Anti-PLVAP Monoclonal Antibody, Clone MECA-32 [FITC] (CABT-50888RM) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-PLVAP monoclonal antibody, clone MECA-32 [FITC] (CABT-50888RM) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rat anti Mouse PLVAP antibody, clone MECA-32 recognizes murine plasmalemma vesicle- associated protein (PLVAP), a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high- grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumour angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target. Flow Cytometry Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.

Specificity PLVAP

Isotype IgG2a

Source/Host Rat

Species Reactivity Mouse

Clone MECA-32

Conjugate FITC

Applications FC

Procedure Conjugated Antibodies

Format Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid

Size 100 μg

Preservative 0.09% Sodium Azide

Storage in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Warnings For research purposes only

GENE INFORMATION

Gene Name Plvap plasmalemma vesicle associated protein [ Mus musculus (house mouse) ]

Official Symbol PLVAP

Synonyms PLVAP; plasmalemma vesicle associated protein; Pv1; MECA32; plasmalemma vesicle- associated protein; MECA-32 antigen; plasmalemma vesicle protein 1;

Entrez Gene ID 84094

Protein Refseq NP_115774

UniProt ID Q91VC4

Chromosome Location 8 B3.3; 8 34.43 cM

Function protein homodimerization activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]