BIOGRAPHICAL SKETCH Provide the Following Information for the Key Personnel in the Order Listed on Form Page 2
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[3 TD$DIFF]Interdisciplinary Team Science in Cell Biology
TICB 1268 No. of Pages 3 Scientific Life Cell biology, beginning largely as micro- detailed physical–chemical mechanisms Interdisciplinary[3_TD$IF] scopic observations, followed[1_TD$IF]the molec- [7]. The data required for these models ular biology revolution, which viewed are now in sight. New gene editing meth- Team Science in genes, cells, and the machinery that ods are providing endogenous expression underlies their activities as molecular sys- of tagged and mutant cells [8], and new Cell Biology tems that could be fully characterized and live-cell imaging methods are promising Rick Horwitz1,* understood using methods of genetics biochemistry in living cells, measuring con- and biochemistry. Viewing the cell as a centrations, dynamics, equilibria, and complex, dynamic molecular composite organization [9]. Similarly, super-resolution The cell is complex. With its multi- brought insights from chemistry and phys- microscopy and cryoEM tomography, tude of components, spatial– ics to bear on biological problems. Just as which allow structure determination and [6_TD$IF] temporal character, and gene the molecular genetic era was codified by organization in situ [3,4], imaging mass expression diversity, it is challeng- the publication of Watson's book, Molec- spectrometry [10], and single-cell and ing to comprehend the cell as an ular Biology of the Gene [1], two decades spatially-resolved genomic approaches integrated system and to develop later[8_TD$IF]the Molecular Biology of the Cell by [11–13], among other image-based tech- models that predict its behaviors. I Alberts, et al. [2] served a similar purpose nologies, all point to a new golden era of suggest an approach to address for cell biology. -
Genomic Divergence and Brain Evolution: How Regulatory DNA Influences Development of the Cerebral Cortex
Prospects & Overviews Review essays Genomic divergence and brain evolution: How regulatory DNA influences development of the cerebral cortex Debra L. Silver1)2)3)4) The cerebral cortex controls our most distinguishing higher Introduction cognitive functions. Human-specific gene expression dif- ferences are abundant in the cerebral cortex, yet we have A large six-layered neocortex is a unique feature of only begun to understand how these variations impact brain mammalian brains. This specialized outer covering of the brain controls our higher cognitive functions including function. This review discusses the current evidence linking abstract thought and language, which together help uniquely non-coding regulatory DNA changes, including enhancers, define us as humans. Our distinguishing cognitive capacities with neocortical evolution. Functional interrogation using are specified within discrete cortical areas and are driven by animal models reveals converging roles for our genome in dynamic communication between neurons of the neocortex key aspects of cortical development including progenitor and other brain regions, as well as glial cell populations (including oligodendrocytes, microglia, and astrocytes). cell cycle and neuronal signaling. New technologies, Neurons are initially generated during human embryonic includingiPS cells and organoids, offerpotential alternatives and early fetal development, where they migrate to appropri- to modeling evolutionary modifications in a relevant species ate regions and begin establishing functional connections context. Several diseases rooted in the cerebral cortex during fetal and postnatal stages (Fig. 1). Disruptions to uniquely manifest in humans compared to other primates, cerebral cortex function arising during either development or thus highlighting the importance of understanding human adulthood, can result in neurodevelopmental and neurode- generative disorders. -
MOLECULAR CLOCKS Definition Introduction
