4: the Types and Estimated Numbers of Vaccine-Related Injuries
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Raised Intracranial Pressure and Hydrocephalus
Raised Intracranial Pressure and Hydrocephalus Sept 2014 Raised Intracranial Pressure 500ml/day CSF made to replenish volume of 150ml. ICP = MAP-CPP. Normal ~10mmHg. Raised = >20mmHg sustained for >15min. ICP monitoring if severe HI & coma, intracerebral haemorrhage, Reye’s, hydrocephalus Causes of raised intracranial pressure Localised mass lesions: traumatic haematomas (extradural, subdural, intracerebral) Neoplasms: glioma, meningioma, metastasis Abscess Focal oedema secondary to trauma, infarction, tumour Disturbance of CSF circulation: obstructive hydrocephalus, communicating hydrocephalus Obstruction to venous sinuses: depressed fractures overlying venous sinuses, cerebral venous thrombosis Diffuse brain oedema or swelling: encephalitis, meningitis, diffuse head injury, SAH, Reye's syndrome, lead encephalopathy, water intoxication, near drowning Idiopathic intracranial hypertension Presentation Headache: nocturnal, on waking, worse on coughing/moving head ↓LOC: lethargy, irritability, slow decision making, abnormal behaviour → stupor, coma and death Vomiting Eye changes: irregularity or dilatation in one eye. Unilateral ptosis or III and VI nerve palsies. In later stages, ophthalmoplegia and loss of vestibulo-ocular reflexes. Papilloedema: blurring of disc margins, loss of venous pulsations, disc hyperaemia, flame haemorrhages. Later, obscured disc margins and retinal haemorrhages. Cushing reflex: ( ↑BP, widened pulse pressure and ↓HR). Other: Late hemiparesis Investigations CT/MRI Check and monitor ABG, blood glucose, renal function, -
Same Dog Bite and Different Outcome in Two Cases – Case Report
DOI: 10.7860/JCDR/2014/9017.4468 Case Report Same Dog Bite and Different Outcome in edicine M ection S Two Cases – Case Report Community GADEKAR RD1, DOMPLE VK2, INAMDAR IF3, ASWAR NR4, DOIBALE MK5 ABSTRACT There is still no cure for rabies and survival from clinical rabies is extremely rare. It is a preventable disease if the post exposure prophylaxis is initiated in time and administered as per WHO guidelines including administration of rabies immunoglobulin. The role of passive rabies immunization products is to provide the immediate availability of neutralizing antibodies at the site of the exposure before it is physiologically possible for the patient to begin producing his or her own antibodies after vaccination. In this case report, the same dog has bitten to a boy and to an adult. Local wound treatment and use of human rabies immunoglobulin as well as gluteal region as a site of bite were the probable reasons for survival of the boy. On the other hand no local wound treatment, no use of rabies immunoglobulin and finger as a site of bite are the probable reasons for death of an adult due to rabies. Keywords: Death, Rabies, Rabies immunoglobulin, Treatment failure CASE REPORT others/unknown (10.2%) [2]. Cats accounted for 1.7% of deaths. A 5-year-old boy from Yavatmal District in Maharashtra State, India The use of rabies immunoglobulin was negligible (1.3%) [2]. was bitten by a pet dog on 7th June 2010, incurring two deep The average incubation period varies from 20-90 days after exposure lacerations on right gluteal region (WHO Class III bite). -
Reye's Syndrome Difficult Its 32A, 381
662 BRITISH MEDICAL JOURNAL 20 SEPTEMBER 1975 5 Dwyer, A. F., Newton, N. C., and Sherwood, A. A., Clinical Orthopaedics amino-acid pattern.7 Confirmation of the diagnosis requires and Related Research, 1969, 62, 192. Br Med J: first published as 10.1136/bmj.3.5985.662 on 20 September 1975. Downloaded from 6 Dewald, R. L., and Ray, R. D., Journal of Bone and Joint Surgery, 1970, liver biopsy, but this is frequently ruled out by the prolonged 52A, 233. prothrombin time. There is variable but often intense fatty 7O'Brien, J. P., et al.,Journal of Bone and Joint Sturgery, 1971, 53B, 217. infiltration of the liver, with diffuse vacuolation of the hepa- 8 MacEwen, G. D., Bunnell, W. P., and Sriram, K., Jrournal of Bonie and Joint Suirgery, 1975, 57A, 404. tocytes without nuclear displacement and no hepatocellular 9 Ransford, A. O., and Manning, C. W. S. F.,3Journal of Bone andJoint Sur- necrosis.8 gery, 1975, 57B, 131. Since the diagnosis of is 1 Ponseti, I. V., and Friedman, B.,Jrournal of Bone andJoint Surgery, 1950, Reye's syndrome difficult its 32A, 381. incidence may be higher than is generally realized. About I James, J. I. P.,3Journal of Bone and Joint Surgery, 1951, 33B, 399. 400/,, of children diagnosed in life die.9 Features associated 12 James, J. I. P., Scoliosis. E. &. S. Livingstone, Edinburgh & London, 1967. 13 Nachemson, A., Acta Orthopaedica Scandinavica, 1968, 39, 466. with poor prognosis include a blood ammonia level higher 14 Nilsonne, U., and Lundgren, K-D., Acta Orthopaedica Scandinavica, than 200 tmol 1, a rapid progression to deep coma, a pro- 1968, 39, 456. -
Rabies Vaccine Tollwut-Impfstoff Vaccin Antirabique
