Hywel Dda Health Board Formulary (Current at 11 th December 2012. Downloaded from http://hywelddahb.inform.wales.nhs.uk/)

01 - Gastro-intestinal system

01.01 - Dyspepsia and gastro-oesophageal reflux disease

01.01.01 - Antacids and Simeticone 1st magnesium trisilicate mixture Magnesium alone may be a laxative. Combining with an aluminium component may overcome this.

1st aluminium hydroxide mixture 1st aluminium & magnesium hydroxide (Mucogel) 2nd Asilone Suspension Asilone oral suspension

1st Infacol Liquid Infacol 40mg/ml oral suspension

H sodium citrate Sodium citrate 0.3M oral solution

01.01.02 - Compound alginates and proprietary indigestion preparations 1st Peptac Suspension Peptac liquid aniseed

Peptac liquid peppermint

1st Gastrocote Gastrocote chewable tablets

Gastrocote liquid

2nd Gaviscon Advance 1st Gaviscon Infant Gaviscon Infant oral powder sachets

01.02 - Antispasmodics and other drugs altering gut motility

Antimuscarinics 2nd hyoscine butylbromide Hyosci ne butylbromide 20mg tablets

Hyoscine butylbromide 20mg/1ml solution for injection ampoules

H propantheline see section 7.4.2

Other antispasmodics 1st peppermint oil Peppermint oil 0.2ml gastro -resistant modified-release capsules

1st mebeverine hydrochloride Mebeverine 135mg tablets

Mebeverine 50mg/5ml oral suspension sugar free

For Paediatric Use or Swallowing Difficulties Only

2nd Alverine Citrate Alverine 60mg capsules

2nd Dicycloverine hydrochloride Dicycloverine 10mg tablets

Dicyc loverine 10mg/5ml oral solution

Motility stimulants 1st metoclopramide (see section 4.6) 1st domperidone (see section 4.6) Others H peppermint water Peppermint water BP 1973

01.03 - Antisecretory drugs and mucosal protectants

01.03.01 - H2-receptor antagonists 2nd cimetidine Cimetidine 200mg tablets

Cimetidine 400mg tablets

Cimetidine 200mg/5ml oral solution

Cimetidine 200mg/2ml solution for injection ampoules

1st ranitidine Ranitidine 150mg tablets

Ranitidine 150mg effervescent t ablets

Ranitidine 75mg/5ml oral solution sugar free

Ranitidine 50mg/2ml solution for injection ampoules

01.03.02 - Selective antimuscarinics

01.03.03 - Chelates and complexes 1st sucralfate Sucralfate 1g tablets

Sucralfate 1g/5ml oral suspension sugar free

01.03.04 - Prostaglandin analogues 2nd misoprostol Misoprostol 200microgram tablets

01.03.05 - Proton pump inhibitors 1st lansoprazole Lansoprazole 15mg gastro -resistant capsules

Lansoprazole 30mg gastro -resistant capsules

2nd lansoprazole - Swallowing difficulties only Lansoprazole 15mg orodispersible tablets

Lansoprazole 30mg orodispersible tablets

1st omeprazole oral Omeprazole 10mg gastro-resistant capsules

Omeprazole 20mg gastro-resistant capsules

Omeprazole 10mg dispersible gastro-resistant tablets

Omeprazole 20mg dispersible gastro-resistant tablets

Omeprazole 40mg dispersible gastro-resistant tablets

H omeprazole injection - First line IV Omeprazole 40mg powder for solution for infusion vials

1st pantoprazole oral Pantoprazole 20mg gastro -resistant tablets

Pantoprazole 40mg gastro -resistant tablets

H pantoprazole injection - Second line IV fluid - restricted patients only Pantoprazole 40mg powder for solution for injection vials

01.04 - Acute diarrhoea

01.04.01 - Adsorbents and bulk-forming drugs Adsorbents such as kaolin are not recommended for acute diarrhoeas. Bulk-forming drugs, such as ispaghula, methylcellulose, and sterculia (section 1.6.1) are useful in controlling diarrhoea associated with diverticular disease.

01.04.02 - Antimotility drugs 1st codeine phosphate Codeine 15mg tablets

Codeine 30mg tablets

1st loperamide Loperamide 2mg capsules

Loperamide 1mg/5ml oral solution

01.05 - Chronic Bowel Disorders

01.05.01 - Aminosalicylates S sulfasalazine Sulfasalazine 500mg tablets

Sulfasalazine 500mg gastro-resistant tablets

Sulfasalazine 250mg/5ml oral suspension

Sulfasalazine 500mg suppositories

S mesalazine Mesalazine 400mg gastro -resistant tablets

Octasa 800mg MR gastro-resistant tablets

Mesalazine 1g/application foam enema

Mesalazine 250mg suppositories

Mesalazine 500mg suppositories

Mesalazine 500mg modified -release tablets

Mesalazine 1g/100ml enema

Mesalazine 1g suppositories

Mesalazin e 1.2g gastro-resistant modified-release tablets

Mesalazine 800mg gastro -resistant tablets

S balsalazide Balsalazide 750mg capsules

01.05.02 - Corticosteroids 1st prednisolone (see section 6.3.2 for oral preparations) Prednisolone sodium phospha te 5mg suppositories

Prednisolone 20mg/100ml enema standard tube

Prednisolone 20mg/100ml enema long tube

Prednisolone 20mg/application foam enema

1st hydrocortisone (see section 6.3.2 for oral preparations) Colifoam 10% aerosol

2nd budesonide Budesonide 3mg gastro-resistant capsules

Budesonide 2mg/100ml enema

01.05.03 - Drugs affecting the immune response S azathioprine - see section 10.1.3 H adalimumab S ciclosporin (cyclosporin) - see section 10.1.3 S mercaptopurine (6-mercaptopurine) Mercaptopurine 50mg tablets

H infliximab Infliximab 100mg powder for solution for infusion vials

01.05.04 - Food Allergy

01.06 - Laxatives

01.06.01 - Bulk-forming laxatives 1st ispaghula husk Ispaghula husk 3.5g effervescent granules sach ets gluten free sugar free

01.06.02 - Stimulant laxatives 1st senna Senna 7.5mg tablets

Senna 7.5mg/5ml oral solution

1st bisacodyl Bisacodyl 5mg gastro -resistant tablets

Bisacodyl 5mg suppositories

Bisacodyl 10mg suppositories

2nd docusate sodium capsules Docusate 100mg capsules

2nd docusate sodium oral solution Docusate 12.5mg/5ml oral solution sugar free

Docusate 50mg/5ml oral solution sugar free

2nd co-danthramer Co-danthramer 25mg/200mg capsules

Co-danthramer 25mg/200mg/5ml oral suspension

Co-danthramer 37.5mg/500mg capsules

Co-danthramer 75mg/1000mg/5ml oral suspension sugar free

2nd glycerin/glycerol Glycerol 1g suppositories

Glycerol 2g suppositories

Glycerol 4g suppositories

2nd sodium picosulfate (sodium picosulphate) Sodium picosulfate 5mg/5ml oral solution sugar free

01.06.03 - Faecal softeners 2nd arachis oil Arachis oil 130ml enema

01.06.04 - Osmotic laxatives S Liquid paraffin + Magnesium hydroxide (For Oncology/Radiology patients only) Mil -Par liquid

1st macrogol paediatric Movicol Paediatric Plain oral powder 6.9g sachets

1st macrogol Laxido Orange oral powder sachets

1st magnesium hydroxide Magnesium hydroxide oral suspension

1st lactulose Lactulose 3.1 -3.7g/5ml oral solution

2nd phosphate enema, suppositories Sodium dihydrogen phosphate dihydrate 18.1% / Disodium hydrogen phosphate dodecahydrate 8% 133ml enema

Phosphates enema (Formula B) 128ml standard tube

Phosphates enema (Formula B) 128ml long tube

2nd sodium citrate compound Sodium citrate compound 5ml enema

01.06.05 - Bowel cleansing preparations 1st macrogol 3350 compound Moviprep Moviprep oral powder sachets

S sodium picosulfate/ magnesium citrate (sodium picosulphate) Picolax oral powder sachets

S macrogol 3350 compound Klean-prep Klean -Prep oral powder 69g sachets

S sodium dihydrogen phosphate (sodium phosphate decahydrate) Sodium dihydrogen phosphate dihydrate 542mg/ml / Disodium hydrogen phosphate dodecahydrate 240mg/ml oral solution sugar free

01.06.06 - Peripheral opioid-receptor antagonists H Methylnaltrexone bromide - Consultant Use only Methylnaltrexone bromide 12mg/0.6ml solution for injection vials

01.06.07 - 5HT4-receptor agonists S Prucalopride (as succinate) See NICE TA211 Prucalopride 1mg tablets

Prucalopride 2mg tablets

01.07 - Local preparations for anal and rectal disorders

01.07.01 - Soothing haemorrhoidal preparations 1st Anusol Anusol ointment

Anusol cream

Anusol suppositories

01.07.02 - Compound haemorrhoidal preparations with corticosteroids 2nd Anusol HC Anusol HC ointment

Anusol HC suppositories

2nd Xyloproct Xyloproct 5%/0.275% ointment

01.07.03 - Rectal sclerosants H oily phenol Oily phenol 5% solution for injection 5ml ampoules

01.07.04 - Management of anal fissures S glyceryl trinitrate (Rectogesic) Glyceryl trinitrate 0.4% rectal ointment

01.08 - Stoma care Please contact your local stoma nurse for advice

01.09 - Drugs affecting intestinal secretions

01.09.01 - Drugs affecting biliary composition and flow 2nd ursodeoxycholic acid Ursodeoxycholic acid 150mg tablets

Ursodeoxycholic acid 250mg tablets

Ursodeoxycholic acid 250mg/5ml oral suspension

H octreotide (see section 8.3.4) H terlipressin (see also section 6.5.2) Terlipressin 1mg/8.5ml solution for injection ampoules

01.09.02 - Bile acid sequestrants 1st colestyramine (cholestyramine) Colestyramine 4g oral powder sachets

01.09.03 - Aprotinin

01.09.04 - Pancreatin S pancreatin Creon 10000 gastro-resistant capsules

Creon 25000 gastro-resistant capsules

Creon 40000 gastro-resistant capsules

Creon Micro Pancreatin 60.12mg gastro-resistant granules

Pancrex V oral powder

Pancrease gastro -resistant capsules

02 - Cardiovascular system Please see NICE Clinical Guidance Hypertension - full guideline (the new recommendations and the evidence they are based on) CG34 June 2006: The management of hypertension in adults in primary care (This is a partial update of CG018 Aug 2004) MI: Secondary prevention in primary and secondary care for patients following a myocardial infarction CG48 May 2007

02.01 - Positive inotropic drugs

02.01.01 - Cardiac glycosides 1st digoxin Digoxin 62.5microgram tablets

Digoxin 125microgram tablets

Digoxin 250microgram tablets

Digoxin 250micrograms/5ml oral solution

Digoxin 500micrograms/2ml solution for infusion ampoules

Digoxin 100micrograms/1ml solution for injection ampoules

Digoxin specific antibody H Digoxin specific antibody (Digifab)

02.01.02 - Phosphodiesterase type-3 inhibitors H enoximone Enoximone 100mg/20ml solution for injection ampoules

H milrinone (Primacor) Milrinone 10mg/10ml solution for injection ampoules

Sympathomimetics - (See section 2.7)

02.02 - Diuretics

02.02.01 - Thiazides and related diuretics 1st bendroflumethiazide (bendrofluazide) Bendroflumethiazide 2.5mg tablets

1st indapamide Indapamide 2.5mg tablets

Indapamide 1.5mg modified-release tablets

S metolazone Metolazone 5mg tablets

S chlorothiazide Chlorothiazide 250mg/5ml oral suspension

02.02.02 - Loop diuretics 1st furosemide (frusemide) Furosemide 20mg tablets

Furosemide 40mg tablets

Furosemide 500mg tablets

Furosemide 5mg/5ml oral solution sugar free

Furosemide 40mg/5ml oral solution sugar free

Furosemide 20mg/2ml solution for injection ampoules

Furosemide 50mg/5ml solution for injection ampoules

Furosemide 250mg/25ml solution for injection ampoules

2nd bumetanide Bumetanide 1mg tablets

Bumetanide 5mg tablets

Bumetanide 1mg/5ml oral solution sugar free

Bumetanide 2mg/4ml solution for injection ampoules

02.02.03 - Potassium-sparing diuretics and aldosterone antagonists 1st amiloride Amiloride 5mg tablets

Amiloride 5mg/5ml oral solution sugar free

Aldosterone antagonists 2nd spironolactone Spironolactone 25mg tablets

Spironolactone 50mg tablets

Spironolactone 100mg tablets

Spironolactone 25mg/5ml oral suspension sugar free

S Eplerenone Eplerenone 25mg tablets

Eplerenone 50mg tablets

02.02.04 - Potassium-sparing diuretics with other diuretics 1st co-amilofruse 2.5/20 Co-amilofruse 2.5mg/20mg tablets

1st co-amilofruse 5/40 Co-amilofruse 5mg/40mg tablets

02.02.05 - Osmotic diuretics H mannitol Mannitol 50g/500ml infusion bags

Mannitol 50g/500ml infusion polyethylene bottles

Mannitol 50g/250ml infusion bags

Mannitol 100g/500ml infusion bags

Mannitol 100g/500ml infusion polyethylene bottles

02.02.06 - Mercurial diuretics

02.02.07 - Carbonic anhydrase inhibitors 1st acetazolamide (see section 11.6)

02.02.08 - Diuretics with potassium

02.03 - Anti-arrhythmic drugs

02.03.01 - Management of arrhythmias

02.03.02 - Drugs for arrhythmias Supraventricular arrhythmias 1st digoxin (see section 2.1.1) S verapamil (see section 2.6.2) S diltiazem (see section 2.6.2) H adenosine Adenosine 6mg/2ml solution for injection vials

Supraventricular and ventricular arrhythmias S amiodarone Amiodarone 100mg tablets

Amiodarone 200mg tablets

Amiodarone 150mg/3ml solution for injection ampoules

S disopyramide Disopyramide 100mg capsules

Disopyramide 150mg capsules

Disopyramide 50mg/5ml solution for injection ampoules

S flecainide Flecainide 50mg tablets

Flecainide 100mg tablets

Flecainide 150mg/15ml solution for injection ampoules

S propafenone Propafenone 150mg tablets

H Dronedarone Dronedarone 400mg tablets

Due to increased risk of liver, lung and CV adverse events, dronedarone should only be prescribed after alternative treatment options have been considered.

Ventricular arrhythmias H lidocaine (lignocaine) Lidocaine 100mg/5ml (2%) solution for injection ampoules

Lidocaine 100mg/5ml (2%) solution for injection pre-filled syringes

Lidocaine 0.4%/500mL in glucose 5%/500mL infusion

H phenytoin (see section 4.8.2) Other anti-arrhythmic drugs H magnesium sulphate Magnesium sulphate 50% solution for injection 20ml ampoules

02.04 - Beta-adrenoceptor blocking drugs 1st atenolol Atenolol 25mg tablets

Atenolol 50mg tablets

Atenolol 100mg tablets

Atenolol 25mg/5ml oral solution sugar free

Atenolol 5mg/10ml solution for injection ampoules

1st metoprolol Metoprolol 50mg tablets

Metoprolol 100mg tablets

Metoprolol 200mg modified-release tablets

1st bisoprolol Bisoprolol 1.25mg tablets

Bisoprolol 3.75mg tablets

Bisoprolol 2.5mg tablets

Bisoprolol 5mg tablets

Bisoprolol 7.5mg tablets

Bisoprolol 10mg tablets

2nd propranolol Propranolol 10mg tablets

Propranolol 40mg tablets

Propranolol 80mg tablets

Propranolol 160mg tablets

Propranolol 40mg/5ml oral solution

Propranolol 80mg modified-release capsules

Propranolol 160mg modified-release capsules

Propranolol 1mg/1ml solution for injection ampoules

S labetalol Labetalol 100mg tablets

Labetalol 200mg tablets

Labetalol 400mg tablets

Labetalol 100mg/20ml solution for injection ampoules

S carvedilol Carvedilol 3.125mg tablets

Carvedilol 6.25mg tablets

Carvedilol 12.5mg tablets

Carvedilol 25mg tablets

S sotalol Sotalol 40mg tablets

Sotalol 80mg tablets

Sotalol 160mg tablets

H esmolol Esmolol 100mg/10ml solution for injection vials

H metoprolol IV Metoprolol 5mg/5ml solution for injection ampoules

02.05 - Hypertension and heart failure

02.05.01 - Vasodilator antihypertensive drugs S hydralazine Hydralazine 25mg tablets

Hydralazine 50mg tablets

Hydralazine 20mg powder for solution for injection ampoules

S minoxidil Minoxidil 2.5mg tablets

Minoxidil 5mg tablets

Minoxidil 10mg tablets

S sildenafil (Revatio) Sildenafil 20mg tablets

H iloprost trometamol Iloprost 10micrograms/1ml nebuliser liquid ampoules

Iloprost 20micrograms/2ml nebuliser liquid ampoules

H sodium nitroprusside Sodium nitroprusside 50mg powder for solution for infusion vials

02.05.02 - Centrally acting antihypertensive drugs 2nd methyldopa Methyldopa 125mg tablets

Methyldopa 250mg tablets

Methyldopa 250mg/5ml oral suspension

Methyldopa 250mg/5mL injection

2nd moxonidine Moxonidine 200microgram tablets

Moxonidine 400microgram tablets

H clonidine Clonidine 150micrograms/1ml solution for injection ampoules

02.05.03 - Adrenergic neurone blocking drugs H guanethidine monosulphate Guanethidine 10mg/1ml solution for injection ampoules

02.05.04 - Alpha-adrenoceptor blocking drugs 2nd doxazosin Doxazosin 1mg tablets

Doxazosin 2mg tablets

Doxazosin 4mg tablets

Phaeochromocytoma H phenoxybenzamine Phenoxybenzamine 10mg capsules

Phenoxybenzamine 100mg/2ml solution for infusion ampoules

H phentolamine Phentolamine 10mg/1ml solution for injection ampoules

02.05.05 - Drugs affecting the renin-angiotensin system

02.05.05.01 - Angiotensin-converting enzyme inhibitors S Captopril For Paediatric use only

Captopril 12.5mg tablets

Captopril 25mg tablets

Captopril 50mg tablets

Captopril 2mg capsules

2nd enalapril Enalapril 2.5mg tablets

Enalapril 5mg tablets

Enalapril 10mg tablets

Enalapril 20mg tablets

1st lisinopril Lisinopril 2.5mg tablets

Lisinopril 5mg tablets

Lisinopril 10mg tablets

Lisinopril 20mg tablets

2nd perindopril Perindopril erbumine 2mg tablets

Perindopril erbumine 4mg tablets

1st ramipril Ramipril 1.25mg capsules

Ramipril 10mg capsules

Ramipril 2.5mg capsules

Ramipril 5mg capsules

02.05.05.02 - Angiotensin-II receptor antagonists 2nd irbesartan Irbesartan 75mg tablets

Irbesartan 150mg tablets

Irbesartan 300mg tablets

1st losartan Losartan 12.5mg tablets

Losartan 25mg tablets

Losartan 50mg tablets

Losartan 100mg tablets

1st valsartan Valsartan 40mg capsules

Valsartan 80mg capsules

Valsartan 160mg capsules

Valsartan 40mg tablets

2nd candesartan Candesartan 2mg tablets

Candesartan 4mg tablets

Candesartan 8mg tablets

Candesartan 16mg tablets

Candesartan 32mg tablets

02.05.05.03 - Renin Inhibitors

02.06 - Nitrates, calcium-channel blockers and other antianginal drugs

02.06.01 - Nitrates 1st glyceryl trinitrate Glyceryl trinitrate 500microgram sublingual tablets

Glyceryl trinitrate 400micrograms/dose sublingual spray

Glyceryl trinitrate 5mg/24hours transdermal patches

Glyceryl trinitrate 10mg/24hours transdermal patches

2nd glyceryl trinitrate Glyceryl trinitrate 1mg modified-release buccal tablets sugar free

Glyceryl trinitrate 2mg modified-release buccal tablets sugar free

Glyceryl trinitrate 3mg modified-release buccal tablets sugar free

Glyceryl trinitrate 5mg modified-release buccal tablets sugar free

1st isosorbide mononitrate Isosorbide mononitrate 10mg tablets

Isosorbide mononitrate 20mg tablets

Isosorbide mononitrate 60mg modified-release tablets

H glyceryl trinitrate injection Glyceryl trinitrate 25mg/5ml solution for infusion ampoules

Glyceryl trinitrate 50mg/10ml solution for infusion ampoules

Glyceryl trinitrate 10mg/10ml solution for infusion ampoules

Glyceryl trinitrate 50mg/50ml solution for infusion vials

02.06.02 - Calcium-channel blockers 1st amlodipine Amlodipine 5mg tablets

Amlodipine 10mg tablets

1st nifedipine Nifedipine 5mg capsules

Nifedipine 10mg capsu les

Nifedipine 10mg modified -release tablets

Nifedipine 20mg modified -release tablets

Nifedipine 30mg modified -release tablets

Nifedipine 60mg modified -release tablets

1st diltiazem Twice a day preparations: (modified-release) Tildiem Retard 90mg tablets

Tildiem Retard 120mg tablets

Adizem-SR 90mg capsules

Adizem-SR 120mg capsules

Adizem-SR 180mg capsules

Adizem-SR 120mg tablets

Dilzem SR 90 capsules

Dilzem SR 120 capsules

Once a day preparations: Tildiem LA 200 capsules

Tildiem LA 300 capsules

Adizem-XL 180mg capsules

Adizem-XL 200mg capsules

Adizem-XL 240mg capsules

Adizem-XL 300mg capsules

Slozem 180mg capsules

Slozem 240mg capsules

Slozem 300mg capsules

2nd lercanidipine (Zanidip) Lercanidipine 10mg tablets

Lercanidipine 20mg tablets

2nd nicardipine Nicardipine 20mg capsules

Nicardipine 30mg capsules

Nicardipine 30mg modified -release capsules

Nicardipine 45mg modified -release capsules

2nd verapamil Verapamil 40mg tablets

Verapamil 80mg tablets

Verapamil 120mg tablets

Verapamil 120mg modified-release tablets

Verapamil 240mg modified-release tablets

Verapamil 40mg/5ml oral solution

H nimodipine Nimodipine 30mg tablets

Nimodipine 10mg/50ml solution for infusion vials

02.06.03 - Other antianginal drugs S Ranolazine Ranolazine 375mg modified-release tablets

Ranolazine 500mg modified-release tablets

Ranolazine 750mg modified-release tablets

2nd nicorandil Nicorandil 10mg tablets

Nicorandil 20mg tablets

S ivabradine Ivabradine 5mg tablets

Ivabradine 7.5mg tablets

02.06.04 - Peripheral vasodilators and related drugs 2.6.4.1 Peripheral vasodilators and related drugs 1st naftidrofuryl oxalate Naftidrofuryl 100mg capsules

H tolazoline Tolazoline 25mg/1ml solution for injection ampoules

02.06.04.01 - For DMD link only

02.07 - Sympathomimetics

02.07.01 - Inotropic sympathomimetics H dobutamine Dobutamine 250mg/5ml solution for infusion ampoules

Dobutamine 250mg/20ml solution for infusion vials

Dobutamine 250mg/20ml solution for infusion ampoules

H dopamine Dopamine 200mg/5ml solution for infusion ampoules

Dopamine 800mg/5ml solution for infusion ampoules

Dopamine 400mg/5ml solution for infusion ampoules

H dopexamine Dopexamine 50mg/5ml solution for infusion ampoules

02.07.02 - Vasoconstrictor sympathomimetics 1st adrenaline (epinephrine) Adrenaline acid tartrate 1mg/1ml (1 in 1,000) solution for injection ampoules

Adrenaline acid tartrate 1mg/10ml (1 in 10,000) solution for injection ampoules

H metaraminol Metaraminol 10mg/1ml solution for injection ampoules

H noradrenaline acid tartrate (norepinephrine bitartrate) Noradrenaline (base) 2mg/2ml solution for infusion ampoules

Noradrenaline (base) 4mg/4ml solution for infusion am poules

Noradrenaline (base) 20mg/20ml solution for infusion ampoules

H phenylephrine Phenylephrine 10mg/1ml solution for injection ampoules

02.07.03 - Cardiopulmonary resuscitation 1st adrenaline (epinephrine)

02.08 - Anticoagulants and protamine

02.08.01 - Parenteral anticoagulants Heparin H heparin sodium Heparin sodium 5,000units/0.2ml solution for injection pre-filled syringes

Heparin sodium 5,000units/5ml solution for injection ampoules

Heparin sodium 25,000units/5ml solution for injection ampoules

Heparin sodium 20,000units/20ml solution for injection ampoules

Low Molecular Weight Heparins S tinzaparin Tinzaparin sodium 10,000units/0.5ml solution for injection pre-filled syringes

Tinzaparin sodium 14,000units/0.7ml solution for injection pre-filled syringes

Tinzaparin sodium 18,000units/0.9ml solution for injection pre-filled syringes

Tinzaparin sodium 3,500units/0.35ml solution for injection pre-filled syringes

Tinzaparin sodium 4,500units/0.45ml solution for injection pre-filled syringes

Tinzaparin sodium 40,000units/2ml solution for injection vials

S enoxaparin Enoxaparin sodium 20mg/0.2ml solution for injection pre-filled syringes

Enoxaparin sodium 40mg/0.4ml solution for injection pre-filled syringes

Enoxaparin sodium 60mg/0.6ml solution for injection pre-filled syringes

Enoxaparin sodium 80mg/0.8ml solution for injection pre-filled syringes

Enoxaparin sodium 100mg/1ml solution for injection pre-filled syringes

Enoxaparin sodium 150mg/1ml solution for injection pre-filled syringes

S dalteparin Dalteparin sodium 2,500units/0.2ml solution for injection pre-filled syringes

Dalteparin sodium 5,000units/0.2ml solution for injection pre-filled syringes

Dalteparin sodium 7,500units/0.3ml solution for injection pre-filled syringes

Dalteparin sodium 10,000units/0.4ml solution for injection pre-filled syringes

Dalteparin sodium 12,500units/0.5ml solution for injection pre-filled syringes

Dalteparin sodium 15,000units/0.6ml solution for injection pre-filled syringes

Dalteparin sodium 18,000units/0.72ml solution for injection pre-filled syringes

Dalteparin sodium 10,000units/4ml solution for injection ampoules

Dalteparin sodium 10,000units/1ml solution for injection ampoules

Dalteparin sodium 100,000units/4ml solution for injection vials

Hirudins H bivalirudin Bivalirudin 250mg powder for solution for injection vials

Heparin Flushes S heparin sodium Please see NPSA Guidance Heparin sodium 50units/5ml patency solution ampoules