MOLECULAR CLOCKS 583 Kishino, H., Thorne, J. L., and Bruno, W. J., 2001. Performance of Thorne, J. L., Kishino, H., and Painter, I. S., 1998. Estimating the a divergence time estimation method under a probabilistic model rate of evolution of the rate of molecular evolution. Molecular of rate evolution. Molecular Biology and Evolution, 18,352–361. Biology and Evolution, 15, 1647–1657. Kodandaramaiah, U., 2011. Tectonic calibrations in molecular dat- Warnock, R. C. M., Yang, Z., Donoghue, P. C. J., 2012. Exploring ing. Current Zoology, 57,116–124. uncertainty in the calibration of the molecular clock. Biology Marshall, C. R., 1997. Confidence intervals on stratigraphic ranges Letters, 8, 156–159. with nonrandom distributions of fossil horizons. Paleobiology, Wilkinson, R. D., Steiper, M. E., Soligo, C., Martin, R. D., Yang, Z., 23, 165–173. and Tavaré, S., 2011. Dating primate divergences through an Müller, J., and Reisz, R. R., 2005. Four well-constrained calibration integrated analysis of palaeontological and molecular data. Sys- points from the vertebrate fossil record for molecular clock esti- tematic Biology, 60,16–31. mates. Bioessays, 27, 1069–1075. Yang, Z., and Rannala, B., 2006. Bayesian estimation of species Parham, J. F., Donoghue, P. C. J., Bell, C. J., et al., 2012. Best practices divergence times under a molecular clock using multiple fossil for justifying fossil calibrations. Systematic Biology, 61,346–359. calibrations with soft bounds. Molecular Biology and Evolution, Peters, S. E., 2005. Geologic constraints on the macroevolutionary 23, 212–226. history of marine animals. Proceedings of the National Academy Zuckerkandl, E., and Pauling, L., 1962. Molecular disease, evolution of Sciences, 102, 12326–12331. -
SCIENCE CITATION INDEX EXPANDED - JOURNAL LIST Total Journals: 8631
SCIENCE CITATION INDEX EXPANDED - JOURNAL LIST Total journals: 8631 1. 4OR-A QUARTERLY JOURNAL OF OPERATIONS RESEARCH 2. AAPG BULLETIN 3. AAPS JOURNAL 4. AAPS PHARMSCITECH 5. AATCC REVIEW 6. ABDOMINAL IMAGING 7. ABHANDLUNGEN AUS DEM MATHEMATISCHEN SEMINAR DER UNIVERSITAT HAMBURG 8. ABSTRACT AND APPLIED ANALYSIS 9. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 10. ACADEMIC EMERGENCY MEDICINE 11. ACADEMIC MEDICINE 12. ACADEMIC PEDIATRICS 13. ACADEMIC RADIOLOGY 14. ACCOUNTABILITY IN RESEARCH-POLICIES AND QUALITY ASSURANCE 15. ACCOUNTS OF CHEMICAL RESEARCH 16. ACCREDITATION AND QUALITY ASSURANCE 17. ACI MATERIALS JOURNAL 18. ACI STRUCTURAL JOURNAL 19. ACM COMPUTING SURVEYS 20. ACM JOURNAL ON EMERGING TECHNOLOGIES IN COMPUTING SYSTEMS 21. ACM SIGCOMM COMPUTER COMMUNICATION REVIEW 22. ACM SIGPLAN NOTICES 23. ACM TRANSACTIONS ON ALGORITHMS 24. ACM TRANSACTIONS ON APPLIED PERCEPTION 25. ACM TRANSACTIONS ON ARCHITECTURE AND CODE OPTIMIZATION 26. ACM TRANSACTIONS ON AUTONOMOUS AND ADAPTIVE SYSTEMS 27. ACM TRANSACTIONS ON COMPUTATIONAL LOGIC 28. ACM TRANSACTIONS ON COMPUTER SYSTEMS 29. ACM TRANSACTIONS ON COMPUTER-HUMAN INTERACTION 30. ACM TRANSACTIONS ON DATABASE SYSTEMS 31. ACM TRANSACTIONS ON DESIGN AUTOMATION OF ELECTRONIC SYSTEMS 32. ACM TRANSACTIONS ON EMBEDDED COMPUTING SYSTEMS 33. ACM TRANSACTIONS ON GRAPHICS 34. ACM TRANSACTIONS ON INFORMATION AND SYSTEM SECURITY 35. ACM TRANSACTIONS ON INFORMATION SYSTEMS 36. ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY 37. ACM TRANSACTIONS ON INTERNET TECHNOLOGY 38. ACM TRANSACTIONS ON KNOWLEDGE DISCOVERY FROM DATA 39. ACM TRANSACTIONS ON MATHEMATICAL SOFTWARE 40. ACM TRANSACTIONS ON MODELING AND COMPUTER SIMULATION 41. ACM TRANSACTIONS ON MULTIMEDIA COMPUTING COMMUNICATIONS AND APPLICATIONS 42. ACM TRANSACTIONS ON PROGRAMMING LANGUAGES AND SYSTEMS 43. ACM TRANSACTIONS ON RECONFIGURABLE TECHNOLOGY AND SYSTEMS 44. -
Biology & Biochemistry
Top Peer Reviewed Journals – Biology & Biochemistry Presented to Iowa State University Presented by Thomson Reuters Biology & Biochemistry The subject discipline for Biology & Biochemistry is made of 14 narrow subject categories from the Web of Science. The 14 categories that make up Biology & Biochemistry are: 1. Anatomy & Morphology 8. Cytology & Histology 2. Biochemical Research Methods 9. Endocrinology & Metabolism 3. Biochemistry & Molecular Biology 10. Evolutionary Biology 4. Biology 11. Medicine, Miscellaneous 5. Biology, Miscellaneous 12. Microscopy 6. Biophysics 13. Parasitology 7. Biotechnology & Applied Microbiology 14. Physiology The chart below provides an ordered view of the top peer reviewed journals within the 1st quartile for Biology & Biochemistry based on Impact Factors (IF), three year averages and their quartile ranking. Journal 2009 IF 2010 IF 2011 IF Average IF ANNUAL REVIEW OF BIOCHEMISTRY 29.87 29.74 34.31 31.31 PHYSIOLOGICAL REVIEWS 37.72 28.41 26.86 31.00 NATURE BIOTECHNOLOGY 29.49 31.09 23.26 27.95 CANCER CELL 25.28 26.92 26.56 26.25 ENDOCRINE REVIEWS 19.76 22.46 19.92 20.71 NATURE METHODS 16.87 20.72 19.27 18.95 ANNUAL REVIEW OF BIOPHYSICS AND 18.95 18.95 BIOMOLECULAR STRUCTURE ANNUAL REVIEW OF PHYSIOLOGY 18.17 16.1 20.82 18.36 Annual Review of Biophysics 19.3 17.52 13.57 16.80 Nature Chemical Biology 16.05 15.8 14.69 15.51 NATURE STRUCTURAL & MOLECULAR 12.27 13.68 12.71 12.89 BIOLOGY PLOS BIOLOGY 12.91 12.47 11.45 12.28 TRENDS IN BIOCHEMICAL SCIENCES 11.57 10.36 10.84 10.92 QUARTERLY REVIEWS OF BIOPHYSICS -
