“What Dr Venter Did on His Holidays”: Exploration, Hacking
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NSABB June-July 2005 Meeting Agenda
First Meeting of the National Science Advisory Board for Biosecurity June 30 – July 1, 2005 Hyatt Regency Bethesda 7400 Wisconsin Ave. Bethesda, Maryland, 20814 USA Hotel Phone: 301-657-1234 Agenda Webcast: To watch the live webcast of the meeting, click here. The webcast can only be viewed when the meeting is in session at 8:00am-6:00pm on June 30 and at 8:00am-1:30pm on July 1 Eastern Time. You will need RealOne Player to view the webcast. If you do not already have RealOne Player on your computer, download here. Presentation slides: To access the following PowerPoint presentations, click on the presentation titles below. June 30, 2005 Opening Remarks and Swearing in Ceremony Elias Zerhouni, M.D. Director of the National Institutes of Health (NIH) Chair's Remarks and Agenda Overview Dennis L. Kasper, M.D. NSABB Chair Harvard Medical School Introduction of NSABB Members NSABB Structure and Operations Thomas Holohan, M.D. NSABB Executive Director, NIH Office of Biotechnology Activities Break Perspectives on Biosecurity in the Life Sciences NSABB Voting Members Impetus for NSABB: Enhancing Biosecurity on the Life Sciences Rajeev Venkayya, M.D. Special Assistant to the President, Senior Director for Biological and Chemical Defense White House Homeland Security Council Perspectives on Biosecurity in the Life Sciences NSABB Ex Officio Members Lunch Session I- The Development of Criteria for Identifying Dual Use Research and Research Results Introduction: Issues of Relevance to Criteria Development Arturo Casadevall, M.D., Ph.D. Professor of Medicine and of Microbiology & Immunology and Chief of Infectious Diseases Albert Einstein College of Medicine National Research Council Perspective: Experiments of Concern Ron Atlas, Ph.D. -
23 Pairs in Humans That Contain Our Genes Genome: Your Entire DNA DNA: Deoxyribonucleic Acid; Contains 4 Base Pairs -Adenine, Thymine, Guanine, Cytosine
Handout for June 20, 2020 Skagit Valley Genealogical Society DNA and Genealogy Definitions Chromosomes: 23 pairs in humans that contain our genes Genome: Your entire DNA DNA: Deoxyribonucleic Acid; contains 4 base pairs -Adenine, Thymine, Guanine, Cytosine. In various combinations these determine your genome Mitochondria DNA (mtDNA): The bodies in a cell but outside the nucleus. They provide the energy for cells to do their work. They contain some DNA. Y-Chromosome: in males only X-Chromosome: Women have two of these; men only have one in combination with a Y-Chromosome MRCA: Most Recent Common Ancestor that you share with a match Centi-Morgans (cM): a centiMorgan is a measurement of how likely a segment of DNA is to recombine from one generation to the next. The important thing to remember: The larger the number of shared cMs, the closer the relationship to a DNA match. DNA Testing Sites Ancestry.com Autosomal testing only 23andme.com Autosomal only FamilyTreeDNA.com Y-DNA, mtDNA and Autosomal MyHeritage.com Autosomal only Many others for specific testing, e.g., African Ancesotrs Blogs and Wikis The Genetic Genealogist thegeneticgenealogist.com Family Search Wiki familysearch.org/wiki The International Society of Genetic Genealogists www.isogg.com DNA Explained https://dna-explained.com More information Reference Groups See: Ancestry.com https://www.ancestry.com/corporate/sites/default/files/AncestryDNA-Matching- White-Paper.pdf MyHeritage: https://faq.myheritage.com/en/article/which-ethnicities-does- myheritage-compare-my-dna-with 23andme: -
Exploring Identity Through Genetic and Genealogical Research: Development of a Collaborative Course Between Humanities and Biology
Quadrivium: A Journal of Multidisciplinary Scholarship Volume 3 Issue 1 Issue 3, Spring 2011 Article 8 4-20-2011 Exploring Identity Through Genetic and Genealogical Research: Development of a Collaborative Course Between Humanities and Biology James Doan Nova Southeastern University, [email protected] Emily F. Schmitt Lavin Nova Southeastern University, [email protected] Follow this and additional works at: https://nsuworks.nova.edu/quadrivium Part of the Arts and Humanities Commons, and the Social and Behavioral Sciences Commons Recommended Citation Doan, James and Schmitt Lavin, Emily F. (2011) "Exploring Identity Through Genetic and Genealogical Research: Development of a Collaborative Course Between Humanities and Biology," Quadrivium: A Journal of Multidisciplinary Scholarship: Vol. 3 : Iss. 1 , Article 8. Available at: https://nsuworks.nova.edu/quadrivium/vol3/iss1/8 This Article is brought to you for free and open access