Epoprostenol H epoprostenol Epoprostenol 500microgram powder and solvent for solution for infusion vials

Fondaparinux H fondaparinux sodium Fondaparinux sodium 1.5mg/0.3ml solution for injection pre-filled syringes

Fondaparinux sodium 2.5mg/0.5ml solution for injection pre-filled syringes

Fondaparinux sodium 5mg/0.4ml solution for injection pre-filled syringes

Fondaparinux sodium 7.5mg/0.6ml solution for injection pre-filled syringes

Fondaparinux sodium 10mg/0.8ml solution for injection pre-filled syringes

02.08.02 - Oral anticoagulants 1st warfarin Warfarin 500microgram tablets

Warfarin 1mg tablets

Warfarin 3mg tablets

Warfarin 5mg tablets

2nd phenindione Phenindione 10mg tablets

Phenindione 25mg tablets

Phenindione 50mg tablets

H dabigatran etexilate Dabigatran etexilate 75mg capsules

Dabigatran etexilate 110mg capsules

H rivaroxaban See NICE TA Rivaroxaban 10mg tablets

02.08.03 - Protamine sulphate H protamine sulphate Protamine sulphate 50mg/5ml solution for injection ampoules

02.09 - Antiplatelet drugs S Ticagrelor To be used inline with ABMU/HDHB pathway Ticagrelor 90mg tablets

1st Aspirin (acetylsalicylic acid) Aspirin 75mg dispersible tablets

Aspirin 300mg dispersible tablets

Aspirin 150mg suppositories

Aspirin 300mg suppositories

2nd dipyridamole Dipyridamole 25mg tablets

Dipyridamole 100mg tablets

Dipyridamole 200mg modified-release capsules

Dipyridamole 10mg/2ml solution for injection ampoules

2nd aspirin and dipyridamole Dipyridamole 200mg modified-release / Aspirin 25mg capsules

2nd clopidogrel Clopidogrel 75mg tablets

Clopidogrel 300mg tablets

S prasugrel Prasugrel 5mg tablets

Prasugrel 10mg tablets

H abciximab Abciximab 10mg/5ml solution for injection vials

H tirofiban Tirofiban hydrochloride 12.5mg/50ml solution for infusion vials

02.10 - Stable angina, acute coronary syndromes and fibrinolysis

02.10.01 - Management of stable angina and acute coronary syndromes

02.10.02 - Fibrinolytic drugs H streptokinase Streptokinase 250,000unit powder for solution for infusion vials

Streptokinase 1.5million unit powder for solution for infusion vials

H alteplase (rt-PA) Alteplase 10mg powder and solvent for solution for injection vials

Alteplase 20mg powder and solvent for solution for injection vials

Alteplase 50mg powder and solvent for solution for infusion vials

Alteplase 2mg powder and solvent for solution for injection vials

H Urokinase Urokinase 10,000unit powder for solution for injection vials

Urokinase 25,000unit powder for solution for injection vials

H tenecteplase Tenecteplase 8,000unit powder and solvent for solution for injection vials

Tenecteplase 10,000unit powder and solvent for solution for injection vials

02.11 - Antifibrinolytic drugs and haemostatics 1st tranexamic acid Tranexamic acid 500mg tablets

Tranexamic acid 500mg/5ml oral solution

Tranexamic acid 500mg/5ml solution for injection ampoules

H etamsylate (ethamsylate) Etamsylate 500mg tablets

Etamsylate 20mg/1ml solution for injection ampoules

Etamsylate 250mg/2ml solution for injection ampoules

Blood Products

02.12 - Lipid-regulating drugs Statins 1st simvastatin Simvastatin 10mg tablets

Simvastatin 20mg tablets

Simvastatin 40mg tablets

Simvastatin 80mg tablets

1st pravastatin Pravastatin 10mg tablets

Pravastatin 20mg tablets

Pravastatin 40mg tablets

2nd atorvastatin Atorvastatin 10mg tablets

Atorvastatin 20mg tablets

Atorvastatin 40mg tablets

Atorvastatin 10mg chewable tablets

Atorvastatin 20mg chewable tablets

Atorvastatin 40mg chewable tablets

Ezetimibe 2nd ezetimibe (Ezetrol) on not recommended list Ezetimibe 10mg tablets

Fibrates 2nd bezafibrate Bezafibrate 200mg tablets

Bezafibrate 400mg modified-release tablets

2nd fenofibrate Fenofibrate micronised 67mg capsules

Fenofibrate micronised 200mg capsules

Fenofibrate micronised 267mg capsules

Fenofibrate micronised 160mg tablets

2nd ciprofibrate Ciprofibrate 100mg tablets

02.13 - Local sclerosants H sodium tetradecyl sulphate (Fibro-vein) Sodium tetradecyl sulfate 0.5% solution for injection 2ml ampoules

Sodium tetradecyl sulfate 1% solution for injection 2ml ampoules

Sodium tetradecyl sulfate 3% solution for injection 2ml ampoules

0dXM8L2k+PGJyIC8+PC90ZD48L3RyPjx0cj48dGQgc3R5bGU9J2hlaWdodDoxMHB4Jz48L3RkPjw vdHI+PHRyPjx0ZCBzdHlsZT0nZm9udC13ZWlnaHQ6IGJvbGQ7IGZvbnQtc2l6ZToxMnB0Oyc+MDMuMTAgLSBTeXN0ZW1pYyBuYXNhbCBkZWNvbmdlc3RhbnRzPC90ZD48L3RyPjx0cj48dGQgc3R5bGU9J3BhZGRpbmctbGVmdDoxMHB4Oyc+PGZvbnQgY29sb3I9J2dyZWVuJz4xPHN1cD5zdDw vc3Vw PiAgIHBzZXVkb2Vw aGVkcmluZSBoeWRyb2NobG9yaWRlPC9mb250Pjw vdGQ+PC90cj48dHI+PHRkIHN0eWxlPSdw YWRkaW5nLWxlZnQ6NDBw eDtjb2xvcjonIzgw ODA4MCc+PGk+UHNldWRvZXBoZWRyaW5lIGh5ZHJvY2hsb3JpZGUgNjBtZyB0YWJsZXRzPC9pPjxiciAvPjw vd

03 - Respiratory system Asthma

Please see 2008 British Guideline on the treatment of Asthma updated June 2009

And NICE Guidance: Asthma (children under 5) - inhaler devices Asthma (in adults) - corticosteroids Asthma (in children) - corticosteroids Asthma (older children) - inhaler devices Asthma (uncontrolled) - omalizumab Choice of inhaler devices for children with chronic asthma

For children under the age of 5 years with chronic stable asthma, NICE TAG 10 (August 2000) recommends Both corticosteroids and bronchodilator therapy should be routinely delivered by pressurized metered dose inhaler (pMDI) and spacer system, with a facemask where necessary. Where this combination is not clinically effective for the child and depending on the child's condition, nebulised therapy may be considered and in the case of children aged 3-5 years, a dry powder inhaler (DPI) may also be considered. Choice of device to be made within the pMDI and spacer range should be primarily governed by specific individual need and the likelihood of good compliance. Once these factors have been taken into account, choice should be made on the basis of cost minimisation. For older children aged 5-15 years, NICE Guidance (No 38 March 2002) recommends the choice of device should take into account the ability to maintain an effective technique, suitability for the child and carers lifestyles and willingness to use a particular device. A pMDI and suitable spacer device is recommended as the first-line choice for the delivery of inhaled corticosteroids. Where adherence to the pMDI and spacer combination is likely to be poor, other alternative devices should be considered, bearing in mind the need to minimise the risks of systemic absorption of corticosteroids. In the case of other inhaled drugs such as bronchodilators, a wider range of devices may be considered to take account of their more frequent spontaneous use and the greater need for portability. Where more than one device satisfies these considerations, it is recommended that the device with the lowest overall cost (taking into account daily required dose and product price per dose) should be chosen. Drug Type Patient Group Device Corticosteroids Adults and Children Standard MDI via spacer (with mask for very young children) Bronchodilators Child under 5 years as above

Child 5 or above Breath-actuated MDI 1 Dry powder device 2 Child with poor co- MDI via spacer ordination Older children and adults Standard MDI - If unable to use a MDI consider: standard MDI + spacer Breath-actuated MDI 1 Dry Powder Device 2 1. Breath-actuated MDIs include the Easi-Breathe and Autohaler. 2. Dry powder devices include Turbohalers, Accuhalers & Easyhalers. Salbutamol diskhalers will not be commercially available after September 2006. Choice of inhaler device should be based on patient response and not on quoted required inspiratory flow rates for each device which are largely similar and not of great relevance in well controlled asthma.

03.01 - Bronchodilators

03.01.01 - Adrenoceptor agonists

03.01.01.01 - Selective beta2 agonists 1st salbutamol Salbutamol 2mg/5ml oral solution sugar free

Salbutamol 5mg/50ml solution for infusion vials

Salbutamol 500micrograms/1ml solution for injection ampoules

Salbutamol 5mg/5ml solution for infusion ampoules

Salbutamol 100micrograms/dose breath actuated inhaler CFC free

Salbutamol 100micrograms/dose inhaler CFC free

Salbutamol 200microgram inhalation powder blisters with device

Salbutamol 100micrograms/dose dry powder inhaler

Salbutamol 200micrograms/dose dry powder inhaler

Salbutamol 2.5mg/2.5ml nebuliser liquid unit dose vials

Salbutamol 5mg/2.5ml nebuliser liquid unit dose vials

2nd terbutaline Terbutaline 500micrograms/1ml solution for injection ampoules

Terbutaline 2.5mg/5ml solution for injection ampoules

Terbutaline 250micrograms/dose inhaler

Terbutaline 500micrograms/dose dry powder inhaler

Terbutaline 5mg/2ml nebuliser liquid unit dose vials

2nd formoterol (eformoterol) Formoterol 6micrograms /dose dry powder inhaler

Formoterol 12micrograms/dose dry powder inhaler

1st salmeterol Salmeterol 25micrograms/dose inhaler

Salmeterol 50micrograms/dose dry powder inhaler

03.01.01.02 - Other adrenoceptor agonists

03.01.02 - Antimuscarinic bronchodilators 1st ipratropium bromide Ipratropium bromide 20micrograms/dose inhaler

Ipratropium bromide 40micrograms/dose inhaler

Ipratropium bromide 20micrograms/dose breath actuated inhaler

Ipratropium bromide 250micrograms/1ml nebuliser liquid unit dose vials

Ipratropium bromide 500micrograms/2ml nebuliser liquid unit dose vials

2nd tiotropium (Spiriva) Tiotropium bromide 18microgram inhalation powder capsules

2nd tiotropium (Spiriva Respimat) Tiotropium bromide 5micrograms/metered inhalation solution for inhalation

03.01.03 - Theophylline 1st theophylline Theophylline 60mg modified-release capsules

Theophylline 125mg modified-release capsules

Theophylline 250mg modified-release capsules

Theophylline 200mg modified-release tablets

Theophylline 300mg modified-release tablets

Theophylline 400mg modified-release tablets

2nd aminophylline Aminophylline hydrate 100mg modified -release tablets

Aminophylline hydrate 225mg modified -release tablets

Aminophylline hydrate 350mg modified-release tablets

Aminophylline 250mg/10ml solution for injection ampoules

03.01.04 - Compound bronchodilator preparations

03.01.05 - Peak flow meters, inhaler devices and nebulisers Nebuliser Therapy For the majority of patients home nebulisers offer no advantage over spacer devices. Before prescribing nebulisers the patient's existing therapy should be optimised. Nebuliser therapy should be initiated subject to a formal assessment by a specialist for objective or subjective benefit. Nebulisers should be serviced at least once on an annual basis with usage and benefit being reviewed by a specialist at the same time.

1. Haleraid is not available on community NHS prescriptions. 2. Nebuhaler devices are compatible with Bricanyl (terbutaline) and Pulmicort (budesonide) inhalers. 3. Volumatic devices:- Volumatics were discontinued for a short period and were replaced by Aerochambers. Following concerns raised by the CSM regarding possible changes in drug delivery, GSK has reintroduced the Volumatic device. National product information for the GSK / Allen & Hanburys metered dose inhaler product range now states that only the Volumatic spacer device should be used with GSK products. 4. Nebuchamber is available as a First Line device for use with Pulmicort Inhalers only. Advice for Prescribers The Commission on Human Medicines advises the following, in relation to patients using spacer devices with GSK pressurised metered dose inhalers:

If you are prescribing any spacer device to a patient for the first time , these patients should be monitored frequently in the normal way for the emergence of or worsening of symptoms of disease or adverse effects. Any patients who are switched to a different device should be regarded in the same way as new patients, and the same careful monitoring is required. Patients who require a spacer device for the first time with Allen & Hanbury inhalers, from 3 January 2006 should be prescribed a Volumatic spacer device (making best use of the limited interim stocks). New patients should only be dispensed an AeroChamber Plus spacer device if interim stocks of the Volumatic are insufficient or not available. Patients who are currently using a Volumatic spacer device should retain the device, and continue to use it in accordance with the manufacturer's instructions. These devices can be replaced with newly manufactured stock from mid-February 2006, as necessary. Patients who have switched to the AeroChamber Plus spacer device have no urgent need to switch back to the Volumatic unless they are experiencing difficulties with the device or their asthma control or the emergence of adverse effects gives cause for concern, therefore: Patients should continue to use the AeroChamber Plus until the new Volumatic becomes available (mid February 2006). These patients should be monitored for the emergence of or worsening of symptoms of disease or adverse effects both before and after switching back to the Volumatic. Priority for switching back to the Volumatic from February 2006 should be given to children and those taking high dose corticosteroids and long-acting

β2 agonists. Patients taking short-acting bronchodilators only (as required) are a low priority for switching back.

For inhaled β 2 agonist bronchodilators the most frequent signs of toxicity are headache, tremor and palpitations; for inhaled corticosteroids the most serious concern from over exposure is adrenal suppression particularly with high doses administered to children and adolescents.

A questions and answers document will be placed on the website of the Medicines and Healthcare products Regulatory Agency www.mhra.gsi.gov.uk.. For further information please call 020 7084 0000. 1st Peak flow meters Peak flow meter standard range

Peak flow meter low range

1st Inhaler devices Aerochamber

Babyhaler

Haleraid

Nebuchamber

Nebuhaler

Paediatric Volumatic

Volumatic

03.02 - Corticosteroids 1st beclometasone dipropionate (beclomethasone) Beclometasone 50micrograms/dose inhaler CFC free

Beclometasone 50micrograms/d ose aerosol inhaler CFC free

Beclometasone 100micrograms/dose inhaler CFC free

Beclometasone 100micrograms/dose aerosol inhaler CFC free

Beclometasone 200micrograms/dose inhaler CFC free

Beclometasone 200micrograms/dose aerosol inhaler CFC free

Beclometasone 250micrograms/dose inhaler CFC free

Beclometasone 250micrograms/dose aerosol inhaler CFC free

Beclometasone 50micrograms/dose breath actuated inhaler CFC free

Beclometasone 100micrograms/dose breath actuated inhaler CFC free

Beclometas one 250micrograms/dose breath actuated inhaler

Beclometasone 100microgram inhalation powder blisters with device

Beclometasone 200microgram inhalation powder blisters with device

1st budesonide Budesonide 50micrograms/dose inhaler

Budesonide 200mi crograms/dose inhaler

Budesonide 100micrograms/dose dry powder inhaler

Budesonide 200micrograms/dose dry powder inhaler

Budesonide 400micrograms/dose dry powder inhaler

S budesonide nebuliser solution Budesonide 1mg/2ml nebuliser liquid unit dose vials

Budesonide 500micrograms/2ml nebuliser liquid unit dose vials

2nd fluticasone propionate Fluticasone 25micrograms/dose inhaler

Fluticasone 50micrograms/dose inhaler CFC free

Fluticasone 125micrograms/dose inhaler CFC free

Fluticasone 250mi crograms/dose inhaler CFC free

Fluticasone 50microgram inhalation powder blisters with device

Fluticasone 100microgram inhalation powder blisters with device

Fluticasone 250microgram inhalation powder blisters with device

Fluticasone 500microgram i nhalation powder blisters with device

S fluticasone propionate nebuliser solution Fluticasone 500micrograms/2ml nebuliser liquid unit dose vials

Fluticasone 2mg/2ml nebuliser liquid unit dose vials

Compound preparations 2nd Fostair 2nd Seretide Fluticasone 100micrograms/dose / Salmeterol 50micrograms/dose dry powder inhaler

Fluticasone 250micrograms/dose / Salmeterol 50micrograms/dose dry powder inhaler

Fluticasone 500micrograms/dose / Salmeterol 50micrograms/dose dry powder inhaler

Fluticas one 50micrograms/dose / Salmeterol 25micrograms/dose inhaler CFC free

Fluticasone 125micrograms/dose / Salmeterol 25micrograms/dose inhaler CFC free

Fluticasone 250micrograms/dose / Salmeterol 25micrograms/dose inhaler CFC free

2nd Symbicort Budeson ide 100micrograms/dose / Formoterol 6micrograms/dose dry powder inhaler

Budesonide 200micrograms/dose / Formoterol 6micrograms/dose dry powder inhaler

Budesonide 400micrograms/dose / Formoterol 12micrograms/dose dry powder inhaler

03.03 - Cromoglic ate and related therapy, leukotriene receptor antagonists and phosphodiesterase type-4 inhibitors

03.03.01 - Cromoglicate and related therapy 1st sodium cromoglicate Sodium cromoglicate 5mg/dose inhaler

Sodium cromoglicate 5mg/dose breath actuated inhaler

03.03.02 - Leukotriene receptor antagonists 2nd montelukast Montelukast 4mg chewable tablets sugar free

Montelukast 5mg chewable tablets sugar free

Montelukast 10mg tablets

Montelukast 4mg granules sachets sugar free

03.03.03 - Phosphodiesterase type-4 inhibitors

03.04 - Antihistamines, hyposensitisation and allergic emergencies

03.04.01 - Antihistamines Sedating Antihistamines 1st chlorphenamine maleate (chlorpheniramine maleate) Chlorphenamine 4mg tablets

Chlorphenamine 2mg/5ml oral solution

Chlorphenamine 10mg/1ml solution for injection ampoules

1st alimemazine tartrate (trimeprazine tartrate) Alimemazine 10mg tablets

Alimemazine 7.5mg/5ml oral solution

Alimemazine 30mg/5ml oral solution

1st promethazine hydrochloride Promethazine hydrochloride 10mg tablets

Promethazine hydrochloride 25mg tablets

Promethazine 5mg/5ml oral solution sugar free

2nd hydroxyzine hydrochloride Hydroxyzine 10mg tablets

Hydroxyzine 25mg tablets

H promethazine hydrochloride injection Promethazine 25mg/1ml solution for injection ampoules

Non -sedating antihistamines 1st cetirizine hydrochloride Cetirizine 10mg tablets

Cetirizine 1mg/ml oral solution sugar free

1st loratadine Loratadine 10mg tablets

Loratadine 5mg/5ml oral solution

2nd fexofenadine Fexofenadine 120mg tablets

Fexofenadine 180mg tablets

03.04.02 - Allergen immunotherapy H omalizumab NICE TA133 Omalizumab 150mg powder and solvent for solution for injection vials

03.04.03 - Allergic emergencies S Icatibant (Firazyr) Icatibant 30mg/3ml solution for injection pre -filled syringes

Recommended as an option for use within NHS Wales for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults (with C1 esterase inhibitor deficiency). This recommendation applies only in circumstances where the approved Wales patient access scheme is utilised. AWMSG is of the opinion that icatibant (Firazyr ®▼) is suitable for specialist only prescribing within NHS Wales for the above indication. 1st adrenaline (epinephrine) Adrenaline acid tartrate 500micrograms/0.5ml (1 in 1,000) solution for injection ampoules

Adrenaline acid tartrate 1mg/1ml (1 in 1,0 00) solution for injection ampoules

Adrenaline 300micrograms/0.3ml (1 in 1,000) solution for injection pre -filled disposable devices

EpiPen Jr. 150micrograms/0.3ml (1 in 2,000) solution for injection auto -injectors

EpiPen 300micrograms/0.3ml (1 in 1, 000) solution for injection auto-injectors

03.05 - Respiratory stimulants and pulmonary surfactants

03.05.01 - Respiratory stimulants H doxapram hydrochloride Doxapram 1g/500ml infusion bags

Doxapram 100mg/5ml solution for injection ampoules

H caffeine citrate Caffeine citrate 10mg/1mL injection

Caffeine 50mg/5ml oral solution

03.05.02 - Pulmonary surfactants H poractant alfa Poractant alfa 120mg/1.5ml endotracheopulmonary suspension vials

3.5.3 Nitric Oxide H nitric oxide

03.06 - Oxygen S oxygen Oxygen cylinders

Oxygen concentrators

03.07 - Mucolytics 1st carbocisteine (Mucodyne) Carbocisteine 375mg capsules

Carbocisteine 250mg/5ml oral solution

S dornase alfa Dornase alfa 2.5mg/2.5ml nebuliser liquid ampoules

S sodium chloride (7%) Nebusal

03.08 - Aromatic inhalations 2nd Benzoin Tincture, Compound, BP

03.09 - Cough preparations Cough preparations are generally not recommended in adults or children as no evidence of efficacy. Simple linctus may be used. Opiate antitussives have a significant adverse side effect profile and are not recommended. Codeine linctus should be avoided because of the potential for abuse and limited evidence to support efficacy.

03.09.01 - Cough suppressants 1st pholcodine Pholcodine 5mg/5ml linctus

03.09.02 - Demulcent and expectorant cough preparations 1st Simple linctus, BP Simple linctus

1st Simple linctus, Paediatric BP Simple linctus paediatric

Palliative Care S methadone hydrochloride Methadone 2mg/5ml linctus

03.10 - Systemic nasal decongestants 1st pseudoephedrine hydrochloride Pseudoephedrine hydrochloride 60mg tablets

Pseudoephedrine 30mg/5ml oral solution

04 - Central Nervous System

04.01 - Hypnotics and anxiolytics •Hypnotics and anxiolytics are indicated for the short-term relief (two to four weeks) of anxiety that is severe, disabling or subjecting the individual to unacceptable distress. Treatment may be solely for anxiety or anxiety in association with insomnia, short-term psychosomatic, organic or psychotic illness. •The use of benzodiazepines to treat short-term ‘mild’ anxiety is inappropriate and unsuitable, the only exception being in the palliative care setting. •Benzodiazepines should be used to treat insomnia only when it is severe, disabling, or causing the patient extreme distress.