Conceptual Breakthroughs in Developmental Biology
Swarthmore College Works Biology Faculty Works Biology 9-1-1998 Conceptual Breakthroughs In Developmental Biology Scott F. Gilbert Swarthmore College, [email protected] Follow this and additional works at: https://works.swarthmore.edu/fac-biology Part of the Biology Commons Let us know how access to these works benefits ouy Recommended Citation Scott F. Gilbert. (1998). "Conceptual Breakthroughs In Developmental Biology". Journal Of Biosciences. Volume 23, Issue 3. 169-176. DOI: 10.1007/BF02720017 https://works.swarthmore.edu/fac-biology/189 This work is brought to you for free by Swarthmore College Libraries' Works. It has been accepted for inclusion in Biology Faculty Works by an authorized administrator of Works. For more information, please contact [email protected]. SCOTT F GILBERT Department of Biology, Martin Laboratories of Biology, Swarthmore College, Swarthmore, PA 19081, USA (Fax, +610-328-8663; Email, [email protected]) I 1. Developmental biologists can indeed explain Introduction development Revising a textbook is a fascinating exercise that allows Fifteen years ago, embryology was what could be char- one to see quite starkly the changes that have occurred acterized as the only field of science that celebrated its in one's discipline through the subsequent editions. As questions more than its answers. We had the greatest I revise a textbook that was originally published in 1985, problems one could imagine: How does the brain develop? I can see the numerous advances that have transformed How do the eyes form? How does our back develop the discipline of developmental biology. But even more differently than our front? How are the arteries and veins important and much rarer than the advances are the true connected to the heart? But we had very few answers. -
Microbiota Interactions: a Need for New Types of Studies
CAUSE TO REFLECT Thoughts & Opinion www.bioessays-journal.com Advancing Our Functional Understanding of Host–Microbiota Interactions: A Need for New Types of Studies Jinru He, Janina Lange, Georgios Marinos, Jay Bathia, Danielle Harris, Ryszard Soluch, Vaibhvi Vaibhvi, Peter Deines, M. Amine Hassani, Kim-Sara Wagner, Roman Zapien-Campos, Cornelia Jaspers, and Felix Sommer* 1. Introduction all associated archaea, bacteria, fungi, and viruses. These associ- ations greatly affect the health and life history of the host, which Multicellular life evolved in the presence of microorganisms and led to a new understanding of “self” and establishment of the formed complex associations with their microbiota, the sum of “metaorganism” concept.[1] The Collaborative Research Centre (CRC) 1182 aims at elucidating the evolution and function of metaorganisms. Its annual conference, the Young Investigator J. He, J. Lange, J. Bathia, D. Harris, V. Vaibhvi, Dr. P. Deines Zoological Institute Research Day (YIRD), serves as a platform for scientists of vari- University of Kiel ous disciplines to share novel findings on host–microbiota inter- Kiel 24118, Germany actions, thereby providing a comprehensive overview of recent G. Marinos developments and new directions in metaorganism research. Institute of Experimental Medicine Even though we have gained tremendous insights into the com- University of Kiel position and dynamics of host-associated microbial communi- Kiel 24105, Germany ties and their correlations with host health and disease, it also R. Soluch Institute for General Microbiology became evident that moving from correlative toward functional University of Kiel studies is needed to examine the underlying mechanisms of in- Kiel 24118, Germany teractions within the metaorganism. -
Security Implications of Emerging Biotechnologies: Workshop Summary, Analysis, and Recommendations
