About Breast Cancer in Men Overview and Types
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
DCIS): Pathological Features, Differential Diagnosis, Prognostic Factors and Specimen Evaluation
Modern Pathology (2010) 23, S8–S13 S8 & 2010 USCAP, Inc. All rights reserved 0893-3952/10 $32.00 Ductal carcinoma in situ (DCIS): pathological features, differential diagnosis, prognostic factors and specimen evaluation Sarah E Pinder Breast Research Pathology, Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK Ductal carcinoma in situ (DCIS) is a heterogeneous, unicentric precursor of invasive breast cancer, which is frequently identified through mammographic breast screening programs. The lesion can cause particular difficulties for specimen handling in the laboratory and typically requires even more diligent macroscopic assessment and sampling than invasive disease. Pitfalls and tips for macroscopic handling, microscopic diagnosis and assessment, including determination of prognostic factors, such as cytonuclear grade, presence or absence of necrosis, size of the lesion and distance to margins are described. All should be routinely included in histopathology reports of this disease; in order not to omit these clinically relevant details, synoptic reports, such as that produced by the College of American Pathologists are recommended. No biomarkers have been convincingly shown, and validated, to predict the behavior of DCIS till date. Modern Pathology (2010) 23, S8–S13; doi:10.1038/modpathol.2010.40 Keywords: ductal carcinoma in situ (DCIS); breast cancer; histopathology; prognostic factors Ductal carcinoma in situ (DCIS) is a malignant, lesions, a good cosmetic result can be obtained by clonal proliferation of cells growing within the wide local excision. Recurrence of DCIS generally basement membrane-bound structures of the breast occurs at the site of previous excision and it is and with no evidence of invasion into surrounding therefore better regarded as residual disease, as stroma. -
A Case of Male Breast Cancer with a BRCA Gene Mutation
CASE REPORT The Ochsner Journal 15:448–451, 2015 Ó Academic Division of Ochsner Clinic Foundation A Case of Male Breast Cancer with a BRCA Gene Mutation Martin A. Benjamin, MD,1 Adam I. Riker, MD, FACS2 1Department of Surgery, University of Illinois at Chicago, Chicago, IL 2Advocate Cancer Institute, Advocate Christ Medical Center, Oak Lawn, IL Background: Male breast cancer (MBC) is an uncommon malignancy with an incidence that accounts for about 1% of all breast cancer cases. It commonly presents as a locally advanced tumor that has already spread to the regional nodal basin. Similar to female breast cancers, MBC gene expression profiling and tumor studies help to detect molecular subtypes of tumors that correlate with clinical outcome and mortality rates. Case Report: We report a relatively uncommon case of a 64-year-old male with a BRCA1þ gene mutation that is also found to be HER2þ on receptor analysis. Initial diagnostic studies with mammography and ultrasound revealed a left-sided hypoechoic mass measuring 2.3 cm, located at the 11 o’clock position adjacent to the nipple-areolar complex. Whole body positron emission tomography–computed tomography scan revealed a hypermetabolic retroareolar left breast mass and enlarged, hypermetabolic left axillary lymph nodes. Final pathology revealed an infiltrating ductal carcinoma with a Nottingham histologic score of 3 (mitotic count score, 3; nuclear pleomorphism score, 3). Of the 19 lymph nodes examined, 15 had evidence of macrometastatic disease. Conclusion: This report highlights a novel case of MBC with a rare genotypic presentation. A need exists to further explore this disease process because the literature is scant with information regarding the long-term treatment and outcomes of MBC, especially in the genotypic form presented here. -
Understanding Ductal Carcinoma in Situ (DCIS)