(19) & (11) EP 1 593 392 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 39/205 (2006.01) A61K 39/42 (2006.01) 28.09.2011 Bulletin 2011/39 C07K 16/10 (2006.01) (21) Application number: 04023168.0 (22) Date of filing: 29.09.2004 (54) Rabies vaccine Tollwut-Impfstoff Vaccin antirabique (84) Designated Contracting States: • LODMELL D L ET AL: "Post-exposure DNA AT BE BG CH CY CZ DE DK EE ES FI FR GB GR vaccination protects mice against rabies virus" HU IE IT LI LU MC NL PL PT RO SE SI SK TR VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD,GB, vol. 19, no. 17-19, 21 March 2001 (30) Priority: 07.05.2004 US 569172 P (2001-03-21), pages 2468-2473, XP004231067 ISSN: 0264-410X (43) Date of publication of application: • SHIMAZAKI Y ET AL: "Immune response to 09.11.2005 Bulletin 2005/45 Japanese rabies vaccine in domestic dogs." JOURNAL OF VETERINARY MEDICINE SERIES (73) Proprietor: Novartis Vaccines and Diagnostics B, vol. 50, no. 2, March 2003 (2003-03), pages GmbH 95-98, XP002306648 ISSN: 0931-1793 35041 Marburg (DE) • ROOIJAKKERS E J M ET AL: "Potency of veterinary rabies vaccines in the Netherlands: A (72) Inventors: case for continued vigilance" VETERINARY • Banzhoff, Angelika, Dr. QUARTERLY, vol. 18, no. 4, 1996, pages 146-150, 35039 Marburg (DE) XP008038725 ISSN: 0165-2176 • Malerczyk, Claudius, Dr. • LODMELL D L ET AL: "Rabies cell culture 35039 Marburg (DE) vaccines reconstituted and stored at 4<o>C for 1 year prior to use protect mice against rabies (74) Representative: UEXKÜLL & STOLBERG virus" VACCINE, BUTTERWORTH SCIENTIFIC. -
Annual Summary of Communicable Disease Reported to MDH, 2003
MINNESOTA DEPARTMENT OF HEALTH DISEASE CONTROL N EWSLETTER Volume 32, Number 4 (pages 33-52) July/August 2004 Annual Summary of Communicable Diseases Reported to the Minnesota Department of Health, 2003 Introduction Minnesota Government Data Practices do not appear in Table 2 because the Assessment is a core public health Act (Section 13.38). Provisions of the influenza surveillance system is based function. Surveillance for communi- Health Insurance Portability and on reported outbreaks rather than on cable diseases is one type of ongoing Accountability Act (HIPAA) allow for individual cases. assessment activity. Epidemiologic routine communicable disease report- surveillance is the systematic collec- ing without patient authorization. Incidence rates in this report were tion, analysis, and dissemination of calculated using disease-specific health data for the planning, implemen- Since April 1995, MDH has participated numerator data collected by MDH and a tation, and evaluation of public health as one of the Emerging Infections standardized set of denominator data programs. The Minnesota Department Program (EIP) sites funded by the derived from U.S. Census data. of Health (MDH) collects disease Centers for Disease Control and Disease incidence may be categorized surveillance information on certain Prevention (CDC) and, through this as occurring within the seven-county communicable diseases for the program, has implemented active Twin Cities metropolitan area (Twin purposes of determining disease hospital- and laboratory-based surveil- Cities metropolitan area) or outside of it impact, assessing trends in disease lance for several conditions, including (Greater Minnesota). occurrence, characterizing affected selected invasive bacterial diseases populations, prioritizing disease control and food-borne diseases. Anaplasmosis efforts, and evaluating disease preven- Human anaplasmosis (HA) is the new tion strategies. -
Atypical Reye Syndrome
Acta Biomed 2021; Vol. 92, Supplement 1: e2021110 DOI: 10.23750/abm.v92iS1.10205 © Mattioli 1885 Case report Atypical Reye syndrome: three cases of a problem that pediatricians should consider and remember Serena Ferretti1, Antonio Gatto2, Antonietta Curatola1, Valeria Pansini2, Benedetta Graglia1, Antonio Chiaretti1,2 1 Department of Woman and Child Health and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; 2 Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy Abstract. Introduction: Reye syndrome is a rare acquired metabolic disorder appearing almost always dur- ing childhood. Its etiopathogenesis, although controversial, is partially understood. The classical disease is typically anticipated by a viral infection with 3-5 days of well-being before the onset of symptoms, while the biochemical explanation of the clinical picture is a mitochondrial metabolism disorder, which leads to a metabolic failure of different tissues, especially the liver. Hypothetically, an atypical response to the preceding viral infection may cause the syndrome and host genetic factors and different exogenous agents, such as toxic substances and drugs, may play a critical role in this process. Reye syndrome occurs with vomiting, liver dys- function and acute encephalopathy, characterized by lack of inflammatory signs, but associated with increase of intracranial pressure and brain swelling. Moreover, renal, and cardiac dysfunction can occur. Metabolic acidosis is always detected, but diagnostic criteria are not specific. Therapeutic strategies are predominantly symptomatic, to manage the clinical and metabolic dysfunctions. Case reports: We describe three cases of chil- dren affected by Reye syndrome with some atypical features, characterized by no intake of potentially trigger substances, transient hematological changes and dissociation between hepatic metabolic impairment, severe electroencephalographic slowdown and slightly altered neurological examination. -
