Breast Reduction and Mastopexy for Repair of Asymmetry After Breast Conservation Therapy: Lessons Learned
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Aesth Plast Surg (2019) 43:600–607 https://doi.org/10.1007/s00266-019-01338-0 ORIGINAL ARTICLE BREAST SURGERY Breast Reduction and Mastopexy for Repair of Asymmetry After Breast Conservation Therapy: Lessons Learned 1 1 1 1 1 Yoav Barnea • Gal Bracha • Ehud Arad • Eyal Gur • Amir Inbal Received: 17 December 2018 / Accepted: 11 February 2019 / Published online: 25 February 2019 Ó Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2019 Abstract occurrence of complications and patients’ demographics, Background Breast conservation therapy (BCT) can cause tumor type, tumor location, and breast tissue resection breast distortion and asymmetry. Repair of this asymmetry (p [ 0.05). by means of breast reduction or mastopexy procedures can Conclusion Only two of our 25 patients had major com- be challenging and harbor considerably high rates of plications following breast reduction and mastopexy for the complications. repair of asymmetry post-BCT. Following our four-step Methods In this retrospective study, we describe our protocol was instrumental in leading to the successful experience in repairing post-BCT breast asymmetry by performance of these procedures. performing breast reduction or mastopexy. The surgical Level of Evidence IV This journal requires that authors protocol we followed consisted of stringent patient selec- assign a level of evidence to each article. For a full tion, thorough surgical planning, basic surgical refine- description of these Evidence-Based Medicine ratings, ments, and patient education for enhancing the likelihood please refer to the Table of Contents or the online of achieving a good outcome with minimal surgical Instructions to Authors www.springer.com/00266. complications. Results Our search of the departmental database identified Keywords Breast conservation therapy Á Breast reduction Á 25 patients with breast asymmetry who had undergone Mastopexy Á Radiated breast breast reduction or mastopexy between 2009 and 2017. Corrective surgery was performed 4 years on average after the completion of radiotherapy, and those patients included Introduction eleven who had undergone breast reduction and fourteen who had undergone mastopexy on the radiated side. Two Breast conservation therapy (BCT) involves tumor resec- patients (8%) had major complications that required further tion with clear margins followed by radiation therapy, and surgery (major fat necrosis, wound infection, and breast it is the current standard of care for isolated breast cancer. deformation), and five patients (20%) had minor compli- It has been shown to attain local oncological control with cations (infection, minor fat necrosis, wound dehiscence, survival rates similar to those of mastectomy [1–3]. BCT and nipple congestion). All complications developed on the allows sparing of the remaining breast tissue, thus leading radiated breast. There was no correlation between the to almost normal breast sensation and improved quality of life [4–8]. However, the combination of wide tumor resection and postoperative radiation-induced fibrosis may & Yoav Barnea [email protected] cause significant breast deformity, asymmetry, fat necrosis, and nipple–areolar complex (NAC) malposition [9, 10]. 1 Plastic and Reconstructive Breast Surgery Unit, Department Improving the breast symmetry in these cases is surgically of Plastic and Reconstructive Surgery, Tel-Aviv Sourasky challenging due to the radiation-induced injury to the Medical Center, Affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizmann St., 6423906 affected breast. Surgical options include local tissue rear- Tel Aviv, Israel rangement or tissue displacement by means of flaps of 123 Aesth Plast Surg (2019) 43:600–607 601 tissue and skin to reconstruct the volume, shape, and Table 1 Patient demographics (n = 25) envelope of the affected breast [4, 11–15]. Age, mean (range) 60.8 (42–74) Patients who have breast ptosis and hypertrophy with BMI, mean (range) 27.7 (21–35) significant asymmetry after undergoing BCT are potential Comorbidities n (%) candidates for local tissue rearrangement in the form of Hypertension 7 (28%) breast reduction or mastopexy, together with adjustment of Hyperlipidemia 6 (24%) the contralateral healthy breast. This procedure can Diabetes mellitus 4 (16%) improve the cosmetic result and the patient’s quality of life. Hypothyroidism 3 (12%) Nevertheless, breast reduction procedures in a previously Hyperthyroidism 3 (12%) operated and radiated breast raise concerns about wound Asthma 2 (8%) healing complications, infection, NAC necrosis, fat necrosis, prolonged edema, and further breast deformation Anemia 1 (4%) [16], leading many plastic