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Open Cyphersthesis FINAL.Pdf
The Pennsylvania State University The Graduate School College of Engineering RESEARCH ON LOW FREQUENCY COMPOSITE TRANSDUCERS FABRICATED USING A SOL-GEL SPRAY-ON METHOD A Thesis in Engineering Science by Robert L. Cyphers c 2012 Robert L. Cyphers Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Science December 2012 The thesis of Robert L. Cyphers was reviewed and approved∗ by the following: Bernhard R. Tittmann Schell Professor of Engineering Science and Mechanics Thesis Advisor Clifford Lissenden Professor of Engineering Science and Mechanics Mark W. Horn Professor of Engineering Science and Mechanics Judith A. Todd Professor of Engineering Science and Mechanics // P. B. Breneman Department Head Head of the Department of Engineering Science and Mechanics ∗Signatures are on file in the Graduate School. Abstract Ultrasonic nondestructive evaluation is currently used in countless applications to maintain a system's operational integrity. Piezoelectric transducers are the devices commonly used in this field to search for defects. A sol-gel fabrication method utilizing a spray-on deposition method has proven to produce ultrasonic transducers useful in harsh environments. This procedure produces thin film transducers, which adhere directly to a substrate making it favorable in use with irregular surface geometries. These transducers operate at relatively high frequencies due to their minute thickness. The objective of this research is to investigate the ability for low frequency operation into the low kilohertz range. Depositing thicker layers of piezoelectric composites, including bismuth titanate and lead zirconate titanate, led to adhesion problems between the metal substrates and ceramic material. Delamination of the piezoelectric elements was determined to be caused by a large mismatch in thermal expansion coefficients. -
Gold(I/III)-Phosphine Complexes As Potent Antiproliferative Agents Jong Hyun Kim, Evan Reeder, Sean Parkin & Samuel G
www.nature.com/scientificreports OPEN Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents Jong Hyun Kim, Evan Reeder, Sean Parkin & Samuel G. Awuah The reaction of gold reagents [HAuCl4•3H2O], [AuCl(tht)], or cyclometalated gold(III) precursor, Received: 17 May 2019 [C^NAuCl2] with chiral ((R,R)-(-)-2,3-bis(t-butylmethylphosphino) quinoxaline) and non-chiral Accepted: 7 August 2019 phosphine (1,2-Bis(diphenylphosphino)ethane, dppe) ligands lead to distorted Au(I), (1, 2, 4, 5) Published: xx xx xxxx and novel cyclometalated Au(III) complexes (3, 6). These gold compounds were characterized by multinuclear NMR, microanalysis, mass spectrometry, and X-ray crystallography. The inherent electrochemical properties of the gold complexes were also studied by cyclic voltammetry and theoretical insight of the complexes was gained by density functional theory and TD-DFT calculations. The complexes efectively kill cancer cells with IC50 in the range of ~0.10–2.53 μΜ across K562, H460, and OVCAR8 cell lines. In addition, the retinal pigment epithelial cell line, RPE-Neo was used as a healthy cell line for comparison. Diferential cellular uptake in cancer cells was observed for the compounds by measuring the intracellular accumulation of gold using ICP-OES. Furthermore, the compounds trigger early – late stage apoptosis through potential disruption of redox homeostasis. Complexes 1 and 3 induce predominant G1 cell cycle arrest. Results presented in this report suggest that stable gold-phosphine complexes with variable oxidation states hold promise in anticancer drug discovery and need further development. Gold-based probe development and drug discovery remain a burgeoning area of biological research and treat- ment for disease indications such as cancer1–5, arthritis6–9, and microbial infection10,11 following the FDA approval of tetra-O-acetylglucose-1-thiolgold(I) triethylphosphine complex (auranofn). -
