Healthy Beginnings DIABETES and PREGNANCY
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2015 Prediabetes Data Summary
The Georgia Department of Public Health Prediabetes Data Summary Diabetes is the 6th leading cause of death among adults and over 800,000 people live with diabetes in Georgia.1 Individuals with prediabetes have an increased risk of developing Type 2 diabetes, heart disease and stroke. Moreover, individuals with prediabetes often possess cardiovascular risk factors such as hypertension, obesity and high cholesterol. Prediabetes almost always occurs among individuals who eventually develop Type 2 diabetes.2 In Type 2 diabetes, the body does not use insulin properly which causes blood glucose (sugar) levels to be higher than normal. Approximately 450,000 adults in Georgia have prediabetes. Prediabetes (also known as borderline diabetes) is a medical condition that occurs when blood glucose levels are higher than normal, but are not high enough to be diagnosed as diabetes.3 Test results among individuals diagnosed with prediabetes include: A1C test value: 5.7% - 6.4% Impaired fasting blood glucose (IFG) levels: 100-125 mg/dl OR Two- hour Oral Glucose Tolerance Test (OGTT) value: 140 mg/dl – 199 mg/dl Making healt hy lifestyle choices, such as eating healthy foods, being physically active and maintaining a healthy weight, may help to bring blood glucose (sugar) levels down to normal and decrease the risk of developing Type 2 diabetes Table 1. Demographic Characteristics among Prediabetics, Georgia, 2013 Demographic Characteristics Percent (%) 95% CI State Total 7.9 (7.2, 8.9) Sex Male 7.8 (6.8, 9.5) Female 7.9 (6.9, 9.1) Race/Ethnicity -
Gestational Diabetes Insipidus, HELLP Syndrome and Eclampsia in a Twin Pregnancy: a Case Report
Journal of Perinatology (2010) 30, 144–145 r 2010 Nature Publishing Group All rights reserved. 0743-8346/10 $32 www.nature.com/jp PERINATAL/NEONATAL CASE PRESENTATION Gestational diabetes insipidus, HELLP syndrome and eclampsia in a twin pregnancy: a case report JL Woelk, RA Dombroski and PR Brezina Department of Obstetrics and Gynecology, East Carolina University, Greenville, NC, USA alanine aminotransferase, 65 U lÀ1; and lactate dehydrogenase, We report a case of eclampsia in a twin pregnancy complicated by HELLP 390 U lÀ1. A 24-h urine collection was begun to quantify proteinuria. syndrome and diabetes insipidus. This confluence of disease processes During the first night of hospitalization, the patient developed suggests that a modification of common magnesium sulfate treatment marked polyuria and polydipsia. Urine output increased to 1500 cc hÀ1 protocols may be appropriate in a certain subset of patients. by the early morning totaling 12 l for the entire night. Repeat Journal of Perinatology (2010) 30, 144–145; doi:10.1038/jp.2009.115 electrolytes were unchanged. The endocrinology service was then Keywords: diabetes insipidus ; eclampsia ; HELLP syndrome ; twin consulted for the management of presumptive DI. Therapy with the pregnancy ; magnesium sulfate administration of dDAVP (1-deamino-8-D-arginine vasopressin) orally twice daily was initiated. Serum osmolality was increased at 296 mOsm kgÀ1, and urine osmolality was decreased to 71 mOsm kgÀ1 Introduction with a specific gravity of 1.000. The 24-h urine results showed a total The association between diabetes insipidus (DI) and liver protein of 780 mg. The patient denied the previously reported dysfunction in a preeclamptic patient has been established in headaches, blurry vision and right upper quadrant pain, and her blood multiple case reports.1 This case is an important example that pressures remained 140 to 155 mmHg (systolic) and 80 to 95 mmHg illustrates how the pathophysiology of DI and the pharmacokinetics (diastolic), consistent with a diagnosis of mild preeclampsia. -
Comparative Evaluation of Fructosamine and Hba1c As a Marker of Glycemic Control in Type 2 Diabetes: a Hospital Based Study
