A Primer on the Role of the Microbiome in Colorectal Neoplasia
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Review Pili in Gram-Negative and Gram-Positive Bacteria – Structure
Cell. Mol. Life Sci. 66 (2009) 613 – 635 1420-682X/09/040613-23 Cellular and Molecular Life Sciences DOI 10.1007/s00018-008-8477-4 Birkhuser Verlag, Basel, 2008 Review Pili in Gram-negative and Gram-positive bacteria – structure, assembly and their role in disease T. Profta,c,* and E. N. Bakerb,c a School of Medical Sciences, Department of Molecular Medicine & Pathology, University of Auckland, Private Bag 92019, Auckland 1142 (New Zealand), Fax: +64-9-373-7492, e-mail: [email protected] b School of Biological Sciences, University of Auckland, Auckland (New Zealand) c Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland (New Zealand) Received 08 August 2008; received after revision 24 September 2008; accepted 01 October 2008 Online First 27 October 2008 Abstract. Many bacterial species possess long fila- special form of bacterial cell movement, known as mentous structures known as pili or fimbriae extend- twitching motility. In contrast, the more recently ing from their surfaces. Despite the diversity in pilus discovered pili in Gram-positive bacteria are formed structure and biogenesis, pili in Gram-negative bac- by covalent polymerization of pilin subunits in a teria are typically formed by non-covalent homopo- process that requires a dedicated sortase enzyme. lymerization of major pilus subunit proteins (pilins), Minor pilins are added to the fiber and play a major which generates the pilus shaft. Additional pilins may role in host cell colonization. be added to the fiber and often function as host cell This review gives an overview of the structure, adhesins. Some pili are also involved in biofilm assembly and function of the best-characterized pili formation, phage transduction, DNA uptake and a of both Gram-negative and Gram-positive bacteria. -
The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio In
microorganisms Review The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease Spase Stojanov 1,2, Aleš Berlec 1,2 and Borut Štrukelj 1,2,* 1 Faculty of Pharmacy, University of Ljubljana, SI-1000 Ljubljana, Slovenia; [email protected] (S.S.); [email protected] (A.B.) 2 Department of Biotechnology, Jožef Stefan Institute, SI-1000 Ljubljana, Slovenia * Correspondence: borut.strukelj@ffa.uni-lj.si Received: 16 September 2020; Accepted: 31 October 2020; Published: 1 November 2020 Abstract: The two most important bacterial phyla in the gastrointestinal tract, Firmicutes and Bacteroidetes, have gained much attention in recent years. The Firmicutes/Bacteroidetes (F/B) ratio is widely accepted to have an important influence in maintaining normal intestinal homeostasis. Increased or decreased F/B ratio is regarded as dysbiosis, whereby the former is usually observed with obesity, and the latter with inflammatory bowel disease (IBD). Probiotics as live microorganisms can confer health benefits to the host when administered in adequate amounts. There is considerable evidence of their nutritional and immunosuppressive properties including reports that elucidate the association of probiotics with the F/B ratio, obesity, and IBD. Orally administered probiotics can contribute to the restoration of dysbiotic microbiota and to the prevention of obesity or IBD. However, as the effects of different probiotics on the F/B ratio differ, selecting the appropriate species or mixture is crucial. The most commonly tested probiotics for modifying the F/B ratio and treating obesity and IBD are from the genus Lactobacillus. In this paper, we review the effects of probiotics on the F/B ratio that lead to weight loss or immunosuppression. -
Contribution of the Human Microbiome and Proteus Mirabilis to Onset and Progression of Rheumatoid Arthritis: Potential for Targeted Therapy