Security Implications of Emerging Biotechnologies: Workshop Summary, Analysis, and Recommendations Diane DiEuliis and Charles Lutes June 2016 Security Implications of Emerging Biotechnologies Workshop Summary, Analysis, and Recommendations Diane DiEuliis and Charles Lutes On April 26th, 2016, the Center for the Study of Weapons of Mass Destruction (CSWMD) at National Defense University held a workshop to explore “Security Implications of Emerging Biotechnologies.” Participants from government, NGOs and academia discussed opportunities and challenges of a new era of biotechnology, one highlighted by the advancing ease with which the genomes of organisms can be engineered for specific purposes, potentially more rapidly than we are prepared to assess and deal responsibly with its ramifications. Synthetic biology and associated genome editing tools will be essential for addressing the global challenge of resource scarcity, provide unprecedented advances in public health and medicine, and create innovative products that can support national defense, as well as commodities that stimulate the US economy. At the same time, new dual-use technologies will present significant challenges to biosecurity, biosafety, and have already begun to generate ethical and moral dilemmas. Participants stressed the need to address these issues in ways that do not stifle the technology’s advancement nor America’s competitiveness in the global bioeconomy. The workshop was convened to consider the potential biosecurity concerns of emerging biotechnologies and their impact on national security. The dual use problem was discussed in the context of “biosecurity by design,” a concept conceived specifically in preparation for the workshop in which government, industry, academia, national laboratories, and individual users should be mindful of developing potential security solutions at each step of technology development. -
Macroevolution of Complex Cytoskeletal Systems in Euglenids Brian S
Review articles Macroevolution of complex cytoskeletal systems in euglenids Brian S. Leander,* Heather J. Esson, and Susana A. Breglia Summary and are capable of photosynthesis. The origin of plastids in Euglenids comprise a group of single-celled eukaryotes eukaryotes involved phagotrophic cells that engulfed and with diverse modes of nutrition, including phagotrophy and photosynthesis. The level of morphological diversity retained cyanobacterial prey, a process called ‘‘primary’’ present in this group provides an excellent system for endosymbiosis. The subsequent evolutionary history of demonstrating evolutionary transformations in morpho- photosynthesis in eukaryotes is exceedingly convoluted and logical characters. This diversity also provides compel- involved at least three independent endosymbiotic events ling evidence for major events in eukaryote evolution, between phagotrophic eukaryotes and eukaryotic prey cells such as the punctuated effects of secondary endo- that already contained primary plastids (e.g. green algae and symbiosis and mutations in underlying developmental (2,3) mechanisms. In this essay, we synthesize evidence for red algae). Once photosynthesis was established in a the origin, adaptive significance and diversification of the previously phagotrophic cell, the evolutionary pressures on euglenid cytoskeleton, especially pellicle ultrastructure, the cytoskeletal systems involved in locomotion and feeding pellicle surface patterns, pellicle strip number and the changed. This gave rise to fundamental modifications -
The Royal Society Moves to Continuous Publication
Insights – 26(2), July 2013 Royal Society moves to continuous publication | Helen Duriez 350 years at the cutting edge of scientific publishing – the Royal Society moves to continuous publication ‘Continuous publication’ is a digital-friendly concept that does exactly what it says on the tin. It is the idea that individual journal articles are published online, in their final format, as soon as they are ready. Collectively, they form a continuous feed of published articles. These articles are no longer constrained by the traditional print schedule, which means that citation details are available straight away and the reader has confidence that they are reading the version of record. A number of newly launched journals have experimented with a continuous format over the past few years, although to see established journals making the switch to a different publication model is still rare. So when the Royal Society, publisher of the world’s first science journal, decided to transition its titles to a continuous