Highly Luminescent 4-Pyridyl-Extended Dithieno[3,2-B:2′,3′-D]Phospholes
Highly Luminescent 4-Pyridyl-Extended Dithieno[3,2-b:2′,3′-d]phospholes Paul Demay-Drouhard, Thomas Baumgartner* Department of Chemistry, York University, 4700 Keele St. Toronto, ON M3J 1P3, Canada Email: [email protected] ABstract. The unexpectedly challenging synthesis of 4-pyridyl-extended dithieno[3,2-b:2′,3′- d]phospholes via Stille cross-coupling is reported. The optical and electrochemical properties of the phosphoryl-bridged species were studied experimentally and computationally, and their properties compared to their non-P-bridged congeners. The 4-pyridyl-extended dithieno- phospholes display quantitative luminescence quantum yields in solution. Due to their very high brightness, even in water, 4-pyridyl-extended dithienophospholes are highly promising candidates for new fluorescent probes. INTRODUCTION Over the past decades, there has been a surge in the development of new organic building blocks with useful optoelectronic properties for practical applications in a variety of organic electronics.1–5 Some representative molecular platforms include oligothiophenes due to their outstanding charge transport properties,6 and viologens for their reversible redox behavior.7 Tuning the properties of these systems via main-group elements is an interesting strategy as it can result in unique changes in terms of luminescence, supramolecular organization, and 1 electrochemistry.8 We have been focusing our attention on phosphorus-containing π- conjugated species,9 especially the highly luminescent dithieno[3,2-b:2′,3′-d]phosphole10 and the related redox-active phosphaviologen11 scaffolds (Figure 1). In these systems, the addition of phosphorus reduces the energy of LUMO level via negative hyperconjugation from endocyclic σ* orbitals with the π* system.8 Figure 1. -
High Temperature Ultrasonic Transducers: a Review
sensors Review High Temperature Ultrasonic Transducers: A Review Rymantas Kazys * and Vaida Vaskeliene Ultrasound Research Institute, Kaunas University of Technology, Barsausko st. 59, LT-51368 Kaunas, Lithuania; [email protected] * Correspondence: [email protected] Abstract: There are many fields such as online monitoring of manufacturing processes, non-destructive testing in nuclear plants, or corrosion rate monitoring techniques of steel pipes in which measure- ments must be performed at elevated temperatures. For that high temperature ultrasonic transducers are necessary. In the presented paper, a literature review on the main types of such transducers, piezoelectric materials, backings, and the bonding techniques of transducers elements suitable for high temperatures, is presented. In this review, the main focus is on ultrasonic transducers with piezoelectric elements suitable for operation at temperatures higher than of the most commercially available transducers, i.e., 150 ◦C. The main types of the ultrasonic transducers that are discussed are the transducers with thin protectors, which may serve as matching layers, transducers with high temperature delay lines, wedges, and waveguide type transducers. The piezoelectric materi- als suitable for high temperature applications such as aluminum nitride, lithium niobate, gallium orthophosphate, bismuth titanate, oxyborate crystals, lead metaniobate, and other piezoceramics are analyzed. Bonding techniques used for joining of the transducer elements such as joining with glue, soldering, -
Redalyc.PHYSICAL-CHEMICAL PROPERTIES of BISMUTH AND
