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Retest Reliability of Eventrelated Potentials: Evidence from a Variety of Paradigms

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Retest Reliability of Eventrelated Potentials: Evidence from a Variety of Paradigms Psychophysiology, •• (2012), ••–••. Wiley Periodicals, Inc. Printed in the USA. Copyright © 2012 Society for Psychophysiological Research DOI: 10.1111/j.1469-8986.2011.01349.x BRIEF REPORT Retest reliability of event-related potentials: Evidence from a variety of paradigms SARAH M. CASSIDY, IAN H. ROBERTSON, and REDMOND G. O’CONNELL School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland Abstract Event-related potentials (ERPs) offer unparalleled temporal sensitivity in tracing the distinct electrocortical processing stages enabling cognition and are frequently utilized in clinical and experimental investigations, yet few studies have investigated their retest reliability. We administered a battery of typical ERP paradigms to elicit a diverse range of components linked to distinct perceptual and cognitive processes (P1, N1, N170, P3a, P3b, error-related negativity, error positivity, P400). Twenty-five participants completed the battery on two occasions, 1 month apart. Analysis of component amplitudes indicated moderate-to-strong split-half and strong test-retest reliability. Peak latency reliability varied sub- stantially across components and ranged from weak to strong. We confirm that a range of prominent ERPs provide highly stable neurophysiological indices of human cognitive function. Descriptors: Cognition, Normal volunteers, EEG/ERP Event-related potentials (ERPs) are a noninvasive method of meas- stability of different categories of components (e.g., early vs. late, uring the distinct electrocortical processing stages enabling cogni- perceptual vs. cognitive) and component measures (e.g., mean tion and have become a popular tool in neuroscience, and amplitude vs. area-under-the-curve, absolute peak vs. difference increasingly in clinical and pharmacological investigations. The waveform). validity of ERPs as endophenotypes or as biomarkers is partly We employed paradigms that are frequently utilized in the dependent on their stability over time. Although ERPs are modu- literature to elicit the components of interest. Task selection was lated state factors including circadian rhythm (Munte, Heinze, designed to ensure a broad sample of ERPs indexing a range of Kunkel, & Scholz, 1987), sleep deprivation (Boonstra, Stins, different perceptual and cognitive processes, including visual- Daffertshofer, & Beek, 2007; Murphy, Richard, Masaki, & evoked components P1 and N1 (early visual selection, Luck, Segalowitz, 2006), and mood (e.g., Cavanagh & Geisler, 2006; Woodman, & Vogel, 2000), the N170 (face processing, Ming-Fang, Olvert & Hajcak, in press), they should exhibit substantial consist- Ye, & Qing-Lin, 2010), the P3a and P3b (attention resource allo- ency over time if they index stable neurophysiological traits. cation, Polich & Criado, 2006), the ERN and Pe (error processing, To date, retest evaluations have focused on a limited range Falkenstein, Hoormann, Christ, & Hohnsbein, 2000), and the P400 of ERP components, primarily the P300 (e.g., Walhovd & Fjell, (memory encoding, Dien, Michelson, & Franklin, 2010). The 2002), mismatch negativity (MMN, e.g., Hall et al., 2006), and current study examines the test-retest and split-half reliability of error-related negativity (ERN, e.g., Segalowitz et al., 2010) and these commonly recorded ERP components across a 1-month have reported moderate-to-strong reliability estimates over periods period. ranging from weeks to years. Our study expands on this work by calculating retest reliability estimates for a diverse range of com- Method monly studied ERP components collected from a single sample of participants. This approach facilitated comparison of the relative Participants Twenty-five right-handed participants (15 females, 19–35 years old; mean age, 24.6; SD, 4.5) with normal or corrected-to-normal This research was supported by an Irish Research Council for Science, vision and no history of head injury, neurological or psychia- Engineering and Technology (IRCSET) Empower Fellowship to R.G.O’C. The authors also acknowledge funding support via the HEA PRTLI Cycle tric disorder. Participants gave written informed consent prior to 3 program of the EU Structural Funds and the Irish Government’s National the study, which was approved by the Trinity College Dublin Development Plan 2002–2006. This work was conducted in association School of Psychology Ethics Committee, and each received €40 for with NIEL (Neuroenhancement for Inequalities in Elder Lives), a research participating. program funded by Atlantic Philanthropies. Address correspondence to: Dr. Redmond O’Connell, Trinity College Two participants were excluded from the Oddball analysis