Author's Accepted Manuscript У Cardiac fibrosis in patients with atrial М fibrillation: Mechanisms and clinical Г implications р Г Mikhail S. Dzeshka, MD, Gregory Y.H. Lip, MD, Viktor Snezhitskiy, PhD, Eduard Shantsila, PhD Journal of the American College of Cardiology й Volume 66, Issue 8, August 2015, P. 943-959 DOI: 10.1016/j.jacc.2015.06.1313 и р о т и з о п е Р STATE OF THE ART REVIEW Cardiac fibrosis in patients with atrial fibrillation: Mechanisms and clinical implications У Mikhail S. Dzeshka MD1,2 М Gregory Y.H. Lip MD1,3 Viktor Snezhitskiy PhD2 Г Eduard Shantsila PhD1 р Г 1University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham B18 7QH, United Kingdom; 2Grodno State Medical University,й Grodno, Belarus; and 3Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. и р Total word count (including references,о figures legends, excluding tables and title page): 9,293 т Brief title: Cardiac fibrosis in иpatients with atrial fibrillation з Corresponding author:о Dr Eduard Shantsilaп , Tel: +44 121 507 5080, Fax: +44 121 554 4083, Email:
[email protected] е Р 1 Competing interests G.Y.H.L. has served as a consultant for Bayer, Astellas, Merck, Sanofi, BMS/Pfizer, Biotronik, Medtronic, Portola, Boehringer Ingelheim, Microlife and Daiichi-Sankyo and has been on the speakers bureau for Bayer, BMS/Pfizer, Medtronic, Boehringer Ingelheim, У Microlife and Daiichi-Sankyo. M.S.D., V.S. and E.S. – none declared.М Г р Г й и р о т и з о п е Р 2 Abstract Atrial fibrillation (AF) is associated with structural, electrical and contractile remodeling of the atria.