by the CAHSS Journals at NSUWorks. It has been accepted for inclusion in Quadrivium: A Journal of Multidisciplinary Scholarship by an authorized editor of NSUWorks. For more information, please contact [email protected]. Doan and Schmitt Lavin: Exploring Identity Through Genetic and Genealogical Research: Dev About the Authors Jim Doan, Ph.D., holds a B.A. in Literature from UC—Santa Cruz, an M.A. in Folklore and Mythology from UCLA, an M.A. in Celtic Languages and Literatures, and a Ph.D. in Folklore and Celtic Studies from Harvard. Since 1988, he has taught courses in literature, the arts, folklore, and mythology at the Farquhar College of Arts and Sciences Division of Humanities. He established the Stolzenberg-Doan Endowment Fund, which supports an International Studies lecture series at NSU, as well as scholarships to allow NSU students to undertake foreign studies. -
Michael S. Brown, MD
DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine. -
A Review of J. Craig Venter's a Life Decoded
A peer-reviewed electronic journal published by the Institute for Ethics and Emerging Technologies ISSN 1541-0099 17(1) – March 2008 A review of J. Craig Venter’s A Life Decoded Randy Mayes, Duke University Journal of Evolution and Technology - Vol. 17 Issue 1 – March 2008 - pgs 71-72 http://jetpress.org/v17/mayes.htm In the early 1980s, a number of researchers suggested sequencing and mapping the human genome to help the science community better understand diseases and evolution. Following the announcement that the human genome had been sequenced, scientists wrote in peer-reviewed journals that we are not as hardwired as was once believed, and that the sequencing of the genome was just the beginning. Today, researchers have a new set of goals. In popular journalism, however, the science was lost in the shuffle. The media focused more on the dynamics of the conflicting philosophies of the private and public projects. This emphasis is also clear in the titles of several books chronicling the Human Genome Project, all appearing prior to the recent release of Craig Venter’s autobiography, A Life Decoded: My Genome: My Life (2007). Readers will find that Robert Cook-Deegan’s The Gene Wars (1995) and The Common Thread by Sir John Sulston and Georgina Ferry (2002), both written by insiders, are biased towards the philosophy of the public project, a commons approach. Sulston is a socialist who grows runner beans and drives a second hand car. By contrast, Venter travels in Lear jets and conducts business from his yacht. Three other books are more objective. -
Humankind 2.0: the Technologies of the Future 6. Biotech
Humankind 2.0: The Technologies of the Future 6. Biotech Piero Scaruffi, 2017 See http://www.scaruffi.com/singular/human20.html for the full text of this discussion A brief History of Biotech 1953: Discovery of the structure of the DNA 2 A brief History of Biotech 1969: Jon Beckwith isolates a gene 1973: Stanley Cohen and Herbert Boyer create the first recombinant DNA organism 1974: Waclaw Szybalski coins the term "synthetic biology” 1975: Paul Berg organizes the Asilomar conference on recombinant DNA 3 A brief History of Biotech 1976: Genentech is founded 1977: Fred Sanger invents a method for rapid DNA sequencing and publishes the first full DNA genome of a living being Janet Rossant creates a chimera combining two mice species 1980: Genentech’s IPO, first biotech IPO 4 A brief History of Biotech 1982: The first biotech drug, Humulin, is approved for sale (Eli Lilly + Genentech) 1983: Kary Mullis invents the polymerase chain reaction (PCR) for copying genes 1986: Leroy Hood invents a way to automate gene sequencing 1986: Mario Capecchi performs gene editing on a mouse 1990: William French Anderson’s gene therapy 1990: First baby born via PGD (Alan Handyside’s lab) 5 A brief History of Biotech 1994: FlavrSavr Tomato 1994: Maria Jasin’s homing endonucleases for genome editing 1996: Srinivasan Chandrasegaran’s ZFN method for genome editing 1996: Ian Wilmut clones the first mammal, the sheep Dolly 1997: Dennis Lo detects fetal DNA in the mother’s blood 2000: George Davey Smith introduces Mendelian randomization 6 A brief History of Biotech -
On Jim Watson's APOE Status: Genetic Information Is Hard to Hide