Institute of Neuroscience, Lloyd Building, Trinity College Dublin, Dublin and one from the Sternberg analysis due to incomplete data col- 2, Ireland. E-mail: [email protected] lection arising from a technical fault. One participant was 1 2 S.M. Cassidy, I.H. Robertson, and R.G. O’Connell removed from the Flanker analysis due to insufficient trial Assessing state factors. Participants completed a brief question- numbers after artifact rejection (<6 errors). Two participants were naire assessing the number of hours of sleep the night before each removed from the Faces analysis: one due to insufficient trial testing session and current levels of stress and energy (single ques- numbers and one due to excessive artifacts. In addition, any par- tion: “How much energy would you say you have right now?” ticipants with extreme outlier values on a given component were responding on a 5-point Likert scale). The Hospital Anxiety and excluded from the reliability estimates for that component only. Depression Scale (HADS; Zigmond & Sims, 1983) was also Final participant numbers for each reliability estimate are pro- administered. Participants were asked to abstain from caffeine and vided in Table 1. nicotine 2 h before testing. Procedure EEG Acquisition Participants performed four cognitive tests on two separate occa- Continuous electroencephalogram (EEG) was acquired through the sions separated by 4 weeks. Each session lasted approximately ActiveTwo BioSemi electrode system from 64 scalp electrodes, 90 min including frequent rest breaks. Each of the four tests is digitized at 512 Hz. Vertical eye movements were recorded with explained below. In all cases, participants fixated on a central cross, two vertical electrooculogram electrodes placed above and below and speed and accuracy were equally emphasized. Participants the left eye, while electrodes at the outer canthus of each eye were tested while seated in an armchair ~65 cm from the computer recorded horizontal movements. EEG preprocessing and analysis screen in a dimly lit, electrically shielded room. Both testing ses- were conducted using BESA 5.2. Data were average referenced sions took place at the same time of day. All participants completed offline and filtered from 0.5–40 Hz. Blinks and eye movements their second session 28 Ϯ 2 days after the first session. were corrected using an algorithm developed by Berg and Scherg (1994). Individual epochs were subjected to an additional artifact Oddball task (P1, N1, P3a, P3b). Standard stimuli consisted of criterion of Ϯ90 mV. 3.5-cm diameter purple circles, which appeared on 75% of trials. Stimulus-locked ERPs were extracted from the Oddball, Stern- Target stimuli were 4-cm diameter purple circles, which appeared berg, and Faces tasks and segmented into epochs of 100 ms before on 12.5% of trials. Distractor stimuli were black and white check- to 800 ms after stimulus onset, and baseline-corrected using the erboards, which appeared on 12.5% of trials. Every 2,075 ms, a prestimulus interval. Scalp locations and measurement windows stimulus appeared on the screen for 75 ms. Participants indicated for each ERP component were based on their spatial extent and Target stimuli by pressing the left mouse button. There were 320 latency after inspection of grand-average waveforms (collapsed trials in total. across the two sessions). Later, ERP components P3a/P3b, Pe, and P400, which do not have well-defined peaks, were measured using Flanker task (ERN, Pe). Five-letter arrays, in which a central a variety of common scoring methods (peak amplitude, mean target letter was flanked on each side by either congruent (SSSSS amplitude, area-under-the-curve). To limit the number of statistical or HHHHH) or incongruent (HHSHH, SSHSS) letters, were seri- comparisons, reliability estimates were calculated for the electrode ally presented at fixation. Participants made a left click if the location at which component amplitude was greatest (see Table 1). central stimulus was H and a right click if the central stimulus The P1 (70–110 ms), N1 (130–180 ms), P3a (300–450 ms) were was S. There were 480 trials in total; 80 congruent array trials elicited by distractor stimuli on the Oddball task, the P3b (300– and160 incongruent array trials for both of the letters. Each array 500 ms) was elicited by target stimuli on the Oddball task, memory was on screen for 200 ms with an interstimulus interval of set stimuli on the Sternberg task elicited the P1 (70–130 ms) and 1,250 ms. N1 (130–210 ms), and positive probe stimuli were used to elicit the P400 (350–450 ms). A comparison of happy versus neutral faces Sternberg task (P1, N1, P400). Participants were presented revealed no significant effects on N170 amplitude or latency at with 100 different memory sets, consisting of five digits serially either session (all t < 1). Nevertheless, separate N170 (120–
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