Dyna ISSN: 0012-7353 [email protected] Universidad Nacional de Colombia Colombia BEDOYA HINCAPIÉ, CLAUDIA MILENA; PINZÓN CÁRDENAS, MANUEL JONATHAN; ALFONSO ORJUELA, JOSE EDGAR; RESTREPO PARRA, ELISABETH; OLAYA FLOREZ, JHON JAIRO PHYSICAL-CHEMICAL PROPERTIES OF BISMUTH AND BISMUTH OXIDES: SYNTHESIS, CHARACTERIZATION AND APPLICATIONS Dyna, vol. 79, núm. 176, diciembre, 2012, pp. 139-148 Universidad Nacional de Colombia Medellín, Colombia Available in: http://www.redalyc.org/articulo.oa?id=49624953018 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative PHYSICAL-CHEMICAL PROPERTIES OF BISMUTH AND BISMUTH OXIDES: SYNTHESIS, CHARACTERIZATION AND APPLICATIONS PROPIEDADES FÍSICO-QUÍMICAS DEL BISMUTO Y OXIDOS DE BISMUTO: SÍNTESIS, CARACTERIZACIÓN Y APLICACIONES CLAUDIA MILENA BEDOYA HINCAPIÉ Ing. Física, Universidad Nacional de Colombia – Sede Bogotá, [email protected] MANUEL JONATHAN PINZÓN CÁRDENAS Ing. Mecatrónico, Universidad Nacional de Colombia – Sede Bogotá, [email protected] JOSE EDGAR ALFONSO ORJUELA PhD. Física, Universidad Nacional de Colombia – Sede Bogotá, [email protected] ELISABETH RESTREPO PARRA PhD. Ingeniería, Universidad Nacional de Colombia - Sede Manizales, [email protected] JHON JAIRO OLAYA FLOREZ PhD. Materiales, Universidad Nacional de Colombia - Sede Bogotá, [email protected] Received for review March 10 th, 2012, accepted June 29th, 2012, final version July, 9 th, 2012 ABSTRACT: The physical-chemical properties of bismuth and its oxides have been studied over the last two decades. As a result of this research, the growth of these materials with different crystallographic structures, showing micro and nanometric dimensions has been achieved by using several techniques (cathodic pulverization, laser pulsed deposition and hydrothermal method, among others). -
1,2,5Thiadiazole 1 -Oxides. 3. an Experimental and Theoretical
J. Am. Chem. Soc. 1982, 104, 1375-1380 1375 inosine (Ino) and 5’-GMP complexes such as [(NH3),F‘t(InoH1)]+ at 80 OC leads to the following observations. Tables I and I1 show and [(NH3),Pt(GMPH_,)]-; there were attributed to polynuclear the relationship klG - klA> k3, = k4A > kZAfor the second-order complex formati~n.’~.’~ association rate constants, which implies that the dissociation of Furthermore, there is clear evidence that none of the species a C1 atom from cis-[Pt(NH,),CI,] is not rate limiting. Considering formed during the reaction is a Pt complex with two 5’-GMP only the 5’-AMP reaction with cis- [Pt(NH,),CI,], we observe that molecules bound via N7 of the guanine ring to the Pt atom from the association rate constant for binding to N7 (klA)is larger than both IH and I9jPt NMR data of the cis-[Pt(NH,),(S’-GMP),] that for binding to N1 (kZA),a finding which correlates inversely complex. The latter exhibits a H8 proton resonance at 3.931 ppm with the smaller pK of N7 compared to N 1 of the adenine ring.25 and a 195Ptresonance of -2451.3 ppm which is considerably shifted However, once a Pt atom is bound to either N1 or N7, the as- to high field from the 19sPtresonances of species IG/IIG and IIIG sociation rate constants (k3* and k4A)for binding to the remaining (see Table 111). Further, the resonances for the HI’ protons in site are equal. This implies an electronic redistribution upon the C~S-[P~(NH,)~(~’-GMP),]complex are at 2.143 ppm, 0.020 binding of a Pt atom to either N1 or N7, such that the reactivity ppm to high field of the corresponding resonance in free 5’-GMP toward cis-[Pt(NH,),CI,] of the remaining available site is less (2.163 ppm), while in species IG, IIG, and IIIG the H1’ signals than that of N7 but greater than that of N1 in free 5’-AMP. -
Cyclopentadienyl Compounds of the First Row Transition Metals And