04.01.01 - Hypnotics 1st temazepam Temazepam 10mg tablets

Temazepam 20mg tablets

Temazepam 10mg/5ml oral solution sugar free

S nitrazepam S chloral hydrate Chloral hydrate 500mg/5ml oral solution

Chloral hydrate 200mg/5ml oral solution

S clomethiazole (chlormethiazole) Clomethiazole 192mg capsules

Clomethiazole 250mg/5ml oral solution sugar free

S melatonin Melatonin 2mg modified-release tablets

1st zopiclone Zopiclone 3.75mg tablets

Zopiclone 7.5mg tablets

S zolpidem

04.01.02 - Anxiolytics Benzodiazepines 1st diazepam Diazepam 2mg tablets

Diazepam 5mg tablets

Diazepam 10mg tablets

Diazepam 2mg/5ml oral solution

Diazepam 5mg/5ml oral solution

Diazepam 10mg/2ml solution for injection ampoules

Diazepam 10mg/2ml emulsion for injection ampoules

Diazepam 2.5mg/1.25ml rectal solution tube

Diazepam 5mg/2.5ml rectal solution tube

Diazepam 10mg/2.5ml rectal solution tube

Diazepam 10mg suppositories

2nd lorazepam Lorazepam 1mg tablets

Lorazepam 2.5mg tablets

Lorazepam 4mg/1ml solution for injection ampoules

S oxazepam Oxazepam 10mg tablets

Oxazepam 15mg tablets

S buspirone Buspirone 5mg tablets

Buspirone 10mg tablets

S chlordiazepoxide Chlordiazepoxide 5mg capsules

Chlordiazepoxide 10mg capsules

04.01.03 - Barbiturates

04.02 - Drugs used in psychoses and related disorders

04.02.01 - Antipsychotic drugs Phenothiazines S chlorpromazine (Existing patients only) Chlorpromazine 10mg tablets

Chlorpromazine 25mg tablets

Chlorpromazine 50mg tablets

Chlorpromazine 100mg tablets

Chlorpromazine 25mg/5ml oral solution

Chlorpromazine 100mg/5ml oral solution

Chlorpromazine 25mg/1ml solution for injection ampoules

Chlorpromazine 50mg/2ml solution for injection ampoules

S promazine Promazine 25mg tablets

Promazine 50mg tablets

Promazine 25mg/5ml oral solution

Promazine 50mg/5ml oral solution

Promazine 50mg/1mL injection

Butyrophenones S Pericyazine Pericyazine 2.5mg tablets

Pericyazine 10mg tablets

Pericyazine 10mg/5ml oral solution

1st haloperidol Haloperidol 500microgram capsules

Haloperidol 1.5mg tablets

Haloperidol 5mg tablets

Haloperidol 10mg tablets

Haloperidol 20mg tablets

Haloperidol 10mg/5ml oral solution sugar free

Haloperidol 5mg/1ml solution for injection ampoules

S benperidol Benperidol 250microgram tablets

Thioxanthenes S zuclopenthixol dihydrochloride Zuclopenthixol 2mg tablets

Zuclopenthixol 10mg tablets

Zuclopenthixol 25mg tablets

H zuclopenthixol acetate Zuclopenthixol acetate 50mg/1ml solution for injection ampoules

Zuclopenthixol acetate 100mg/2ml solution for injection ampoules

Substituted benzamides S sulpiride Sulpiride 200mg tablets

Sulpiride 400mg tablets

Sulpiride 200mg/5ml oral solution sugar free

Atypical antipsychotics S risperidone Risperidone 500microgram tablets

Risperidone 1mg tablets

Risperidone 2mg tablets

Risperidone 3mg tablets

Risperidone 4mg tablets

Risperidone 6mg tablets

Risperidone 500microgram orodispersible tablets sugar free

Risperidone 1mg orodispersible tablets sugar free

Risperidone 2mg orodispersible tablets sugar free

Risperidone 3mg orodispersible tablets sugar free

Risperidone 4mg orodispersible tablets sugar free

Risperidone 1mg/ml oral solution sugar free

S olanzapine Olanzapine 2.5mg tablets

Olanzapine 5mg tablets

Olanzapine 7.5mg tablets

Olanzapine 10mg tablets

Olanzapine 15mg tablets

Olanzapine 5mg oral lyophilisates sugar free

Olanzapine 10mg oral lyophilisates sugar free

Olanzapine 15mg oral lyophilisates sugar free

Olanzapine 20mg oral lyophilisates sugar free

S amisulpride Amisulpride 50mg tablets

Amisulpride 200mg tablets

Amisulpride 400mg tablets

S quetiapine Quetiapine 25mg tablets

Quetiapine 100mg tablets

Quetiapine 150mg tablets

Quetiapine 200mg tablets

Quetiapine 50mg modified-release tablets

Quetiapine 200mg modified-release tablets

Quetiapine 400mg modified-release tablets

S aripiprazole Aripiprazole 5mg tablets

Aripiprazole 10mg tablets

Aripiprazole 30mg tablets

Aripiprazole 1mg/ml oral solution

Aripiprazole 9.75mg/1.3ml solution for injection vials

H clozapine Clozapine 25mg tablets

Clozapine 100mg tablets

04.02.02 - Antipsychotic depot injections S flupentixol decanoate (flupenthixol decanoate) Flupentixol 20mg/1ml solution for injection ampoules

Flupentixol 50mg/0.5ml solution for injection ampoules

Flupentixol 100mg/1ml solution for injection ampoules

Flupentixol 200mg/1ml solution for injection ampoules

S fluphenazine decanoate Fluphenazine decanoate 12.5mg/0.5ml solution for injection ampoules

Fluphenazine decanoate 25mg/1ml solution for injection ampoules

Fluphenazine decanoate 50mg/2ml solution for injection ampoules

Fluphenazine decanoate 50mg/0.5ml solution for injection ampoules

Fluphenazine decanoate 100mg/1ml solution for injection ampoules

S haloperidol decanoate Haloperidol decanoate 50mg/1ml solution for injection ampoules

Haloperidol decanoate 100mg/1ml solution for injection ampoules

S zuclopenthixol decanoate Zuclopenthixol decanoate 200mg/1ml solution for injection ampoules

Zuclopenthixol decanoate 500mg/1ml solution for injection ampoules

S pipotiazine palmitate (pipothiazine palmitate) Pipotiazine 50mg/1ml solution for injection ampoules

Pipotiazine 100mg/2ml solution for injection ampoules

H olanzapine (IM) Olanzapine 10mg powder for solution for injection vials

S risperidone Risperdal Consta Risperidone 25mg powder and solvent for suspension for injection vials

Risperidone 37.5mg powder and solvent for suspension for injection vials

Risperidone 50mg powder and solvent for suspension for injection vials

04.02.03 - Antimanic drugs S lithium carbonate Lithium carbonate 200mg modified-release tablets

Lithium carbonate 400mg modified-release tablets

S lithium citrate Lithium citrate 520mg/5ml oral solution sugar free

S carbamazepine (see section 4.8.1) S valproic acid as (semisodium valproate) Valproic acid 250mg gastro-resistant tablets

Valproic acid 500mg gastro-resistant tablets

04.03 - Antidepressant drugs

04.03.01 - Tricyclic and related antidepressant drugs Tricyclic antidepressants S Nortriptyline Nortriptyline 10mg tablets

Nort riptyline 25mg tablets

S lofepramine Lofepramine 70mg tablets

Lofepramine 70mg/5ml oral solution

S imipramine Imipramine 10mg tablets

Imipramine 25mg tablets

Imipramine 25mg/5ml oral solution

Imipramine 70mg/5ml oral solution

S amitriptyline Amitriptyline 10mg tablets

Amitriptyline 25mg tablets

Amitriptyline 50mg tablets

Amitriptyline 25mg/5ml oral solution sugar free

Amitriptyline 50mg/5ml oral solution sugar free

Amitriptyline 10mg/1mL injection

S clomipramine Clomipramine 10mg capsules

Clomipramine 20mg capsules

Clomipramine 50mg capsules

Clomipramine 75mg modified-release tablets

Clomipramine 25mg/2ml solution for injection ampoules

Clomipramine 25mg/5ml oral solution

Clomipramine 75mg/5ml oral solution

Related antidepressants 2nd trazodone Trazodone 50mg capsules

Trazodone 100mg capsules

Trazodone 150mg tablets

Trazodone 50mg/5ml oral solution

04.03.02 - Monoamine-oxidase inhibitors S phenelzine Phenelzine 15mg tablets

Reversible MAOIs S moclobemide Moclobemide 150mg tablets

Moclobemide 300mg tablets

04.03.03 - Selective serotonin re-uptake inhibitors SSRIs 1st citalopram Citalopram 10mg tablets

Citalopram 20mg tablets

Citalopram 40mg tablets

Citalopram 40mg/ml oral drops sugar free

1st fluoxetine Fluoxetine 20mg capsules

Fluoxetine 20mg/5ml oral solution

1st paroxetine Paroxetine 20mg tablets

Paroxetine 30mg tablets

Paroxetine 10mg/5ml oral solution

1st sertraline Sertraline 50mg tablets

Sertraline 100mg tablets

S escitalopram on not recommended list - prescribe on Consultant recommendation only Escitalopram 10mg tablets

Escitalopram 20mg tablets

Escitalopram 10mg/ml oral drops sugar free

04.03.04 - Other antidepressant drugs 2nd flupentixol (flupenthixol) Flupentixol 500microgram tablets

Flupentixol 1mg tablets

2nd mirtazapine Mirtazapine 15mg tablets

Mirtazapine 30mg tablets

Mirtazapine 45mg tablets

Mirtazapine 15mg orodispersible tablets

Mirtazapine 30mg orodispersible tablets

Mirtazapine 45mg orodispersible tablets

1st venlafaxine Venlafaxine 37.5mg tablets

Venlafaxine 75mg tablets

Venlafaxine 75mg modified-release tablets

Venlafaxine 150mg modified-release tablets

S duloxetine Duloxetine 30mg gastro-resistant capsules

Duloxetine 60mg gastro-resistant capsules

S reboxetine Reboxetine 4mg tablets

S agomelatine prescribe on Consultant recommendation only Agomelatine 25mg tablets

04.04 - CNS stimulants and drugs used for attention deficit hyperactivity disorder S Modafinil Modafinil 100mg tablets

Modafinil 200mg tablets

S atomoxetine Atomoxetine 10mg capsules

Atomoxetine 18mg capsules

Atomoxetine 25mg capsules

Atomoxetine 40mg capsules

Atomoxetine 60mg capsules

S methylphenidate Methylphenidate 5mg tablets

Methylphenidate 10mg tablets

Methylphenidate 18mg modified-release tablets

Methylphenidate 27mg modified-release tablets

Methylphenidate 36mg modified-release tablets

Methylphenidate 10mg modified-release capsules

Methylphenidate 20mg modified-release capsules

Methylphenidate 30mg modified-release capsules

Methylphenidate 40mg modified-release capsules

04.05 - Drugs used in the treatment of obesity

04.05.01 - Anti-obesity drugs acting on the gastro-intestinal tract 1st orlistat Orlistat 120mg capsules

04.05.02 - Centrally acting appetite suppressants Phentermine and diethylpropion are central stimulants; they are not recommended for the treatment of obesity. Phentermine has been associated with a risk of pulmonary hypertension. Sibutramine, dexfenfluramine, and fenfluramine have been withdrawn because the benefit of treatment does not outweigh the risk of serious adverse effects.

04.06 - Drugs used in nausea and vertigo Antihistamines 1st cinnarizine Cinnarizine 15mg tablets

1st cyclizine Cyclizine 50mg tablets

Cyclizine 50mg/1ml solution for injection ampoules

1st promethazine teoclate Promethazine teoclate 25mg tablets

1st promethazine hydrochloride (see section 3.4.1) Phenothiazines and related drugs H Droperidol (To be used in theatres only) Droperidol 2.5mg/1ml solution for injection ampoules

1st prochlorperazine Prochlorperazine 5mg tablets

Prochlorperazine 5mg/5ml oral solution

Prochlorperazine 12.5mg/1ml solution for injection ampoules

Prochlorperazine 3mg buccal tablets

2nd trifluoperazine (see section 4.2.1) 2nd haloperidol (see section 4.2.1) 2nd chlorpromazine (see section 4.2.1) 2nd levomepromazine (methotrimeprazine) Levomepromazine 25mg tablets

Levomepromazine 25mg/1ml solution for injection ampoules

Domperidone and metoclopramide 1st domperidone Domperidone 10mg tablets

Domperidone 5mg/5ml oral suspension sugar free

Domperidone 30mg suppositories

1st metoclopramide Metoclopramide 10mg tablets

Metoclopramide 5mg/5ml oral solution sugar free

Metoclopramide 10mg/2ml solution for injection ampoules

Metoclopramide 100mg/20ml solution for injection ampoules

5HT3 antagonists H Granisetron (For use in Theatres only) Granisetron 1mg/1ml concentrate for solution for injection ampoules

S ondansetron Ondansetron 4mg tablets

Ondansetron 8mg tablets

Ondansetron 4mg orodispersible tablets

Ondansetron 8mg orodispersible tablets

Ondansetron 4mg/5ml oral solution

Ondansetron 16mg suppositories

Ondansetron 4mg/2ml solution for injection ampoules

Ondansetron 8mg/4ml solution for injection ampoules

Neurokinin receptor antagonist H aprepitant Aprepitant 80mg capsules

Aprepitant 125mg capsules

Hyoscine 2nd hyoscine hydrobromide Hyoscine hydrobromide 300microgram tablets

Hyoscine hydrobromide 400micrograms/1ml solution for injection ampoules

Hyoscine hydrobromide 600micrograms/1ml solution for injection ampoules

Hyoscine 1mg/72hours transdermal patches

Other drugs for Meniere's disease S betahistine Betahistine 8mg tablets

Betahistine 16mg tablets

04.07 - Analgesics

04.07.01 - Non-opioid analgesics and compound analgesic preparations 1st aspirin Aspirin 300mg dispersible tablets

1st paracetamol Paracetamol 500mg tablets

Paracetamol 500mg soluble tablets

Paracetamol 120mg/5ml oral solution paediatric

Paracetamol 250mg/5ml oral solution

Paracetamol 30mg suppositories

Paracetamol 60mg suppositories

Paracetamol 125mg suppositories

Paracetamol 240mg suppositories

Paracetamol 500mg suppositories

Paracetamol 1g suppositories

H paracetamol IV (Perfalgan) Paracetamol 500mg/50ml solution for infusion vials

Paracetamol 1g/100ml solution for infusion vials

Compound analgesic preparations 2nd co-dydramol Co-dydramol 10mg/500mg tablets

1st co-codamol 8/500 Co-codamol 8mg/500mg tablets

1st co-codamol 30/500 Co-codamol 30mg/500mg tablets

Co-codamol 30mg/500mg effervescent tablets

04.07.02 - Opioid analgesics S Tapentadol (Palexia SR) Tapentadol 50mg modified-release tablets

Tapentadol 100mg modified-release tablets

Tapentadol 150mg modified-release tablets

Tapentadol 200mg modified-release tablets

Tapentadol 250mg modified-release tablets

Recommended as an option for restricted use within NHS Wales, only in the following subpopulation within its licensed indication: Patients with severe chronic pain, in whom morphine sulphate modified release has failed to provide adequate pain control or is not tolerated. Not recommended for the management of s evere chronic pain in adults, which can be adequately managed only with opioid analgesics, outside of the subpopulation described above. AWMSG is of the opinion that tapentadol prolonged release (Palexia® SR▼) should be initially prescribed by a specialist*. Prescribing may be continued in primary care with appropriate communication and specialist input. (*Specialist implies specialist team or GP with special interest (GPwSI) with appropriate accreditation from the specialist faculty). This recommendation only applies to the use of tapentadol prolonged release tablets (Palexia® SR▼). AWMSG does not recommend the use of tapentadol film-coated tablets (Palexia®) even under restriction.

1st codeine phosphate Codeine 15mg tablets

Codeine 15mg/5ml linctus

Codeine 30mg tablets

Codeine 60mg tablets

Codeine 25mg/5ml oral solution

Codeine 60mg/1ml solution for injection ampoules

1st dihydrocodeine Dihydrocodeine 30mg tablets

Dihydrocodeine 10mg/5ml oral solution

Dihydrocodeine 60mg modified-release tablets

Dihydrocodeine 90mg modified-release tablets

Dihydrocodeine 120mg modified-release tablets

Dihydrocodeine 50mg/1ml solution for injection ampoules

1st morphine sulphate Morphine hydrochloride 10mg/5ml oral solution

Morphine hydrochloride 100mg/5ml oral solution

Morphine 10mg tablets

Morphine 20mg tablets

Morphine 50mg tablets

Morphine 5mg modified-release tablets

Morphine 10mg modified-release tablets

Morphine 15mg modified-release tablets

Morphine 30mg modified-release tablets

Morphine 60mg modified-release tablets

Morphine 100mg modified-release tablets

Morphine 200mg modified-release tablets

Morphine sulphate 20mg suppositories

Morphine sulphate 30mg suppositories

Morphine sulphate 60mg suppositories

Morphine sulphate 100mg suppositories

Morphine sulphate 200mg suppositories

Morphine sulphate 10mg/1ml solution for injection ampoules

Morphine sulphate 15mg/1ml solution for injection ampoules

Morphine sulphate 30mg/1ml solution for injection ampoules

2nd morphine sulphate (Swallowing difficulties only) Morphine 20mg modified-release granules sachets sugar free

Morphine 30mg modified-release granules sachets sugar free

Morphine 100mg modified-release granules sachets sugar free

Morphine 200mg modified-release granules sachets sugar free

1st diamorphine Diamorphine 5mg powder for solution for injection ampoules

Diamorphine 10mg powder for solution for injection ampoules

Diamorphine 30mg powder for solution for injection ampoules

Diamorphine 100mg powder for solution for injection ampoules

Diamorphine 500mg powder for solution for injection ampoules

2nd buprenorphine Buprenorphine 200microgram sublingual tablets sugar free

Buprenorphine 300micrograms/1ml solution for injection ampoules

Buprenorphine 5micrograms/hour transdermal patches

Buprenorphine 10micrograms/hour transdermal patches

Buprenorphine 20micrograms/hour transdermal patches

S buprenorphine (Transtec) Buprenorphine 35micrograms/hour transdermal patches

Buprenorphine 52.5micrograms/hour transdermal patches

Buprenorphine 70micrograms/hour transdermal patches

2nd pethidine Pethidine 50mg tablets

Pethidine 50mg/1ml solution for injection ampoules

Pethidine 100mg/2ml solution for injection ampoules

2nd tramadol Tramadol 50mg capsules

Tramadol 100mg modified-release tablets

Tramadol 150mg modified-release tablets

Tramadol 200mg modified-release tablets

Tramadol 50mg soluble tablets sugar free

Tramadol 100mg/2ml solution for injection ampoules

2nd fentanyl patches (prescribe by brand - Matrifen first line, Duogesic second line) swallowing difficulties only Fentanyl 12micrograms/hour transdermal patches

Fentanyl 25micrograms/hour transdermal patches

Fentanyl 50micrograms/hour transdermal patches

Fentanyl 75micrograms/hour transdermal patches

Fentanyl 100micrograms/hour transdermal patches

2nd oxycodone Oxycodone 5mg capsules

Oxycodone 10mg capsules

Oxycodone 20mg capsules

Oxycodone 5mg/5ml oral solution

Oxycodone 10mg/ml oral solution sugar free

Oxycodone 10mg/1ml solution for injection ampoules

Oxycodone 5mg modified-release tablets

Oxycodone 10mg modified-release tablets

Oxycodone 20mg modified-release tablets

Oxycodone 40mg modified-release tablets

Oxycodone 80mg modified-release tablets

S meptazinol Meptazinol 200mg tablets

Meptazinol 100mg/1ml solution for injection ampoules

S methadone Methadone 5mg tablets

Methadone 1mg/ml oral solution sugar free

Methadone 10mg/ml oral solution sugar free

Methadone 10mg/1ml solution for injection ampoules

S fentanyl Fentanyl 200microgram lozenges

Fentanyl 400microgram lozenges

Fentanyl 600microgram lozenges

Fentanyl 800microgram lozenges

Fentanyl 100microgram sublingual tablets sugar free

Fentanyl 200microgram sublingual tablets sugar free

Fentanyl 300microgram sublingual tablets sugar free

Fentanyl 400microgram sublingual tablets sugar free

Fentanyl 600microgram sublingual tablets sugar free

Fentanyl 800microgram sublingual tablets sugar free

Fentanyl 50micrograms/dose nasal spray

Fentanyl 100micrograms/dose nasal spray

Fentanyl 200micrograms/dose nasal spray

Fentanyl 400micrograms/dose nasal spray

S hydromorphone Hydromorphone 2.6mg capsules

Hydromorphone 4mg modified-release capsules

Hydromorphone 16mg modified-release capsules

H morphine sulphate epidural (Depodur) Morphine sulphate 10mg/1ml suspension for injection vials

With anti-emetic 2nd morphine tartrate with cyclizine tartrate Morphine tartrate 10mg/1ml / Cyclizine tartrate 50mg/1ml solution for injection ampoules

Morphine tartrate 15mg/1ml / Cyclizine tartrate 50mg/1ml solution for injection ampoules

04.07.03 - Neuropathic pain Trigeminal neuralgia 1st Amitriptyline (See section 4.3.1) S Gabapentin (See section 4.8.1) S Nortriptyline (See Section 4.3.1) 1st carbamazepine (see section 4.8.1) 2nd capsaicin Capsaicin 0.075% cream

2nd phenytoin (see section 4.8.1) S pregabalin (on not recommended list) (see section 4.8.1) (For children on advice of a Paediatrician) Pregabalin 25mg capsules

Pregabalin 50mg capsules

Pregabalin 75mg capsules

Pregabalin 100mg capsules

Pregabalin 150mg capsules

Pregabalin 200mg capsules

Pregabalin 300mg capsules

Ketamine is sometimes used under specialist supervision for neuropathic pain that respond poorly to opioid analgesics. For preparations see section 15.1.1 Please note This is unlicensed for this indication

04.07.04 - Antimigraine drugs

04.07.04.01 - Treatment of acute migraine 1st paracetamol with metoclopramide Paracetamol 500mg / Metoclopramide 5mg tablets

Paracetamol 500mg / Metoclopramide 5mg effervescent powder sachets sugar free

S zolmitriptan Zolmitriptan 2.5mg tablets

Zolmitriptan 2.5mg orodispersible tablets sugar free

Zolmitriptan 5mg orodispersible tablets sugar free

2nd sumatriptan Sumatriptan 50mg tablets

Sumatriptan 10mg/0.1ml nasal spray unit dose

Sumatriptan 100mg tablets

Sumatriptan 6mg/0.5ml solution for injection pre-filled syringes with device

Sumatriptan 6mg/0.5ml solution for injection syringe refill

04.07.04.02 - Prophylaxis of migraine 1st pizotifen Pizotifen 500microgram tablets

Pizotifen 1.5mg tablets

Pizotifen 250micrograms/5ml oral solution sugar free

1st propranolol (see section 2.4) 1st metoprolol (see section 2.4)

04.07.04.03 - Cluster headache and the trigeminal autonomic cephalalgias

04.08 - Antiepileptic drugs

04.08.01 - Control of the epilepsies Antiepileptic agents S Pregabalin (To be used inline with NICE Guidelines) Pregabalin 100mg capsules

Pregabalin 150mg capsules

Pregabalin 200mg capsules

Pregabalin 225mg capsules

Pregabalin 300mg capsules

Pregabalin 50mg capsules

Pregabalin 75mg capsules

Pregabalin 25mg capsules

2nd Sodium valproate (Episenta) Episenta 150mg modified-release capsules

Episenta 300mg modified-release capsules

Episenta 500mg modified-release granules sachets

Episenta 1000mg modified-release granules sachets

Episenta 300mg/3ml solution for injection ampoules

Episenta 1g/10ml solution for injection ampoules

Recommended as an option for use within NHS Wales for the treatment of manic episode in bipolar disorder when lithium is contraindicated or not tolerated. The continuation of treatment after manic episode could be considered in patients who have responded to sodium valproate (Episenta®) for acute mania.

1st carbamazepine Carbamazepine 100mg tablets

Carbamazepine 200mg tablets

Carbamazepine 400mg tablets

Carbamazepine 100mg/5ml oral solution

Carbamazepine 125mg suppositories

Carbamazepine 250mg suppositories

Carbamazepine 200mg modified-release tablets

Carbamazepine 400mg modified-release tablets

Carbamazepine 100mg chewable tablets sugar free

Carbamazepine 200mg chewable tablets sugar free

1st phenytoin Phenytoin sodium 25mg capsules

Phenytoin sodium 50mg capsules

Phenytoin sodium 100mg capsules

Phenytoin sodium 300mg capsules

Phenytoin 30mg/5ml oral suspension

Phenytoin 90mg/5ml oral solution

Phenytoin 50mg chewable tablets

1st sodium valproate Sodium valproate 100mg tablets

Sodium valproate 300mg/3ml solution for injection ampoules

Sodium valproate 200mg gastro-resistant tablets

Sodium valproate 500mg gastro-resistant tablets

Sodium valproate 200mg modified-release tablets

Sodium valproate 300mg modified-release tablets

Sodium valproate 500mg modified-release tablets

Sodium valproate 200mg/5ml oral solution

Sodium valproate 400mg powder and solvent for solution for injection vials

2nd lamotrigine Lamotrigine 25mg tablets

Lamotrigine 50mg tablets

Lamotrigine 100mg tablets

Lamotrigine 200mg tablets

Lamotrigine 5mg dispersible tablets sugar free

Lamotrigine 25mg dispersible tablets sugar free

Lamotrigine 100mg dispersible tablets sugar free

2nd gabapentin Gabapentin 100mg capsules

Gabapentin 300mg capsules

Gabapentin 400mg capsules

2nd topiramate Topiramate 25mg tablets

Topiramate 50mg tablets

Topiramate 100mg tablets

Topiramate 200mg tablets

Topiramate 15mg capsules

Topiramate 25mg capsules

Topiramate 50mg capsules

2nd oxcarbazepine Oxcarbazepine 150mg tablets

Oxcarbazepine 300mg tablets

Oxcarbazepine 600mg tablets

S ethosuximide Ethosuximide 250mg capsules

Ethosuximide 250mg/5ml oral solution

S lacosamide (Vimpat) Lacosamide 50mg tablets

Lacosamide 100mg tablets

Lacosamide 150mg tablets

Lacosamide 200mg tablets

Lacosamide 15mg/ml oral solution sugar free

Lacosamide 200mg/20ml solution for infusion vials

S levetiracetam Levetiracetam 250mg tablets

Levetiracetam 100mg/ml oral solution sugar free

Levetiracetam 500mg tablets

Levetiracetam 1g tablets

Levetiracetam 500mg/5ml solution for infusion vials

S phenobarbital (phenobarbitone) Phenobarbital 15mg tablets

Phenobarbital 15mg/5ml elixir

Phenobarbital 30mg tablets

Phenobarbital 60mg tablets

Phenobarbital 60mg/1ml solution for injection ampoules

Phenobarbital 200mg/1ml solution for injection ampoules

S primidone Primidone 250mg tablets

Primidone 50mg tablets

Primidone 250mg/5ml oral suspension

Benzodiazepines S clobazam Clobazam 10mg tablets

S clonazepam Clonazepam 500microgram tablets

Clonazepam 2mg tablets

Other drugs S rufinamide Rufinamide 100mg tablets

Rufinamide 200mg tablets

Rufinamide 400mg tablets

S tiagabine Tiagabine 5mg tablets

Tiagabine 10mg tablets

Tiagabine 15mg tablets

S vigabatrin Vigabatrin 500mg tablets

Vigabatrin 500mg oral powder sachets sugar free

S zonisamide Zonisamide 25mg capsules

Zonisamide 50mg capsules

Zonisamide 100mg capsules

04.08.02 - Drugs used in status epilepticus 1st diazepam Diazepam 2.5mg/1.25ml rectal solution tube

Diazepam 5mg/2.5ml rectal solution tube

Diazepam 10mg/2.5ml rectal solution tube

Diazepam 20mg/2.5ml rectal solution tube

Diazepam 10mg/2ml solution for injection ampoules

Diazepam 10mg/2ml emulsion for injection ampoules

S midazolam buccal Midazolam maleate 10mg/ml oromucosal solution

Midazolam hydrochloride 5mg/1ml oromucosal solution pre-filled syringes

Midazolam (BUCCOLAM) should be prescribed by brand name to reduce risk of medication errors H clonazepam Clonazepam 1mg/1ml solution for injection ampoules and diluent

H lorazepam Lorazepam 4mg/1ml solution for injection ampoules

H phenytoin sodium Phenytoin sodium 250mg/5ml solution for injection ampoules

H paraldehyde Paraldehyde 100% solution for injection 5ml ampoules

Paraldehyde 50% in Olive oil rectal solution

04.08.03 - Febrile convulsions See BNF - Brief febrile convulsions need no specific treatment; antipyretic medication (e.g paracetamol, section 4.7.1) is commonly used to reduce fever and prevent further convulsions but evidence to support this practice is lacking. Prolonged febrile convulsions (those lasting 5 minutes or longer) or recurrent febrile convulsions without recovery must be treated actively (as for convulsive status epilepricus, section 4.8.2) Long-term anticonvulsant prophylaxis for febrile convulsions is rarely indicated.