International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Comparative Evaluation of Fructosamine and HbA1c as a Marker of Glycemic Control in Type 2 Diabetes: A Hospital Based Study Dr. Jyoti Goyal1, Dr. Nibhriti Das2, Dr. Navin Kumar3, Ms. Seema Raghav4, Dr. Paramjeet Singh Bhatia5, Dr. Karunesh Prasad Singh6, Dr. Sabari Das7 1DNB, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India- 281003, 2Ex-Director of Laboratory services and Additional Dean Research and Academics, Nayati Healthcare and Research Centre, Mathura, India- 281003, 3Ph.D, Biostatistitian, Department of Biostatistics, Nayati Healthcare and Research Centre, Mathura, India-281003. 4M.Sc., Certified Diabetes Educator, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India-281003. 5MD, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India-281003. 6MD Physician, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India-281003. 7Department of Laboratory Medicine, Nayati Healthcare and Research Centre, Mathura, India- 281003, Corresponding Author: Dr. Jyoti Goyal ABSTRACT Introduction: Management of type 2 diabetes revolves around achievement of target glycemic control with the help of antidiabetic drugs or insulin. There are various markers for measurement of glyceamic control like HbA1c, Mean Blood Glucose and fructosamine levels. Though HbA1c is a well validated standard method for assessment of glycemic control but it has also got certain limitations. Fructosamine, a less explored method may be used as an alternative marker for an assessment of glycemic control in cases where HbA1c is unreliable or unavailable. The objective of this study is to compare the fructosamine levels with HbA1c in assessment of glycemic control in type 2 diabetics so as to assess the utility of fructosamine as an alternative marker for evaluation of glucose control. -
Module 2: Hypertensive Disorders of Pregnancy and Gestational Diabetes FINAL Description Text
Module 2: Hypertensive Disorders of Pregnancy and Gestational Diabetes FINAL Description Text Welcome to the module Hypertensive Disorders of Pregnancy and Gestational Diabetes. In this module, we will be discussing hypertensive Slide 1 disorders of pregnancy, including pregnancy induced hypertension and preeclampsia. We will also discuss Gestational Diabetes as well as nutrition solutions related to these issues Slide 2 We will begin by discussing hypertensive disorders in pregnancy. There are at least 5 distinct categories of hypertension and related disorders that occur during pregnancy. These categories are: preeclampsia/eclampsia, chronic hypertension, preeclampsia Slide 3 superimposed upon chronic hypertension, gestational hypertension and transient hypertension. Each of these will be discussed individually throughout the module, with recommendations based on best practices provided. Blood pressure is the force of blood on the walls of the arteries. Systolic blood pressure is measured when the ventricles are contracting while diastolic pressure is measured when the ventricles are relaxed. Normal Slide 4 blood pressure is typically 120/80 mm Hg.The general definition of high blood pressure in adults is a systolic BP > 140 mg HG or a diastolic blood pressure > 90 mm Hg. These criteria should be used for women throughout pregnancy. Chronic hypertension often exists prior to pregnancy and continues throughout pregnancy. It may not be noticed until the second trimester of pregnancy if prenatal care is delayed or if women have suffered from prolonged nausea and vomiting or morning sickness. If hypertension is Slide 5 diagnosed in early pregnancy and persists past 6 weeks postpartum, it would be considered to be a chronic health condition. -
Role of Maternal Age and Pregnancy History in Risk of Miscarriage
RESEARCH Role of maternal age and pregnancy history in risk of BMJ: first published as 10.1136/bmj.l869 on 20 March 2019. Downloaded from miscarriage: prospective register based study Maria C Magnus,1,2,3 Allen J Wilcox,1,4 Nils-Halvdan Morken,1,5,6 Clarice R Weinberg,7 Siri E Håberg1 1Centre for Fertility and Health, ABSTRACT Miscarriage and other pregnancy complications might Norwegian Institute of Public OBJECTIVES share underlying causes, which could be biological Health, PO Box 222 Skøyen, To estimate the burden of miscarriage in the conditions or unmeasured common risk factors. N-0213 Oslo, Norway Norwegian population and to evaluate the 2MRC Integrative Epidemiology associations with maternal age and pregnancy history. Unit at the University of Bristol, Introduction Bristol, UK DESIGN 3 Miscarriage is a common outcome of pregnancy, Department of Population Prospective register based study. Health Sciences, Bristol Medical with most studies reporting 12% to 15% loss