Internet Journal of Allied Health Sciences and Practice Volume 19 Number 3 Article 6 2021 Contribution of the Human Microbiome and Proteus mirabilis to Onset and Progression of Rheumatoid Arthritis: Potential for Targeted Therapy Jessica Kerpez Nova Southeastern University, [email protected] Marc Kesselman Nova Southeastern University, [email protected] Michelle Demory Beckler Nova Southeastern University, [email protected] Follow this and additional works at: https://nsuworks.nova.edu/ijahsp Part of the Genetic Phenomena Commons, Genetic Processes Commons, Immune System Diseases Commons, Medical Biochemistry Commons, and the Musculoskeletal Diseases Commons Recommended Citation Kerpez J, Kesselman M, Demory Beckler M. Contribution of the Human Microbiome and Proteus mirabilis to Onset and Progression of Rheumatoid Arthritis: Potential for Targeted Therapy. The Internet Journal of Allied Health Sciences and Practice. 2021 Jan 01;19(3), Article 6. This Review Article is brought to you for free and open access by the College of Health Care Sciences at NSUWorks. It has been accepted for inclusion in Internet Journal of Allied Health Sciences and Practice by an authorized editor of NSUWorks. For more information, please contact [email protected]. Contribution of the Human Microbiome and Proteus mirabilis to Onset and Progression of Rheumatoid Arthritis: Potential for Targeted Therapy Abstract The human microbiome has been shown to play a role in the regulation of human health, behavior, and disease. Data suggests that microorganisms that co-evolved within humans have an enhanced ability to prevent the development of a large spectrum of immune-related disorders but may also lead to the onset of conditions when homeostasis is disrupted. -
Health Impact and Therapeutic Manipulation of the Gut Microbiome
Review Health Impact and Therapeutic Manipulation of the Gut Microbiome Eric Banan-Mwine Daliri 1 , Fred Kwame Ofosu 1 , Ramachandran Chelliah 1, Byong Hoon Lee 2,3,* and Deog-Hwan Oh 1 1 Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea; [email protected] (E.B.-M.D.); [email protected] (F.K.O.); [email protected] (R.C.); [email protected] (D.-H.O.) 2 Department of Microbiology/Immunology, McGill University, Montreal, QC H3A 2B4, Canada 3 SportBiomics, Sacramento Inc., Sacramento, CA 95660, USA * Correspondence: [email protected] Received: 24 March 2020; Accepted: 19 July 2020; Published: 29 July 2020 Abstract: Recent advances in microbiome studies have revealed much information about how the gut virome, mycobiome, and gut bacteria influence health and disease. Over the years, many studies have reported associations between the gut microflora under different pathological conditions. However, information about the role of gut metabolites and the mechanisms by which the gut microbiota affect health and disease does not provide enough evidence. Recent advances in next-generation sequencing and metabolomics coupled with large, randomized clinical trials are helping scientists to understand whether gut dysbiosis precedes pathology or gut dysbiosis is secondary to pathology. In this review, we discuss our current knowledge on the impact of gut bacteria, virome, and mycobiome interactions with the host and how they could be manipulated to promote health. Keywords: microbiome; biomarkers; personalized nutrition; microbes; metagenomics 1. Introduction The human body consists of mammalian cells and many microbial cells (bacteria, viruses, and fungi) which co-exist symbiotically. -
Doctoral Dissertation Template
UNIVERSITY OF OKLAHOMA GRADUATE COLLEGE METAGENOMIC INSIGHTS INTO MICROBIAL COMMUNITY RESPONSES TO LONG-TERM ELEVATED CO2 A DISSERTATION SUBMITTED TO THE GRADUATE FACULTY in partial fulfillment of the requirements for the Degree of DOCTOR OF PHILOSOPHY By QICHAO TU Norman, Oklahoma 2014 METAGENOMIC INSIGHTS INTO MICROBIAL COMMUNITY RESPONSES TO LONG-TERM ELEVATED CO2 A DISSERTATION APPROVED FOR THE DEPARTMENT OF MICROBIOLOGY AND PLANT BIOLOGY BY ______________________________ Dr. Jizhong Zhou, Chair ______________________________ Dr. Meijun Zhu ______________________________ Dr. Fengxia (Felicia) Qi ______________________________ Dr. Michael McInerney ______________________________ Dr. Bradley Stevenson © Copyright by QICHAO TU 2014 All Rights Reserved. Acknowledgements At this special moment approaching the last stage for this degree, I would like to express my gratitude to all the people who encouraged me and helped me out through the past years. Dr. Jizhong Zhou, my advisor, is no doubt the most influential and helpful person in pursuing my academic goals. In addition to continuous financial support for the past six years, he is the person who led me into the field of environmental microbiology, from a background of bioinformatics and plant molecular biology. I really appreciated the vast training I received from the many interesting projects I got involved in, without which I would hardly develop my broad experienced background from pure culture microbial genomics to complex metagenomics. Dr. Zhili He, who played a role as my second advisor, is also the person I would like to thank most. Without his help, I could be still struggling working on those manuscripts lying in my hard drive. I definitely learned a lot from him in organizing massed results into logical scientific work—skills that will benefit me for life. -