04.09 - Drugs used in parkinsonism and related disorders

04.09.01 - Dopaminergic drugs used in Parkinson’s disease 1st co-beneldopa (levodopa with benserazide) Co-beneldopa 12.5mg/50mg capsules

Co-beneldopa 25mg/100mg capsules

Co-beneldopa 50mg/200mg capsules

Co-beneldopa 12.5mg/50mg dispersible tablets sugar free

Co-beneldopa 25mg/100mg dispersible tablets sugar free

Co-beneldopa 25mg/100mg modified-release capsules

1st co-careldopa (levodopa with carbidopa) Co-careldopa 12.5mg/50mg tablets

Co-careldopa 10mg/100mg tablets

Co-careldopa 25mg/100mg tablets

Co-careldopa 25mg/250mg tablets

Co-careldopa 25mg/100mg modified-release tablets

Co-careldopa 50mg/200mg modified-release tablets

2nd levodopa, carbidopa & entacapone (Stalevo) Stalevo 50mg/12.5mg/200mg tablets

Stalevo 75mg/18.75mg/200mg tablets

Stalevo 100mg/25mg/200mg tablets

Stalevo 125mg/31.25mg/200mg tablets

Stalevo 150mg/37.5mg/200mg tablets

S amantadine for prophylaxis of influenza Amantadine 100mg capsules

Amantadine 50mg/5ml oral solution sugar free

S apomorphine Apomorphine 20mg/2ml solution for injection ampoules

APO-go PFS 50mg/10ml solution for infusion pre-filled syringes

Apomorphine 50mg/5ml solution for injection ampoules

Apomorphine 30mg/3ml solution for injection pre-filled disposable devices

2nd entacapone Entacapone 200mg tablets

S pergolide Pergolide 50microgram tablets

Pergolide 250microgram tablets

Pergolide 1mg tablets

S pramipexole Pramipexole 1.05mg modified-release tablets

Pramipexole 1.57mg modified-release tablets

Pramipexole 2.1mg modified-release tablets

Pramipexole 2.62mg modified-release tablets

Pramipexole 260microgram modified-release tablets

Pramipexole 3.15mg modified-release tablets

Pramipexole 520microgram modified-release tablets

Pramipexole 88microgram tablets

Pramipexole 180microgram tablets

Pramipexole 350microgram tablets

Pramipexole 700microgram tablets

S rasagiline Rasagiline 1mg tablets

S ropinirole Ropinirole 250microgram tablets

Ropinirole 500microgram tablets

Ropinirole 1mg tablets

Ropinirole 2mg tablets

Ropinirole 5mg tablets

Ropinirole 2mg modified-release tablets

Ropinirole 4mg modified-release tablets

Ropinirole 8mg modified-release tablets

S rotigotine Rotigotine 2mg/24hours transdermal patches

Rotigotine 1mg/24hours transdermal patches

Rotigotine 3mg/24hours transdermal patches

Rotigotine 4mg/24hours transdermal patches

Rotigotine 6mg/24hours transdermal patches

Rotigotine 8mg/24hours transdermal patches

S selegiline Selegiline 5mg tablets

Selegiline 10mg/5ml oral solution

04.09.02 - Antimuscarinic drugs used in parkinsonism S trihexyphenidyl hydrochloride (benzhexol hydrochloride) Trihexyphenidyl 2mg tablets

Trihexyphenidyl 5mg tablets

Trihexyphenidyl 5mg/5ml oral solution

S procyclidine Procyclidine 5mg tablets

Procyclidine 10mg/2ml solution for injection ampoules

Procyclidine 5mg/5ml oral solution

S orphenadrine Orphenadrine 50mg tablets

Orphenadrine 25mg/5ml oral solution sugar free

04.09.03 - Drugs used in essential tremor, chorea, tics and related disorders S propranolol see section 2.4 S tetrabenazine Tetrabenazine 25mg tablets

S riluzole Riluzole 50mg tablets

Torsion dystonias and other involuntary movements H botulinum A toxin Botulinum toxin type A 100unit powder for solution for injection vials

Botulinum toxin type A 500unit powder for solution for injection vials

04.10 - Drugs used in substance dependence

04.10.01 - Alcohol dependence S acamprosate Acamprosate 333mg gastro-resistant tablets

S disulfiram Disulfiram 200mg tablets

04.10.02 - Nicotine dependence 1st nicotine replacement products See BNF/MIMS for products available 2nd bupropion (amfebutamone) Bupropion 150mg modified-release tablets

2nd varenicline Varenicline 500microgram tablets

Varenicline 1mg tablets

04.10.03 - Opioid dependence S methadone Methadone 1mg/ml oral solution

Methadone 10mg/ml oral solution sugar free

Methadone 20mg/ml oral solution sugar free

S buprenorphine Buprenorphine 400microgram sublingual tablets sugar free

Buprenorphine 2mg sublingual tablets sugar free

Buprenorphine 8mg sublingual tablets sugar free

S buprenorphine/naloxone Buprenorphine 2mg / Naloxone 500microgram sublingual tablets sugar free

Buprenorphine 8mg / Naloxone 2mg sublingual tablets sugar free

S lofexidine Only to be prescribed on the advice of a Substance Misuse Specialist Lofexidine 200microgram tablets

S naltrexone Naltrexone 50mg tablets

04.11 - Drugs for dementia H donepezil Donepezil 5mg tablets

Donepezil 10mg tablets

Donepezil 5mg orodispersible tablets sugar free

Donepezil 10mg orodispersible tablets sugar free

H rivastigmine Rivastigmine 1.5mg capsules

Rivastigmine 3mg capsules

Rivastigmine 4.5mg capsules

Rivastigmine 6mg capsules

Rivastigmine 2mg/ml oral solution sugar free

Rivastigmine 4.6mg/24hours transdermal patches

Rivastigmine 9.5mg/24hours transdermal patches

H galantamine Galantamine 8mg tablets

Galantamine 12mg tablets

Galantamine 8mg modified-release capsules

Galantamine 16mg modified-release capsules

Galantamine 24mg modified-release capsules

Galantamine 20mg/5ml oral solution sugar free

H memantine Memantine 10mg tablets

Memantine 20mg tablets

Memantine 10mg/ml oral solution sugar free

05 - Infections

05.01 - Antibacterial drugs

05.01.01 - Penicillins

05.01.01.01 - Benzylpenicillin and phenoxymethylpenicillin 1st benzylpenicillin (Penicillin G) Benzylpenicillin 600mg powder for solution for injection vials

Benzylpenicillin 1.2g powder for solution for injection vials

1st phenoxymethylpenicillin (Penicillin V) Phenoxymethylpenicillin 250mg tablets

Phenoxy methylpenicillin 125mg/5ml oral solution

Phenoxymethylpenicillin 250mg/5ml oral solution

05.01.01.02 - Penicillinase-resistant penicillins 1st flucloxacillin Flucloxacillin 250mg capsules

Flucloxacillin 500mg capsules

Flucloxacillin 125mg/5ml o ral suspension

Flucloxacillin 250mg/5ml oral suspension

Flucloxacillin 250mg powder for solution for injection vials

Flucloxacillin 500mg powder for solution for injection vials

Flucloxacillin 1g powder for solution for injection vials

05.01.01.03 - Broad-spectrum penicillins 1st amoxicillin (amoxycillin) Amoxicillin 250mg capsules

Amoxicillin 500mg capsules

Amoxicillin 125mg/5ml oral suspension

Amoxicillin 250mg/5ml oral suspension

Amoxicillin 3g oral powder sachets sugar free

Amoxi cillin 250mg powder for solution for injection vials

Amoxicillin 500mg powder for solution for injection vials

Amoxicillin 1g powder for solution for injection vials

2nd ampicillin only on microbiology advice/ paediatric use Ampicillin 125mg/5ml ora l suspension

Ampicillin 250mg/5ml oral suspension

Ampicillin 250mg capsules

Ampicillin 500mg capsules

Ampicillin 500mg powder for solution for injection vials

2nd co-amoxiclav Can be used first line for certain indications. Please refer to the HDHB Antibiotic Guidelines for further information. Co-amoxiclav 250mg/125mg tablets

Co-amoxiclav 500mg/125mg tablets

Co-amoxiclav 250mg/125mg dispersible tablets sugar free

Co-amoxiclav 125mg/31mg/5ml oral suspension

Co-amoxiclav 250mg/62mg/5ml oral suspension

Co-amoxiclav 400mg/57mg/5ml oral suspension sugar free

Co-amoxiclav 500mg/100mg powder for solution for injection vials

Co-amoxiclav 1000mg/200mg powder for solution for injection vials

05.01.01.04 - Antipseudomonal penicillins H piperacillin with tazobactam Piperacillin 2g / Tazobactam 250mg powder for solution for injection vials

Piperacillin 4g / Tazobactam 500mg powder for solution for injection vials

05.01.01.05 - Mecillinams

05.01.02 - Cephalosporins, carbapenems and other beta-lactams

05.01.02.01 - Cephalosporins 1st Cefotaxime

Primary Care Guidelines recommend that cefotaxime can be given by GPs for the initial empiric treatment of meningitis if benzylpenicillin cannot be given. Cefotaxime 500mg powder for solution for injection vials

Cefotaxime 1g powder for solution for injection vials

Cefotaxime 2g powder for solution for injection vials

1st cefalexin (cephalexin) Cefalexin 250mg tablets

Cefalexin 500mg tablets

Cefalexin 125mg/5ml oral suspension

Cefalexin 250mg/5ml oral suspension

Cefalexin 500mg/5ml oral suspension

2nd cefixime Cefixime 200mg tablets

Cefixime 100mg/5ml oral suspension

H cefuroxime Cefuroxime 250mg powder for injection vials

Cefuroxime 750mg powder for injection vials

Cefuroxime 1.5g powder for injection vials

H cefotaxime Primary Care Guidelines recommend that cefotaxime can be given by GPs for the initial empiric treatment of meningitis if benzylpenicillin cannot be given. Cefotaxime 500mg powder for solution for injection vials

Cefotaxime 1g powder for solution for injection vials

Cefotaxime 2g powder for solution for injection vials

H ceftazidime Ceftazidime 500mg powder for solution for injection vials

Ceftazidime 1g powder for solution for injection vials

Ceftazidime 2g powder for solution for injection vials

Ceftazidime 3g powder for solution for injection vials

H ceftriaxone only on microbiology advice/ paediatric use Ceftriaxone 250mg powder for solution for injection vials

Ceftriaxone 1g powder for solution for injection vials

Ceftriaxone 2g powder for solution for injection vials

05.01.02.02 - Carbapenems On recommendation of Consultant microbiologist only H Ertapenem (To be used on microbiology advise only) Ertapenem 1g powder for solution for infusion vials

H Imipenem + Cilastatin Imipenem 500mg / Cilastatin 500mg powder for solution for infusion vials

H Meropenem Meronem 500mg powder for solution for injection vials

Meronem 1g powder for solution for injection vials

05.01.02.03 - Other Beta-Lactam Antibiotics

05.01.03 - Tetracyclines S Demeclocycline (See Section 6.5.2) 2nd oxytetracycline Oxytetracycline 250mg tablets

1st doxycycline Doxycycline 50mg capsules

Doxycycline 100mg capsules

2nd lymecycline Lymecycline 408mg capsules

H tigecycline only on microbiology advice - see MHRA warning Tigecycline 50mg powder for solution for infusion vials

05.01.04 - Aminoglycosides H gentamicin

Not recommended for use in cystic fibrosis Gentamicin 20mg/2ml solution for injection vials

Gentamicin 80mg/2ml solution for injection ampoules

H neomycin Neomycin 500mg tablets

S tobramycin only on microbiology advice Tobramycin 40mg/1ml solution for injection ampoules

Tobramycin 80mg/2ml solution for injection vials

Tobramycin 240mg/6ml solution for injection vials

H Palacos-R with gentamicin Palacos R -20 with Gentamicin cement 20.4g sachets

Palacos R -40 with Gentamicin cement 40.8g sachets

H Collatamp EG Gentamicin-impregnanted collagen sponge

H Amikacin only on microbiology advice Amikacin 100mg/2ml solution for injection vials

Amikacin 500mg/2ml solution for injection vials

05.01.05 - Macrolides 2nd erythromycin Erythromycin 250mg gastro -resistant tablets

Erythromycin ethyl succi nate 125mg/5ml oral suspension

Erythromycin ethyl succinate 250mg/5ml oral suspension

Erythromycin 1g powder for solution for infusion vials

1st clarithromycin Clarithromycin 250mg tablets

Clarithromycin 500mg tablets

Clarithromycin 250mg granules sachets

Clarithromycin 125mg/5ml oral suspension

Clarithromycin 250mg/5ml oral suspension

Clarithromycin 500mg powder for solution for infusion vials

1st azithromycin Azithromycin 250mg capsules

Azithromycin 200mg/5ml oral suspension

05.01.06 - Clindamycin 2nd clindamycin Clindamycin 75mg capsules

Clindamycin 150mg capsules

Clindamycin 75mg/5ml oral solution

Clindamycin 300mg/2ml solution for injection ampoules

Clindamycin 600mg/4ml solution for injection ampoules

05.01.07 - Some other antibacterials S Rifaximin (Xifaxanta) Rifaximin 200mg tablets

H chloramphenicol (only on microbiology advice) Chloramphenicol 250mg capsules

Chloramphenicol 1g powder for solution for injection vials

2nd sodium fusidate Sodium fusidate 250mg tablets

Sodium fusidate 250mg/5mL oral suspension

Sodium fusidate 500mg powder and solvent for solution for infusion vials

H linezolid (only on microbiology advice) Linezolid 600mg tablets

Linezolid 100mg/5ml oral suspension

Linezolid 60 0mg/300ml infusion bags

H daptomycin (only on microbiology advice) Daptomycin 350mg powder for solution for infusion vials

Daptomycin 500mg powder for solution for infusion vials

H vancomycin Vancomycin 125mg capsules

Vancomycin 250mg capsules

Vancomycin 500mg powder for solution for infusion vials

Vancomycin 1g powder for solution for infusion vials

H teicoplanin Teicoplanin 200mg powder and solvent for solution for injection vials

Teicoplanin 400mg powder and solvent for solution for injection vials

S colistin Colistimethate 2million unit powder for solution for injection vials

Colistimethate 1million unit powder for solution for injection vials

S fosfomycin (only on microbiology advice)

This is an unlicensed drug Fosfomycin 3g granules sachets

H pristinamycin (only on microbiology advice) This is an unlicensed drug Pristinamycin 500mg tablets

05.01.08 - Sulfonamides and trimethoprim 1st trimethoprim Trimethoprim 100mg tablets

Trimethoprim 200mg tablets

Trimethoprim 50mg/5ml oral suspension sugar free

S co-trimoxazole (only on microbiology advice or in PCP patients) Co-trimoxazole 40mg/200mg/5ml oral suspension sugar free

Co-trimoxazole 80mg/400mg/5ml oral suspension

Co-trimoxazole 80mg/400mg tablets

Co-trimoxazole 160mg/800mg tablets

Co-trimoxazole 80mg/400mg/5ml solution for infusion ampoules

S Sulfadiazine (only on microbiology advcie) Sulfadiazine 500mg tablets

Sulfadiazine 1g/4ml solution for injection ampoules

05.01.09 - Antituberculosis drugs S rifampicin Rifampicin 150mg capsules

Rifampicin 300mg capsules

Rifampicin 100mg/5ml oral suspension

Rifampicin 600mg powder and solvent for solution for infusion vials

S isoniazid Isoniazid 50mg tablets

Isoniazid 100mg tablets

Isoniazid 50mg/5ml oral solution

Isoniazid 50mg/2ml solution for injection ampoules

S rifampicin with isoniazid (Rifinah) Rifampicin 150mg / Isoniazid 100mg tablets

Rifampicin 300mg / Isoniazid 150mg tablets

S rifampicin with isoniazid and pyrazinamide (Rifater) Rifampicin 120mg + isoniazid 50mg + pyrazinamide 300mg tablets

S pyrazinamide Pyrazinamide 500mg tablets

S ethambutol Ethambutol 100mg tablets

Ethambutol 400mg tablets

S streptomycin Streptomycin 1g powder for solution for injection vials

05.01.10 - Antileprotic drugs S dapsone Dapsone 50mg tablets

Dapsone 100mg tablets

05.01.11 - Metronidazole and tinidazole 1st metronidazole Metronidazole 200mg tablets

Metronidazole 400mg tablets

Metronidazole 200mg/5ml oral suspension

Metronidazole 500mg suppositories

Metronidazole 1g suppositories

Metronidazole 100mg/20ml solution for infusion ampoules

Metronidazole 500mg/100ml infusion 100ml bags

05.01.12 - Quinolones 1st ciprofloxacin Ciprofloxacin 100mg tablets

Ciprofloxacin 250mg tablets

Ciprofloxacin 500mg tablets

Ciprofloxacin 750mg tablets

Ciprofloxacin 250mg/5ml oral suspension

Ciprofloxacin 100mg/50ml solution for infusion bottles

Ciprofloxacin 200mg/100ml solution for infusion bottles

Ciprofloxacin 400mg/200ml solution for infusion bottles

1st ofloxacin GUM use only Ofloxacin 200mg tablets

Ofloxacin 400mg tablets

S levofloxacin (only on microbiology advice or respiratory specialist) Levofloxacin 250mg tablets

Levofloxacin 500mg tablets

Levofloxacin 500mg/100ml solution for infusion vials

05.01.13 - Urinary-tract infections 1st nitrofurantoin Nitrofurantoin 50mg capsules

Nitrofurantoin 100mg capsules

Nitrofurantoin 100mg modified -release capsules

Nitrofurantoin 25mg/5ml oral su spension sugar free

05.02 - Antifungal drugs 1st Nystatin (See section 12.03.02 oraopharyngeal anti-infective drugs) 1st Miconazole (See section 12.03.02 oraopharyngeal anti-infective drugs)

05.02.01 - Triazole antifungals 1st fluconazole Flucon azole 50mg capsules

Fluconazole 150mg capsules

Fluconazole 200mg capsules

Fluconazole 50mg/5ml oral suspension

Fluconazole 200mg/5ml oral suspension

Fluconazole 50mg/25ml solution for infusion vials

Fluconazole 200mg/100ml solution for infusion vials

2nd itraconazole Itraconazole 100mg capsules

Itraconazole 250mg/25ml solution for infusion ampoules and diluent

Itraconazole 50mg/5ml oral suspension

S voriconazole (only on microbiology advice/haematology use) Voriconazole 50mg tablets

Voriconazole 200mg tablets

Voriconazole 200mg/5ml oral suspension

Voriconazole 200mg powder for solution for infusion vials

05.02.02 - Imidazole antifungals S ketoconazole Ketoconazole 200mg tablets

05.02.03 - Polyene antifungals H Amphotericin B (lipid formulation) (only on microbiology advice/Haematology use) AmBisome 50mg powder for solution for infusion vials

H amphotericin B (only on microbiology advice/Haematology use) Fungizone Intravenous 50mg powder for solution for infusion vial s

05.02.04 - Echinocandin antifungals H anidulafungin only on microbiology advice Anidulafungin 100mg powder for solution for infusion vials

H caspofungin only on microbiology advice/Haematology use Caspofungin 50mg powder for solution for infusion vials

Caspofungin 70mg powder for solution for infusion vials

05.02.05 - Other antifungals 1st griseofulvin Griseofulvin 125mg tablets

Griseofulvin 500mg tablets

1st terbinafine Terbinafine 250mg tablets

05.03 - Antiviral drugs

05.03.01 - HIV infection

Non -nucleoside reverse transcriptase inhibitors H Nevirapine Nevirapine 400mg modified -release tablets

H Rilpivirine (Edurant) Rilpivirine 25mg tablets

Nucleoside reverse transcriptase inhibitors H Emtricitabine + Rilpivirine + Tenofovir (Eviplera) Emtricitabine 200mg / Rilpivirine 25mg / Tenofovir 245 mg tablets

H tenofovir disoproxil with emtricitabine Truvada (DOH Rec) for PEP (Seek expert opinion on treatment regime) Emtricitabine 200mg / Tenofovir 245mg tablets

Proteas e inhibitors H Darunavir (Prezista)

800mg once daily, co-administered with low dose ritonovir H lopinavir with ritonavir Kaletra (Seek expert opinion on treatment regime) Lopinavir 133.3mg / Ritonavir 33.3mg capsules

Lopinavir 400mg/5ml / Ritonavir 100mg/5ml oral solution

05.03.02 - Herpesvirus infections

05.03.02.01 - Herpes simplex and varicella-zoster infection 1st aciclovir Aciclovir 200mg dispersible tablets

Aciclovir 200mg tablets

Aciclovir 400mg dispersible tablets

Aciclovir 400 mg tablets

Aciclovir 800mg dispersible tablets

Aciclovir 800mg tablets

Aciclovir 200mg/5ml oral suspension sugar free

Aciclovir 250mg powder for solution for infusion vials

Aciclovir 400mg/5ml oral suspension sugar free

Aciclovir 500mg powder f or solution for infusion vials

Aciclovir 1g/40ml solution for infusion vials

05.03.02.02 - Cytomegalovirus infection H Valganciclovir (To be used inline with AWMSG guidance) Valganciclovir 450mg tablets

Valganciclovir 50mg/ml oral solution sugar free

Valganciclovir 570mg/5ml oral solution

05.03.03 - Viral hepatitis Chronic Hepatitis B S Entecavir (Baraclude) Entecavir 1mg tablets

Entecavir 500microgram tablets

Entecavir 50micrograms/ml oral solution sugar free recommended as an option for use within NHS Wales for the treatment of chronic hepatitis B virus infection in adults with decompensated liver disease. Oral solution should only be used in circumstances where the tablet form is not a clinical option. Treatment should normally be initiated following dialogue with a specialist liver unit. AWMSG is of the opinion that entecavir (Baraclude®▼) is suitable for specialist only prescribing within NHS Wales for the above indication. H peginterferon alfa see below Chronic Hepatitis C H peginterferon alfa Peginterferon alfa -2a 135micrograms/0.5ml solution for injection pre-filled syringes

Peginterferon alfa -2a 180micrograms/0.5ml solution for injection pre-filled syringes

Peginterferon alfa -2b 50microgram powder and solvent for solution for injection pre-filled disposable devices

Peginterf eron alfa-2b 80microgram powder and solvent for solution for injection pre-filled disposable devices

Peginterferon alfa -2b 100microgram powder and solvent for solution for injection pre-filled disposable devices

Peginterferon alfa -2b 120microgram powder and solvent for solution for injection pre-filled disposable devices

Peginterferon alfa -2b 150microgram powder and solvent for solution for injection pre-filled disposable devices

H ribavirin (tribavirin) Ribavirin 6g powder for nebuliser solution v ials

Ribavirin 200mg capsules

05.03.03.01 - Chronic hepatitis B

05.03.03.02 - Chronic hepatitis C

05.03.04 - Influenza 2nd zanamivir (Relenza) follow national guidance Zanamivir 5mg inhalation powder blisters with device

2nd oseltamivir (Tamiflu) follow national guidance Oseltamivir 75mg capsules

Oseltamivir 30mg capsules

Tamiflu 12mg/ml oral suspension

05.03.05 - Respiratory syncytial virus H ribavirin (tribavirin) Ribavirin 6g powder for nebuliser solution vials

Ribavirin 200m g capsules

H palivizumab Palivizumab 50mg powder and solvent for solution for injection vials

Palivizumab 100mg powder and solvent for solution for injection vials

05.04 - Antiprotozoal drugs

05.04.01 - Antimalarials Order on advice by Consultant Microbiology S Dihydroartemisinin + piperaquine phosphate (Eurartesim)

05.04.02 - Amoebicides (Only on microbiology advice) 1st metronidazole See 5.1.11 for preparations

05.04.03 - Trichomonacides

05.04.04 - Antigiardial drugs

05.04.05 - Leishmaniacides

05.04.06 - Trypanocides

05.04.07 - Drugs for toxoplasmosis

05.04.08 - Drugs for pneumocystis pneumonia H co-trimoxazole See 5.1.8 for preparations H pentamidine Pentamidine 300mg powder for solution for injection vials

Pentam idine 300mg/5ml nebuliser liquid

H dapsone See 5.1.10 for preparations

05.05 - Anthelmintics

05.05.01 - Drugs for threadworms 1st mebendazole Mebendazole 100mg chewable tablets sugar free

Mebendazole 100mg/5ml oral suspension

1st piperazine with sennosides (Pripsen) Piperazine 4g / Senna 15.3mg oral powder sachets sugar free

05.05.02 - Ascaricides

05.05.03 - Drugs for tapeworm infections

05.05.04 - Drugs for hookworms

05.05.05 - Schistosomicides

05.05.06 - Filaricides

05.05.07 - Drugs for cutaneous larva migrans

05.05.08 - Drugs for strongyloidiasis

06 - Endocrine system

06.01 - Drugs used in diabetes

06.01.01 - Insulins All insulin doses must be measured and administered using an insulin syringe or commercial insulin pen device

06.01.01.01 - Short-acting insulins soluble insulin - Human sequence S Human Actrapid S Humulin S Recombinant hu man insulin analogue S Insulin Lispro (Humalog) S Insulin Aspart (NovoRapid) S Insulin Glulisine (Apidra)

06.01.01.02 - Intermediate- and long-acting insulins

Non -biphasic Insulins Isophane insulin - Human sequence S Humulin I

Insulin detemir S Levemir Insulin glargine S Lantus

Biphasic Insulins Biphasic isophane insulin - Human sequence S Humulin M3 S Insuman Comb 25 Biphasic insulin aspart S Novomix 30 Biphasic insulin lispro S Humalog Mix25 S Humalog Mix50

06.01.01.03 - Hypodermic equipment All insulin doses must be measured and administered using an insulin syringe or commercial insulin pen device

06.01.02 - Antidiabetic drugs

06.01.02.01 - Sulfonylureas 1st gliclazide Gliclazide 40mg tablets

Gliclazide 80mg tablets

2nd gliclazide Gliclazide 30mg modified-release tablets

1st glibenclamide Glibenclamide 2.5mg tablets

Glibenclamide 5mg tablets

1st glimepiride Glimepiride 1mg tablets

Glimepiride 2mg tablets

Glimepiride 3mg tablets

Glimepiride 4mg tablets

06.01.02.02 - Biguanides 1st metformin Metformin 500mg tablets

Metformin 850mg tablets

2nd metformin sachets Metformin 500mg oral powder sachets sugar free

Metformin 1g oral powder sachets sugar free

2nd metformin modified release Metformin 500mg modified-release tablets

Metformin 1g modified -release tablets

06.01.02.03 - Other antidiabetic drugs 1st acarbose Acarbose 50mg tablets

Acarbose 100mg tablets

S exenatide Exenatide 2mg powder and solvent for suspension for injection via ls

Modified Release preparation - Patients changing from standard-release exenatide formulation may experience initial transient increase in blood glucose.