among School, Bristol, UK SETTING recognised pregnancies by 20 weeks of gestation.1-4 4Epidemiology Branch, National Medical Birth Register of Norway, the Norwegian Quantifying the full burden of miscarriage is Institute of Environmental Patient Register, and the induced abortion register. challenging because rates of pregnancy loss are Health Sciences, Durham, NC, USA PARTICIPANTS high around the time that pregnancies are clinically 5Department of Clinical Science, All Norwegian women that were pregnant between recognised. As a result, the total rate of recognised University of Bergen, Bergen, 2009-13. loss is sensitive to how early women recognise their Norway pregnancies. There are also differences across countries 6 MAIN OUTCOME MEASURE Department of Obstetrics and studies in distinguishing between miscarriage and and Gynecology, Haukeland Risk of miscarriage according to the woman’s age and University Hospital, Bergen, pregnancy history estimated by logistic regression. -
Metformin for Prediabetes
FACT SHEET FOR PATIENTS AND FAMILIES Metformin for Prediabetes What is metformin? Metformin [met-FORE-min] is a medication that is often prescribed for prediabetes in order to help prevent type 2 diabetes. It is taken by mouth (orally) as a pill. Like other prediabetes medications, it works best when you follow the rest of your treatment plan, like improving your nutrition by eating more fruits and vegetables, being physically active every day, and in most cases, losing weight. What does it do? Metformin helps lower your blood glucose (blood sugar). It does this by: Does metformin cause hypoglycemia • Decreasing the amount of glucose released by your (low blood glucose)? liver. Less glucose enters into your bloodstream. No. Metformin doesn’t cause hypoglycemia by itself. • Increasing the ability of your muscles to use glucose But combined with other medications, vigorous for energy. As more glucose is used, more glucose exercise, or too little food, it can make your blood leaves your bloodstream. glucose drop too low. Why is metformin important Since low blood glucose can be dangerous, make sure for my health? that you and your family know the symptoms. These include feeling shaky, sweaty, hungry, and irritable. Metformin can’t cure your prediabetes. But, by If you have these symptoms, take some quick-acting helping control your blood glucose, it can help sugar. Good sources are 3 or 4 glucose tablets, a half- prevent type 2 diabetes, especially among those at cup of fruit juice or regular soda, or a tablespoon of highest risk for developing type 2 diabetes. -
Prediabetes: What Is It and What Can I Do?
Prediabetes: What Is It and What Can I Do? What is prediabetes? Weight loss can delay or prevent diabetes. Prediabetes is a condition that comes before Reaching a healthy weight can help you a lot. diabetes. It means your blood glucose levels are If you’re overweight, any weight loss, even higher than normal but aren’t high enough to be 7 percent of your weight (for example, losing called diabetes. about 15 pounds if you weigh 200), may lower your risk for diabetes. There are no clear symptoms of prediabetes. You can have it and not know it. If I have prediabetes, what does it mean? It means you might get type 2 diabetes soon or down the road. You are also more likely to get heart disease or have a stroke. The good news is that you can take steps to delay or prevent type 2 diabetes. How can I delay or prevent type 2 diabetes? You may be able to delay or prevent type 2 diabetes with: Daily physical activity, such as walking. Weight loss, if needed. Losing even a few pounds will help. Medication, if your doctor prescribes it. If you have prediabetes, these steps may bring your blood glucose to a normal range. But you are still at a higher risk for type 2 diabetes. Regular physical activity can delay or prevent diabetes. Being active is one of the best ways to delay or prevent type 2 diabetes. It can also lower your weight and blood pressure, and improve cholesterol levels. Ask your health care team about activities that are safe for you. -
Gestational Diabetes Insipidus (GDI) Associated with Pre-Eclampsia