Engineering the Human Microbiome, a Natural Double-Barreled Approach Towards Solving Both Our Current Antibiotic Resistance and Sepsis Problems
American Journal of www.biomedgrid.com Biomedical Science & Research ISSN: 2642-1747 --------------------------------------------------------------------------------------------------------------------------------- Opinion Copy Right@ Toleman MA Engineering the Human Microbiome, A Natural Double-Barreled Approach Towards Solving both our Current Antibiotic Resistance and Sepsis Problems Martins W1, Mathias J1, Babenko D2 and Toleman MA1* 1Cardiff University Medical school, Department of Immunology and Infection, The Heath hospital, UK 2Karaganda Medical University, Kazakhstan *Corresponding author: Toleman MA, Cardiff University Medical school, Department of Immunology and Infection, The Heath hospital, Cardiff, UK. To Cite This Article: Martins W, Mathias J, Babenko D, Toleman MA, Engineering the Human Microbiome, A Natural Double-Barreled Approach Towards Solving both our Current Antibiotic Resistance and Sepsis Problems. Am J Biomed Sci & Res. 2020 - 11(3). AJBSR.MS.ID.001632. DOI: 10.34297/AJBSR.2020.11.001632. Received: December 12, 2020; Published: December 18, 2020 Opinion resistance mechanism responsible for this rise was an enzyme Many of the bacteria that cause life-threatening infection live called CTX-M-15 that gave resistance to the penicillin, monobactam, in very close association with us. Escherichia coli, for example and cephalosporin classes of the ß-lactam family of antibiotics (c. causes 80% of common community associated urinary tract infections and is also the main cause of serious (blood-stream) in several enteric pathogens including E. coli in New Delhi, India infection throughout Europe [1,2]. However, E. coli routinely lives 50% of all antibiotics) [7]. Its gene blaCTX-M-15 was first isolated in 2000 [8]. Later publications indicated that it was widespread as a commensal organism in our gut. -
The Human Microbiome, Diet, and Health: Workshop Summary
This PDF is available from The National Academies Press at http://www.nap.edu/catalog.php?record_id=13522 The Human Microbiome, Diet, and Health: Workshop Summary ISBN Leslie Pray, Laura Pillsbury, and Emily Tomayko, Rapporteurs; Food 978-0-309-26585-0 Forum; Food and Nutrition Board; Institute of Medicine 181 pages 6 x 9 PAPERBACK (2013) Visit the National Academies Press online and register for... Instant access to free PDF downloads of titles from the NATIONAL ACADEMY OF SCIENCES NATIONAL ACADEMY OF ENGINEERING INSTITUTE OF MEDICINE NATIONAL RESEARCH COUNCIL 10% off print titles Custom notification of new releases in your field of interest Special offers and discounts Distribution, posting, or copying of this PDF is strictly prohibited without written permission of the National Academies Press. Unless otherwise indicated, all materials in this PDF are copyrighted by the National Academy of Sciences. Request reprint permission for this book Copyright © National Academy of Sciences. All rights reserved. The Human Microbiome, Diet, and Health: Workshop Summary Workshop Summary The Human Microbiome, Diet, and Health Leslie Pray, Laura Pillsbury, and Emily Tomayko, Rapporteurs Food Forum Food and Nutrition Board Copyright © National Academy of Sciences. All rights reserved. The Human Microbiome, Diet, and Health: Workshop Summary THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001 NOTICE: The project that is the subject of this report was approved by the Govern- ing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineer- ing, and the Institute of Medicine. This study was supported by Contract Nos. -
Skin Microbiome Analysis for Forensic Human Identification: What Do We Know So Far?