Exenatide 5micrograms/0.02ml solution for injection 1.2ml pre -filled disposable devices

Exe natide 10micrograms/0.04ml solution for injection 2.4ml pre-filled disposable devices

2nd pioglitazone Generic - approved for use for glycaemic control of Type 2 diabetes for all indications (December 2011). Pioglitazone 15mg tablets

Pioglitazone 30m g tablets

Pioglitazone 45mg tablets

2nd sitagliptin (Januvia) Sitagliptin 100mg tablets

2nd saxagliptin (Onglyza) Saxagliptin 5mg tablets

S nateglinide Nateglinide 60mg tablets

Nateglinide 120mg tablets

Nateglinide 180mg tablets

S liraglutide Liraglutide 6mg/ml solution for injection 3ml pre -filled disposable devices

06.01.03 - Diabetic ketoacidosis

06.01.04 - Treatment of hypoglycaemia 1st glucose Glucose 40% oral gel

1st glucagon Glucagon 1mg powder and solvent for solution for injection vials

06.01.05 - Treatment of diabetic nephropathy and neuropathy

06.01.06 - Diagnostic and monitoring devices for diabetes mellitus

06.02 - Thyroid and antithyroid drugs

06.02.01 - Thyroid hormones 1st levothyroxine sodium (thyroxine sodium) Levothyroxine sodium 25microgram tablets

Levothyroxine sodium 50microgram tablets

Levothyroxine sodium 100microgram tablets

S liothyronine sodium Liothyronine 20microgram tablets

Liothyronine 20microgram solution for injection ampou les

06.02.02 - Antithyroid drugs 2nd carbimazole Carbimazole 5mg tablets

Carbimazole 20mg tablets

S propylthiouracil Propylthiouracil 50mg tablets

S aqueous iodine Iodine aqueous oral solution

06.03 - Corticosteroids

06.03.01 - Replacement therapy S fludrocortisone acetate Fludrocortisone 100microgram tablets

06.03.02 - Glucocorticoid therapy 1st prednisolone Prednisolone 1mg tablets

Prednisolone 5mg tablets

Prednisolone 25mg tablets

Prednisolone 5mg soluble tablets

2nd prednisolone EC reserved for second line use when plain tablets are not tolerated Prednisolone 2.5mg gastro -resistant tablets

Prednisolone 5mg gastro -resistant tablets

2nd betamethasone Betamethasone 500microgram soluble tablets sugar free

Betameth asone 4mg/1ml solution for injection ampoules

1st dexamethasone Dexamethasone 500microgram tablets

Dexamethasone 2mg tablets

Dexamethasone 2mg/5ml oral solution sugar free

Dexamethasone 4mg/1ml solution for injection ampoules

Dexamethasone 8mg/2 ml solution for injection vials

1st hydrocortisone Hydrocortisone 10mg tablets

Hydrocortisone 20mg tablets

Hydrocortisone 24mg/mL injection

1st hydrocortisone sodium succinate Hydrocortisone sodium succinate 100mg powder and solvent for solution for injection vials

1st hydrocortisone sodium phosphate Hydrocortisone sodium phosphate 100mg/1ml solution for injection ampoules

H methylprednisolone (Sodium Succinate) Methylprednisolone sodium succinate 40mg powder and solvent for solution for inj ection vials

Methylprednisolone sodium succinate 125mg powder and solvent for solution for injection vials

Methylprednisolone sodium succinate 500mg powder and solvent for solution for injection vials

Methylprednisolone sodium succinate 1g powder and solvent for solution for injection vials

Methylprednisolone sodium succinate 2g powder and solvent for solution for injection vials

1st triamcinolone Triamcinolone acetonide 40mg/1ml suspension for injection vials

Triamcinolone acetonide 40mg/1ml suspension for injection pre-filled syringes

Triamcinolone acetonide 80mg/2ml suspension for injection pre-filled syringes

1st Methylprednisolone (Acetate)

Methylprednisolone acetate 40mg/1ml suspension for injection vials

06.04 - Sex hormones

06.04.01 - Female sex hormones

06.04.01.01 - Oestrogens and HRT Women with uterus 1. Sequential Combined (“Cyclical”) HRT 1st Climagest Climagest 1mg tablets

Climagest 2mg tablets

1st Prempak-C Prempak -C 0.625mg tablets

Prempak -C 1.25mg tablets

1st Nuvelle Estradiol valerate 2mg / Levonorgestrel 75microgram tablets

1st Femoston Estradiol 1mg / Dydrogesterone 10mg tablets

Estradiol 2mg / Dydrogesterone 10mg tablets

2nd Tridestra Tridestra tablets

2nd Trisequens Trisequens tablets

2nd Evorel Sequi patches Evorel Sequi patches

2nd FemSeven Sequi patches FemSeven Sequi patches

2nd Elleste Duet Elleste Duet 1mg tablets

Elleste Duet 2mg tablets

2. Continuous Combined (“Period-Free”) HRT 1st Femoston-conti Femoston -conti 1mg/5mg tablets

1st Premique Premique 0.625mg/5mg tablets

2nd Kliovance Kliovance tablets

2nd Kliofem Kliofem tablets

2nd Livial Tibolone 2.5mg tablets

2nd Evorel Conti patches Evorel Conti patches

2nd Elleste-Duet Conti Estradiol 2mg / Nore thisterone acetate 1mg tablets

2nd Nuvelle continuous Nuvelle Continuous tablets

Women without uterus 1st conjugated oestrogens Conjugated oestrogens 625microgram tablets

Conjugated oestrogens 1.25mg tablets

1st estradiol (oestradiol) Estradiol 1mg tablets

Estradiol 2mg tablets

2nd estradiol (oestradiol) patches and gel Estradiol 25micrograms/24hours transdermal patches

Estradiol 50micrograms/24hours transdermal patches

Estradiol 75micrograms/24hours transdermal patches

Estradiol 100m icrograms/24hours transdermal patches

Estradiol 0.06% gel

Estradiol 0.1% gel

H estradiol (oestradiol) implant Estradiol 25mg implant

Estradiol 50mg implant

Raloxifene 2nd raloxifene Raloxifene 60mg tablets

Tibolone 2nd tibolone Tibolone 2.5mg tablets

Ethinylestradiol S ethinylestradiol (ethinyloestradiol) Ethinylestradiol 2microgram tablets

Ethinylestradiol 10microgram tablets

Ethinylestradiol 50microgram tablets

Ethinylestradiol 1mg tablets

06.04.01.02 - Progestogens

Adjunct s to oestrogen for HRT 1st norethisterone Norethisterone 1mg tablets

Norethisterone 5mg tablets

1st dydrogesterone 1st medroxyprogesterone acetate Medroxyprogesterone 2.5mg tablets

Medroxyprogesterone 5mg tablets

Medroxyprogesterone 10mg tablet s

2nd progesterone Progesterone 200mg pessaries

Progesterone 400mg pessaries

Progesterone 25mg/1ml solution for injection ampoules

Progesterone 50mg/1ml solution for injection ampoules

Progesterone 100mg/2ml solution for injection ampoules

H progesterone (Crinone) gel Progesterone 8% vaginal gel 1.125g applicators

06.04.02 - Male sex hormones and antagonists 2nd dutasteride Dutasteride 500microgram capsules

S testosterone Testosterone 40mg capsules

Testosterone 50mg gel sachets

Testosterone 100mg implant

Testosterone 200mg implant

Testosterone enantate 250mg/1ml solution for injection ampoules

S finasteride Finasteride 5mg tablets

S flutamide Flutamide 250mg tablets

S cyproterone acetate Cyproterone 50mg tablets

06.04.03 - Anabolic steroids

06.05 - Hypothalamic and pituitary hormones and anti-oestrogens

06.05.01 - Hypothalamic and anterior pituitary hormones and anti-oestrogens

Anti -oestrogens S clomifene citrate (clomiphene citrate) Clomifene 50mg tablets

S tamoxifen (see section 8.3.4.1)

Corticotrophins H tetracosactide (tetracosactrin) Tetracosactide 250micrograms/1ml solution for injection ampoules

Tetracosactide 1mg/1ml suspension for injection ampoules

Gonadotrophins H chorionic gonadotrophin Chorionic gonadotrophin 2,000unit powder and solvent for solution for injection ampoules

Chorionic gonadotrophin 5,000unit powder and solvent for solution for injection ampoules

Chorionic gonadotrophin 10,000unit powder and solvent for solution for injection ampoules

H chorionic gonadotrophin alfa Ovitrelle 250micrograms/0.5ml solution for injection pre-filled syringes

H follitropin alfa Follitropin alfa 37.5unit powder and solvent for solution for injection ampoules

Follitropin alfa 75unit po wder and solvent for solution for injection ampoules

Follitropin alfa 150unit powder and solvent for solution for injection ampoules

Follitropin alfa 1,200unit multidose vial

H follitropin beta Follitropin beta 50units/0.5ml solution for injection v ials

Follitropin beta 100units/0.5ml solution for injection vials

Follitropin beta 150units/0.5ml solution for injection vials

Follitropin beta 200units/0.5ml solution for injection vials

Follitropin beta 300units/0.36ml solution for injection cart ridges

Follitropin beta 600units/0.72ml solution for injection cartridges

H human menopausal gonadotrophins Menotrophin 75unit powder and solvent for solution for injection vials

Growth hormone S somatropin Somatropin (rbe) 200microgram powder and solvent for solution for injection pre-filled disposable devices

Somatropin (rbe) 400microgram powder and solvent for solution for injection pre-filled disposable devices

Somatropin (rbe) 600microgram powder and solvent for solution for injection pre-filled disposable devices

Somatropin (epr) 5mg/1.5ml solution for injection cartridges

Somatropin (epr) 10mg/1.5ml solution for injection cartridges

Somatropin (epr) 15mg/1.5ml solution for injection cartridges

Somatropin (rbe) 6mg powder and solvent for solution for injection cartridges

Somatropin (rbe) 12mg powder and solvent for solution for injection pre-filled disposable devices

Somatropin (rbe) 24mg powder and solvent for solution for injection cartridges

Somatropin (rmc) 1.33mg powder and solvent for solution for injection vials

Somatropin (rmc) 3.33mg powder and solvent for solution for injection vials

Somatropin (rmc) 8mg powder and solvent for solution for injection vials

Hypothalamic hormones (for diagnostic purposes in hospita ls only) H gonadorelin Gonadorelin 100microgram powder and solvent for solution for injection vials

H protirelin Protirelin 200micrograms/2ml solution for injection ampoules

06.05.02 - Posterior pituitary hormones and antagonists

Posterior pituit ary hormones H terlipressin Terlipressin 1mg powder and solvent for solution for injection vials

S desmopressin Desmopressin 200microgram tablets

Desmopressin 60microgram oral lyophilisates sugar free

Desmopressin 120microgram oral lyophilisates s ugar free

Desmopressin 240microgram oral lyophilisates sugar free

Desmopressin 100micrograms/ml intranasal solution

Desmopressin 10micrograms/dose nasal spray

S vasopressin Pitressin 20units/1ml solution for injection ampoules

H desmopressin injection Desmopressin 4micrograms/1ml solution for injection ampoules

Desmopressin 15micrograms/1ml solution for injection ampoules

Antidiuretic hormone antagonists S demeclocycline Demeclocycline 150mg capsules

06.06 - Drugs affecting bone metabolism

06.06.01 - Calcitonin and parathyroid hormone S calcitonin (salcatonin) Calcitonin (salmon) 400units/2ml solution for injection vials

H teriparatide (Forsteo) Teriparatide 750micrograms/3ml solution for injection pre-filled disposable devices

06.06.02 - Bisphosphonates and other drugs affecting bone metabolism

Osteoporosis 1st alendronic acid - First choice Alendronic acid 10mg tablets

Alendronic acid 70mg tablets

2nd risedronate sodium - Second choice Risedronate sodium 5mg tablets

Risedronate sodium 35mg tablets

S ibandronic acid tablets (Bonviva) - Third choice Ibandronic acid 150mg tablets

H ibandronic acid injection (Bonviva) - Third choice Ibandronic acid 3mg/3ml solution for injection pre -filled syringes

S strontium ranelate (Protelos) - Fourth choice Strontium ranelate 2g granules sachets sugar free

H denosumab (Prolia) H zoledronic acid (Aclasta) - To be used in accordance to NICE CG Zoledronic acid 5mg/100ml infusion bottles

Paget's Disease S risedronate sodium Risedronate sodium 30mg tablets

H disodium pamidronate Disodium pamidronate 15mg powder for solution for infusion vials

Disodium pamidronate 30mg powder for solution for injection vials

Disodium pamidronate 60mg powder for solution for injecti on vials

Disodium pamidronate 90mg powder for solution for injection vials

H zoledronic acid (Aclasta®) Zoledronic acid 5mg/100ml infusion bottles

Malignancy S sodium clodronate Sodium clodronate 400mg capsules

Sodium clodronate 520mg tablets

Sodium clodronate 800mg tablets

Sodium clodronate 300mg/5ml solution for infusion ampoules

H disodium pamidronate Disodium pamidronate 15mg powder for solution for infusion vials

Disodium pamidronate 30mg powder for solution for injection vials

Di sodium pamidronate 90mg powder for solution for injection vials

H zoledronic acid (Zometa®) Zoledronic acid 4mg/5ml solution for infusion vials

H ibandronic acid Ibandronic acid 50mg tablets

Ibandronic acid 2mg/2ml solution for infusion ampoules

06.07 - Other endocrine drugs

06.07.01 - Bromocriptine and other dopaminergic drugs S bromocriptine S cabergoline Cabergoline 500microgram tablets

06.07.02 - Drugs affecting gonadotrophins 2nd danazol Danazol 100mg capsules

Danazol 200mg ca psules

Gonadorelin analogues S goserelin Goserelin 3.6mg implant pre-filled syringes

Goserelin 10.8mg implant pre-filled syringes

S leuprorelin acetate Leuprorelin 3.75mg powder and solvent for suspension for injection vials

Leuprorelin 11.25mg powder and solvent for suspension for injection vials

S buserelin Buserelin 150micrograms/dose nasal spray

Buserelin 5.5mg/5.5ml solution for injection vials

S triptorelin acetate Triptorelin acetate 3.75mg powder and solvent for suspension for injection pre-filled disposable devices

Triptorelin embonate 3mg powder and solvent for suspension for injection vials

Triptorelin embonate 11.25mg powder and solvent for suspension for injection vials

06.07.03 - Metyrapone and trilostane S metyrapone Metyrapone 250mg capsules

06.07.04 - Somatomedins

07 - Obstetrics, gynaecology and urinary-tract disorders

07.01 - Drugs used in obstetrics

07.01.01 - Prostaglandins and oxytocics H ergometrine Ergometrine 500micrograms/1ml solution for injection ampoules

H ergometrine with oxytocin Ergometrine 500micrograms/1ml / Oxytocin 5units/1ml solution for injection ampoules

H oxytocin Oxytocin 5units/1ml solution for injection ampoules

Oxytocin 10units/1ml solution for injection ampoules

H carboprost Carboprost 250micrograms/1ml solution for injection ampoules

H dinoprostone Dinoprostone 750micrograms/0.75ml solution f or infusion ampoules

Dinoprostone 5mg/0.5ml solution for infusion ampoules

Dinoprostone 3mg pessaries

Dinoprostone 5mg/0.5mL extra -amniotic solution

Dinoprostone 5mg removable pessaries

Dinoprostone 1mg/2.5ml vaginal gel

Dinoprostone 2mg/2.5ml vaginal gel

H gemeprost Gemeprost 1mg pessaries

H misoprostol Misoprostol 200microgram tablets

07.01.01.01 - Drugs affecting the ductus arteriosus

Maintenance of patency H dinoprostone Dinoprostone 750micrograms/0.75ml solution for infusion am poules

H alprostadil Closure of ductus arteriosus H indometacin (indomethacin) Indometacin 1mg powder for solution for injection vials

07.01.02 - Mifepristone H mifepristone See specialist Guidance Mifepristone 200mg tablets

07.01.03 - Myometrial relaxants S nifedipine Nifedipine 10mg capsules

Nifedipine 10mg modified -release tablets

Nifedipine 20mg modified -release tablets

S ritodrine Ritodrine 10mg tablets

Ritodrine 50mg/5ml solution for injection ampoules

S indometacin Indom etacin 100mg suppositories

Indometacin 25mg capsules

H atosiban Atosiban 6.75mg/0.9ml solution for injection vials

Atosiban 37.5mg/5ml solution for infusion vials

07.02 - Treatment of vaginal and vulval conditions

07.02.01 - Preparations for vaginal and vulval changes Topical HRT 1st estradiol (oestradiol) Estradiol 25microgram pessaries

1st estriol (oestradiol) Estriol 0.1% cream

2nd estradiol (oestradiol) vaginal ring Estradiol 2mg vaginal ring

07.02.02 - Vaginal and vulval infections

Fungal infections 1st clotrimazole Clotrimazole 1% cream

Clotrimazole 10% vaginal cream

Clotrimazole 100mg pessaries

Clotrimazole 200mg pessaries

Clotrimazole 500mg pessaries

1st fluconazole Fluconazole 150mg capsules

1st miconazole Miconazole 2% cream

2nd clotrimazole and hydrocortisone Hydrocortisone 1% / Clotrimazole 1% cream

2nd miconazole and hydrocortisone Hydrocortisone 1% / Miconazole 2% cream

Hydrocortisone 1% / Miconazole 2% ointment

S itraconazole Itraconazole 1 00mg capsules

Itraconazole 50mg/5ml oral suspension

Other vaginal infections 1st metronidazole Metronidazole 400mg tablets

2nd metronidazole gel Metronidazole 0.75% gel

2nd clindamycin Clindamycin 2% vaginal cream

2nd povidone-iodine Povidon e-Iodine 200mg pessaries

Povidone -Iodine 10% vaginal cleansing solution

07.03 - Contraceptives

07.03.01 - Combined hormonal contraceptives See National Contraceptive Guidelines

07.03.02 - Progestogen-only contraceptives See National Contraceptive Guidelines

07.03.02.01 - Oral progestogen-only contraceptives

07.03.02.02 - Parenteral progestogen-only contraceptives 1st medroxyprogesterone acetate Medroxyprogesterone 150mg/1ml suspension for injection pre -filled syringes

1st etonogestrel Etonogestrel 68mg implant

07.03.02.03 - Intra-uterine progestogen-only device 1st levonorgestrel Levonorgestrel 20micrograms/24hours intrauterine device

07.03.03 - Spermicidal contraceptives

Spermicides 1st nonoxinol '9' Nonoxinol -9 2% gel

07.03.04 - Contraceptive devices

Intra -uterine devices 1st Multiload Cu375 1st Nova-T380 1st GyneFix GyneFix intrauterine contraceptive device

Contraceptive Caps 1st Type A Contraceptive pessary 1st Type B Contraceptive pessary 1st Type C Contraceptive pessary Contraceptive Diaphragms 1st Type A 1st Type B 1st Type C

07.03.05 - Emergency Contraception 1st levonorgestrel levonelle 1500 Levonorgestrel 1.5mg tablets

1st Ulipristal acetate EllaOne Ulipristal 30mg tablets

07.04 - Drugs for genito-urinary disorders

07.04.01 - Drugs for urinary retention

Alpha -blockers 2nd alfuzosin Alfuzosin 2.5mg tablets

Alfuzosin 5mg modified -release tablets

Alfuzosin 10mg modified -release tablets

2nd doxazosin (see section 2.5.4) 2nd indoramin Doralese Indoramin 20mg tablets

S tamsulosin Tamsulosin 400microgram modified-release capsules

S phenoxybenzamine Phenoxybenzamine 10mg capsules

Parasympathomimetics S distigmine bromide Distigmine bromide 5mg tablets

07.04.02 - Drugs for urinary frequency, enuresis and incontinence Urinary incontinence 2nd Trospium chloride 1st oxybutynin Oxybutynin 2.5mg tablets

Oxybutynin 3mg tablets

Oxybutynin 5mg tablets

Oxybutynin 2.5mg/5ml oral solution

2nd fesoterodine fumarate Fesoterodine 4mg modified-release tablets

Fesoterodine 8mg modified -release tablets

2nd tolterodine Tolterodine 1mg tablets

Tolterodine 2mg tablets

2nd trospium Trospium chloride 20mg tablets

Trospium chloride 60mg modified-release capsules

Regurin XL® – Added to the formulary for the symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in patients with overactive bladder.

2nd solifenacin Solifenacin 5mg tablets

Solifenacin 10mg tablets

H propantheline Propantheline bromide 15mg tablets

H duloxetine (Yentreve brand) Duloxetine 20mg gastro -resistant capsules

Duloxetine 40mg gastro -resistant capsules

Nocturnal enuresis S desmopressin Desmopressin 120microgram oral lyophilisates sug ar free

Desmopressin 240microgram oral lyophilisates sugar free

07.04.03 - Drugs used in urological pain

Alkalinisation of urine 1st potassium citrate Potassium citrate mixture

2nd sodium bicarbonate Sodium bicarbonate 500mg capsules

Sodium bicarbonate 1g capsules

Sodium bicarbonate 600mg tablets

Acidification of urine S ascorbic acid (see section 9.6.3)

07.04.04 - Bladder instillations and urological surgery Urological surgery H sodium chloride Sodium chloride 0.9% infusion 1litre bags

Sodium chloride 0.9% infusion 2litre bags

Sodium chloride 0.9% irrigation solution 3litre bags

H glycine Glycine 1.5% irrigation solution 2litre bottles

Maintenance of indwelling urinary catheters 1st chlorhexidine Chlorhexidine 0.02% 100ml sachet

1st sodium chloride Sodium chloride 0.9% infusion 100ml bags

2nd solution G Solution G citric acid 3.23% catheter maintenance solution

2nd solution R Solution R citric acid 6% catheter maintenance solution

Others H dimethyl sulfoxide (dimethyl sulphoxide) Dimethyl sulfoxide 50% solution for instillation

H dimethyl sulfoxide and hydrocortisone cocktail (dimethyl sulphoxide) H BCG Immunotherapeutic ImmuCyst 81mg powder for reconstitution for instillation vials

07.04.05 - Drugs for erectile dysfunction S alprostadil Alprostadil 5microgram powder and solvent for solution for injection vials

Alprostadil 10microgram powder and solvent for solution for injection vials

Alprostadil 20microgram powder and solvent for solution for inj ection cartridges

Alprostadil 40microgram powder and solvent for solution for injection cartridges

S papaverine Papaverine 30mg/2mL injection

Papaverine 60mg/1ml injection

Papaverine 60mg/2ml solution for injection vials

H sildenafil This has been approved for restricted use by Rheumatology Consultants, in line with the Health Board protocol for the treatment of Raynaud's phenomenon. "Off-label use" to be prescribed and supplied by secondary care. Sildenafil 25mg tablets

Sildenafil 50mg tablets

Sildenafil 100mg tablets

S tadalafil (Cialis) Tadalafil 2.5mg tablets

Tadalafil 5mg tablets

Tadalafil 10mg tablets

Tadalafil 20mg tablets

S vardenafil Vardenafil 5mg tablets

Vardenafil 10mg tablets

Vardenafil 20mg tablets

08 - Malignant disease and immunosuppression The National Institute for Health and Clinical Excellence (NICE) has produced guidance on the use of several agents and techniques relating to the treatment of malignant disease. Please see full details at www.nice.org.uk All drugs are for specialist initiation only. In many cases they will only be used or supplied from hospitals (H). Drugs which GPs may prescribe, following specialist initiation, are marked (S). Strengths and formulations have been omitted. Please refer to local policies for measurable doses of parenteral cytotoxics.

08.01 - Cytotoxic drugs

08.01.01 - Alkylating drugs H busulfan (busulphan) H carmustine H chlorambucil H cyclophosphamide H ifosfamide H lomustine H melphalan H chlormethine hydrochloride (mustine hydrochloride) H thiotepa H treosulfan Urothelial toxicity H Mesna

08.01.02 - Anthracyclines and other cytotoxic antibiotics H aclarubicin H bleomycin H dactinomycin (actinomycin D) H daunorubicin H doxorubicin H doxorubicin (pegylated liposomal) H epirubicin hydrochloride H idarubicin hydrochloride H mitomycin H mitoxantrone (mitozantrone)

08.01.03 - Antimetabolites H Azacitidine Azacitidine 100mg powder for suspension for injection vials

H capecitabine (Xeloda) H cladribine H cytarabine H clofarabine H fludarabine phosphate H fluorouracil H gemcitabine S mercaptopurine S methotrexate H nelarabine (Atriance) H pemetrexed H tioguanine (thioguanine) H tegafur with uracil Folinic acid rescue H calcium folinate (calcium leucovorin)

08.01.04 - Vinca alkaloids and etoposide H etoposide H vinblastine sulphate H vincristine sulphate H vindesine sulphate H vinorelbine H vinorelbine (oral)

08.01.05 - Other antineoplastic drugs H Everolimus (Afinitor) Everolimus 5mg tablets

Everolimus 10mg tablets

H asparaginase H amsacrine H bortezomib H carboplatin H cetuximab H cisplatin H crisantaspase H dacarbazine H docetaxel (Taxotere) H erlotinib H gefitinib H hydroxycarbamide (hydroxyurea) H imatinib (Glivec) H irinotecan hydrochloride H oxaliplatin H paclitaxel H paclitaxel albumin (Abraxane) monotherapy H pentostatin H porfimer sodium H procarbazine H sunitinib H temozolomide H topotecan H trabectedin H trastuzumab H tretinoin

08.02 - Drugs affecting the immune response Clinical Governance Note 1:

Care in prescribing / dispensing different brands of immunosuppressive medications to renal transplant recipients: risk of serious adverse drug events

Inadvertent, unintentional or unsupervised switching between different brands may lead to under or over immunosuppression, with the resultant risks of graft rejection or drug toxicity, respectively. In order to avoid these risks, and in line with MHRA advice: All prescriptions for immunosuppressive drugs should be prescribed by brand name, with the dose and dose frequency clearly stated. Pharmacists should always dispense the exact pharmaceutical form and strength, or brand and strength, of the immunosuppressive drug that has been prescribed. Pharmacists should contact the prescriber if the prescription detail is not clear, to ensure that the appropriate medicine is dispensed. Patients should be advised to take careful note of the name of their immunosuppressive medications. Patients should check with their doctor or pharmacist if they receive an unfamiliar medicine or if they have questions about the dose.

