Department of

Graduate Education in the Department of Pathology Molecular and Tumor Training Program Molecular Oncology and Overview Tumor Immunology (MOTI)

Molecular Oncology and Tumor Immunology (MOTI) is an integrated Enormous advances have been made in recent years in and function of stem cells, and regulation of understanding the underlying molecular, cellular, and genetic expression and signal transduction pathways; basic studies of program focusing on Cancer Biology, Tumor Immunology, and the causes of human cancer. Of particular importance has been tumor progression over a wide range of cancer models including interface between these disciplines. The program is broadly defined, the realization of the interrelationships between oncogenesis, breast, prostate, bladder, and pancreatic cancer, melanoma, , and innate and adaptive immunity. The Molecular neuroblastoma and leukemias; and more applied approaches with a major emphasis on the intersection across related disciplines. It is Oncology and Tumor Immunology (MOTI) Program offers to cancer and immunity, such as targeted tumor cell killing, unique training at the interface between cancer biology and tumor gene , production of anti-tumor vaccines, and a well-established program, with an extensive and experienced faculty. immunology. Coursework provides students with a solid immunological and molecular approaches to cancer therapy. foundation in all aspects of modern cancer biology, the immune The Program brings together investigators from across the We encourage you to review the detailed description of the MOTI system, and the interrelationship between the two disciplines, School of , who employ cutting edge tools of molecular with an emphasis on molecular, genetic, cell biological and biology and genetics, sophisticated imaging technologies, graduate training program contained in this booklet and to contact pathophysiological aspects of cancer and immunity, as well as and genomewide genetic, chemical, and proteomic analysis of translational discovery and clinical cancer biology. Research cancer and immunity. the faculty and program advisors if you want to learn more about it. projects in the Program emphasize the study of animal models The program is administered in the Department of Pathology, and human disease as well as molecular genetic and cell taking full advantage of being at the interface of the basic and biological approaches. Laboratory research opportunities clinical research efforts of the department, while drawing its run the gamut of basic studies of cancer cell biology, such faculty from across many departments and institutes in the as control, the function of oncogenes and tumor School of Medicine. suppressors, regulation of degradation, maintenance of genome and chromosomal integrity, analysis of the nature

LEADERSHIP

Director Co-Director Graduate Advisor „ You may also want to visit the Department of Pathology website at: David E. Levy, PhD William L. Carroll, MD Tony Huang, PhD www.med.nyu.edu/pathology/education/graduate-programs/molecular-oncology-and-immunology [email protected] [email protected] [email protected] 212.263.8192 212.263.3019 212.263.9046

2 Molecular Oncology and Tumor Courses Immunology Program Curriculum Outline

Students spend the first year taking Sackler Institute required courses and participating in three lab- COURSE NAME DIRECTOR(S) SEMESTER oratory rotations. In addition, courses in Topics in Molecular Biology, Intro to Immunology, Molecular Oncology, Intro to Biostatistics, Cell Biology, Intro to Molecular Genetics, and Translating Cancer Introduction to Research Angus Wilson, PhD Fall Discovery are required by this program and must be taken within the first two years. Topics in Molecular Biology Angus Wilson, PhD Fall In the second year, students continue to take courses to fulfill their credit requirements and begin formal research in the laboratory they have selected for their dissertation projects. At the end of the second Introduction to Immunology Alan Frey, PhD Fall year, students write a proposal and take an oral qualifying examination in molecular oncology and immu- nology, which is read by their pre-thesis committee. Students continue to meet with this committee at Translating Cancer Discovery into Clinical Practice William L. Carroll, MD Fall least once per year until their thesis research is completed. Throughout their tenure within the Program, (Prerequisite: Molecular Oncology) students are expected to attend the Work-In-Progress Series, Cancer Center Seminar, Immunology Seminar, and others being offered at NYU Langone Medical Center. Stuart Brown, PhD Topics in Bioinformatics Fall David Fenyö, PhD

Research in Pathology Tony Huang, PhD Fall

In addition to the standard Sackler Curriculum, the following specific courses Introduction to Molecular Genetics James Borowiec, PhD Spring are required for MOTI students: Cell Biology Pamela Cowin, PhD Spring

REQUIRED COURSES FOR THE MOTI PROGRAM Introduction to Biostatistics Itai Yanai, PhD Spring • Topics in Molecular Biology (Fall) • Introduction to Molecular Genetics (Spring) • Introduction to Immunology (Fall) • Cell Biology (Spring) Molecular Oncology David Levy, PhD Spring • Translating Cancer Discovery into Clinical Practice • Research in Pathology Advanced Immunology Juan Lafaille, PhD Spring (Prerequisite: Molecular Oncology) • Work in Progress (Student/Postdoc seminar series) • Introduction to Biostatistics (Spring) Only second year and beyond Molecular Pathology in the Omics Era Adriana Heguy, PhD Spring • Molecular Oncology (Spring) Stem Cell Biology E. Jane Hubbard, PhD Spring