Understanding ductal carcinoma in situ (DCIS) and deciding about treatment Understanding ductal carcinoma in situ (DCIS) and deciding about treatment Developed by National Breast and Ovarian Cancer Centre Funded by the Australian Government Department of Health and Ageing Understanding ductal carcinoma in situ Contents Acknowledgements .........................................................................................2 How to use this resource ..............................................................................3 Introduction ...........................................................................................................4 Why do I need treatment for DCIS? .........................................................5 Surgery ......................................................................................................................7 Radiotherapy ......................................................................................................11 What is the risk of developing invasive breast cancer or Understanding ductal carcinoma in situ (DCIS) and deciding about treatment was prepared and produced by: DCIS after treatment? ....................................................................................12 National Breast and Ovarian Cancer Centre What follow-up will I need? .......................................................................17 Level 1 Suite 103/355 Crown Street Surry Hills NSW 2010 How can I get more emotional support? .........................................18 Locked Bag 3 -
Male Breast Cancer - Wikipedia, the Free Encyclopedia Pagina 1 Van 5
Male breast cancer - Wikipedia, the free encyclopedia pagina 1 van 5 Male breast cancer From Wikipedia, the free encyclopedia Male breast cancer is a relatively rare cancer in Male breast cancer men that originates from Classification and external resources the breast. As it presents a ICD-10 C50 similar pathology as female breast cancer, assessment (http://apps.who.int/classifications/icd10/browse/2010/en#/C50) and treatment relies on ICD-9 175 (http://www.icd9data.com/getICD9Code.ashx? experiences and guidelines icd9=175),175.0 that have been developed (http://www.icd9data.com/getICD9Code.ashx? [1][2][3] in female patients. icd9=175.0),175.9 The optimal treatment is (http://www.icd9data.com/getICD9Code.ashx?icd9=175.9), currently not known. [4] OMIM 114480 (http://omim.org/entry/114480) MedlinePlus 000913 Contents (http://www.nlm.nih.gov/medlineplus/ency/article/000913.htm) eMedicine radio/115 (http://www.emedicine.com/radio/topic115.htm#) ■ 1 Incidence MeSH D001943 (http://www.nlm.nih.gov/cgi/mesh/2013/MB_cgi? ■ 2 Pathology field=uid&term=D001943) ■ 3 Diagnosis ■ 3.1 Staging ■ 4 Differences from female breast cancer ■ 5 Treatment ■ 5.1 Chemotherapeutic and hormonal options in male breast cancer ■ 6 Prognosis ■ 7 References Incidence About one percent of breast cancer develops in males. [4] It is estimated that about 2,140 new cases are diagnosed annually in the US and about 300 in the UK, and the number of annual deaths is about 450 in the US. [2][3] In a study from India, eight out of 1,200 (0.7%) male cancer diagnoses in a pathology review represented breast cancer. -
Evaluation of the Symptomatic Male Breast
Revised 2018 American College of Radiology ACR Appropriateness Criteria® Evaluation of the Symptomatic Male Breast Variant 1: Male patient of any age with symptoms of gynecomastia and physical examination consistent with gynecomastia or pseudogynecomastia. Initial imaging. Procedure Appropriateness Category Relative Radiation Level Mammography diagnostic Usually Not Appropriate ☢☢ Digital breast tomosynthesis diagnostic Usually Not Appropriate ☢☢ US breast Usually Not Appropriate O MRI breast without and with IV contrast Usually Not Appropriate O MRI breast without IV contrast Usually Not Appropriate O Variant 2: Male younger than 25 years of age with indeterminate palpable breast mass. Initial imaging. Procedure Appropriateness Category Relative Radiation Level US breast Usually Appropriate O Mammography diagnostic May Be Appropriate ☢☢ Digital breast tomosynthesis diagnostic May Be Appropriate ☢☢ MRI breast without and with IV contrast Usually Not Appropriate O MRI breast without IV contrast Usually Not Appropriate O Variant 3: Male 25 years of age or older with indeterminate palpable breast mass. Initial imaging. Procedure Appropriateness Category Relative Radiation Level Mammography diagnostic Usually Appropriate ☢☢ Digital breast tomosynthesis diagnostic Usually Appropriate ☢☢ US breast May Be Appropriate