08.02.01 - Antiproliferative immunosuppressants S azathioprine H mycophenolate mofetil (CellCept) H mycophenolic acid (Myfortic)

08.02.02 - Corticosteroids and other immunosuppressants S prednisolone (see section 6.3.2) S ciclosporin (Neoral) Shared care protocol S tacrolimus (Prograf)

Tacrolimus must be prescribed and dispensed by brand for transplant patients - See letter from Cardiff Transplant Unit S sirolimus (Rapamune) H horse lymphoglobulin H rabbit thymoglobulin H basiliximab H daclizumab

08.02.03 - Anti-lymphocyte monoclonal antibodies H alemtuzumab MabCampath H rituximab MabThera

08.02.04 - Other immunomodulating drugs H Glatiramer H Interferon beta 1b H Interferon beta-1a H aldesleukin H interferon alfa H peginterferon H natalizumab H thalidomide H lenalidomide

08.03 - Sex hormones and hormone antagonists in malignant disease

08.03.01 - Oestrogens S Diethylstilbestrol (Stiboestrol) Diethylstilbestrol 1mg tablets

08.03.02 - Progestogens S medroxyprogesterone acetate S megestrol acetate

08.03.03 - Androgens

08.03.04 - Hormone antagonists

08.03.04.01 - Breast cancer S anastrozole S exemestane S fulvestrant Faslodex 250mg injection - Added in line with the South West Wales Breast Cancer guidelines and to be reviewed when NICE release their planned Technology Appraisal in January 2012. Only to be prescribed and administered in secondary care. S letrozole S tamoxifen

08.03.04.02 - Gonadorelin analogues and gonadotrophin-releasing hormone antagonists S Abiraterone (Zytiga) Abiraterone 250mg tablets

Recommended with prednisone or prednisolone for the treatment of metastatic castration resistant prostate cancer in adult men whose disease has progressed on or after a docetaxel-based chemotherapy regimen. This recommendation applies only in circumstances where the approved Wales Patient Scheme for access to medicines is utilised. AWMSG is of the opinion that abiraterone (Zytiga ®▼) is suitable for specialist only prescribing within NHS Wales for the above indication S bicalutamide S buserelin S cyproterone acetate S flutamide Flutamide 250mg tablets

S goserelin S leuprorelin acetate S triptorelin

08.03.04.03 - Somatostatin analogues S lanreotide S octreotide

09 - Nutrition and blood

09.01 - Anaemias and some other blood disorders

09.01.01 - Iron-deficiency anaemias

09.01.01.01 - Oral iron 1st Ferrous fumarate Ferrou s fumarate 210mg tablets

Ferrous fumarate 322mg tablets

2nd Ferrous sulphate Ferrous sulphate 200mg tablets

Liquid preparations 1st Ferrous fumarate Ferrous fumarate 140mg/5ml oral solution

1st Polysaccharide-iron complex Polysaccharide -iron complex 100mg/5ml oral solution sugar free

1st Sodium feredetate (Sodium iconedetate) Sodium feredetate 190mg/5ml oral solution sugar free

Iron and folic acid 1st Ferrous fumarate and Folic acid Ferrous fumarate 322mg / Folic acid 350microgram tablets

09.01.01.02 - Parenteral iron S iron sucrose Iron sucrose 100mg/5ml solution for injection ampoules

H iron dextran Iron dextran 100mg/2ml solution for injection ampoules

09.01.02 - Drugs used in megaloblastic anaemias 1st folic acid Folic a cid 400microgram tablets

Folic acid 5mg tablets

Folic acid 2.5mg/5ml oral solution

S hydroxocobalamin Hydroxocobalamin 1mg/1ml solution for injection ampoules

S folinic acid see section 8.1.3

09.01.03 - Drugs used in hypoplastic, haemolytic and renal anaemias

Erythropoetins S darbepoetin alfa (Aranesp) supplied by tertiary centre for managing ACKD Darbepoetin alfa 10micrograms/0.4ml solution for injection pre -filled syringes

Darbepoetin alfa 15micrograms/0.375ml solution for injection pre -filled syringes

Darbepoetin alfa 20micrograms/0.5ml solution for injection pre -filled syringes

Darbepoetin alfa 30micrograms/0.3ml solution for injection pre -filled syringes

Darbepoetin alfa 40micrograms/0.4ml solution for injection pre -filled syringes

Darbepoetin alfa 50micrograms/0.5ml solution for injection pre -filled syringes

Darbepoetin alfa 60micrograms/0.3ml solution for injection pre -filled syringes

Darbepoetin alfa 80micrograms/0.4ml solution for injection pre -filled syringes

Darbepoet in alfa 100micrograms/0.5ml solution for injection pre-filled syringes

Darbepoetin alfa 150micrograms/0.3ml solution for injection pre -filled syringes

S epoetin alfa (erythropoietin, Eprex) supplied by tertiary centre for managing ACKD Epoetin alfa 1, 000units/0.5ml solution for injection pre-filled syringes

Epoetin alfa 2,000units/0.5ml solution for injection pre -filled syringes

Epoetin alfa 3,000units/0.3ml solution for injection pre -filled syringes

Epoetin alfa 4,000units/0.4ml solution for inj ection pre-filled syringes

Epoetin alfa 5,000units/0.5ml solution for injection pre -filled syringes

Epoetin alfa 6,000units/0.6ml solution for injection pre -filled syringes

Epoetin alfa 7,000units/0.7ml solution for injection pre -filled syringes

Ep oetin alfa 8,000units/0.8ml solution for injection pre-filled syringes

Epoetin alfa 9,000units/0.9ml solution for injection pre -filled syringes

Epoetin alfa 10,000units/1ml solution for injection pre -filled syringes

S epoetin beta (NeoRecormon) supplied by tertiary centre for managing ACKD Epoetin beta 4,000units/0.4mL solution for injection pre -filled syringes

Epoetin beta 500units/0.3ml solution for injection pre -filled syringes

Epoetin beta 1,000units/0.3ml solution for injection pre -filled syringes

Epoetin beta 2,000units/0.3ml solution for injection pre -filled syringes

Epoetin beta 3,000units/0.3ml solution for injection pre -filled syringes

Epoetin beta 4,000units/0.3ml solution for injection pre -filled syringes

Epoetin beta 5,000unit s/0.3ml solution for injection pre-filled syringes

Epoetin beta 6,000units/0.3ml solution for injection pre -filled syringes

Epoetin beta 10,000units/0.3mL solution for injection pre -filled syringes

NeoRecormon 10,000unit powder and solvent for soluti on for injection cartridges

NeoRecormon 20,000unit powder and solvent for solution for injection cartridges

NeoRecormon 60,000unit powder and solvent for solution for injection cartridges

S epoetin theta (Eporatio) supplied by tertiary centre for managing ACKD H methoxy polyethylene glycol-epoetin beta (Mircera) Methoxy polyethylene glycol -epoetin beta 30micrograms/0.3ml solution for injection pre-filled syringes

Methoxy polyethylene glycol -epoetin beta 50micrograms/0.3ml solution for injection pre-filled syringes

Methoxy polyethylene glycol -epoetin beta 75micrograms/0.3ml solution for injection pre-filled syringes

Methoxy polyethylene glycol -epoetin beta 100micrograms/0.3ml solution for injection pre-filled syringes

Methoxy polyethylene glyc ol-epoetin beta 120micrograms/0.3ml solution for injection pre-filled syringes

Methoxy polyethylene glycol -epoetin beta 150micrograms/0.3ml solution for injection pre-filled syringes

Methoxy polyethylene glycol -epoetin beta 200micrograms/0.3ml solution for injection pre-filled syringes

Methoxy polyethylene glycol -epoetin beta 250micrograms/0.3ml solution for injection pre-filled syringes

Methoxy polyethylene glycol -epoetin beta 350micrograms/0.3ml solution for injection pre-filled syringes

Iron ov erload H deferasirox (Exjade) Deferasirox 125mg dispersible tablets sugar free

Deferasirox 250mg dispersible tablets sugar free

Deferasirox 500mg dispersible tablets sugar free

H desferrioxamine Desferrioxamine 500mg powder for solution for inject ion vials

Paroxysmal nocturnal haemoglobinuria H eculizumab (Soliris) Eculizumab 300mg/30ml solution for infusion vials

09.01.04 - Drugs used in platelet disorders

Primary (essential) thrombycythaemia S anagrelide Anagrelide 500microgram capsule s

09.01.05 - G6PD deficiency

09.01.06 - Drugs used in neutropenia H filgrastim Filgrastim 30million units/1ml solution for injection vials

Filgrastim 30million units/0.5ml solution for injection pre -filled syringes

Filgrastim 48million units/0 .8ml solution for injection pre-filled syringes

H lenograstim Lenograstim 13.4million unit powder and solvent for solution for injection vials

Lenograstim 33.6million unit powder and solvent for solution for injection vials

H pegfilgrastim Pegfilgr astim 6mg/0.6ml solution for injection pre-filled syringes

Pegfilgrastim 6mg/0.6ml solution for injection pre -filled disposable devices

09.01.07 - Drugs used to mobilise stem cells H plerixafor Plerixafor 24mg/1.2ml solution for injection vials

09.02 - Fluids and electrolytes

09.02.01 - Oral preparations for fluid and electrolyte imbalance

09.02.01.01 - Oral potassium 1st Sando-K Sando-K effervescent tablets

S potassium chloride Kay -Cee-L syrup

Potassium removal H calcium polystyrene sulphonate Calcium polystyrene sulphonate powder sugar free

09.02.01.02 - Oral sodium and water S sodium chloride Sodium chloride 300mg capsules

Sodium chloride 600mg modified-release tablets

Sodium chloride 30mmol/10mL oral liquid

Oral rehydration therapy 1st oral rehydration Dioralyte oral powder sachets plain

09.02.01.03 - Oral bicarbonate S sodium bicarbonate Sodium bicarbonate 500mg capsules

Sodium bicarbonate 1g capsules

Sodium bicarbonate 600mg tablets

09.02.02 - Parenteral preparations for fluid and electrolyte imbalance

Sodium chloride infusions/injections H sodium chloride 0.18% Sodium chloride 0.18% infusion 500ml polyethylene bottles

H sodium chloride 0.45% Sodium chloride 0.45% infusion 500ml bags

H sodium chloride 0.9% Sodium chloride 0.9% infusion 50ml bags

Sodium chloride 0.9% infusion 100ml bags

Sodium chloride 0.9% infusion 250ml bags

Sodium chloride 0.9% infusion 500ml bags

Sodium chloride 0.9% infusion 1litre bags

Sodium chloride 0.9% infusion 500ml polyethylene bottles

Sodium chloride 0.9% solution for injection 5ml ampoules

Sodium chloride 0.9% solution for injection 10ml ampoules

Sodium chloride 0.9% solution for injection 50ml ampoules

H sodium chloride 1.8% Sodium chloride 0.18% infusion 500ml polyethylene bottles

H sodium chloride 30mmol/10mL Sodium chloride 30mmol/10mL injection

H sodium chloride 5% Sodium chloride 5% infusion 500ml polyethylene bottles

Glucose infusions H glucose 5% Glucose 5% infusion 50ml bags

Glucose 5% infusion 100ml bags

Glucose 5% infusion 250ml bags

Glucose 5% infusion 500ml bags

Glucose 5% infusion 1litre bags

Glucose 5% infusion 500ml polyethylene bottles

H glucose 10% Glucose 10% infusion 500ml bags

Glucose 10% infusion 1litre bags

H glucose 20% Glucose 20% infusion 500ml bags

H glucose 25% Glucose 25% (25ml) injection

H glucose 40% Glucose 40% infusion 500ml bags

H glucose 50% Glucose 50% infusion 500ml bags

Glucose 50% solution for infusion 50ml ampoules

Glucose 50% solution for infusion 50ml pre-filled syringes

Mixed infusions H glucose and sodium chloride 2.5%/0.45% Sodium chloride 0.45% / Glucose 2.5% infusion 500ml bags

H glucose and sodium chloride 5%/0.45% Sodium chloride 0.45% / Glucose 5% infusion 500ml bags

H glucose and sodium chloride 10%/0.18% Sodium chloride 0.18% / Glucose 10% infusion 500ml bags

H glucose and sodium chloride 4%/0.18% Sodium chloride 0.18% / Glucose 4% infusion 500ml bags

Sodium chloride 0.18% / Glucose 4% infusion 1litre bags

H glucose 5% with paediatric electrolytes UHW formula H glucose 10% with paediatric electrolytes UHW formula H glucose 20% with paediatric electrolytes UHW formula H sodium lactate compound (Hartmann's) Sodium lactate compound infusion 500ml bags

Sodium lactate compound infusion 1litre bags

H sodium lactate compound (Hartmann's) half strength infusion Sodium lactate compound infusion 500ml bags

Sodium lactate compound infusion 1litre bags

H sodium chloride compound (Ringer's) Sodium chloride compound 500mL polyfusor

Potassium -containing infusions / injections H glucose 5% with potassium chloride 20mmol/l Potassium chloride 0.15% (potassium 20mmol/1litre) / Glucose 5% infusion 1litre bags

H glucose 5% with potassium chloride 27mmol/l Potassium chloride 0.2% (potassium 27mmol/1litre) / Glucose 5% infusion 1litre bags

H glucose 5% with potassium chloride 40mmol/l Potassium chloride 0.6% (potassium 40mmol/500ml) / Glucose 5% infusion 500ml bags

Potassium chloride 0.3% (pot assium 40mmol/1litre) / Glucose 5% infusion 1litre bags

H glucose 5% with potassium chloride 60mmol/l Potassium chloride 60mmol/1litre / Glucose 5% polyfusor

H glucose and sodium chloride 4%/0.18% with potassium chloride 20mmol/l Potassium chloride 0 .3% (potassium 20mmol/500ml) / Glucose 4% / Sodium chloride 0.18% infusion 500ml bags

Potassium chloride 0.15% (potassium 20mmol/1litre) / Glucose 4% / Sodium chloride 0.18% infusion 1litre bags

H glucose and sodium chloride 4%/0.18% with potassium chloride 27mmol/l Potassium chloride 0.2% (potassium 27mmol/1litre) / Glucose 4% / Sodium chloride 0.18% infusion 1litre bags

H glucose and sodium chloride 4%/0.18% with potassium chloride 40mmol/l Potassium chloride 0.3% (potassium 40mmol/1litre) / Gluco se 4% / Sodium chloride 0.18% infusion 1litre bags

H potassium chloride 15% (20mmol in 10mL) (see restrictions above and note 1) Potassium chloride 15% (potassium 20mmol/10ml) solution for infusion 10ml ampoules

H sodium chloride 0.9% with potassium chloride 20mmol/l Potassium chloride 0.15% (potassium 20mmol/1litre) / Sodium chloride 0.9% infusion 1litre bags

H sodium chloride 0.9% with potassium chloride 27mmol/l Potassium chloride 0.2% (potassium 27mmol/1litre) / Sodium chloride 0.9% infusion 1l itre bags

H sodium chloride 0.9% with potassium chloride 40mmol/l Potassium chloride 0.6% (potassium 40mmol/500ml) / Sodium chloride 0.9% infusion 500ml bags

Potassium chloride 0.3% (potassium 40mmol/1litre) / Sodium chloride 0.9% infusion 1litre bags

H sodium chloride 0.9% with potassium chloride 60mmol/l Potassium chloride 0.45% (potassium 60mmol/1litre) / Sodium chloride 0.9% infusion 1litre bags

Sodium lactate H sodium lactate (1/6 molar) Sodium lactate 9.25g/500ml infusion bags

Sodium bic arbonate infusions/injections H sodium bicarbonate 1.26% Sodium bicarbonate 1.26% infusion 500ml polyethylene bottles

H sodium bicarbonate 1.4% Sodium bicarbonate 1.4% infusion 500ml polyethylene bottles

H sodium bicarbonate 2.74% Sodium bicarbonate 2.74% infusion 500ml polyethylene bottles

H sodium bicarbonate 4.2% Sodium bicarbonate 4.2% infusion 500ml polyethylene bottles

H sodium bicarbonate 8.4% Sodium bicarbonate 8.4% (1mmol/ml) infusion 200ml polyethylene bottles

Sodium bicarbonate 8.4% (1mmol/ml) solution for injection 10ml pre-filled syringes

Sodium bicarbonate 8.4% (1mmol/ml) solution for injection 50ml pre-filled syringes

Sodium bicarbonate 8.4% (1mmol/ml) solution for injection 10ml ampoules

Sodium bicarbonate 8.4%/2ml (2mmol/2ml) solution for injection ampoules

Phosphate infusions H sodium phosphate 2.9%/ potassium hydrogen phosphate 0.259% Sodium phosphate 2.9%/500mL + potassium hydrogen phosphate 0.259%/500mL polyfusor

Water for injections H water for injections Water for injection 2ml ampoules

Water for injection 5ml ampoules

Water for injection 10ml ampoules

Water for injection 20ml ampoules

Water for injection 100ml vials

Water for infusion 500ml polyethylene bottles

09.02.02.01 - Electrolytes and water

09.02.02.02 - Plasma and plasma substitutes H dextran 70 in sodium chloride 0.9% Dextran '70' 6% / Sodium chloride 0.9% infusion 500ml bags

H gelatin (succinylated) 4% and sodium chloride 0.9% Gelatin 4% infusion 500ml bags

H polygeline Pol ygeline 17.5g/500ml solution for injection bottles

H pentastarch 10% in sodium chloride 0.9% Pentastarch 10% / Sodium chloride 0.9% infusion 500ml bags

H pentastarch 6% in sodium chloride 0.9% Pentastarch 6% / Sodium chloride 0.9% infusion 500ml bags

H albumin 5% for resuscitation H albumin 20% H hydroxyethyl starch 6% in sodium chloride 0.9% Tetrastarch 6% infusion 500ml bags

09.03 - Intravenous nutrition Seek guidance from local dietetic team

09.04 - Oral nutrition Seek guidance from local dietetic team

09.04.01 - Foods for special diets

09.04.02 - Enteral nutrition

09.05 - Minerals

09.05.01 - Calcium and magnesium

09.05.01.01 - Calcium supplements 1st Sandocal-400 Calcium lactate gluconate 930.8mg / Calcium carbonate 700mg effervescent tablets sugar free

1st Sandocal-1000 Calcium lactate gluconate 2.263g / Calcium carbonate 1.75g effervescent tablets sugar free

1st Adcal Calcium carbonate 600mg chewable tablets

1st Calcium-Sandoz Calcium-Sandoz syrup

H calcium chloride 10% Calcium chloride 10% solution for injection 10ml pre-filled syringes

H calcium gluconate 10% Calcium gluconate 10% solution for injection 10ml ampoules

09.05.01.02 - Hypercalcaemia and hypercalciuria S cinacalcet Cinacalcet 30mg tablets

Cinacalcet 60mg tablets

Cinacalcet 90mg tablets

09.05.01.03 - Magnesium S magnesium glycerophosphate Magnesium glycerophosphate (magnesium 97.2mg (4mmol)) tablets

H magnesium sulphate Magnesium sulphate 50% solution for injection 10ml pr e-filled syringes

09.05.02 - Phosphorus

09.05.02.01 - Phosphate supplements S Phosphate-Sandoz Sodium dihydrogen phosphate anhydrous 1.936g effervescent tablets

H phosphate Phosphate 50mmol/500mL infusion

09.05.02.02 - Phosphate-binding agents S aluminium hydroxide Aluminium hydroxide 475mg capsules

S calcium acetate Calcium acetate 1g tablets

S lanthanum Lanthanum carbonate 500mg chewable tablets sugar free

Lanthanum carbonate 750mg chewable tablets sugar free

Lanthanum carbonat e 1g chewable tablets sugar free

S sevelamer Sevelamer 403mg capsules

09.05.03 - Fluoride S sodium fluoride Sodium fluoride 2.2mg tablets

Sodium fluoride 2% mouthwash sugar free

09.05.04 - Zinc S zinc sulphate Zinc sulphate 220mg capsules

Zinc sulphate monohydrate 125mg effervescent tablets sugar free

09.05.05 - Selenium

09.06 - Vitamins

09.06.01 - Vitamin A 1st vitamins A & D Vitamins A and D capsules

09.06.02 - Vitamin B group 1st pyridoxine hydrochloride Pyridoxine 10 mg tablets

Pyridoxine 20mg tablets

Pyridoxine 50mg tablets

Pyridoxine 25mg/1ml solution for injection vials

1st vitamin B Compound Strong Vitamin B compound strong tablets

1st thiamine Thiamine 25mg tablets

Thiamine 50mg tablets

Thiamine 100mg tablets

H vitamins B and C Pabrinex Intramuscular High Potency solution for injection 5ml and 2ml ampoules

Pabrinex Intravenous High Potency solution for injection 5ml and 5ml ampoules

09.06.03 - Vitamin C 1st ascorbic acid Ascorbic acid 100 mg tablets

Ascorbic acid 200mg tablets

Ascorbic acid 500mg tablets

09.06.04 - Vitamin D S Calcichew D3 Forte

For chemocare patients only 1st Colecalciferol (Fultium D3) Colecalciferol 800unit capsules

1st calcium and ergocalciferol Calcium carbonate 400mg / Ergocalciferol 2.5microgram tablets

1st Calceos Calceos chewable tablets

1st Adcal-D3 Adcal -D3 Lemon chewable tablets

Adcal -D3 chewable tablets tutti frutti

Adcal D3 Caplets - Approved - for use in patients with swallowing difficulties with the chewable tablets. The caplets are a different strength to the original Adcal D3 tablets and this would need to be highlighted to prescribers 2nd Calfovit D3 Calfovit D3 oral powder sachets

2nd Kalcipos-D Forte Kalcipos -D 500mg/800unit chewable tablets

S alfacalcidol Alfacalcidol 250nanogram capsules

Alfacalcidol 1microgram capsules

Alfacalcidol 2micrograms/ml oral drops sugar free

S calciferol Ergocalcifer ol 1.25mg tablets

Ergocalciferol 250microgram tablets

Ergocalciferol 300,000units/1ml solution for injection ampoules

S calcitriol Calcitriol 250nanogram capsules

Calcitriol 1micrograms/1ml solution for injection ampoules

09.06.05 - Vitamin E S alpha tocopheryl acetate Alpha tocopheryl acetate 500mg/5ml oral suspension

Alpha tocopheryl acetate 100mg/2ml solution for injection ampoules

09.06.06 - Vitamin K 1st menadiol sodium phosphate Menadiol 10mg tablets

S phytomenadione Phytomen adione 1mg capsules

Phytomenadione 10mg/1ml solution for injection ampoules

Phytomenadione 2mg/0.2ml solution for injection ampoules

09.06.07 - Multivitamin preparations

Sanatogen A-Z Complete - See HDHB Adult Refeeding Guidelines Centrum - See HDHB Adult Refeeding Guidelines

1st vitamins BPC Vitamins capsules

1st Abidec Abidec Multivitamin drops

1st Dalivit Dalivit oral drops

Sanatogen A -Z Complete and Centrum can be prescribed inline with HDHB Adult Refeeding Guidelines 1st Forceval Forceval capsules

Forceval Junior capsules

1st Ketovite Ketovite tablets

Ketovite liquid

09.07 - Bitters and tonics

09.08 - Metabolic disorders

09.08.01 - Drugs used in metabolic disorders

Mucopolysaccharidosis I S sodium phenylbutyrate Sodium phenylbutyrate 500mg tablets

Sodium phenylbutyrate 1g/5ml solution for infusion ampoules

Sodium phenylbutyrate 2g/10ml solution for infusion ampoules

Sodium phenylbutyrate 940mg/g granules sugar free

09.08.02 - Acute porphyrias

10 - Musculoskeletal and joint diseases

10.01 - Drugs used in rheumatic diseases and gout

Approved for use by Orthopaedic Consultants, in line with the Health Board Viscosupplementation pathway. S sodium hyaluronate (Durolane) Restricted use for Orthopaedic consultants in line with HDHB Protocol S Hylan G-F 20 (Synvisc) Restricted use for Orthopaedic consultants in line with HDHB Protocol

10.01.01 - Non-steroidal anti-inflammatory drugs 1st ibuprofen low dose ≤1200mg/day Ibuprofen 200mg tablets

Ibuprofen 400mg tablets

Ibuprofen 600mg tablets

Ibuprofen 100mg/5ml oral suspension

Ibuprofen 800mg modified -release tablets

2nd ibuprofen doses >1200mg/day 2nd diclofenac sodium See MHRA warning Diclofenac sodium 25mg gastro -resistant tablets

Diclofenac sodium 50mg gastro -resistant tablets

Diclofenac 50mg dispersible tablets sugar free

Diclofenac sodium 100mg modified -release tablets

Diclofenac 75mg/3ml solution for injection ampoules

Diclofenac 12.5mg suppositories

Diclofenac 25mg suppositories

Diclofenac 50mg suppositories

Dicl ofenac 100mg suppositories

1st naproxen Naproxen 250mg gastro -resistant tablets

Naproxen 250mg tablets

Naproxen 500mg tablets

Naproxen 500mg gastro -resistant tablets

Naproxen 125mg/5ml oral suspension

Naproxen 500mg suppositories

2nd mefenamic acid Mefenamic acid 250mg capsules

Mefenamic acid 500mg tablets

Mefenamic acid 50mg/5ml oral suspension

2nd indometacin (indomethacin) Indometacin 25mg capsules

Indometacin 50mg capsules

Indometacin 75mg modified -release capsules

Indometacin 25mg modified -release capsules

Indometacin 50mg modified -release tablets

Indometacin 75mg modified -release tablets

Indometacin 25mg/5ml oral solution

Indometacin 100mg suppositories

2nd etodolac Etodolac 600mg modified -release tablets

2nd nabumetone Nabumetone 500mg tablets

2nd meloxicam Meloxicam 7.5mg tablets

Meloxicam 15mg tablets

Meloxicam 7.5mg suppositories

Meloxicam 15mg suppositories

2nd celecoxib Celecoxib 100mg capsules

Celecoxib 200mg capsules

2nd etoricoxib Etoricoxib 60mg tablets

Etoricoxib 90mg tablets

Etoricoxib 120mg tablets

S phenylbutazone Phenylbutazone 100mg tablets

S tenoxicam Tenoxicam 20mg powder and solvent for solution for injection vials

H diclofenac sodium (Dyloject) Diclofenac 75mg/2ml solution for injection vials

10.01.02 - Corticosteroids

10.01.02.01 - Systemic corticosteroids

10.01.02.02 - Local corticosteroid injections 1st methylprednisolone acetate Methylprednisolone a cetate 40mg/1ml suspension for injection vials

Methylprednisolone acetate 80mg/2ml suspension for injection vials

1st methylprednisolone acetate with lidocaine Methylprednisolone 40mg/1ml / Lidocaine 10mg/1ml (1%) suspension for injection vials

Methylprednisolone 80mg/2ml / Lidocaine 20mg/2ml (1%) suspension for injection vials