publication model, it was a bold move. This case study examines the reasons behind the move and the lessons that were learned. Introduction The Royal Society publishes nine peer-reviewed journals across the physical and biological sciences, including the world’s first science journal: Philosophical Transactions (now published in two parts, A1 and B2). In recent years, digital usage of its suite of journals has steadily overtaken print, to the point where the journals are now primarily found and downloaded from the internet. With the introduction of systematic digital archiving and curation, it has become clear that the future of published research will almost exclusively HELEN DURIEZ be online, and therefore steps are being taken towards removing the constraints that print ePublishing Manager production places upon online publication. -
Editorial to My Article in Open Biology Journal Richard H W Funk* Institute of Anatomy and Center for Regenerative Therapies, Dresden, Germany
tems: ys Op Funk, Biol Syst 2013, 2:2 l S e a n A ic c g c DOI: 10.4172/bso.1000e105 o l e s o i s B Biological Systems: Open Access ISSN: 2329-6577 Editorial Open Access Editorial to my Article in Open Biology Journal Richard H W Funk* Institute of Anatomy and Center for Regenerative Therapies, Dresden, Germany It is hard to believe, but it is true: some facts in modern cell biology The review by FUNK in this issue demonstrates by many well are ignored and disregarded, still. One example is the driving forces published studies that such ion gradients generate electric fields and in the early embryonic development and morphogenesis in general. direct currents, which are able to form patterns within cell membranes Recently, a very well compiled commentary summed up the history (e.g. in the early embryo), cell arrays (e.g. in the developing lens) and of the physical (mostly mechanical) forces in early embryogenesis [1] tissues (e.g. neural tube formation). Furthermore, not only small ions but one physical force was left out completely: the electric force or the like sodium or potassium can be involved in this field patterning but charges of molecules and ions and their gradients. Another example also larger biomolecules (which possess nearly all electrical charges) like is left – right pattern formation in early embryogenesis where most tissue factors, growth hormones, transmitters and signaling molecules theories set the starting point at the asymmetric beat of cilia moving the like serotonin and others. By the activity of ion pumps and channels as flow of growth factors or other signaling molecules into one preferred well as via charged transmitter molecules these electric phenomena are direction [2]. -
Culture Coevolution and the Nature of Human Sociality − Gene
Downloaded from rstb.royalsocietypublishing.org on February 14, 2011 Gene−culture coevolution and the nature of human sociality Herbert Gintis Phil. Trans. R. Soc. B 2011 366, 878-888 doi: 10.1098/rstb.2010.0310 References This article cites 64 articles, 15 of which can be accessed free http://rstb.royalsocietypublishing.org/content/366/1566/878.full.html#ref-list-1 Article cited in: http://rstb.royalsocietypublishing.org/content/366/1566/878.full.html#related-urls Rapid response Respond to this article http://rstb.royalsocietypublishing.org/letters/submit/royptb;366/1566/878 Subject collections Articles on similar topics can be found in the following collections behaviour (1807 articles) cognition (452 articles) ecology (2145 articles) evolution (2433 articles) Receive free email alerts when new articles cite this article - sign up in the box at the top Email alerting service right-hand corner of the article or click here To subscribe to Phil. Trans. R. Soc. B go to: http://rstb.royalsocietypublishing.org/subscriptions This journal is © 2011 The Royal Society Downloaded from rstb.royalsocietypublishing.org on February 14, 2011 Phil. Trans. R. Soc. B (2011) 366, 878–888 doi:10.1098/rstb.2010.0310 Review Gene–culture coevolution and the nature of human sociality Herbert Gintis1,2,* 1Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA 2Central European University, Nador u. 9, 1051 Budapest, Hungary Human characteristics are the product of gene–culture coevolution, which is an evolutionary dynamic involving the interaction of genes and culture over long time periods. Gene–culture coevolution is a special case of niche construction.