MOJ Women’s Health Case Report Open Access Gestational diabetes insipidus (GDI) associated with pre-eclampsia Abstract Volume 5 Issue 6 - 2017 Gestational diabetes insipidus (GDI) is a rare complication of pregnancy, usually developing in the third trimester and remitting spontaneously 4-6weeks post-partum. Afsoon Razavi, Muhammad Umair, Zehra It is mainly caused by excessive vasopressinase activity, an enzyme expressed by Tekin, Issac Sachmechi placental trophoblasts which metabolizes arginine vasopressin (AVP). The treatment Department of medicine, Icahn School of Medicine at Mount requires desmopressin. A 38year old G3P0A2 women with no significant medical Sinai/NYC Health+ Hospital/Queens, USA history was admitted to obstetrical service on 36th week of gestation due to significant malaise, anorexia, nausea, vomiting, polyuria, nocturia, and polydipsia, worsening Correspondence: Afsoon Razavi, MD, Department of in the 2weeks prior to presentation. Physical examination demonstrated decreased Medicine, Icahn School of Medicine at Mount Sinai/NYC skin turgor, hyperactive tendon reflexes and no pedal edema, and her blood pressure Health+Hospital/Queens, Diabetes center, 4th floor, Suit P-432, Pavilion building, Queens hospital center, 82-68 164th street, was 170/100mmHg, heart rate 67beats/min and weight 60kg (BMI 23.1kg/m2). Her Jamaica, New York, 11432, USA, Tel +8183843165, laboratory results a month prior to admission showed normal basic metabolic panel Email [email protected] and liver function tests. On admission she found to have urine osmolality112mOsmol/ kg (350-1000); serum osmolality 308mOsmol/kg (278-295); Urinalysis revealed Received: July 25, 2017 | Published: August 16, 2017 specific gravity less than 1005 with proteinuria. serum sodium 151mmol/L (135-145); potassium 4.1mmol/L (3.5-5.0); Cl 128mmol/L, urea 2.2 mmol/L (2.5-6.7), creatinine 1.4mg/dL, Bilirubin 1.3mg/dL, AST 1270 U/L, alkaline phosphatase, 717U/L, uric acid 10.1mg/dL and INR 1.1. -
Standards of Medical Care in Diabetes—2018
Diabetes Care Volume 41, Supplement 1, January 2018 S137 13. Management of Diabetes American Diabetes Association in Pregnancy: Standards of Medical Care in Diabetesd2018 Diabetes Care 2018;41(Suppl. 1):S137–S143 | https://doi.org/10.2337/dc18-S013 13. MANAGEMENT OF DIABETES IN PREGNANCY The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA’s current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee, are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence-grading system for ADA’s clinical practice recommendations, please refer to the Standards of Care Introduction. Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC. DIABETES IN PREGNANCY The prevalence of diabetes in pregnancy has been increasing in the U.S. The majority is gestational diabetes mellitus (GDM) with the remainder primarily preexisting type 1 diabetes and type 2 diabetes. The rise in GDM and type 2 diabetes in parallel with obesity both in the U.S. and worldwide is of particular concern. Both type 1 diabetes and type 2 diabetes in pregnancy confer significantly greater maternal and fetal risk than GDM, with some differences according to type of diabetes as outlined below. In general, specific risks of uncontrolled diabetes in pregnancy include spontaneous abortion, fetal anomalies, preeclampsia, fetal demise, macrosomia, neonatal hy- poglycemia, and neonatal hyperbilirubinemia, among others. -
Screening for Gestational Diabetes Mellitus: a Systematic Review to Update the 2014 U.S
Evidence Synthesis Number 204 Screening for Gestational Diabetes Mellitus: A Systematic Review to Update the 2014 U.S. Preventive Services Task Force Recommendation Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract No. HHSA-290-2015-00009-I Prepared by: Pacific Northwest Evidence-Based Practice Center Oregon Health & Science University Mail Code: BICC 3181 SW Sam Jackson Park Road Portland, OR 97239 www.ohsu.edu/epc University of Alberta Evidence-Based Practice Center 4-474 Edmonton Clinic Health Academy 11405 – 87 Avenue Edmonton, Alberta, Canada T6G 1C9 Investigators: Jennifer Pillay, MSc Lois Donovan, MD Samantha Guitard, MSc Bernadette Zakher, MD Christina Korownyk, MD Michelle Gates, PhD Allison Gates, PhD Ben Vandermeer, MSc Christina Bougatsos, MPH Roger Chou, MD Lisa Hartling, PhD AHRQ Publication No. 21-05273-EF-1 February 2021 This report is based on research conducted by the Pacific Northwest Evidence-based Practice Center (EPC) and the University of Alberta EPC under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. HHSA-290-2015-00009-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents, and do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. The information in this report is intended to help health care decisionmakers—patients and clinicians, health system leaders, and policymakers, among others—make well-informed decisions and thereby improve the quality of health care services. -
