination Email: [email protected] with sugars or Sorbitol to reduce the sugar concentration in the formulation. The Keywords: use of sugars in oral formulations for children and patients with diabetes mellitus is to be avoided. The present review discusses about the Artificial sweetening agents Sugar free syrup, which are generally used while the preparation of Sugar-free Syrup. Artificial sweeteners, Diabetes mellitus, Sucralose, and Aspartame. 1. Introduction Syrups are highly concentrated, aqueous solutions of sugar or a sugar substitute that traditionally contain a flavoring agent, e.g. cherry syrup, cocoa syrup, orange syrup, raspberry syrup. -
The Skinny on Sweeteners FA CT S HE E T
The Skinny on Sweeteners FA CT S HE E T Aspartame (Equal) S ucralose (Splenda) S accharin (Sweet’N Low) 1. How sweet is it? Aspartame is about 200 times Sucralose is about 600 times Saccharin is about 300 times sweeter than table sugar. sweeter than table sugar. sweeter than table sugar. 2. How is it made? Aspartame is made by joining Sucralose is made through a Saccharin is made through a together two amino acids with multi-step process, which multi-step process combining a methyl ester group. These results in three chlorine groups two chemical groups, including components are also found in being substituted onto a sugar a sulfur molecule. foods eaten everyday. molecule. 3. Is it safe? Yes. Aspartame is safe and FDA Yes. Sucralose is safe and FDA Yes. Saccharin is safe and FDA approved. approved. approved. The FDA has studied aspartame More than 100 scientific studies Saccharin has been the subject throughout the last 23 years, and on sucralose, done over a 20-year of extensive scientific research. has never had any safety period, have demonstrated the It is one of the most studied concerns. safety of sucralose. ingredients in the food supply. 4. How is it handled Aspartame is digested by the Most sucralose passes through Saccharin passes through the by the body? body. the body unchanged; a small body unchanged. percentage of sucralose is absorbed and metabolized. 5. How many studies More than 200 scientif c studies More than 100 scientific studies More than 30 human studies have been conducted? done over 35 years have of sucralose done over 20 years done over 20 years have demonstrated the safety of have demonstrated the safety of demonstrated the safety of aspartame. -
Does the Australian Health Star Rating System Encourage Added Sugar Reformulation? Trends in Sweetener Use in Australia
nutrients Article Does the Australian Health Star Rating System Encourage Added Sugar Reformulation? Trends in Sweetener Use in Australia Cherie Russell 1,* , Sarah Dickie 1 , Phillip Baker 1,2 and Mark Lawrence 1,2 1 School of Exercise and Nutrition Sciences, Deakin University, Geelong 3217, Australia; [email protected] (S.D.); [email protected] (P.B.); [email protected] (M.L.) 2 Institute for Physical Activity and Nutrition, Deakin University, Geelong 3217, Australia * Correspondence: [email protected] Abstract: Dietary risk factors, including excess added sugar intake, are leading contributors to Australia’s burden of disease. An objective of the Australian Health Star Rating (HSR) system is to encourage the reformulation of packaged foods. Manufacturers may improve a product’s HSR by replacing added sugar with non-nutritive sweeteners (NNS). Concerns have been raised regarding the potential substitution effects of ultra-processed foods containing NNS for whole foods, and the long-term impact this may have on population health. The aim of this study was to determine whether the implementation of the HSR system has impacted the use of added sugars and NNS in the food supply. Four product categories were used: products with no added sweetener, products containing added sugar only, products containing NNS only, and products containing a combination of added sugar and NNS. Of 6477 newly released products analyzed displaying a HSR in Australia between 2014–2020, 63% contained added sugars. The proportion of new products sweetened with added sugars increased over time, while NNS use did not, despite a higher average and median Citation: Russell, C.; Dickie, S.; Baker, P.; Lawrence, M.