O MRI breast without and with IV contrast Usually Not Appropriate O MRI breast without IV contrast Usually Not Appropriate O Variant 4: Male 25 years of age or older with indeterminate palpable breast mass. Mammography or digital breast tomosynthesis indeterminate or suspicious. Procedure Appropriateness Category Relative Radiation Level US breast Usually Appropriate O MRI breast without and with IV contrast Usually Not Appropriate O MRI breast without IV contrast Usually Not Appropriate O ACR Appropriateness Criteria® 1 Evaluation of the Symptomatic Male Breast Variant 5: Male of any age with physical examination suspicious for breast cancer (suspicious palpable breast mass, axillary adenopathy, nipple discharge, or nipple retraction). -
Original Article Molecular Subtypes of Male Breast Cancer by Immunohistochemistry
Int J Clin Exp Med 2017;10(1):1670-1677 www.ijcem.com /ISSN:1940-5901/IJCEM0041401 Original Article Molecular subtypes of male breast cancer by immunohistochemistry Huiling Li1*, Yumei Yang2*, Dapeng Wang3, Zhengtian Li4, Dan Zhang5, Fengjuan Xu1 Departments of 1Medical Records and Statistics Room, 4General Surgery, 5Ultrasound, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Road, Harbin, China; 2Department of Operation Room, The Second Af- filiated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, China; 3Department of Human Resources, The Third Affiliated Hospital of Harbin Medical University, 150 Haping Road, Harbin, China. *Co-first authors. Received August 11, 2016; Accepted November 20, 2016; Epub January 15, 2017; Published January 30, 2017 Abstract: Male breast cancer is a rare disease, accounting for less than 1% of all breast cancer cases worldwide. Compared to female breast cancer, the incidence of male breast cancer has risen in recent years, and the relation- ship between molecular subtype and clinical behavior has rarely been studied. In this study, we examined the mo- lecular subtypes of male breast cancers based on the expression profile of immunomarkers and their association with clinicopathological features. A total of 98 male breast carcinoma patients were investigated retrospectively using immunostaining for estrogen receptor (ER), progesterone receptor (PR), HER2, Ki-67, and P53. Results were interpreted based on the molecular subtype classification of the 13th St Gallen International Expert Consensus (2013). HER2 expression that was 2+ or 3+ was also evaluated by fluorescent in situ hybridization (FISH) for further validation. The luminal subtype A was the most common in all patients (83.7%, 82/98), followed by the luminal subtype B (16.3%, 16/98). -
Ductal Carcinoma in Situ
Breast Cancer Definition of Ductal Carcinoma In Situ Terms What is Ductal Carcinoma What characterizes DCIS? Ductal: Relating In Situ (DCIS)? DCIS is characterized by pre-can- to the breast’s milk Ductal Carcinoma In Situ is the cerous or early-stage cell abnor- ducts, the parts of the earliest possible and most treat- malities in the breast ducts. On a breast through which able diagnosis of breast cancer. mammogram, DCIS appears as milk fl ows. Some experts consider it to be areas of calcifi cation. “pre-malignant.” The most com- Carcinoma: A type mon form of non-invasive breast How does the pathologist of cancerous, or ma- cancer, DCIS accounts for about make a diagnosis? lignant, tumor. 25 percent of all breast cancers. The pathologist examines biopsy Sometimes, DCIS is seen in as- specimens, In Situ: In its original sociation with an invasive form of along with place. breast cancer. other tests if The diagnosis of DCIS is in- necessary. If Non-invasive: Not spreading beyond the creasing because more women are mammogra- inside of the breast receiving regular mammograms phy shows duct. – and because of advancements in suspicious mammography technology, which fi ndings, a Calcifi cation: Cal- can now fi nd small areas of calci- biopsy may cium deposits in the fi cation in the breast. If untreated, be recom- breast can be associ- about 30 percent of women with mended. A ated with Ductal Car- DCIS will develop invasive breast biopsy is the Ductal Carcinoma cinoma In Situ. Clus- cancer within 10 years of the ini- most widely used method for In Situ is the earliest ters of these deposits tial making a fi rm diagnosis of breast possible and most may indicate cancer. -