1st triamcinolone acetonide Triamcinolone acetonide 40mg/1ml suspension for injection vials

1st dexamethasone phosphate Dexamethasone 8mg/2ml solution for injection vials

10.01.03 - Drugs that suppress the rheumatic disease process Gold S sodium aurothiomalate Sodium aurothiomalate 10mg/0.5ml solution for injection ampoules

Sodium aurothiomalate 20mg/0.5ml solution for injection ampoules

Sodium aurothiomalate 50mg/0.5ml solution for injection ampoules

S auranofin Auranofin 3mg tablets

Penicillamine S penicillamine Penicillamine 125mg tablets

Penicillamine 250mg tablets

Antimalarials S hydroxychloroquine sulphate Hydroxychloroq uine 200mg tablets

Immunosuppressants S azathioprine (see section 8.2.1) Shared care Protocol S ciclosporin (cyclosporin) (see section 8.2.2) Shared care Protocol S methotrexate (see section 8.1.3) Shared care Protocol H cyclophosphamide (see section 8.1.1) S leflunomide Shared care Protocol Leflunomide 10mg tablets

Leflunomide 20mg tablets

Leflunomide 100mg tablets

H abatacept Abatacept 250mg powder for solution for infusion vials

H adalimumab Adalimumab 40mg/0.8ml solution for injection pre -filled syringes

Adalimumab 40mg/0.8ml solution for injection pre -filled disposable devices

H certolizumab pegol Certolizumab pegol 200mg/1ml solution for injection pre-filled syringes

H etanercept Etanercept 25mg powder and solvent for solution for injection vials

Etanercept 25mg/0.5ml solution for injection pre -filled syringes

Etanercept 50mg/1ml solution for injection pre -filled syringes

H golimumab Golimumab 50mg/0.5ml solution for injection pre-filled syringes

H infliximab Infliximab 100mg powder for solution for infusion vials

H rituximab Rituximab 100mg/10ml solution for infusion vials

Rituximab 500mg/50ml solution for infusion vials

H tocilizumab Tocilizumab 80mg/4ml solution for infusion vials

Tocilizumab 200mg/10ml solution for infusion vials

Sulfasalazine S sulfasalazine (sulphasalazine) Shared care Protocol Sulfasalazine 500mg gastro-resistant tablets

10.01.04 - Gout and cytotoxic-induced hyperuricaemia

Acute attacks of gout 1st NSAIDs (see 10.1.1 for choice) 2nd colchicine Colchicine 500microgram tablets

Long term control of gout 1st allopurinol Allopurinol 100mg tablets

Allopurinol 300mg tablets

2nd probenecid Probenecid 500mg tablets

S febuxostat Febuxostat 80mg tablets

Febuxostat 120mg tablets

Hyperuricaemia associated with cytotoxic drugs S allopurinol see previous page H rasburicase Rasburicase 1.5mg powder and solvent for solution for infusion vials

10.01.05 - Other drugs for rheumatic diseases

10.02 - Drugs used in neuromuscular disorders

10.02.01 - Drugs that enhance neuromuscular transmission S neostigmine Neostigmine 15mg tablets

Neostigmine 2.5mg/1ml solution for injection ampoules

S pyridostigmine bromide Pyridostigmine bromide 60mg tablets

S edrophonium chloride Edrophonium chloride 10mg/1ml solution for injection ampoules

10.02.02 - Skeletal muscle relaxants 1st diazepam (see section 4.1.2) 2nd baclofen Baclofen 10mg ta blets

Baclofen 5mg/5ml oral solution sugar free

S dantrolene sodium Dantrolene 25mg capsules

Dantrolene 100mg capsules

S tizanidine Tizanidine 2mg tablets

Tizanidine 4mg tablets

Nocturnal leg cramps 1st quinine sulphate Quinine sulphate 200mg tablets

Quinine sulphate 300mg tablets

10.03 - Drugs for the treatment of soft-tissue disorders and topical pain relief

10.03.01 - Enzymes S Collagenase clostridium histolyticum (Xiapex) Collagenase clostridium histolyticum 900microgram powder and solvent for solution for injection vials

Recommended as an option for restricted use within NHS Wales for the treatment of Dupuytren’s contracture in adult patients with a palpable cord.

It should be restricted for use as an alternative to fasciectomy in a subset of adult patients with a total of two or less affected joints per hand where percutaneous needle fasciotomy is not appropriate, using up to three injections per cord, with no more than six injections per patient.

AWMSG is of the opinion that it is not suitable for shared care within NHS Wales for the above indication. H hyaluronidase Hyaluronidase 1,500unit powder for solution for injection ampoules

10.03.02 - Rubefacients, topical NSAIDs, capsaicin and poultices Topical NSAIDs and counter-irritants H Capsaicin Capsaicin 179mg cutaneous patches

1st Algesal Algesal cream

1st ibuprofen Ibuprofen 5% gel

2nd Capsaicin (Axsain) Capsaicin 0.075% cream

11 - Eye

General Notes on Administration of Drugs To The Eye Ey e drops and eye ointments are administered into the pocket formed by gently pulling down the lower eyelid and keeping the eye closed for as long as possible after application, preferably 1-2 minutes. For eye drops, one drop is all that is needed as long as instillation is successful. When two different drops are required at the same time of day, the patient should leave an interval of 5 minutes to avoid dilution and overflow. Many eye preparations contain a preservative e.g. benzalkonium chloride. Those patients sensitive to preservative usually develop the allergy after chronic use. Single use and unpreserved eye drops should be reserved for patients with chronic known allergy to preservatives and/or for diagnostic purposes only. Specials may be supplied when the clinical need for an individual patient demands, given no commercial alternative. Specials do not have a product licence.

11.01 - Administration of drugs to the eye

11.02 - Control of microbial contamination

11.03 - Anti-infective eye preparations

11.03.01 - Antibacterials 1st chloramphenicol Chloramphenicol 0.5% eye drops

Chloramphenicol 1% eye ointment

Chloramphenicol 0.5% eye drops 0.5ml unit dose preservative free

2nd fusidic acid Fusidic acid 1% modified -release eye drops

Ocular antibacterials H ciprofloxacin Ciprofloxacin 0.3% eye drops

H gentamicin Gentamicin 0.3% ear/eye drops

Gentamicin 0.3% eye drops 0.5ml unit dose preservative free

Gentamicin 1.5% eye drops

H ofloxacin Exocin 0.3% eye drops

H propamidine isetionate Propamidine 0.1% eye drops

H polymyxin B sulphate Polyfax ophthalmic ointment

H chlortetracycline Chlortetracycline 1% eye ointment

11.03.02 - Antifungals

11.03.03 - Antivirals 1st aciclovir (acyclovir) Aciclovir 3% eye ointment

S ganciclovir (Virgan) Ganciclovir 0.15% eye gel

11.04 - Corticosteroids and other anti-inflammatory preparations

11.04.01 - Corticosteroids 1st prednisolone Prednisolone sodium phosphate 0.5% eye drops

Prednisolone sodium phosphate 0.5% eye drops 0.5ml unit dose preservative free

S prednisolone 1% Prednisolone acetate 1% eye drops

Prednisolone sodium phosphate 1% eye drops preservative free

S prednisolone with neomycin Prednisolone 0.5% / Neomycin 0.5% ear/eye drops

S dexamethasone Dexamethasone sodium phosphate 0.1% eye drops 0.5ml unit dose preservative free

S betamethasone sodium phosphate Betamethasone 0.1% ear/eye/nose drops

Betameth asone 0.1% eye ointment

S betamethasone with neomycin Betamethasone 0.1% / Neomycin 0.5% ear/eye/nose drops

Betamethasone 0.1%/Neomycin 0.5% eye ointment

S dexamethasone with hypromellose Maxidex 0.1% eye drops

S dexamethasone/ framycetin/gramicidin Sofradex ear/eye drops

S dexamethasone/neomycin/ polymixin B Maxitrol eye ointment

H fluorometholone Fluorometholone 0.1% eye drops

H loteprednol Loteprednol 0.5% eye drops

H rimexolone Rimexolone 1% eye drops

11.04.02 - Other anti-inflammatory preparations 1st sodium cromoglicate (sodium cromoglycate) Sodium cromoglicate 2% eye drops

S antazoline sulphate & xylometazoline (Otrivin-Antistin) Antazoline 0.5% / Xylometazoline 0.05% eye drops

1st lodoxamide Lodoxamide 0.1% eye drops

2nd olopatadine (Opatanol) Olopatadine 0.1% eye drops

11.05 - Mydriatics and cycloplegics

Antimuscarinics 1st tropicamide Tropicamide 0.5% eye drops 0.5ml unit dose preservative free

Tropicamide 1% eye drops 0.5ml unit dose preservative free

S cyclopentolate hydrochloride Cyclopentolate 0.5% eye drops

Cyclopentolate 1% eye drops

Cyclopentolate 0.5% eye drops 0.5ml unit dose preservative free

Cyclopentolate 1% eye drops 0.5ml unit dose preservative free

H atropine sulphate Atropine 1% eye drops

Atropine 1% eye ointment

Atropine 1% eye drops 0.5ml unit dose preservative free

Sympathomimetics H phenylephrine hydrochloride Phenylephrine 2.5% eye drops 0.5ml unit dose preservative free

Phenylephrine 10% eye drops 0.5ml unit dose preservative free

11.06 - Treatment of glaucoma

Miotics S pilocarpine Pilocarpine hydrochloride 1% eye drops

Pilocarpine hydrochloride 2% eye drops

Pilocarpine hydrochloride 4% eye drops

Pilocarpine nitrate 1% eye drops 0.5ml unit dose preservative free

Pilocarpine nitrate 4% eye drops 0.5ml unit dose preservative free

Pilocarpine hydrochloride 4% eye gel

Sympathomimetics S brimonidine tartrate Brimonidine 0.2% eye drops

S brimonidine tartrate with timolol Brimonidine 2mg/ml / Timolol 5mg/ml eye drops

Beta -blockers S betaxolol hydrochloride Betoptic 0.25% suspension eye drops

Betoptic 0.5% eye drops

Betoptic 0.25% eye drops suspension 0.25ml unit dose

S timolol maleate Timolol 0.25% eye drops

Timolol 0.25% eye gel

S carteolol hydrochloride Carteolol 1% eye drops

Carteolol 2% eye drops

S Levobunolol Levobunolol 0.5% eye drops

Carbonic anhydrase inhibitors and systemic drugs S brinzolamide Brinzolamide 10mg/ml eye drops

S dorzolamide Dorzolamide 2% eye drops

S acetazolamide modified-release capsules Acetazolamide 250mg modified -release capsules

H acetazolamide Acetazolamide 250mg tablets

Acetazolamide 500mg powder for solution for injection vials

Carbonic anhydrase inhibitors with timolol S brinzolamide with timolol (Azarga) Brinzolamide 10mg/ml / Timolol 5mg/ml eye drops

S dorzolamide with timolol (Cosopt) Dorzolamide 2% / Timolol 0.5% eye drops

S dorzolamide with timolol (Cosopt preservative-free) Dorzolamide 2% / Timolol 0.5% eye drops 0.2ml unit dose preservative free

Prostaglandin analogue S bimatoprost Bimatoprost 300micrograms/ml eye drops

S latanoprost Latanoprost 50micrograms/ml eye drops

S travoprost (Travatan) Travoprost 40micrograms/ml eye drops

Prostaglandin analogue with timolol S latanoprost with timolol maleate (Xalacom) Latanoprost 50micrograms/ml / Timolol 5mg/ml eye drops

S bimatoprost with timolol maleate (Ganfort) Bimatoprost 300micrograms/ml / Timolol 5mg/ml eye drops

S travoprost with timolol maleate (DuoTrav) Travoprost 40micrograms/ml / Timolol 5mg/ml eye drops

Others H mannitol Mannitol 100g/500ml infusion bags

11.07 - Local anaesthetics 1st oxybuprocaine hydrochloride Oxybuprocaine 0.4% eye drops 0.5ml unit dose preservative free

H proxymetacaine hydrochloride Proxymetacaine 0.5% eye drops 0.5ml unit dose preservative free

H tetracaine hydrochloride (amethocaine hydrochloride) Tetracaine 0.5% eye drops 0.5ml unit dose preservative free

Tetracaine 1% eye drops 0.5ml unit dose preservative free

H proxymetacaine and fluorescein Proxymetacaine 0.5% / Fluorescein 0.25% eye drops 0.5ml unit dose preservative free

11.08 - Miscellaneous ophthalmic preparations

11.08.01 - Tear deficiency, ocular lubricants and astringents 1st sodium chloride Sodium chloride 0.9% eye drops 0.5ml unit dose preservative free

Sodium chloride 0.9% solution

1st carbomers Carbomer '980' 0.2% eye drops

1st hypromellose Hypromellose 0.3% eye drops

S sodium hyaluronate (Hylo-Forte, Hylo-Tear) Added to the formulary for the treatment of dry eye conditions in patients intolerant of preservative containing preparations. To be prescribed as per the Health Board pathway for dry eye conditions. Sodium hyaluronate 0.1% eye drops preservative free

Hylo-Forte 0.2% eye drops

Hylo -Tear 0.1% eye drops

Sodium hyaluronate 0.2% eye drops

2nd carmellose sodium Carmellose 0.5% eye drops 0.4ml unit dose

Carmellose 1% eye drops 0.4ml unit dose

2nd carmellose sodium in glycerol Carmellose 0.5% eye drops

2nd liquid paraffin Liquid paraffin eye drops

2nd polyvinyl alcohol Polyvinyl alcohol 1.4% eye drops

Polyvinyl alcohol 1.4% eye drops 0.4ml unit dose preservative free

S hydroxyethylcellulose Artificial Tears Hydroxyethy lcellulose 0.44% single use eye drops

H acetylcysteine with hypromellose Ilube 5% eye drops

H balanced salt solution H BSS plus H povidone-iodine Povidone K25 5% eye drops 0.4ml unit dose preservative free

11.08.02 - Ocular diagnostic and peri-operative preparations and photodynamic treatment Ocular diagnostic preparations 1st fluorescein sodium Fluorescein 2% eye drops 0.5ml unit dose preservative free

Fluorescein 1mg ophthalmic strips

H rose bengal Rose bengal 1% eye drops 0.5ml unit dose preservative free

Ocular peri-operative drugs H acetylcholine Acetylcholine chloride 20mg powder and solvent for solution for intraocular irrigation vials

H apraclonidine Apraclonidine 1% eye drops 0.25ml unit dose preservative free

H betamethasone Betamethasone 4mg/1ml solution for injection ampoules

H diclofenac Diclofenac 0.1% eye drops 0.3ml unit dose preservative free

H flurbiprofen Flurbiprofen 0.03% eye drop s 0.4ml unit dose preservative free

S ketorolac Ketorolac 0.5% eye drops

1st sodium chloride Sodium chloride 0.9% infusion 500ml bags

Sodium chloride 0.9% solution for injection 10ml ampoules

H sodium hyaluronate Sodium hyaluronate 500micrograms/5mL syringe

Sodium hyaluronate 7.7mg/0.55mL syringe

Other preparations used in ophthalmology H Ranibizumab ( Lucentis ) H mydricaine H ciclosporin (cyclosporin)

11.09 - Contact lenses

11.10 Unit Dose (Preservative-Free) Eye Drops S chloramphenicol S prednisolone sodium phosphate S artificial tears H gentamicin H betaxolol H timolol The following unit dose eye drops should be available for SINGLE use in eye clinics, wards and theatres: 1st benoxinate 1st chloramphenicol 1st fluorescein 1st sodium chloride 1st tropicamide 1% H tetracaine amethocaine 1% H atropine H cyclopentolate 0.5%, 1% H lidocaine/fluorescein (lignocaine/fluorescein) H metipranolol H phenylephrine 2.5%, 10% H pilocarpine 1%, 4% H proxymetacaine H proxymetacaine + fluorescein H rose bengal

The following drugs should also be available for single use in OPDs 1st Viscotears 1st chloramphenicol H NSAID (Ocufen or Voltarol) H apraclonidine 1% H fluorets

12 - Ear, nose and oropharynx

12.01 - Drugs acting on the ear

12.01.01 - Otitis externa

Astringent preparations S aluminium acetate Aluminium acetate 8% ear drops

Anti -inflammatory preparations 1st betamethasone sodium phosphate Betamethasone 0.1% ear/eye/nose drops

With antibacterial 1st dexamethasone with neomycin Otomize ear spray

1st flumetasone with clioquinol (flumethasone with clioquinol) Flumetasone 0.02% / Clioquinol 1% ear drops

1st hydrocortisone with gentamicin (Gentisone-HC) Gentamicin 0.3% / Hydrocortisone acetate 1% ear drops

2nd betamethasone with neomycin Betamethasone 0.1% / Neomycin 0.5% ear/eye/nose drops

Anti -infective preparations 1st clotrimazole Clotrimazole 1% solution

1st gentamicin Gentamicin 0.3% ear/eye drops

1st chloramphenicol Chloramphenicol 5% ear drops

Chloramphenicol 10% ear drops

Other compound anti-infective preparations 1st hydrocortisone 1%, neomycin sulphate 3400 units, polymyxin B sulphate 10,000 units/mL Hydrocortisone 1.5% / Neomycin 0.5% ear/eye drops

1st dexamethasone 0.05%, framycetin sulphate 0.5%, gramicidin 0.005% Sofradex ear/eye drops

H triamcinolone acetonide 0.1%, gramicidin 0.025%, neomycin 0.25%, nystatin 100,000units/g Hospital only Tri-Adcortyl Otic ointment

12.01.02 - Otitis media

12.01.03 - Removal of ear wax 1st olive oil Olive oil ear drops

1st sodium bicarbonate Sodium bicarbonate 5% ear drops

2nd Cerumol Cerumol ear drops

12.02 - Drugs acting on the nose

12.02.01 - Drugs used in nasal allergy 1st beclometasone dipropionate Beclometasone 50micrograms/dose nasal spray

1st azelastine hydrochloride Azelastine 140micrograms/dose nasal spray

1st budesonide Budesonide 100micrograms/dose nasal spray

1st sodium cromoglicate (sodium cromoglycate) Sodium cromoglicate 4% nasal spray

2nd fluticasone furoate Fluticasone furoate 27.5micrograms/dose nasal spray

2nd mometasone furoate Mometasone 50micrograms/dose nasal spray

2nd betamethasone sodium phosphate Betamethasone 0.1% ear/eye/nose drops

12.02.02 - Topical nasal decongestants

Sympathomimetics 1st ephedrine hydrochloride Ephedrine 0.5% nasal drops

Ephedrine 1% nasal drops

1st xylometazoline hydrochloride Xylometazoline 0.1% nasal drops

Xylometazoline 0.05% nasal drops

1st sodium chloride Sodium chloride 0.9% nasal drops

1st steam inhalations

Antimuscarinic 1st ipratropium bromide Ipratropium bromide 21micrograms/dose nasal spray

12.02.03 - Nasal preparations for infection

Nasal staphylococci 1st chlorhexidine with neomycin Neomycin 0.5% / Chlorhexidine hydrochloride 0.1% cream

1st mupirocin Mupirocin 2% nasal ointment

Epistaxis 1st bismuth subnitrate & iodoform (BIPP) Bismuth subnitrate 20% / Iodoform 40% paste impregnated gauze dressing 1.25cm x 100cm

Bismuth subnitrate 20% / Iodoform 40% paste impregnated gauze dressing 2.5cm x 100cm

12.03 - Drugs acting on the oropharynx

12.03.01 - Drugs for oral ulceration and inflammation 1st triamcinolone acetonide Adcortyl in Orabase 0.1% oromucosal paste

1st hydrocortisone Hydrocortisone 2.5mg muco -adhesive buccal tablets sugar free

1st benzydamine hydrochloride Benzydamine 0.15% mouthwash sugar free

Benzydamine 0.15% oromucosal sp ray sugar free

1st chlorhexidine gluconate (see 12.3.4 for preparations) 2nd carmellose sodium Carmellose oral paste

2nd choline salicylate Choline salicylate 8.7% oromucosal gel sugar free

12.03.02 - Oropharyngeal anti-infective drugs 1st nystatin Nystatin 100,000units/ml oral suspension sugar free

Nystatin 100,000unit pastilles

1st miconazole Miconazole 20mg/g oromucosal gel sugar free

1st amphotericin Amphotericin B 100mg/ml oral suspension sugar free

Amphotericin B 10mg lozenges sugar free

12.03.03 - Lozenges and sprays 2nd chlorhexidine gluconate & chlorobutanol Eludril mouthwash

12.03.04 - Mouthwashes, gargles and dentifrices 1st chlorhexidine gluconate Chlorhexidine gluconate 0.2% mouthwash

Chlorhexidine 1% dental gel sugar free

Chlorhexidine 0.2% oral spray sugar free

2nd thymol Thymol mouthwash solution

Thymol tablets

2nd hydrogen peroxide Hydrogen peroxide 6% solution

2nd povidone-iodine Povidone -Iodine 1% mouthwash sugar free

12.03.05 - Treatment of dry mouth

Local treatment 1st Glandosane Saliva replacement oromucosal spray

1st Salivix Salivix pastilles

H glycerin and lemon Glycerin + lemon mouthwash

Glycerin + lemon sticks

Systemic treatment H pilocarpine hydrochloride Pilocarpine 5mg tablets

13 - Skin

13.01 - Management of skin conditions

13.01.01 - Vehicles

13.01.02 - Suitable quantities for prescribing

13.01.03 - Excipients and sensitisation

13.02 - Emollient and barrier preparations

13.02.01 - Emollients 2nd Balneum 2nd Balneum Plus 1st Doublebase 1st Hydromol 2nd Hydromol Intensive 1st Cetraben emollient 2nd Calmurid 2nd Oilatum 2nd Aqueous 2nd Dermol 200 2nd Emulsifying 2nd Dermol 500 H Kamillosan Maternity use only 1st white soft paraffin/liquid paraffin 50/50 2nd Aveeno 2nd Dermol 500 Lotion 2nd Diprobase cream + ointment 1st Epaderm Ointment only

13.02.01.01 - Emollient bath additives and shower preparations 2nd Dermol 2nd Oilatum Emollient 2nd Oilatum shower emollient 2nd Balneum Plus 2nd Dermol 600 Bath emollient 2nd Aveeno bath oil

13.02.02 - Barrier preparations 1st Zinc compound 1st Zinc and castor oil ointment 2nd Metanium ointment 2nd Sprilon 2nd Sudocrem S Cavilon

13.03 - Topical local anaesthetics and antipruritics 1st Menthol 1% in Aqueous cream Menthol 1% in Aqueous cream

Menthol 2% in Aqueous cream

1st Crotamiton cream 10% S doxepin cream 5% (Xepin)

13.04 - Topical corticosteroids

MILD 1st hydrocortisone Hydrocortisone 0.5% cream

Hydrocortisone 1% cream

Hydrocortisone 0.5% ointment

Hydrocortisone 1% ointment

Mild with antimicrobials 1st Canesten HC Hydrocortisone 1% / Clotrimazole 1% cream

1st Daktacort Hydrocortisone 1% / Miconazole 2% cream

Hydrocortisone 1% / Miconazole 2% ointment

1st Timodine Timodine cream

2nd Fucidin H Hydrocortisone acetate 1% / Sodium fusidate 2% ointment

MODERATELY POTENT 1st Eumovate clobetasone butyrate 0.05% Eumovate 0.05% cream

Eumovate 0.05% ointment

2nd Betnovate RD betamethasone 0.025% (as valerate) Betamethasone valerate 0.025% cream

Betamethasone valerate 0.025% ointment

1st Trimovate clobetasone butyrate 0.05%, oxytetracycline 3%, nystatin 100,000units/g Trimovate cream

POTENT 1st Betnovate betamethasone 0.1% (as valerate) Betamethasone valerate 0.1% cream

Betamethasone valerate 0.1% ointment

Betamethasone valerate 0.1% scalp application

1st Synalar fluocinolone acetonide 0.025% Fluocinolone 0.025% cream

Fluocinolone 0.025% ointment

Fluocinolone 0.025% gel

2nd Elocon mometasone furoate 0.1% Mometasone 0.1% cream

Mometasone 0.1% ointment

Mometasone 0.1% scalp lotion

2nd Cutivate fluticasone propionate 0.005% Fluticasone 0.05% cream

Fluticasone 0.005% ointment

2nd Locoid hydrocortisone butyrate 0.1% Hydrocortisone butyrate 0.1% cream

Hydrocortisone butyrate 0.1% ointment

Hydrocortisone butyrate 0.1% scalp lotion

S Haelan fludroxycortide/flurandrenolone 4micrograms/cm Fludroxycortide 4micrograms/square cm tape 7.5cm

Potent with salicylic acid 1st Diprosalic betamethasone with salicylic acid ointment 0.05%/3% Betameth asone dipropionate 0.05% / Salicylic acid 2% scalp application

Potent with antimicrobials 1st Betnovate-C betamethasone 0.1%, clioquinol 3% Betamethasone valerate 0.1% / Clioquinol 3% cream

Betamethasone valerate 0.1% / Clioquinol 3% ointment

1st Fucibet betamethasone 0.1%, fusidic acid 2% Betamethasone valerate 0.1% / Fusidic acid 2% cream

S Locoid C hydrocortisone butyrate with chlorquinaldol Locoid C cream

Locoid C ointment

VERY POTENT 2nd Dermovate clobetasol propionate 0.05% Clobetasol 0.05% scalp application

Clobetasol 0.05% ointment

Clobetasol 0.05% cream

2nd Dermovate-NN clobetasol propionate 0.05%, neomycin 0.5%, nystatin 100,000units/g Dermovate -NN cream

Dermovate -NN ointment

13.05 - Preparations for eczema and psoriasis

13.05.01 - Preparations for eczema

Oral retinoid for eczema H Alitretinoin Alitretinoin 10mg capsules

Alitretinoin 30mg capsules

13.05.02 - Preparations for psoriasis Topical preparations for psoriasis 1st Alphosyl HC 2nd Polytar 2nd Salicylic acid Salicylic acid 2% in White soft paraffin

H 8-Methoxypsoralen 1st Dovonex calcipotriol Calcipotriol 50micrograms/g cream

Calcipotriol 50micrograms/ml scalp solution

Calcipotriol 50micrograms/g ointment

1st Cocois coal tar soln 12%' salicylic acid 2%, precipitated sulphur 4% Cocois ointment