SEARG Report 2001
W. H. O. PROCEEDINGS OF THE SOUTHERN AND EASTERN AFRICAN RABIES GROUP / WORLD HEALTH ORGANIZATION MEETING SUDAN ERITREA ETHIOPIA UGANDA RWANDA KENYA BURUNDI TANZANIA MALAWI ZAMBIA MOZAMBIQUE ZIMBABWE MADAGASCAR BOTSWANA NAMIBIA SWAZILAND LESOTHO SOUTH AFRICA LILONGWE, MALAWI – 18-22 JUNE 2001 Sixth SEARG meeting, Lilongwe 18-21 June 2001 Official opening CONTENTS OFFICIAL OPENING PROGRAMME OF THE MEETING .............................................................................................................................. 4 Southern and Eastern African Rabies Group conference Lilongwe MALAWI: 18 to 21 June 2001 ................... 4 OPENING SPEECH................................................................................................................................................... 7 OPENING SPEECH................................................................................................................................................... 9 OPENING SPEECH................................................................................................................................................. 10 COUNTRY REPORTS RABIES IN BOTSWANA......................................................................................................................................... 13 RABIES IN BURUNDI IN 1999 AND 2000............................................................................................................... 17 RABIES IN ERITREA ............................................................................................................................................ -
Raised Drug in Patient Recovered Completely Etiology Or Reye
upwards fixed gaze. The liver was enlarged and hypoglycemia and raised transaminases were noted. The encephalopathy and dystonic reactions were considered secondary to the anti-emetic drug in combination with liver disease most probably due to viral infection. Neurological examination was normal after 36 hours and the patient recovered completely after 10 days. The author stresses the need to consider drugs other than salicylates in the etiology or Reye syndrome and particularly the use anti-emetics (Casteels- VanDaele M. Reye syndrome or side effects of anti-emetics? Eur J Pediatr May 1991; 150:456-4591. COMMENT. In the 1960's several cases of toxic encephalopathy resembling Reye syndrome were reported in patients who had received the anti-emetic Tigan for vomiting. Dr. John Pepper, the Director of Toxicological Studies at Hoffman Laroche Company investigated these reports with customary thoroughness and with the aid of many consultants. No specific correlation between the use of Tigan and the toxic encephalopathy was determined. The lack of association of Reye syndrome with aspirin use has been reported from Australia (Orlowski J P et al. A catch in the Reye Pediatrics 1987; 80:638. See Ped Neur Briefs Nov 1987). HEADACHE CHOCOLATE IS A MIGRAINE-PROVOKING AGENT Patients with migraine who believe that chocolate could provoke their attacks were challenged with either chocolate or a closely matching placebo in a double-blind parallel group study at the Princess Margaret Migraine Clinic, Charing Cross Hospital, London, England. The placebo contained no cocoa butter or cocoa powder and the carob powder used in the placebo was also added to the chocolate and successfully disguised by the use of a peppermint- masking flavor. -
Influenza a Virus and Reye's Syndrome in Adults
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.43.6.516 on 1 June 1980. Downloaded from Journal of Neurology, Neurosurgery, and Psychiatry, 1980, 43, 516-521 Influenza A virus and Reye's syndrome in adults LARRY E DAVIS AND MARIO KORNFELD From the Neurology Service, Veterans Administration Medical Center and Department of Neurology and Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico S U M M A R Y We report fatal Reye's syndrome in two adults following proven influenza A viral infections. Reye's syndrome is, therefore, not confined to children but may also occur in adults. Many reported cases of postinfluenza A encephalopathy have clinical and pathological features of Reye's syndrome suggesting that they are not due to postinfectious perivenous demyelination. In 1963, Reye, Morgan, and Baral described 21 died. No one in his family had ever had illnesses children who, following a prodromal illness, suggesting abnormalities of the urea cycle. developed vomiting, seizures, coma and death.' Laboratory tests included a normal brain com- Noninflammatory cerebral oedema and fatty meta- puterised tomogram (CT), blood count, and serum morphosis of the liver was found at necropsy. An electrolytes. A traumatic lumbar puncture done Protected by copyright. increasing number of similar cases have since on admission had a normal opening pressure. The been reported worldwide. Reye's syndrome is gen- cerebrospinal fluid (CSF) contained 900 fresh red erally thought to occur only in children. The blood cells per mm3, 5 lymphocytes per mm3, 250 aetiology is unknown, but the syndrome has been mg per dl protein, 150 mg per dl glucose, and associated with epidemics of influenza B virus2 sterile bacterial and fungal cultures. -