University of Vermont ScholarWorks @ UVM Graduate College Dissertations and Theses Dissertations and Theses 2017 Cyclopentadienyl Compounds of the First Row Transition Metals and Early Actinides: Novel Main-Group Bond Forming Catalysis and New Metallacycles Justin Kane Pagano University of Vermont Follow this and additional works at: https://scholarworks.uvm.edu/graddis Part of the Chemistry Commons Recommended Citation Pagano, Justin Kane, "Cyclopentadienyl Compounds of the First Row Transition Metals and Early Actinides: Novel Main-Group Bond Forming Catalysis and New Metallacycles" (2017). Graduate College Dissertations and Theses. 700. https://scholarworks.uvm.edu/graddis/700 This Dissertation is brought to you for free and open access by the Dissertations and Theses at ScholarWorks @ UVM. It has been accepted for inclusion in Graduate College Dissertations and Theses by an authorized administrator of ScholarWorks @ UVM. For more information, please contact [email protected]. CYCLOPENTADIENYL COMPOUNDS OF THE FIRST ROW TRANSITION METALS AND EARLY ACTINIDES: NOVEL MAIN-GROUP BOND FORMING CATALYSIS AND NEW METALLACYCLES A Dissertation Presented by Justin Kane Pagano to The Faculty of the Graduate College of The University of Vermont In Partial Fulfilment of the Requirements For the Degree of Doctor of Philosophy Specializing in Chemistry May, 2017 Defense Date: November 29, 2016 Dissertation Examination Committee: Rory Waterman, Ph. D., Advisor John M. Hughes, Ph. D., Chairperson Matthias Brewer, Ph. D. Jaqueline L. Kiplinger, Ph. D. Matthew D. Liptak, Ph. D. Cynthia J. Forehand, Ph. D., Dean of the Graduate College ABSTRACT Cyclopentadienyl first row transition-metal compounds have been well studied 5 since the 1950’s, with the nearly ubiquitous CpFe(CO)2Me (FpMe) (Cp = η -C5H5) being one of the first organometallics to be fully characterized. -
PVD Material Listing
P. O. Box 639 NL - 5550 AP Valkenswaard Tel: +31 (0)40 204 69 31 Fergutec Fax: +31 (0)40 201 39 81 E - mail: [email protected] PVD Material Listing Pure Metals Aluminum, Al Antimony, Sb Beryllium, Be Bismuth, Bi Boron, B Cadmium, Cd Calcium, Ca Carbon, C Cerium, Ce Chromium, Cr Cobalt, Co Copper, Cu Erbium, Er Gadolinium, Gd Gallium, Ga Germanium, Ge Gold, Au Hafnium, Hf Indium, In Iridium, Ir Iron, Fe Lanthanum, La Lead, Pb Magnesium, Mg Manganese, Mn Molybdenum, Mo Neodymium, Nd Nickel, Ni Niobium, Nb Osmium, Os Palladium, Pd Platinum, Pt Praseodymium, Pr Rhenium, Re Rhodium, Rh Ruthenium, Ru Samarium, Sm Selenium, Se Silicon, Si Silver, Ag Tantalum, Ta Fergutec b.v. P.O. Box 639, NL - 5550 AP Valkenswaard Heistraat 64, NL - 5554 ER Valkenswaard Bankaccount 45.80.36.714 ABN - AMRO Valkenswaard C.o.C. Eindhoven no. 17098554 VAT - ID NL8095.60.185.B01 The Standard Terms and Conditions, lodged at the Chamber of Commerce in Eindhoven, are applicable to all transactions. Tellurium, Te Terbium, Tb Tin, Sn Titanium, Ti Tungsten, W Vanadium, V Ytterbium, Yb Yttrium, Y Zinc, Zn Zirconium, Zr Precious Metals Gold Antimony, Au/Sb Gold Arsenic, Au/As Gold Boron, Au/B Gold Copper, Au/Cu Gold Germanium, Au/Ge Gold Nickel, Au/Ni Gold Nickel Indium, Au/Ni/In Gold Palladium, Au/Pd Gold Phosphorus, Au/P Gold Silicon, Au/Si Gold Silver Platinum, Au/Ag/Pt Gold Tantalum, Au/Ta Gold Tin, Au/Sn Gold Zinc, Au/Zn Palladium Lithium, Pd/Li Palladium Manganese, Pd/Mn Palladium Nickel, Pd/Ni Platinum Palladium, Pt/Pd Palladium Rhenium, Pd/Re Platinum Rhodium, -
Download Author Version (PDF)
RSC Advances This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication. Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. This Accepted Manuscript will be replaced by the edited, formatted and paginated article as soon as this is available. You can find more information about Accepted Manuscripts in the Information for Authors. Please note that technical editing may introduce minor changes to the text and/or graphics, which may alter content. The journal’s standard Terms & Conditions and the Ethical guidelines still apply. In no event shall the Royal Society of Chemistry be held responsible for any errors or omissions in this Accepted Manuscript or any consequences arising from the use of any information it contains. www.rsc.org/advances Page 1 of 7 RSC Advances Graphic Abstract for: Electroluminescence and Fluorescence Response towards Acid Vapors Depending on the Structures of Indole-fused Phospholes Manuscript Accepted Advances RSC PleaseRSC do not Advances adjust margins Page 2 of 7 Journal Name ARTICLE Electroluminescence and Fluorescence Response towards Acid Vapors Depending on the Structures of Indole-fused Phospholes Received 00th January 20xx, a a, a b a a a, Accepted 00th January 20xx Peng Gong , Kaiqi Ye *, Jingbo Sun , Peng Chen , Pengchong Xue , Hao Yang and Ran Lu * DOI: 10.1039/x0xx00000x New isomers of phosphole heteroacenes 2-DIPO and 3-DIPO , in which indoles were fused with phospholes in different manners, have been synthesized. -
WO 2013/089962 Al 20 June 2013 (20.06.2013) W P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2013/089962 Al 20 June 2013 (20.06.2013) W P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every B01J 31/04 (2006.01) B01J 31/18 (2006.01) kind of national protection available): AE, AG, AL, AM, B01J 31/14 (2006.01) B01J 31/22 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (21) Number: International Application DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US20 12/065285 HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (22) International Filing Date: KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, 15 November 2012 (15.1 1.2012) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (25) Filing Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, (26) Publication Language: English TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 13/323,328 12 December 201 1 (12. 12.201 1) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant (for all designated States except US): CHEV¬ GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, RON PHILLIPS CHEMICAL COMPANY LP UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, [US/US]; 10001 Six Pines Drive, The Woodlands, Texas TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 77380 (US). -
Synthesis and Applications in Fluorescence Imaging
Phosphole P Oxide Containing π Electron Materials: Synthesis and ─ Applications─ in Fluorescence─ Imaging Shigehiro Yamaguchi, 1,2* Aiko Fukazawa, 2 and Masayasu Taki 1 1* Institute of Transformative Bio ─ Molecules (WPI ─ ITbM), Nagoya University 2* Furo, Chikusa, Nagoya 464 ─ 8602, Japan Department of Chemistry, Graduate School of Science, and Integrated Research Consortium on Chemical Sciences (IRCCS), Nagoya University Furo, Chikusa, Nagoya 464 ─ 8602, Japan (Received September 8, 2017; E ─ mail: [email protected]) Abstract: Phosphole P ─ oxide is a useful building block for π ─ conjugated materials due to its nonaromatic and electron ─ accepting character. We have synthesized a series of ring ─ fused derivatives of phosphole P ─ oxide based on the intramolecular nucleophilic cyclization of appropriate alkyne precursors or radical phosphany- lations. Some of the thus obtained compounds exhibited intriguing uorescence properties and were applied to uorescence imaging. A donor ─ acceptor ─ type benzo[b]phosphole P ─ oxide with a (diphenylamino)phenyl group exhibited large solvatochromism in its uorescence spectra, and could hence be used as a staining agent for lipid droplets. C ─ Naphox and PB430, which consist of fully ring ─ fused π ─ conjugated ladder ─ type scaf- folds, exhibited outstanding photostability and their absorption and emission properties were suitable for super ─ resolution STED imaging. Moreover, using PB430 ─ conjugated antibodies, we carried out a 3 ─ D recon- struction of the STED images and developed -
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