THE BLOOM of HEMP Emerging Opportunities in Food, Wellness + Personal Care PRESENTERS

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THE BLOOM OF HEMP Emerging Opportunities in Food, Wellness + Personal Care PRESENTERS

LORA LASSLEY • VP, Product Development, Ecofibre Limited • 20 year veteran in the beauty industry with the majority of her career at Dermalogica • Passionate about blending premium hemp extract with classic skincare ingredients, newly discovered botanical extracts, and the latest advancements in sustainable chemistry

DR. ALEX CAPANO, DNP, CRNP, FNP-BC • Chief Science Officer, Ecofibre Limited • First doctoral candidate of any discipline who focused on cannabinoid science • Champions Ecofibre’s IRB-approved and FDA-approved research programs to advance the clinical evidence of hemp extract

HEMP 101

Cannabis with 0.3% or less THC by weight

WHAT ARE CANNABINOIDS? • Organic molecules that interact with or effect the body’s endocannabinoid system (ECS) • Over 100 cannabinoids identified; Abundant in cannabis plants, some other sources exist • Synthetic vs. Plant-derived

LEGALITY SUSTAINABILITY • 2018 Farm Bill Insights • Can be farmed without pesticides • Federally legal in the U.S. • No excess water requirements • Emerging global market • No need for fallow fields WHAT IS CBD?

• CBD = cannabidiol • Benefits without intoxication • Future role for minor cannabinoids

ECOFIBRE’S FULL SPECTRUM HEMP EXTRACT CANNABINOID PROFILE HEMP PLANT ARCHITECTURE

FLOWERS • Hemp extract, “CBD oil” • Types of products: topicals, ingestibles • Full Spectrum vs. Broad Spectrum vs. Isolate Hemp Extract

SEEDS • Food: Hemp seed oil, flour, protein, omega opportunity

HURD • Textiles THE HEMP TODAY TOMORROW Global market: US CBD market: Estimates + CBD MARKET $9.6B in 2020 $15B USD by 2025 to >$20 (source: Grandview Research) billion by 2024 (Sources: Cowen & Co. Investment Bank, BDS analytics, Arcview Market Research)

Global estimate: $89B USD by 2026 (source: Global Market Insights)

Health & Beauty ONLY: $3B US by 2024 (Source: Market Reports World as seen in Cosmetic and Toiletries –9/02/20) REGULATORY PARAMETERS

• Farm Bill expiration in October 2021 - what does this mean for the future of Cannabinoids? • FDA Monograph potential • Pharmacists are embracing CBD products for both ingestion and topical use, will the FDA? • State imposed restrictions REGULATORY CLAIMS DOSING PARAMETERS:DO • Cannot make claims on • “Suggested Use” OK s +DON’Ts CBD alone • Dosing directions too risky • Must combine with other • Packaging & Transparency ingredient

PACKAGING • Work with a reputable partner who knows what should be on the label • What is required varies by state distribution OUR COMMITMENT TO ADVANCING THE CLINICAL EVIDENCE OF HEMP EXTRACT AND FORMULATIONS BACKED BY SCIENCE OPIOID STUDY • Over 50% of participants reduced opioids in 8 weeks • 94% of participants reported improved quality of life • Statistically significant improvements in sleep and pain (CI 95%)

CIPN & ALZHEIMER’S STUDIES (ONGOING) • Phase II Clinical Trials • DMF and IND with FDA • Outcomes measured: Pain, Sleep, Agitation, Anxiety, Caregiver Burden

ENDOMETRIOSIS, SUBSTANCE USE DISORDERS, AND SKINCARE SITES OF CANNABINOID RECEPTORS IN SKIN AND IMMUNE CELLS

1. Promotes cell turnover which prevents wrinkles and improves appearance of fine lines 2. Reduces erythema via anti-inflammatory mechanisms 3. Deep moisturizing agent 4. Halts proliferation of unhealthy or infected cells; promotes necessary apoptosis (boosts complexion and prevents wrinkles) 5. Potent anti-inflammatory agent, reducing puffiness, redness and preventing the development of fine lines 6. Kills P. acnes bacteria at concentrations of 0.4% 2. Is sebostatic and promotes anti-proliferative and anti- inflammatory effects on human sebocytes 7. Does NOT contribute to antimicrobial resistance of P. acnes; all current topical anti-acne antimicrobials risk resistance. To avoid this, they need to be used concurrently with benzoyl peroxide, a substance that is irritating, drying, and often carries an unpleasant odor. It also risks bleaching skin, pillows, and clothing. Ananda offers an alternative solution to kill without bacterial resistance risk and need for use of harsh chemicals like benzoyl peroxide. 8. Formula can act against other major pathogenic features of acne, including lipogenesis, proliferation and inflammation through distinct molecular pathways. WHY ANANDA FULL SPECTRUM HEMP EXTRACT FOR BODY CARE?

1. Anti-inflammatory properties improve source of pain and aid in muscle recovery

2. Anti-nociceptive properties of Ananda extract reduce perception of pain

3. Immunomodulation via multiple mechanisms, including reducing histamine release from mast cells, alleviate inflammatory skin conditions (i.e. atopic dermatitis, psoriasis, eczema, rheumatoid arthritis, insect bite reactions, etc.)

4. Calms irritation ANTIMICROBIAL RESEARCH

1. >99.9% bactericidal on multiple pathogens • Staph (MSSA), MRSA, Streptococcus, P. acnes

2. Serial passage study: No risk of antimicrobial resistance HEMP FOOD OVERVIEW

• Complete plant protein that’s easily digestible (2 main protein are edestin and albumin)

• Omega 3 and 6 fatty acids in same ratio as our bodies

• High in fiber and low in sugars

• Good source of plant-based iron, magnesium WHAT TO CONSIDER WHEN RESEARCHING HEMP PARTNERS QUESTIONS TO ASK – HEMP EXTRACT SUPPLIERS IMPORTANCE OF SUPPLY CHAIN QUALITY CONTROL 1. Who and where is your supplier? 1. Does the supplier offer 3rd party testing for pesticides, residual solvents, heavy metals, 2. What are their farming and manufacturing aflatoxins? standards? 2. At what points? 3. What is their grower(s) knowledge and experience? 3. Assay confirmation - Did you get what you ordered? 4. Crops location, soil quality, harvest timing? 4. What is the consistency of products? Any 5. What is the extraction and manufacturing standardization methods? process?

6. How much transparency and traceability do HEMP EXPERTISE they offer to partners and end consumers? At what points of supply chain? 1. Can they validate answers with research? 2. What are their relationships with regulatory authorities? 3. Can they offer formulation support? COA Sample REQUEST A CERTIFICATE OF ANALYSIS …then question it. QUESTIONS TO ASK – HEMP FOOD SUPPLIERS

1. Where is your hemp coming 4. How long is the hemp dehulled? from? 5. How are the end products packaged to 2. Is the supplier BRCGS preserve the nutritional profile? approved? 6. What testing is completed? Hemp is a 3. How quickly is the hemp dried bio accumulator – if there are heavy once it is harvested? metals in the soil the plant will absorb them. This is why it is important to select where you grow and follow up with testing to verify WHO IS GOING TO MAKE IT IN HEMP AND CBD MARKET?

• Success ultimately comes down to identifying a quality supplier

• If your CBD is not high quality and consistent, consumers won’t see results

• Secure loyal customers by producing products that work

• Avoid risks and protect your business with safe, compliant suppliers. NEXT STEPS

• Ask a question!

• Request a sample through UL Prospector

• Meet with the Ecofibre team to discuss bulk and white label opportunities