microorganisms Review Skin Microbiome Analysis for Forensic Human Identification: What Do We Know So Far? Pamela Tozzo 1,*, Gabriella D’Angiolella 2 , Paola Brun 3, Ignazio Castagliuolo 3, Sarah Gino 4 and Luciana Caenazzo 1 1 Department of Molecular Medicine, Laboratory of Forensic Genetics, University of Padova, 35121 Padova, Italy; [email protected] 2 Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35121 Padova, Italy; [email protected] 3 Department of Molecular Medicine, Section of Microbiology, University of Padova, 35121 Padova, Italy; [email protected] (P.B.); [email protected] (I.C.) 4 Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy; [email protected] * Correspondence: [email protected]; Tel.: +39-0498272234 Received: 11 May 2020; Accepted: 8 June 2020; Published: 9 June 2020 Abstract: Microbiome research is a highly transdisciplinary field with a wide range of applications and methods for studying it, involving different computational approaches and models. The fact that different people host radically different microbiota highlights forensic perspectives in understanding what leads to this variation and what regulates it, in order to effectively use microbes as forensic evidence. This narrative review provides an overview of some of the main scientific works so far produced, focusing on the potentiality of using skin microbiome profiling for human identification in forensics. This review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The examined literature clearly ascertains that skin microbial communities, although personalized, vary systematically across body sites and time, with intrapersonal differences over time smaller than interpersonal ones, showing such a high degree of spatial and temporal variability that the degree and nature of this variability can constitute in itself an important parameter useful in distinguishing individuals from one another. -
Clostridium Amazonitimonense, Clostridium Me
ORIGINAL ARTICLE Taxonogenomic description of four new Clostridium species isolated from human gut: ‘Clostridium amazonitimonense’, ‘Clostridium merdae’, ‘Clostridium massilidielmoense’ and ‘Clostridium nigeriense’ M. T. Alou1, S. Ndongo1, L. Frégère1, N. Labas1, C. Andrieu1, M. Richez1, C. Couderc1, J.-P. Baudoin1, J. Abrahão2, S. Brah3, A. Diallo1,4, C. Sokhna1,4, N. Cassir1, B. La Scola1, F. Cadoret1 and D. Raoult1,5 1) Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France, 2) Laboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, 3) Hopital National de Niamey, BP 247, Niamey, Niger, 4) Campus Commun UCAD-IRD of Hann, Route des pères Maristes, Hann Maristes, BP 1386, CP 18524, Dakar, Senegal and 5) Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia Abstract Culturomics investigates microbial diversity of the human microbiome by combining diversified culture conditions, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene identification. The present study allowed identification of four putative new Clostridium sensu stricto species: ‘Clostridium amazonitimonense’ strain LF2T, ‘Clostridium massilidielmoense’ strain MT26T, ‘Clostridium nigeriense’ strain Marseille-P2414T and ‘Clostridium merdae’ strain Marseille-P2953T, which we describe using the concept of taxonogenomics. We describe the main characteristics of each bacterium and present their complete genome sequence and annotation. © 2017 Published by Elsevier Ltd. Keywords: ‘Clostridium amazonitimonense’, ‘Clostridium massilidielmoense’, ‘Clostridium merdae’, ‘Clostridium nigeriense’, culturomics, emerging bacteria, human microbiota, taxonogenomics Original Submission: 18 August 2017; Revised Submission: 9 November 2017; Accepted: 16 November 2017 Article published online: 22 November 2017 intestine [1,4–6]. -
Potential Role of Microbiome in Oncogenesis, Outcome Prediction