Nipple Adenoma in a Female Patient Presenting with Persistent Erythema
Spohn et al. BMC Dermatology (2016) 16:4 DOI 10.1186/s12895-016-0041-6 CASEREPORT Open Access Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin Gina P. Spohn1*, Shannon C. Trotter1, Gary Tozbikian2 and Stephen P. Povoski3* Abstract Background: Nipple adenoma is a very uncommon, benign proliferative process of lactiferous ducts of the nipple. Clinically, it often presents as a palpable nipple nodule, a visible nipple skin erosive lesion, and/or with discharge from the surface of the nipple skin, and is primarily seen in middle-aged women. Resultantly, nipple adenoma can clinically mimic the presentation of mammary Paget’s disease of the nipple. The purpose of our current case report is to present a comprehensive review of the available data on nipple adenoma, as well as provide useful information to health care providers (including dermatologists, breast health specialists, and other health care providers) who evaluate patients with dermatologic conditions of the breast skin for appropriately clinically recognizing, diagnosing, and treating patients with nipple adenoma. Case presentation: Fifty-three year old Caucasian female presented with a one year history of erythema and induration of the skin of the inferior aspect of the right nipple/areolar region. Skin punch biopsies showed subareolar duct papillomatosis. The patient elected to undergo complete surgical excision with right central breast resection. Final histopathologic evaluation confirmed nipple adenoma. The patient is doing well 31 months after her definitive surgical therapy. -
42 Male Breast Cancer C
42 Male Breast Cancer C. Bernard-Marty, E. Azambuja, L. Dal Lago, M.J. Piccart, and F. Cardoso 42.1 Introduction The earliest reference to breast cancer (BC) in men dates from 3000–2500 BCE, on an Egyptian papyrus [11], and the first clinical report was described in the 14th cen- tury by John of Arderne [71]. Carcinoma of the male breast is a relatively rare disease that accounts for less than 1% of all cases of cancer in men. Therefore, BC in men has largely taken a back seat to the worldwide effort to control this disease in women. Similarly, the literature regarding male BC consists mainly of case-control and retrospective studies involv- ing small numbers of patients [28]. The statistical accuracy of the clinical character- istics of male BC is not fully established and knowledge relevant to specific aspects of the disease in men is still limited. Consequently, treatment strategies have been largely guided by extrapolation from experience in women. In this chapter, the available information on risk, prognostic factors, clinical fea- tures, and treatment modalities of male BC has been summarized. Tailored pro- spective clinical trials in this disease, through large Intergroup networks, should be initiated. 42.2 Incidence According to the American Cancer Society, of the 212,600 new cases of BC diag- nosed in 2003, 1,300 (1%) were diagnosed in men and resulted in 400 deaths (30%) [39]. In contrast to the increasing incidence of BC in women, the incidence of BC in men has remained stable over the past 4 decades [47]. -
Breast Cancer in Men: a 10-Year Experience © Permanyer 2019 © Permanyer 2019 of an Oncology Reference Center in Northeast
www.journalofcancerology.com PERMANYER J Cancerol. 2019;6:21-7 www.permanyer.com JOURNAL OF CANCEROLOGY HOT TOPIC Breast cancer in men: A 10-year experience © Permanyer 2019 © Permanyer 2019 of an oncology reference center in Northeast . Mexico CARLOS EDUARDO SALAZAR-MEJÍA*, ALAN BURGUETE-TORRES, JUAN FRANCISCO GONZÁLEZ-GUERRERO, DANIEL ALbeRTO GALLEGOS-ARGUIJO, BLANCA OTILIA WImeR-CASTILLO, BRENDA ALEJANDRA SAMANIEGO-SÁENZ, LOURDES PAOLA CHAPA-MONTALVO AND OSCAR VIDAL-GUTIÉRREZ of the publisher Centro Universitario Contra el Cáncer, University Hospital “Dr. José Eleuterio González” and Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, México ABSTRACT Introduction: Breast cancer in men (BCM) accounts for approximately 1% of all breast cancer cases. The present study aimed at describing the clinical and demographic characteristics of BCM in