2nd Dithrocream dithranol Dithranol 0.1% cream

Dithranol 0.25% cream

Dithranol 0.5% cream

Dithranol 1% cream

Dithranol 2% cream

1st Silkis calcitriol Calcitriol 3micrograms/g ointment

2nd Exorex prepared coal tar Exorex 1% lotion

2nd Dovobet betamethasone 0.05%, calcipotriol 50micrograms/g Dovobet ointment

2nd Psorin dithranol 0.11%, coal tar 1%, salicylic acid 1.6% Dithranol 0.11%, coal tar 1%, salicylic acid 1.6% Ointment

Oral retinoids for psoriasis H acitretin Acitretin 10mg capsules

Acitretin 25mg capsules

Oral preparations for psoriasis H 5 methoxypsoralen 5-Methoxypsoralen 20mg tablets

H 8 methoxypsoralen 8-methoxypsoralen 10mg tablets

8-methoxypsoralen 1.2% bath additive

13.05.03 - Drugs affecting the immune response Mycophenolate mofetil (Cellcept) - see section 8.2.1 Hydroxychloroquine Sulphate - see section 10.1.3 S Azathioprine (See section 10.1.3) 2nd tacrolimus Tacrolimus 0.03% ointment

Tacrolimus 0.1% ointment

S ciclosporin (cyclosporin) S methotrexate

Cytokine modulators

13.06 - Acne and rosacea

13.06.01 - Topical preparations for acne

Benzoyl peroxide and azalaic acid 1st Differin 2nd Adapalene + Benzoyl peroxide Epiduo 0.1%/2.5% gel

1st PanOxyl PanOxyl 2.5 Aquagel

PanOxyl 5 Acnegel

PanOxyl 10 Aquagel

2nd Skinoren Azelaic acid 20% cream

Topical antibacterials 1st Zindaclin 1st Dalacin T clindamycin 1% Clindamycin 1% alcoholic solution

Clindamycin 1% aqueous lotion

1st Duac Once daily Benzoyl peroxide 5%, clindamycin 1% Benzoyl peroxide 5% / Clindamycin 1% gel

1st Stiemycin erythromycin 2% Erythromycin 2% solution

Topical retinoids and related preparations 1st tretinoin Tretinoin 0.025% cream

Tretinoin 0.025% gel

1st Isotrexin isotretinoin 0.05%, erythromycin 2% Isotretinoin 0.05% / Erythromycin 2% gel

13.06.02 - Oral preparations for acne

Hormone treatment for acne 1st Oxytetracycline 1st Doxycycline 1st Erythromycin stearate 1st cyproterone with ethinylestradiol (Co-cyprindiol) Dianette tablets

Oral retinoid for acne H isotretinoin Isotretinoin 5mg capsules

Isotretinoin 10mg capsules

Isotretinoin 20mg capsules

13.07 - Preparations for warts and calluses H Trichloroacetic Acid (TCA) 90% 1st Salicylic acid 2% ointment 1st Salicylic acid collodion 1st Salactol paint 1st Silver Nitrate Silver nitrate 75% caustic applicators

Silver nitrate 95% caustic applicators

1st Duofilm 1st Occlusal 1st Salatac Salicylic acid 12% / Lactic acid 4% gel

1st Verrugon 2nd Glutarol 2nd Formaldehyde Formaldehyde 0.75% gel

Genital warts 2nd Aldara imiquimod Imiquimod 5% cream 250mg sachets

S Podophyllin 25% in Compound benzoin Podophyllin 25% in Compound benzoin tincture

S Warticon fem Podophyllotoxin 0.5% solution

Podophyllotoxin 0.15% cream

13.08 - Sunscreens and camouflagers

13.08.01 - Sunscreen preparations H Dundee Sunscreen 1st Sunsense Ultra Sunsense ultra lotion SPF 60

2nd Uvistat Ultrablock Uvistat Ultrablock cream SPF 30

2nd RoC Total Sunblock RoC Sante Soleil sunblock cream SPF 25

2nd Uvistat lipscreen

Photodamage S Fluorouracil/Salicylic acid (Actikerall) Recommended as an option for use within NHS Wales for the topical treatment of slightly palable and/or moderately thick hyperkeratotic actinic keratosis (grade I/II) in immunocompetent adult patients

2nd diclofenac sodium For treatment of actinic keratoses only if Fluorouracil (Efudix) is not tolerated Diclofenac sodium 3% gel

1st fluorouracil First line treatment for actinic keratoses Fluorouracil 5% cream

S Imiquimod Alternative to Efudix cream for second line treatment of small superficial basal cell carcinoma and actinic keratoses. Imiquimod 5% cream 250mg sachets

13.08.02 - Camouflagers S Veil Cover S Veil Finishing Veil finishing powder translucent

S Covermark Cover S Covermark Finishing Covermark finishing powder

13.09 - Shampoos and other preparations for scalp and hair conditions 1st T/Gel 1st Selsun 2nd Etrivex 1st Capasal Capasal Therapeutic shampoo

1st Alphosyl 2 in 1 Alphosyl 2 in 1 shampoo

1st Nizoral 2% Ketoconazole 2% shampoo

1st Cocois Cocois scalp ointment

Cocois ointment

1st Synalar Fluocinolone 0.025% gel

2nd Coal tar with salicylic acid Coal tar 6% + salicylic acid 3% in Cetomacrogol cream

Hirsutism S Eflornithine Vaniqa 11.5% cream

13.10 - Anti-infective skin preparations

13.10.01 - Antibacterial preparations

13.10.01.01 - Antibacterial preparations only used topically 1st Flamazine silver sulfadiazine (silver sulphadiazine) Flamazine 1% cream

1st Polyfax polymyxin 10,000units, bacitracin zinc 500units/g Polyfax ointment

2nd Bactroban mupirocin Mupirocin 2% ointment

Mupirocin 2% cream

13.10.01.02 - Antibacterial preparations also used systemically 2nd Fucidin fusidic acid Fusidic acid 2% cream

For Rosacea 1st Metrogel metronidazole Metronidazole 0.75% gel

1st Rozex metronidazole Metronidazole 0.75% cream

For malodorous tumours and skin ulcers 2nd Metrotop metronidazole Metronidazole 0.8% gel

2nd Anabact metronidazole Metronidazole 0.75% gel

13.10.02 - Antifungal preparations 1st clotrimazole Clotrimazole 1% solution

Clotrimazole 1% cream

Clotrimazole 1% spray

1st miconazole Miconazole 2% cream

1st ketoconazole Ketoconazole 2% cream

1st terbinafine Terbinafine 1% cream

13.10.03 - Antiviral preparations 1st aciclovir Aciclovir 5% cream

13.10.04 - Parasiticidal preparations

Head Lice Scabies 1st Derbac-M Malathion 0.5% aqueous liquid

1st Lyclear Permethrin 5% cream

13.10.05 - Preparations for minor cuts and abrasions 1st Savlon dry powder spray Povidone -Iodine 1.14% dry powder spray

S Proflavine cream

Preparations for boils 1st magnesium sulphate paste Collodion 1st Flexible Collodion BP Surgical tissue adhesive H Liquiband

13.11 - Skin cleansers, antiseptics and desloughing agents

13.11.01 - Alcohols and saline 1st Industrial Methylated Spirit , BP Industrial methylated spirit 70%

Industrial methylated spirit 95%

1st Surgical spirit , BP 1st Normasol (sodium chloride 0.9%) Sodium chloride 0.9% irrigation solution 25ml sachets

1st Skin prep 1st Sodium Chloride 0.9% Sodium chloride 0.9% infusion 1litre bags

1st Sodium Chloride 0.9% Steripod 0.9% Sodium chloride 0.9% irrigation solution 20ml unit dose

13.11.02 - Chlorhexidine salts 1st chlorhexidine Hibiscrub 4% solution

Chlorhexidine 0.5% gel

Chlorhexidine gluconate 1% cream

Chlorhexidine gluconate 4% solution

Chlorhexidine 0.5% spirit

Chlorhexidine gluconate 0.05% solution 25ml sachets

Chlorhexidine gluconate 0.05% solution 100ml sachets

H chlorhexidine (Chloraprep) Chlorhexidine gluconate 2% / Isopropyl alcohol 70% solution 0.67ml applicators

Chlorhexidine gluconate 2% / Isopropyl alcohol 70% solution 1.5ml applicators

Chlorhexidine gluconate 2% / Isopropyl alcohol 70% solution 3ml applicators

Chlorhexidine gluconate 2% / Isopropyl alcohol 70% solution 10.5ml applicators

Chlorhexidine gluconate 2% / Isopropyl alcohol 70% solution 26ml applicators

with cetrimide 2nd chlorhexidine with cetrimide Chlorhexidine gluconate 0.015% / Cetrimide 0.15% solution 25ml sachets

Chlorhexidine gluconate 0.015% / Cetrimide 0.15% solution 100ml sachets

concentrates 1st chlorhexidine gluconate Chlorhexidine gluconate 5% solution

Chlorhexidine gluconate 20% solution

13.11.03 - Cationic surfactants and soaps

13.11.04 - Iodine 1st sodium dichloroisocyanurate Sodium dichloroisocyanurate 50% granules

1st povidone-iodine Povidone -Iodine 10% alcoholic solution

Povidone -Iodine 10% antiseptic solution

Povidone -Iodine 7.5% surgical scrub solution

Povidone -Iodine 10% paint

Povidone -Iodine 4% skin cleanser solution

Povidone -Iodine 2.5% dry powder spray

Povidone -Iodine 10% ointment

13.11.05 - Phenolics 2nd Ster-Zac triclosan Ster-Zac 2% bath concentrate

13.11.06 - Oxidisers and dyes H Sodium Hypochlorite (Milton Fluid) 2% 1st potassium permanganate Potassium permanganate 0.1% solution

1st Permitabs S hydrogen peroxide 6% Hydrogen peroxide 6% solution

S hydrogen peroxide 3% Hydrogen peroxide 3% solution

S aluminium acetate Aluminium acetate lotion

S Crystal violet Crystal violet paint

13.11.07 - Desloughing agents

13.12 - Antiperspirants 1st Anhydrol Forte aluminium chloride hexahydrate 20% 2nd glycopyrronium bromide Glycopyrronium bromide 0.05% solution

1st Driclor aluminium chloride hexahydrate 20% 1st ZeaSORB aldioxa 0.22%, chloroxylenol 0.5%

13.13 - Topical circulatory preparations

13.14 - For DMD link only

14 - Immunological products and vaccines Advice in this chapter reflects that in the handbook Immunisation against Infectious Disease (2006), which in turn reflects the guidance of the Joint Committee on Vaccination and Immunisation (JCVI). The advice in this chapter also incorporates changes announced by the Chief Medical Officer and Health Department Updates.

Please contact your local hospital for information on supply of vaccines and immunoglobulins. For prescribing information please see:

BNF Chapter 14 and

Immunisation Against Infectious Diseases (DoH "Green book"):

DoH Green Book Part 1 Principles, practices and procedures Download Contents, preface and acknowledgements (PDF, 71K) Download Chapter 1 : Immunity and how vaccines work (PDF, 59K) Download Chapter 2 : Consent (PDF, 77K) Download Chapter 3 : Storage, distribution and disposal of vaccines (PDF, 79K) Download Chapter 4 : Immunisation procedures - updated 28 May 2010 (PDF, 113K) Download Chapter 5 : Immunisation by nurses and other health professionals (PDF, 60K) Download Chapter 6 : Contraindications and special considerations - updated 17 September 2008 (PDF, 315K) Download Chapter 7: Immunisation of individuals with underlying medical conditions - updated 7 May 2010 (PDF, 92K) Download Chapter 8 : Vaccine safety and adverse events following immunisation - updated 7 April 2009 (PDF, 475K) Download Chapter 9 : Surveillance and monitoring for vaccine safety (PDF, 78K) Download Chapter 10: Vaccine Damage Payment Scheme - updated 29 October 2008 (PDF, 46K) Download Chapter 11 : Immunisation schedule (PDF, 58K) Download Chapter 12 : Immunisation of healthcare and laboratory staff (PDF, 77K)

DoH Green Book Part 2 The diseases, vaccinations and vaccines Download Chapter 13 : Anthrax (PDF, 56K) Download Chapter 14 : Cholera - updated 19 September 2007 (PDF, 2015K) Download Chapter 15 : Diphtheria - updated 19 November 2009 (PDF, 134K) Download Chapter 16 : Haemophilus influenzae type (Hib) - updated 19 November 2009 (PDF, 132K) Download Chapter 17: Hepatitis A (file replaced 8 January 2009) (PDF, 148K) Download Chapter 18: Hepatitis B - updated 19 November 2009 (PDF, 693K) Download Chapter 18a Human papillomavirus (HPV) - updated 5 November 2008 (PDF, 120K) Download Chapter 19 : Influenza - file replaced 29 October 2009 (PDF, 179K) Download Chapter 20 : Japanese encephalitis - file replaced 4 March 2010 (PDF, 100K) Download Chapter 21 : Measles - file replaced 8 June 2010 (PDF, 212K) Download Chapter 22 : Meningococcal - file replaced 4 June 2010 (PDF, 383K) Download Chapter 23 : Mumps - file replaced 8 June 2010 (PDF, 234K) Download Chapter 23a: Pandemic influenza A(H1N1)v 2009 - updated 16 February 2010 (PDF, 159K) Download Chapter 24 : Pertussis - updated 19 November 2009 (PDF, 333K) Download Chapter 25: Pneumococcal - updated 6 April 2010 (PDF, 179K) Download Chapter 26 : Polio - updated 19 November 2009 (PDF, 144K) Download Chapter 27 : Rabies (PDF, 81K) Download Chapter 28 : Rubella - file replaced 8 June 2010 (PDF, 176K) Download Chapter 29 : Smallpox and vaccinia (PDF, 28K) Download Chapter 30 : Tetanus - updated 10 August 2009 (PDF, 144K) Download Chapter 31 : Tick-borne encephalitis (PDF, 47K) Download Chapter 32 : Tuberculosis - file replaced 4 June 2010 (PDF, 225K) Download Chapter 33 : Typhoid - updated 9 February 2009 (PDF, 93K) Download Chapter 34 : Varicella - file replaced 1 April 2010 (PDF, 155K) Download Chapter 35: Yellow fever (PDF, 482K)

NICE Guidance available

Anti-D (Rh o) immunoglobulin. Routine antenatal anti-D prophylaxis for women who are rhesus D negative - NICE TA156 August 2008. Replaces NICE TA41

14.01 - Active immunity

See current guidance from the Department of Health

14.02 - Passive immunity

See current guidance from the Department of Health

14.03 - Storage and use

14.04 - Vaccines and antisera

See current guidance from the Department of Health Active immunity vaccines See current guidance from the Department of Health

Passive immunity vaccines See current guidance from the Department of Health

Vaccines and antisera 1st Diphtheria + Tetanus + Pertussis + Poliomyelitis + Haemophilus influenzae type B vaccine 1st Diphtheria + Tetanus + Poliomyelitis vaccine 1st Diphtheria + Tetanus + Pertussis + Poliomyelitis vaccine 1st Haemophilus influenzae type b + Meningococcal group C vaccine 1st Hepatitis B vaccine 1st Meningococcal group C vaccine 1st Influenza vaccine 1st Human papillomavirus vaccine 1st Prevenar 1st Pneumovax II 1st Measles + Mumps + Rubella vaccine See current guidance from the Department of Health

14.05 - Immunoglobulins

14.05.01 - Normal Immunoglobulin H Normal immunoglobulin for IV Infusion Vigam Liquid 2.5g/50ml solution for infusion vials

Vigam Liquid 5g/100ml solution for infusion vials

Vigam Liquid 10g/200ml solution for infusion vials

H Normal immunoglobulin for IM use

14.05.02 - Disease-Specific immunoglobulins H Tetanus immunoglobulin H Hepatitis B immunoglobulin H Varicella immunoglobulin

14.05.03 - Anti-D (Rh0) Immunoglobulin

14.06 - International travel

15 - Anaesthesia

15.01 - General anaesthesia

15.01.01 - Intravenous anaesthetics

Barbiturates H thiopental (thiopentone) Thiopental 500mg powder for solution for injection vials

Thiopental 2.5g/100mL injection

Other intravenous anaesthetics H Ketamine Ketamine 1g/10ml solution for injection vials

Ketamine 500mg/10ml solution for injection vials

Ketamine 200mg/20ml solution for injection vials

Ketamine 50mg/5ml oral solution

For Neuropathic pain see section 4.7.3 H etomidate Etomidate 20mg/10ml solution for injection ampoules

H propofol Propofol 200mg/20ml emulsion for injection ampoules

Propofol 500mg/50ml emulsion for infusion vials

Propofol 1g/100ml emulsion for infusion vials

Propofol 1g/50ml emulsion for infusion vials

Propofol 500mg/50ml emulsion for infusion pre -filled syringes

Propofol 1g/50ml emulsion for infusion pre -filled syringes

15.01.02 - Inhalational anaesthetics

Volatile liquid anaesthetics H desflurane H halothane H isoflurane H sevoflurane Nitrous oxide H nitrous oxide H nitrous oxide 50% and oxygen 50% Nitrous oxide 50% / Oxygen 50%

15.01.03 - Antimuscarinic drugs H atropine Atropine 600micrograms/1ml solution for injection ampoules

Atropine 500micrograms/5ml solution for injection pre -filled syringes

Atropine 1mg/10ml solution for injection pre -filled syringes

Atropine 3mg/10ml solution for injection pre -filled syringes

Atropine 1mg/5ml solution for injection pre -filled syringes

Atropine 3mg/10ml solution for injection pre -filled syringes

H glycopyrronium bromide Glycopyrronium bromide 200micrograms/1ml solution for injection ampoules

Glycopyrronium bromide 600micrograms/3ml solution for injection ampoules

H hyoscine hydrobromide Hyoscine hydrobromide 400micrograms/1ml solution for injection ampoules

15.01.04 - Sedative and analgesic peri-operative drugs

15.01.04.01 - Benzodiazepines

Benzodiazepines H midazolam Midazolam 10mg/5ml solution for injection ampoules

Midazola m 10mg/2ml solution for injection ampoules

Midazolam 50mg/50ml solution for infusion vials

Midazolam 2.5mg/ml oral solution

1st diazepam (see section 4.1.2) 1st temazepam (see section 4.1.1) 1st lorazepam (see section 4.1.2)

15.01.04.02 - Non-opioid analgesics H ketorolac Ketorolac 10mg/1ml solution for injection ampoules

Ketorolac 30mg/1ml solution for injection ampoules

H parecoxib Parecoxib 40mg powder for solution for injection vials

15.01.04.03 - Opioid analgesics 1st morphine (see section 4.7.2) 2nd pethidine (see section 4.7.2) 2nd tramadol (see section 4.7.2) S buprenorphine (see section 4.7.2) S meptazinol (see section 4.7.2) H alfentanil Alfentanil 1mg/2ml solution for injection ampoules

Alfentanil 5mg/1ml solution for injection ampoules

H fentanyl Fentanyl 100micrograms/2ml solution for injection ampoules

Fentanyl 500micrograms/10ml solution for injection ampoules

H papaveretum Papaveretum 15.4mg/1ml solution for injection ampoule s

H remifentanil PCA for use in labour. Restricted use by Consultant Obstetric Anaesthetists. Secondary care use only. An audit of use needs to be undertaken. The policy will need to be drafted into the Hywel Dda Health Board policy format and indicated that use is unlicensed. To confirm that CEAC have approved as new procedure. Remifentanil 1mg powder for solution for injection vials

Remifentanil 2mg powder for solution for injection vials

Remifentanil 5mg powder for solution for injection vials

15.01.04.04 - Other drugs for sedation Dexmedetomidine (Dexdor) Injection Recommended as an option for use within NHS Wales for the sedation of adult intensive care unit (ICU) patients requiring a sedation level not deeper than arousal in response to verbal stimulation (corresponding to Richmond Agitation-Sedation Scale [RASS] 0 to -3). H Dexmedetomidine

15.01.05 - Neuromuscular blocking drugs Non -depolarising muscle relaxants H atracurium Atracurium besilate 25mg/2.5ml solution for injection ampoules

Atracurium besilate 50mg/5ml solution for injection ampoules

Atracurium besilate 250mg/25ml solution for injection ampoules

H mivacurium Mivacurium chloride 10mg/5ml solution for injection ampoules

Mivacurium chloride 20mg/10ml solution for injection ampoules

H pancuronium Pancuronium bromide 4mg/2ml solution for injection ampoules

H rocuronium Rocuronium bromide 50mg/5ml solution for injection vials

H vecuronium Vecuronium bromide 10mg powder and solvent for solution for injection vials

Depolarising muscle relaxants H suxamethonium Suxamethonium chloride 100mg/2ml solution for injection ampoules

15.01.06 - Drugs for reversal of neuromuscular blockade 1st edrophonium (see section 10.2.1) H neostigmine Neostigmine 2.5mg/1ml solutio n for injection ampoules

H glycopyrronium with neostigmine Neostigmine 2.5mg/1ml / Glycopyrronium bromide 500micrograms/1ml solution for injection ampoules

H physostigmine Physostigmine 2mg/1mL injection

Other drugs for reversal of neuromuscular blockade H sugammadex Sugammadex 200mg/2ml solution for injection vials

Sugammadex 500mg/5ml solution for injection vials

15.01.07 - Antagonists for central and respiratory depression 1st flumazenil Fluma zenil 500micrograms/5ml solution for injection ampoules

1st naloxone Naloxone 400micrograms/1ml solution for injection ampoules

Naloxone 40micrograms/2ml solution for injection ampoules

H doxapram Doxapram 100mg/5ml solution for injection ampoules

Doxapram 1g/500ml infusion bags

15.01.08 - Drugs for malignant hyperthermia H dantrolene sodium Dantrolene 20mg powder for solution for injection vials

15.02 - Local anaesthesia

Lidocaine/Lignocaine S lidocaine (lignocaine) Lidocaine 50mg/10 ml (0.5%) solution for injection ampoules

Lidocaine 100mg/10ml (1%) solution for injection pre -filled syringes

Lidocaine 20mg/2ml (1%) solution for injection ampoules

Lidocaine 50mg/5ml (1%) solution for injection ampoules

Lidocaine 100mg/10ml (1%) solution for injection ampoules

Lidocaine 200mg/20ml (1%) solution for injection ampoules

Lidocaine 100mg/5ml (2%) solution for injection pre-filled syringes

Lidocaine 40mg/2ml (2%) solution for injection ampoules

Lidocain e 100mg/5ml (2%) solution for injection ampoules

Lidocaine 400mg/20ml (2%) solution for injection ampoules

Lidocaine 4% solution

Lidocaine 10% spray sugar free

Lidocaine 5% ointment

Lidocaine 2% gel

Lidocaine 5% medicated plasters

S lidocaine with adrenaline (lignocaine with adrenaline) Lidocaine 11mg/2.2ml (0.5%) / Adrenaline 11micrograms/2.2ml (1 in 200,000) solution for injection prefilled syringe

Lidocaine 100mg/20ml (0.5%) / Adrenaline 100micrograms/20ml (1 in 200,000) solut ion for injection vials

Lidocaine 200mg/20ml (1%) / Adrenaline 100micrograms/20ml (1 in 200,000) solution for injection vials

Lidocaine 400mg/20ml (2%) / Adrenaline 100micrograms/20ml (1 in 200,000) solution for injection vials

Lidocaine 44mg/2.2ml ( 2%) / Adrenaline 27.5micrograms/2.2ml (1 in 80,000) solution for injection cartridges

S lidocaine with chlorhexidine (lignocaine with chlorhexidine) Lidocaine 2% and Chlorhexidine gel

S lidocaine with prilocaine (lignocaine with prilocaine) Lidocaine 2.5% / Prilocaine 2.5% cream

Bupivacaine H bupivacaine injection Bupivacaine 25mg/10ml (0.25%) solution for injection ampoules

Bupivacaine 50mg/10ml (0.5%) solution for injection ampoules

H bupivacaine sterile wrapped injection Bupivacaine 25mg/10ml (0.25%) solution for injection ampoules

Bupivacaine 50mg/10ml (0.5%) solution for injection ampoules

H bupivacaine infusion Bupivacaine 100mg/100ml (0.1%) solution for infusion bags

Bupivacaine 250mg/250ml (0.1%) solution for i nfusion bags

Bupivacaine 312.5mg/250ml (0.125%) solution for infusion bags

Bupivacaine 625mg/250mL (0.25%) solution for infusion bags

H bupivacaine with adrenaline Bupivacaine 25mg/10ml (0.25%) / Adrenaline 50micrograms/10ml (1 in 200,000) solution for injection ampoules

Bupivacaine 50mg/10ml (0.5%) / Adrenaline 50micrograms/10ml (1 in 200,000) solution for injection ampoules

H bupivacaine with glucose Bupivacai ne 20mg/4ml (0.5%) / Glucose 320mg/4ml solution for injection ampoules

Levobupivacaine H levobupivacaine Levobupivacaine 25mg/10ml solution for injection ampoules

Levobupivacaine 50mg/10ml solution for injection ampoules

Lidocaine/prilocaine H lidocaine/prilocaine Emla Lidocaine 2.5% / Prilocaine 2.5% cream

Prilocaine S prilocaine 4% Prilocaine 80mg/2ml solution for injection 2ml cartridges

S prilocaine with felypressin Prilocaine 60mg/2ml / Felypre ssin 0.06units/2ml solution for injection cartridges

H prilocaine Prilocaine 100mg/20mL (0.5%) injection

Prilocaine 250mg/50mL (0.5%) injection

Prilocaine 200mg/20ml solution for injection vials

Prilocaine 500mg/50ml solution for injection vials

H prilocaine hydrochloride hyperbaric 2% solution (Prilotekal®) Approved for use by Consultant Anaesthetists for patients requiring short-acting spinal anaesthesia in an ambulatory surgery setting, such as, a day surgery unit (December 2011). Tetracaine/amethocaine S tetracaine (amethocaine) Tetracaine 4% gel

Other local anaesthetics 1st alcohol, dehydrated S ethyl chloride Ethyl chloride spray

S cocaine Cocaine 10% paste

Cocaine 25% paste

Cocaine 5% topical solution

Cocaine 10% topical solution

Cocaine 5% nasal solution

S cocaine with adrenaline (epinephrine) Cocaine 10% with adrenaline 0.1% topical solution

S mepivacaine Mepivacaine 66mg/2.2ml solution for injection cartridges

H soda lime

A5 - Wound management Please refer to Hwyel Dda Woundcare Formulary and Lymphoedema Formulary

Downloaded 11 th December 2012