European Journal of Human Genetics (2009) 17, 147–150 & 2009 Macmillan Publishers Limited All rights reserved 1018-4813/09 $32.00 www.nature.com/ejhg LETTERS 15.6 (95% CI, 10.9–22.5) and 4.3 (95% CI, 3.3–5.5) for APOE e4 homozygotes and e4/e3 heterozygotes respectively, 6 On Jim Watson’s APOE compared to e3 homozygotes. The meta-analytic odds ratios in population-based Caucasian samples were 11.8 status: genetic (95% CI, 7.0–19.8) and 2.8 (95% CI, 2.3–3.5), respec- tively.6 In a large Rotterdam (Netherlands), population- information is hard to based prospective study of people aged 55 years or above, it hide was estimated that 17% of the overall risk of AD could be attributed to the e4 allele, with 3% (95% CI, 0–6%) of cases attributed to the e4/e4 genotype, and 14% (95% CI, 7–21%) European Journal of Human Genetics (2009) 17, 147–149; 7 to the e4/e3 genotype. doi:10.1038/ejhg.2008.198; published online 22 October 2008 A recent investigation of LD for 50 SNPs in and surrounding APOE in 550 Caucasians identified multiple SNPs in the TOMM40 gene B15 kb upstream of APOE, and The recent publication and release to public databases of at least one SNP in the other surrounding genes LU, PVRL2, Dr James Watson’s sequenced genome,1 with the exception APOC1, APOC4 and CLPTM1 were associated with LOAD of all gene information about apolipoprotein E (ApoE), risk.8 In particular, the C allele of SNP rs157581 in provides a pertinent example of the challenges concerning TOMM40 is in strong LD (r240.6) with the C allele of privacy and the complexities of informed consent in the rs429358 in APOE, which defines the e4 allele. -
Synthetic Biology - Mapping the Patent Landscape Paul Oldham 1,2 Stephen Hall 3 1
bioRxiv preprint doi: https://doi.org/10.1101/483826; this version posted November 30, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Synthetic Biology - Mapping the Patent Landscape Paul Oldham 1,2 Stephen Hall 3 1. Industrial Fellow, Manchester Institute of Innovation Research, Alliance Manchester Business School, Manchester University. 2 Senior Visiting Fellow, Institute for the Advanced Study of Sustainability, United Nations University 3. Information System Services, Lancaster University Abstract This article presents the global patent landscape for synthetic biology as a new and emerging area of science and technology. The aim of the article is to provide an overview of the emergence of synthetic biology in the patent system and to contribute to future research by providing a high quality tagged core dataset with 7,424 first filings and 71,887 family members. This dataset is intended to assist with evidence based exploration of synthetic biology in the patent system and with advancing methods for the analysis of new and emerging areas of science and technology. The starting point for the research is recognition that traditional methods of patent landscape analysis based on key word searches face limitations when addressing new and emerging areas of science and technology. Synthetic biology can be broadly described as involving the design, synthesis and assembly of biological parts, circuits, pathways, cells and genomes. As such synthetic biology can be understood as emerging from a combination of overlaps and convergences between existing fields and disciplines, such as biotechnology, genetic engineering, protein engineering and systems biology. -
How Anne Wojcicki Took the Start-Up Firm from the Brink of Failure to Scientific Pre-Eminence
THE RISE, FALL AND RISE AGAIN OF 23ANDME HOW ANNE WOJCICKI TOOK THE START-UP FIRM FROM THE BRINK OF FAILURE TO SCIENTIFIC PRE-EMINENCE. BY ERIKA CHECK HAYDEN 174 | NATURE | VOL 550 | 12 OCTOBER©2017 2017Mac millan Publishers Li mited, part of Spri nger Nature. All ri ghts reserved. ©2017 Mac millan Publishers Li mited, part of Spri nger Nature. All ri ghts reserved. FEATURE NEWS Anne Wojcicki founded the Alzheimer’s disease. Surfing a wave of positive news, the company has consumer-genetics firm since launched an advertising blitz to dramatically expand its customer 23andme in 2006 and aims base to 10 million people. to expand its customer 23andme has always been the most visible face of direct-to-consumer base to 10 million. genetic testing, and it is more formidable now than ever before. In September, the company announced that it had raised US$250 million: more than the total amount of capital raised by the company since its inception. Investors estimate that it is worth more than $1 billion, making it a ‘unicorn’ in Silicon Valley parlance — a rare and valuable thing to behold. But for scientists, 23andme’s real worth is in its data. With more than 2 million customers, the company hosts by far the largest collection of gene-linked health data anywhere. It has racked up 80 publications, signed more than 20 partnerships with pharmaceutical firms and started a therapeutics division of its own. “They have quietly become the largest genetic study the world has ever known,” says cardiologist Euan Ashley at Stanford University, California. -
Why Is This $99 Home DNA Kit Causing Such an Uproar?
