S-Nitrosoglutathione

Catalog Number N4148 Storage Temperature –20 °C

CAS RN 57564-91-7 Preparation Instructions Synonym: GSNO This product is soluble in water (20 mg/ml).

Product Description Storage/Stability Molecular Formula: C10H16N4O7S Store the product at –20 °C. Molecular Weight: 336.32 GSNO decomposes rapidly in solution to glutathione This product is a NO-generating compound in vivo, disulfide. The decomposition rate is ~5% per hour in smooth muscle relaxant and vasodilator, and it inhibits water at room temperature. platelet activation.1,2 It is also reported to be a substrate for g-glutamyl transpeptidase, which References hydrolyzes the g-glutamyl moiety of glutathione to give 1. Jansen, A. et al., The relaxant properties in guinea glutamate and cysteinylglycine. This enzyme catalyzes pig airways of S-nitrosothiols. J. Pharmacol. Exp. the decomposition of S-nitrosoglutathione to Ther., 261(1), 154-160 (1992). S-nitrosocysteinylglycine. The KM value for 2. Radomski, M.W. et al., S-nitroso-glutathione S-nitrosoglutathione is 28 mM.3 inhibits platelet activation in vitro and in vivo. Br. J. Pharmacol., 107(3), 745-749 (1992). Precautions and Disclaimer 3. Hogg, N. et al., S-Nitrosoglutathione as a This product is for R&D use only, not for drug, substrate for gamma-glutamyl transpeptidase. household, or other uses. Please consult the Safety Biochem. J., 323(Pt. 2), 477-481 (1997). Data Sheet for information regarding hazards and safe handling practices. RC,HLD,RXR,RGC,MAM 08/15-1

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