CD5 Recombinant Cat. No.: 92-560

CD5 Recombinant Protein

Specifications

SPECIES: Mouse

SOURCE SPECIES: Human Cells

SEQUENCE: Gln24-Asn370

FUSION TAG: C-6 His tag

TESTED APPLICATIONS:

APPLICATIONS: This recombinant protein can be used for biological assays. For research use only.

PREDICTED MOLECULAR 38.9 kD WEIGHT:

Properties

Greater than 95% as determined by reducing SDS-PAGE. PURITY: Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

PHYSICAL STATE: Lyophilized

Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to BUFFER: reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

September 23, 2021 1 https://www.prosci-inc.com/cd5-recombinant-protein-92-560.html Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks. STORAGE CONDITIONS: Reconstituted protein solution can be stored at 4-7˚C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚C for 3 months.

Additional Info

OFFICIAL SYMBOL: Cd5

T-cell surface glycoprotein CD5, CD5, CD5 antigen, CD5 antigen (p56-62), CD5 molecule, ALTERNATE NAMES: LEU1T-cell surface glycoprotein CD5, antigen T1, Leu-1, T1, Ly-1

ACCESSION NO.: P13379

PROTEIN GI NO.: 189054143

GENE ID: 12507

Background and References

CD5 is a transmembrane glycoprotein of the conserved scavenger receptor cysteine-rich (SRCR) superfamily and expressed on , peripheral T cells and a subset of B cells (B1-a). Moreover, CD5 also was found expressed in small lymphocytic , hairy cell leukaemia and cells. The long cytoplasmic tail of CD5 has no intrinsic enzymatic activity, but contains four tyrosine phosphorylation sites, including an immunoreceptor tyrosine-based (ITAM)-like motif (pseudo-ITAM) and an BACKGROUND: immunoreceptor tyrosine-based inhibitory (ITIM)-like motif (pseudo-ITIM), as well as multiple potential serine and threonine phosphorylation sites. It physically associates with the antigen receptor (TCR) and antigen receptor (BCR), where it negatively modulates the activation and differentiation signals transduced by these receptors. CD5 also plays an important role in protection from activation-induced cell death and in the recognition of pathogen associated molecular patterns (PAMPS) present on fungal surfaces.

ANTIBODIES FOR RESEARCH USE ONLY.

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September 23, 2021 2 https://www.prosci-inc.com/cd5-recombinant-protein-92-560.html