http://genomemag.com/ Your Health Is Personal Why Is This $99 Home DNA Kit Causing Such an Uproar? 23andMe says it can provide you with valuable health information about your genes. The FDA says prove it. What the consumer genetic testing battle means for you. BY JOSEPH GUINTO Would you give someone you love a small plastic vial for her birthday and ask her to spit into it? Rob Abrams did. His wife, Caitlin, couldn’t have been happier. She liked it so much she gave Rob the same thing for Christmas. “It was,” Caitlin says, “the most nerdy gift I have ever given and received.” The package — a small tube, removable cap, and sealable spit funnel — was a genetic testing kit from California company 23andMe. The Abramses spent $299 on each kit in 2011. Once the couple mailed in their tubes, 23andMe tested their saliva for hundreds of genetic markers. The markers pointed toward clinically useless but nevertheless interesting ancestral information (look, Caitlin had 2.9 percent Neanderthal DNA!). They also pointed toward dozens of potential health risks. By comparing some of the couple’s DNA to a database of genetic indicators, the company said it could tell them whether they were at increased risk for a range of diseases, including Alzheimer’s disease, breast or prostate cancer, type 2 diabetes, hypertension, heroin addiction, and amyotrophic lateral sclerosis. And celiac disease, which Caitlin already knew she had. “I was most interested in possible inherited diseases,” she says. “I’d been diagnosed with celiac disease only a year or two prior, and given that my husband and I planned to have children, I thought it might be helpful to see if I was genetically predisposed to it. -
Scientists Create Cell Based on Man-Made Genetic Instructions
25-5-2010 Scientists create cell based on man-m… Scientists create cell based on man•made genetic instructions By David Brown Friday, M ay 21, 2010; A03 Scientists reported Thursday that they have created a cell controlled entirely by man•made genetic instructions •• the latest step toward creating life from scratch. The achievement is a landmark in the emerging field of "synthetic biology," which aims to control the behavior of organisms by manipulating their genes. Although the ultimate goal of creating artificial organisms is still far off, the experiment points to a future in which microbes could be manufactured with novel functions, such as the ability to digest pollutants or produce fuels. Some ethicists fear that the strategy could also be used to produce biological weapons and other dangerous life forms. In a paper published online by the journal Science, researchers from the J. Craig Venter Institute described using off•the•shelf chemicals and the DNA sequence of Mycoplasma mycoides's genes to make an artificial copy of the bacterium's genome. The scientists then transplanted that genome into the cell of a different (but closely related) microbe. The donor genome reprogrammed the recipient cell, which went on to replicate and divide. The result was new colonies of Mycoplasma mycoides. "We think these are the first synthetic cells that are self• replicating and whose genetic heritage started in the computer. That changes conceptually how I think about life," said J. Craig Venter, 63, who gained fame a decade ago as the co•sequencer of the human genome. His institute has laboratories and offices in Rockville and San Diego. -
Dalton DNA Project Report
1 of 7 Dalton International DNA Project Report: Update, June 6, 2019 . there is probably no person capable of the least degree of reflection, who has not, in an idle moment, amused himself with some little speculation of the probable origin of his own name. Mark Antony Lower, English Surnames: Essays on Family Nomenclature, Preface to first edition, (1842), p.viii What is DNA, this molecule that allows us to travel so far back in the past—this history book we carry around like a gift from a long line of ancestors? Spencer Wells, National Geographic, 2007, p.13 Submitted by Elizabeth (Beth) Balkite, MS, Certified Genetic Counselor Introduction 2 of 7 It has been seven (7) decades since scientists demonstrated that DNA is the molecule of heredity. Since then the only constant in the world of DNA has been change—the evolution of information about DNA. We are now at a time when new information seems to become available weekly through scientific journals, print and television, as well as social media. This report is an update from the report of 2014 for members of the Dalton Internation- al DNA Project (DIDP). It includes a summary of information and recommendations. Some of the information included is known by long term members but may be new to those who have recently joined the project. One of the biggest changes in the world of DNA testing is in the area of privacy and management of accounts at the different companies, including FTDNA. So, I have in- cluded information on this topic at the conclusion of the report with a section on Ethi- cal-Legal Social Issues for all members.