Oral Oncology 99 (2019) 104453 Contents lists available at ScienceDirect Oral Oncology journal homepage: www.elsevier.com/locate/oraloncology Review Potential role of microbiome in oncogenesis, outcome prediction and therapeutic targeting for head and neck cancer T ⁎ Ester Orlandia,b, , Nicola Alessandro Iacovellib, Vincenzo Tombolinic, Tiziana Rancatid, Antonella Polimenie, Loris De Ceccof, Riccardo Valdagnia,d,g, Francesca De Felicec a Department of Radiotherapy 1, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy b Department of Radiotherapy 2, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy c Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy d Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy e Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I, “Sapienza” University of Rome, Italy f Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy g Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy ARTICLE INFO ABSTRACT Keywords: In the last decade, human microbiome research is rapidly growing involving several fields of clinical medicine Head and neck cancer and population health. Although the microbiome seems to be linked to all sorts of diseases, cancer has the Biomarkers biggest potential to be investigated. Microbiome Following the publication of the National Institute of Health - Human Microbiome Project (NIH-HMP), the Microbiota link between Head and Neck Cancer (HNC) and microbiome seems to be a fast-moving field in research area. Oncogenesis However, robust evidence-based literature is still quite scarce. Nevertheless the relationship between oral mi- Radiotherapy Immunotherapy crobiome and HNC could have important consequences for prevention and early detection of this type of tumors. -
Current Issues of Nano-Bio-Science
Current Issues of Nano-Bio-Science CeNS Winterschool 2003 Mauterndorf, Austria 24-28 February 2003 Current Issues of Nano-Bio-Science CeNS Winterschool 2003 Mauterndorf, Austria 24-28 February 2003 in cooperation with SFB 486 and SFB 513 Program Committee Organisation Christoph Bräuchle Monika Kaempfe Jan von Delft Evelyn Morgenroth Hermann Gaub Joachim Rädler Jörg P. Kotthaus Paul Leiderer Joachim Rädler Internal Students’ Seminar: Schedule Saturday, 22nd February 7:30 pm Meeting in front of the castle’s lower gate to go the “Skialm” together 8:00 pm Get-together at the „Skialm“ in Mauterndorf (in the Skiing center) (kitchen closes at 9:30 pm) Sunday, 23rd February 9:45 am Introduction (W. Parak, F. Simmel) 10:00 am Simon Keller (AG Rädler) 10:30 am Stefan Griessl (AG Heckl) 11:00 am Coffee break 11:30 am Christine Meyer (AG Kotthaus) 12:00 pm Michael Sindel (AG von Delft) 12:30 pm Lunch (not provided), informal discussions 5:00 pm Ferdinand Kühner (AG Gaub) 5:30 pm Stefan Beyer (NG Simmel) Teresa Pellegrino (NG Parak) 6:00 pm Stefan Kowarik (AG Feldmann) 6:30 pm Break 7:00 pm Niklolay Petkov (AG Bein) 7:30 pm Sebastian Gritschneder (AG Reichling) 8:00 pm Ralf Bausinger / Johanna Kirstein (AG Bräuchle) 8:30 pm Conclusion Program Monday, 24th February 2003 8.30 – 8.45 Opening 8.45 – 9.45 Cees Dekker, Delft University of Technology Carbon nanotubes as model systems for nanoelectronics and nanosensors 9.45 – 10.45 Ulf Diederichsen, Universität Göttingen Molecular architecture with biooligomers 10.45 – 11.15 Coffee Break 11.15 – 12.15 Wolfgang -
Cell Structure and Function in the Bacteria and Archaea
4 Chapter Preview and Key Concepts 4.1 1.1 DiversityThe Beginnings among theof Microbiology Bacteria and Archaea 1.1. •The BacteriaThe are discovery classified of microorganismsinto several Cell Structure wasmajor dependent phyla. on observations made with 2. theThe microscope Archaea are currently classified into two 2. •major phyla.The emergence of experimental 4.2 Cellscience Shapes provided and Arrangements a means to test long held and Function beliefs and resolve controversies 3. Many bacterial cells have a rod, spherical, or 3. MicroInquiryspiral shape and1: Experimentation are organized into and a specific Scientificellular c arrangement. Inquiry in the Bacteria 4.31.2 AnMicroorganisms Overview to Bacterialand Disease and Transmission Archaeal 4.Cell • StructureEarly epidemiology studies suggested how diseases could be spread and 4. Bacterial and archaeal cells are organized at be controlled the cellular and molecular levels. 5. • Resistance to a disease can come and Archaea 4.4 External Cell Structures from exposure to and recovery from a mild 5.form Pili allowof (or cells a very to attach similar) to surfacesdisease or other cells. 1.3 The Classical Golden Age of Microbiology 6. Flagella provide motility. Our planet has always been in the “Age of Bacteria,” ever since the first 6. (1854-1914) 7. A glycocalyx protects against desiccation, fossils—bacteria of course—were entombed in rocks more than 3 billion 7. • The germ theory was based on the attaches cells to surfaces, and helps observations that different microorganisms years ago. On any possible, reasonable criterion, bacteria are—and always pathogens evade the immune system. have been—the dominant forms of life on Earth.