Mexican population. Methods: We performed a retrospective analysis of the men with newly diagnosed breast cancer treated in an oncology referral center in Northeast Mexico from 2007 to 2017. Results: Fifteen patients were included in the analysis. Mean age at diagnosis was 60.7 years and median time from diagnosis to the start of treatment was 2 months. About 73% of patients presented with locoregional disease (clinical stage [CS] I-III) and 26.7% were classified as Stage IV disease on their first assessment. All patients had invasive ductal carcinoma and 60.0% were Grade II tumors. Twelve cases were positive for hormone receptors and none showed overexpression of human epidermal growth factor receptor 2. Regarding primary treatment, 12 patients underwent a modified radical mastectomy and two underwent breast-conserving surgery. The majority of patients received chemotherapy and radiotherapy in the adjuvant setting and tamoxifen was the drug of choice in all patients considered as candidates for hor- monal therapy. -
Of Male Breast Cancer
2.6 HOURS Continuing Education ORIGINAL RESEARCH By Eileen Thomas, PhD, RN Men’s Awareness and Knowledge of Male Breast Cancer A STUDY OF MEN A T HIGHER RISK PROVIDES A N EVIDENCE -B A SED UNDER - ST A NDING OF MEN ’S PERCEPTIONS OF THIS DISE A SE . reast cancer in men is uncommon, account - ABSTRACT ing for less than 1% of all breast cancers This article reports on the findings of a qualitative Objective: and less than 1% of all carcinomas in men.1 study that explored the awareness and knowledge of male breast Incidence trends are less clear. One large U.S. cancer among English-speaking men. The primary goal was to elicit population–based study by Giordano and information to guide both clinical practice and the development of Bcolleagues revealed that, between 1973 and 1998, the gender-specific educational interventions. incidence of male breast cancer increased by 26%, Methods: Interviews with 28 adult men, all of whom had no while that of female breast cancer rose by 52%.1 More history of breast cancer themselves but had at least one maternal recently, the American Cancer Society (ACS) has re - blood relative with the disease, were conducted and analyzed, using ported that although the rate of female breast cancer qualitative methods, to describe participants’ awareness of male has been declining,2 “the number of breast cancer cases breast cancer, their knowledge of the disease, and how they thought in men relative to the population has been fairly stable awareness of male breast cancer could be increased in health care over the last 30 years.”3 The ACS also estimates that, providers and the lay public. -
Incidental Detection of Carcinoma in Situ in Fibroadenoma of Breast in a Young Woman: a Rare Finding
Online - 2455-3891 Vol 12, Issue 1, 2019 Print - 0974-2441 Case Report INCIDENTAL DETECTION OF CARCINOMA IN SITU IN FIBROADENOMA OF BREAST IN A YOUNG WOMAN: A RARE FINDING NIKITHA VALERINA KAIRANNA1*, BRIJMOHAN KUMAR SINGH2, PAVITHRA P1 1Department of Pathology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. 2 Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Email: [email protected] Received 07 July 2018, Revised and Accepted: 17 August 2018 ABSTRACT Fibroadenoma is the most common benign tumor of the breast in young females. Breast cancer arising within a fibroadenoma is a rare phenomenon. The incidence of carcinoma within a fibroadenoma is reported to be between 0.1% and 0.3% in a screened population, with a peak age of occurrence between the 4th and 5th decade. We present a case of 29-year-old female with ductal carcinoma in situ in a background of fibroadenoma. There is a low percentage of fibroadenomas harboring carcinoma; however, all breast lumps should be seriously managed; extirpation and histological examination is recommended. Keywords: Fibroadenoma, Carcinoma in situ, Benign tumor. © 2019 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4. 0/) DOI: http://dx.doi.org/10.22159/ajpcr.2019.v12i1.28326 INTRODUCTION Ultrasound of both the breasts revealed well-circumscribed, homogenous, and hypoechoic lesions. The features were suggestive of Fibroadenoma is the most common benign tumor of the breast in fibroadenoma of bilateral breasts (Fig.