Practice Corner Suggested Resources American Society of Clinical Oncology. Understanding immunotherapy and side effects of immunotherapy. Retrieved from https://www.cancer.net/navigating-cancer-care Bartholomew, J., Washington, T., Bergeron, S., Nielson, D., Saggio, J., & Quirk, L. (2017). : A novel immunotherapy in the treatment of pediatric patients with high-risk . Journal of Pediatric Oncology Nursing, 34(1), 5–12. Kline, N. E. (2014). Essentials of pediatric hematology oncology nursing: A core curriculum. Chicago, IL: Association of Pediatric Hematology/Oncology Nurses.

COG Feature of the Quarter References Crompton, B. D., Goldsby, R. E., Weinburg, V. K., Feren, R., O’Donnell, R. J., & Albin, A. R. (2006). Survival after recurrence of osteosarcoma: A 20-year experience at a single institution. Pediatric Blood & Cancer, 47, 255–259. Isakoff, M. S., Bielack, S. S., Meltzer, P., & Gorlick, R. (2015). Osteosarcoma: Current treatment and a collaborative pathway to success. Journal of Clinical Oncology, 33(27), 3029–3035. Roth, M., Linkowski, M., Tarim, J., Piperdi, S., Sowers, R., Geller, D.,… & Gorlick, R. (2014). Ganglioside GD2 as a therapeutic target for antibody-mediated therapy in patients with osteosarcoma. Cancer, 120(4), 548–554.

APN Updates References Jabbour, E., O’Brien, S., Ravandi, F., & Kantarjian, H. (2015). Monoclonal antibodies in acute lymphoblastic leukemia. Blood, 125(26), 4010–4016. Kebriaei, P., Cutler, C., De Lima, M., Giralt, S., Lee, S. J., Marks, D., . . . Stelljes, M. (2018). Management of important adverse events associated with : Expert panel review. Bone Marrow Transplantation, 53(4). Marini, B. L., Benitez, L. L., Zureick, A. H., Salloum, R., Gauthier, A. C., Brown, J., . . . Koschmann, C. (2017). Blood-brain barrier-adapted precision medicine therapy for pediatric brain tumors. Translational Research, 188(27), e1–e14.

Suggested Resources Thota, S. & Advani, A. (2017). Inotuzumab ozogamicin in relapsed B-cell acute lymphoblastic leukemia. European Journal of Hematology, 95, 425–434. Von Stackelberg, A., Locatelli, F., Zugmaier, G., Handgretinger, R., Trippett, T.M., . . . Gore, L. (2016). Phase I/Phase II study of in pediatric patients with relapsed/refractory acute lymphoblastic leukemia. Journal of Clinical Oncology, 34(36), 4381–4389.

Chemotherapy/Biotherapy News References Anderson, J. A., Salazar-Abshire, M. S., & Herring, R. A. (in press). Biological therapies: Principles and agents. In Herring, R. A. (Ed.) The chemotherapy and biotherapy course curriculum (4th ed.). Chicago, IL: Association of Pediatric Hematology/Oncology Nurses. Yu, S., Li, A., Liu, Q., Yuan, X., Xu, H., Jiao, D., … , Wu, K. (2017). Recent advances of bispecific antibodies in solid tumors. Journal of Hematology & Oncology, 10, 1–16.

Evidence-Based Practice/Research References Gore, L., DeGregori, J. & Porter, C. (2013). Targeting developmental pathways in children with cancer: What price success? Lancet Oncology, 14, e70–78. National Cancer Institute. (2018). Targeted Cancer Therapies. Retrieved from https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted- therapies-fact-sheet Northcott, P. A., Pfister, S. M., & Jones, D. T. W. (2015). Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies. Lancet Oncology, 16, e293–e302. Ostrom, Q. T., Gittleman, H., Xu, J., Kromer, C., Wolinsky, Y., Kruchko, C., & Barnholtz- Sloan, J. S. (2016). CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2009–2013. Neuro-Oncology, 18(suppl 5), v1–v75. Ostrom, Q. T., Gittleman, H., Fulop, J., Liu, M., Blanda, R., Kromer, C.,…Barnholtz-Sloan, J. S. (2015). CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008–2012. Neuro-oncology, 17(4), iv1–iv62. Tihan, T., Ersen, A., Qaddoumi, I., Sughayer, M. A., Tolunay, S., Al-Hussaini, M.,…Baneerjee, A. (2012). Pathologic characteristics of pediatric intracranial pilocytic astrocytomas and their impact on outcome in 3 countries: A multi-institutional study. Am J Surg Pathol, 36(1), 43–55.

Treatment Innovations References Casucci, M. & Bondanza, A. (2011). Suicide gene therapy to increase the safety of chimeric receptor-redirected T lymphocytes. Journal of Cancer, 2, 378–382. Food and Drug Administration. (2017a). Yescarta package insert. Retrieved from https://www.fda.gov/downloads/UCM581226.pdf Food and Drug Administration. (2017b). Kymriah package insert. Retrieved from https://www.fda.gov/downloads/UCM573941.pdf Goodman, A. (January 25, 2018). Update on CAR T-Cell ‘breakthrough’ therapy in lymphoma. The ASCO Post. Retrieved from http://www.ascopost.com/issues/january-25-2018/update- on-car-t-cell-breakthrough-therapy-in-lymphoma Mullin, E. (January 3, 2018). 2017 Was the Year of Gene Breakthroughs. MIT Technology Review. Retrieved from https://www.technologyreview.com/s/609643/2017-was-the-year- of-gene-therapy-breakthroughs National Cancer Institute. (December 14, 2017). CAR T cells: Engineering patients’ immune cells to treat their cancers. Retrieved from https://www.cancer.gov/about- cancer/treatment/research/car-t-cells Nelson, R. (September 21, 2017). New guidelines for managing CAR T-cell acute toxicities. Retrieved from https://www.medscape.com/viewarticle/886005 Pulsipher, M. Personal communication, February 12, 2018. Zhang, E & Xu, H. (2017). A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy. Journal of Hematology & Oncology, 10(1), 1–11.

Local Chapter News Suggested Resources Dansereau, C. (2014). Biologic Response Modifiers. In N. E. Kline (Author), Essentials of Pediatric Hematology/Oncology Nursing: A Core Curriculum (4th ed., pp. 244-251). Glenview, IL: Association of Pediatric Hematology/Oncology Nurses. Ruccionne, K. (2011). The Biologic Basis of Cancer (G. Foley, D. Fochtman, & K. Kelly, Eds.). In C. Baggott (Author), Nursing Care of Children and Adolescents with Cancer and Blood Disorders (4th ed.). Glenview, IL: Association of Pediatric Hematology/Oncology Nurses. Targeted cancer therapies. (n.d.). National Cancer Institute Web site. Retrieved from www.cancer.gov/cancertopics/factsheet/Therapy/targeted. Accessed April 1, 2018.