RECOMMENDED COURSES Topics in Protein Modifications in Cell Signaling Tony Huang, PhD Spring • Advanced Immunology (Spring) • Protein Modifications in Cell Signaling (Spring) • Molecular Pathology in the Omics Era (Spring) Stefan Feske, MD Seminar in Immunology Fall/Spring Sergei Koralov, PhD

Work in Progress (Seminar in Pathology) David Levy, PhD Fall/Spring RECOMMENDED SEMINARS • Cancer Center and/or Immunology Seminars Cancer Center Seminar

4 Molecular Oncology and Tumor Immunology Faculty

Iannis Aifantis, PhD Eva Hernando-Monge, PhD Susan K. Logan, PhD Daniel B. Rifkin, PhD Hematopoietic stem cell differentiation, leukemia, Cell-of-origin and ‘cancer stem cells’ in sarcoma and melanoma Cell Growth Regulation through the Androgen Extracellular control of action Ubiquitin ligases initiation and Progression George Miller, MD Hyung Don Ryoo, PhD Erika Bach, PhD Tony Huang, PhD Tumor immunology in of the liver and pancreas Cellular stress responses and apoptosis in Mechanisms of stem cell self-renewal, cellular growth, Regulation of ubiquitination and deubiquitination in DNA repair development and cancer Daniel Meruelo, PhD proliferation and pattern formation by the JAK/STAT pathway and cancer susceptibility pathways , Cancer, Alzheimer’s disease Robert Schneider, PhD Dafna Bar-Sagi, PhD Stevan R. Hubbard, PhD Altered regulation of and translation Moosa Mohammadi, PhD Oncogene function in pancreatic cancer Crystallographic studies of tyrosine kinase oncoproteins carcinogenesis and cell stress Structural and functional studies of fibroblast growth factor Tim Cardozo, MD, PhD Tomas Kirchhoff, PhD receptors Markus Schober, PhD discovery Identification of the genetic basis of cancer susceptibility Role of stem cells in skin cancer initiation and dormancy Benjamin Neel, MD, PhD William Carroll, MD Hannah L. Klein, PhD Signal transduction pathways regulating normal and malignant Susan R. Schwab, PhD Treatment of childhood cancer, especially leukemias and the DNA damage, genomic instability, homologous recombination cell proliferation, differentiation, and survival Role of S1P and S1P-generating enzymes in tumor growth common solid tumor Neuroblastoma Sergei B. Koralov, PhD Iman Osman, MB, BCh, MD Jane A. Skok, PhD Pamela Cowin, PhD Role of Th17 driven inflammation in lymphomagenesis as well Genetic and genomic analysis of melanoma initiation, Nuclear organization of immunoglobulin and genomic Breast cancer, cell adhesion, and Wnt signaling as understanding the role of non-coding RNAs in lymphocyte progression, and treatment aberrations in lymphoma development Gregory David, PhD Michele Pagano, MD Edward Y. Skolnik, MD Chromatin modifications in development and oncogenesis Michelle Krogsgaard, PhD Ubiquitin system, cell division cycle checkpoints, cancer Signal transduction mechanisms of cell proliferation T-cell recognition, cancer immunology, self-, cancer and growth control Brian Dynlacht, PhD Thales Papagiannakopeoulos, PhD Cancer, transcription, cell cycle, centrosome biology, Elucidating the mechanisms of cancer initiation and progression Susan Smith, PhD Peng Lee, MD, PhD using genetically engineered mouse models Telomeres, tankyrase, cohesion; genome integrity in cancer Stefan Feske, MD Androgen receptor function, cofactors and target genes in activation, immunity and development, calcium channels Mark Philips, MD David Zagzag, MD, PhD prostate and breast cancer Processing and membrane targeting of GTPases involved Angiogenesis, vasculogenesis, brain tumors, extracelluar matrix Alan B. Frey, PhD David E. Levy, PhD in growth control Function of tumor infiltrating lymphocytes in human breast Role of STAT in tumorigenesis, metabolism cancer Dimitris Placantonakis, MD, PhD and development Heterogeneity and diversity of cancer stem cells in glioblastoma Michael Garabedian, PhD Dan R. Littman, MD, PhD Mechanism of Steroid Hormone Receptor Action in cell growth Richard L. Possemato, PhD T cell development; mechanisms of inflammation; Metabolic regulation of tumor cells Lawrence Gardner, MD AIDS pathogenesis Molecular mechanisms of hypoxia that augment Boris Reizis, PhD malignant cell growth Development of myeloid and dendritic cells; myeloid leukemia

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1 Department of Pathology 550 First Avenue Medical Sciences Building, 5th Floor New York, NY 10016