surgeons to reject these high-risk IHD 1 (4%) cases. There has been an ongoing search for surgical Other malignancy 1 (4%) modifications and refinements to achieve a good outcome Smokers 5 (20%) with minimal complications for these challenging cases. Previous breast surgery 2 (8%) Recent studies have demonstrated acceptable complica- BRCA gene mutation 0 (0%) tion rates for breast reductions in post-radiated patients BSO 0 (0%) when refined surgical techniques are used and compre- BMI body mass index; IHD ischemic heart disease; BSO bilateral hensive patient education is provided [17–22]. Surgical salpingo-oophorectomy refinements described in the literature include avoiding skin undermining [17–22], planning a wide NAC pedicle [18–20], and dissecting thick skin flaps [18–20, 22]. A current smokers were required to stop smoking at least major limitation of these studies is the small number of 1 month prior to surgery. The postoperative outcome and patients in each series [17–22]. In the current retrospective complications are summarized in Table 3. study, we report the largest number of patients who All the study patients were approved for surgery and underwent breast reduction and mastopexy in previously followed up by the multidisciplinary breast team, including irradiated BCT deformities. We present our surgical mandatory recent breast imaging before surgery (breast approach for these cases, from patient selection and edu- ultrasound, mammography and/or magnetic resonance cation to planning and refinements in the surgical tech- imaging). Surgery was scheduled at least 6 months after nique—all of which are based on lessons learned. We completing the radiation therapy. The surgery planned for believe that these cumulative data can serve to reduce the patients with significant skin damage or substantial fat complication rate and ensure a better outcome in these necrosis following radiation therapy was postponed in the challenging high-risk cases. anticipation of future improvement and softening of the breast tissue. All patients signed an informed consent, after the limitations of surgery in a radiated field, including Patients and Methods postoperative breast asymmetry and complications, had been clearly explained in detail. We reviewed all consecutive patients who underwent breast reduction and mastopexy for asymmetry repair after Surgical Technique breast conservation therapy in our department between 2009 and 2017. Patients with previous breast reduction, Preoperative marking was done after photographing the bilateral tumors, or loss to follow-up were excluded from chest with the patient standing. Each breast was assessed the study. All surgeries were performed in our institution for volume, shape, and nipple position in order to strategize and in a private clinic by the two senior authors (YB and the reduction technique and volume. The radiated breast AI) who used the same surgical approach. The study was was further assessed for skin and soft tissue quality and the approved by the institutional review board (IRB). location of the previous scar and tissue deficit. The new The patients’ demographics, comorbidities, smoking nipple position was drawn on the central meridian of the history, oncological staging, treatment, radiation therapy, breast, typically 1–2 cm below the projected inframam- and surgical data were retrospectively collected from our mary fold (IMF). Nipple position of the radiated breast was database (Tables 1, 2). Removal of C 100 g of breast drawn 1 cm below that of the healthy breast, because of tissue was defined as breast reduction, while removal of \ 100 g was defined as mastopexy. Patients who were 123 602 Aesth Plast Surg (2019) 43:600–607 Table 2 Oncologic data (n = 25) anticipated sagging of the healthy breast which has more Characteristics Number (%) skin laxity compared to the radiated breast. The skin resection was drawn in a dome-mosque con- Tumor type figuration, with the vertical limbs marked by displacement DCIS 3 (12%) of the breast medially and laterally along the breast IDC 16 (64%) meridian (the Lassus maneuver). Skin resection marking LCIS 1 (4%) was more conservative on the radiated breast, with roughly ILC 4 (16%) 1 cm less for each limb. In cases of previous lower-pole Unknown 1 (4%) lumpectomy and scars, the skin resection was even more Lymph node surgery conservative, and the skin was only de-epithelialized and Sentinel lymph node biopsy 13 (52%) sutured in a vest-over-pants fashion, to add volume to the Axillary lymph node dissection 12 (48%) lower pole in selected cases. The skin resection marking Chemotherapy was adjusted to incorporate the previous lower-pole scar, Neoadjuvant 2 (8%) even if the vertical scar turned out oblique, off the meridian Neoadjuvant ? biologic 3 (12%) line. Adjuvant 3 (12%) The vascular