What Everyone Needs to Know About Prediabetes
diaTribe.org provides free cutting-edge diabetes insights and actionable tips for people with diabetes. Our mission is to help individuals better understand their diabetes and to make our readers happier & healthier. What Everyone Needs to Know about Prediabetes: Symptoms, Diagnosis, Prevention, and more! What is prediabetes? Prediabetes is a condition where blood sugar levels are higher than normal, but not high enough to be diagnosed as type 2 diabetes. This occurs when the body has problems in processing glucose properly, and sugar starts to build up in the bloodstream instead of fueling cells in muscles and tissues. Insulin is the hormone that tells cells to take up glucose, and in prediabetes, people typically initially develop insulin resistance (where the body’s cells can’t respond to insulin as well), and over time the ability to produce sufficient insulin is reduced (if no actions are taken to reverse the situation). People with prediabetes also commonly have high blood pressure as well as abnormal blood lipids (e.g. cholesterol.) These often occur prior to the rise of blood glucose levels. What are the symptoms of prediabetes? People typically do not have symptoms of prediabetes, which is partially why up to 90% of people don’t know they have it. The ADA reports that some people with prediabetes may develop symptoms of type 2 diabetes, though even many people diagnosed with type 2 diabetes show little or no symptoms initially at diagnosis. These symptoms include: Urinating often Blurry vision Feeling very thirsty Feeling very hungry, even Cuts/bruises that Tingling, pain, or though you are eating are slow to heal numbness in the hands/ feet Extreme fatigue /diaTribeNews @diaTribeNews diaTribe.org “ People typically do not have symptoms of prediabetes, which is partially why up to 90% of people don’t know they have it.” Who is at risk of developing prediabetes? Overweight and obese adults (a BMI >25 kg/m2) are at significantly greater risk for developing prediabetes, as well as people with a family history of type 2 diabetes. -
Pregnancy-Related Conditions As Disabilities Under the ADA
Pregnancy-Related Conditions as Disabilities under the ADA Following passage of the Americans with Disabilities Act Amendments Act of 2008 (“ADAAA”),1 the legal landscape of pregnancy accommodation has changed dramatically.2 That the ADAAA has expanded coverage for non-pregnant individuals is beyond dispute: the statutory language of the ADAAA has broadened the term “disability” and makes it unequivocally clear that it should “be construed in favor of broad coverage of individuals.”3 Under the broadened definition, most pregnancy-related conditions are likely to be considered disabilities the employers will have to reasonably accommodate. The Pregnancy Discrimination Act (PDA) mandates that pregnant workers be treated the same as other workers with a similar ability or inability to work.4 This mandate means that pregnant women, who often experience diseases identical to those experienced in the general population, are to be afforded the same accommodations. For example, pregnant women frequently get carpal tunnel syndrome, and should receive the same breaks, job modifications, or supportive devices as non-pregnant employees with the syndrome. Otherwise, a nonsensical result occurs: a worker with carpal tunnel syndrome may qualify for ADA accommodation if the syndrome stems from any condition in the world other than pregnancy, but not if it stems from pregnancy. In addition, pregnant women often experience symptoms similar or identical to those experienced by non-pregnant workers. For example, if a non-pregnant worker with back problems that prohibits him from lifting more than 20 pounds for several months would have a qualifying disability under the ADA, then the same must be true for a pregnant woman suffering from back pain that requires her to request a lifting restriction.