Reye Syndrome
Number 84 January 2019 Reye Syndrome What is Reye Syndrome? Diarrhea and rapid breathing in infants and Reye Syndrome is a rare disease that mainly toddlers affects children and teenagers when they have, Persistent vomiting in children and teenagers or recently had, a viral infection such as Changes in personality or behaviour such as chickenpox or influenza. Reye Syndrome confusion, irritability or aggression. Reye causes swelling of the liver and brain, and it Syndrome may also cause strange behavior can also cause death. such as staring and slurred speech How can I prevent Reye Syndrome? Seizures and comas The use of acetylsalicylic acid (ASA or Loss of consciousness Aspirin®) has been strongly linked to Reye Syndrome. Do not give ASA or Aspirin® to Reye Syndrome occurs 3 to 7 days after the anyone under 18 years of age to manage beginning of an infection or illness caused by a symptoms such as fever, headache and muscle virus, or during recovery from the infection or aches. illness. Reye Syndrome can be misdiagnosed as swelling of the brain, also known as Instead, use acetaminophen for anyone under encephalitis or swelling of the lining of the 18 years of age. Examples of medications with brain (meningitis), diabetes, drug overdose, acetaminophen are Tylenol®, Tempra® and poisoning, sudden infant death syndrome Atasol®. (SIDS) or a psychiatric illness. You can also use ibuprofen for relief of What is the treatment? symptoms in children under 18 years of age. Early diagnosis and treatment in a hospital can Examples of ibuprofen include Advil® and save your child’s life. -
Rabies Prevention in Travellers
CLINICAL Rabies Amy A Neilson Prevention in travellers Cora A Mayer There are seven known genotypes within the genus This article forms part of our travel medicine series for 2010, providing a summary of Lyssavirus; all cause rabies-like illnesses. Rabies prevention strategies and vaccination for infections that may be acquired by travellers. virus is genotype 1. Australian bat lyssavirus (ABL) The series aims to provide practical strategies to assist general practitioners in giving is genotype 7, and is more closely related to rabies travel advice, as a synthesis of multiple information sources which must otherwise be virus than the other genotypes.3–5 consulted. Rabies virus is present in the saliva of an Background infected animal and can be transmitted via animal Rabies is an acute, almost invariably fatal, progressive encephalomyelitis caused by bite, and rarely, via other exposures such as neurotropic lyssaviruses of the Rhabdoviridae family. scratches to skin, licks to open wounds or mucous Objective membranes, or after organ transplantation.5,6 Rabies prevention, vaccines and postexposure prophylaxis are discussed, and Rather than entering the bloodstream, the highly information regarding vaccines, immunoglobulin products and vaccine regimens that neurotropic virus7 is taken up at nerve synapses and may be encountered overseas is also given. travels to the brain along the nerve by retrograde Discussion axoplasmic flow. Symptoms start once the brain Rabies viruses are present in most parts of the world, although it is mainly a problem in is reached and viral replication occurs within developing countries with more than 50 000 people dying from rabies each year, usually neurons. -
Wo 2009/004641 A2
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date PCT (10) International Publication Number 8 January 2009 (08.01.2009) WO 2009/004641 A2 (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C12N 7/00 (2006.01) C12N 5/06 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 39/205 (2006.01) AO, AT,AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, (21) International Application Number: EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, PCT/IN2008/000262 IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, (22) International Filing Date: 24 April 2008 (24.04.2008) LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, (25) Filing Language: English PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW (30) Priority Data: 1275/MUM/2007 3 July 2007 (03.07.2007) IN (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): CADILA GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, HEALTHCARELIMITED [IN/IN] ; Zydus Tower, Satel ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), lite Cross Roads, Amedadabad 380 015, Gujara (IN).