Section II an Introduction to Emerging Waterborne Zoonoses and General Control Principles
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COVID-19: Perspective, Patterns and Evolving Strategies
COVID-19: Perspective, Patterns and Evolving strategies Subject Category: Clinical Virology Vinod Nikhra* Department of Medicine, Hindu Rao Hospital & NDMC Medical College, New Delhi, India Submitted: 02 June 2020 | Approved: 06 July 2020 | Published: 09 July 2020 Copyright: © 2020 Nikhra V. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: https://dx.doi.org/10.29328/ebook1003 ORCID: https://orcid.org/0000-0003-0859-5232 *Corresponding author: Dr. Vinod Nikhra, M.D. Consultant and Faculty, Department of Medicine, Hindu Rao Hospital & NDMC Medical College, New Delhi, India, Tel: 91-9810874937; Email: [email protected]; drvinodnikhra@rediff mail.com Open Access COVID-19: Perspective, Patterns and Evolving strategies Table of Contents - 7 Chapters Sl No Chapters Title Pages The Trans-Zoonotic Virome Interface: Measures to 1 Chapter 1 003-011 Balance, Control and Treat Epidemics Exploring Pathophysiology of COVID-19 Infection: Faux 2 Chapter 2 012-020 Espoir and Dormant Therapeutic Options The Agent and Host Factors in COVID-19: Exploring 3 Chapter 3 021-036 Pathogenesis and Therapeutic Implications Adverse Outcomes for Elderly in COVID-19: Annihilation 4 Chapter 4 037-047 of the Longevity Dream Identifying Patterns in COVID-19: Morbidity, Recovery, 5 Chapter 5 048-058 and the Aftermath The New Revelations: Little-known Facts about COVID-19 6 Chapter 6 059-068 and their Implications Fear, Reaction and Rational Behaviour to COVID-19 in 7 Chapter 7 069-076 Public, Health Professionals and Policy Planners La Confusion: Caring for COVID-19 patients 8 Postscript 077-079 and the raging, engulfi ng and debilitating pandemic 9 Acknowledgement 080-080 *Corresponding HTTPS://WWW.HEIGHPUBS.ORG author: Dr. -
Assembling Evidence for Identifying Reservoirs of Infection
TREE-1806; No. of Pages 10 Review Assembling evidence for identifying reservoirs of infection 1 1,2 1,3 1 4 Mafalda Viana , Rebecca Mancy , Roman Biek , Sarah Cleaveland , Paul C. Cross , 3,5 1 James O. Lloyd-Smith , and Daniel T. Haydon 1 Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK 2 School of Computing Science, University of Glasgow, Glasgow G12 8QQ, UK 3 Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA 4 US Geological Survey, Northern Rocky Mountain Science Center 2327, University Way, Suite 2, Bozeman, MT 59715, USA 5 Department of Ecology and Evolutionary Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA Many pathogens persist in multihost systems, making patterns of incidence and prevalence (see Glossary) that the identification of infection reservoirs crucial for result from the connectivity between source and target devising effective interventions. Here, we present a con- populations (black arrows in Figure I in Box 1). We then ceptual framework for classifying patterns of incidence review methods that allow us to identify maintenance or and prevalence, and review recent scientific advances nonmaintenance populations (squares or circles in Figure that allow us to study and manage reservoirs simulta- I, Box 1), how they are connected (arrows in Figure I, Box neously. We argue that interventions can have a crucial 1), and the role that each of these populations has in role in enriching our mechanistic understanding of how maintaining the pathogen (i.e., reservoir capacity). -
The Impacts of Beach Pollution Polluted Beach Water Makes Swimmers Sick and Hurts Coastal Economies
TESTING THE WATERS 24TH EDITION The Impacts of Beach Pollution Polluted beach water makes swimmers sick and hurts coastal economies. Illnesses associated with polluted beach water include stomach flu, skin rashes, pinkeye, respiratory infections, meningitis, and hepatitis. In addition to the health effects of polluted beach water, there may be deep financial impacts as well. Economists have estimated that a typical swimming day is worth approximately $35 for each beach visitor, so the economic loss for each day on which a beach is closed or under advisory for water quality problems can be quite significant. HEALTH RISKS Sensitive populations such as children, the elderly, or those with a weakened immune system are particularly at risk Diseases Caused by Pathogens in Bathing Waters for long-term effects. For example, research has shown that Polluted waters may contain disease-causing organisms children under the age of nine have more reports of diarrhea called pathogens. The most common types of pathogens— and vomiting from exposure to waterborne pathogens bacteria, viruses, and protozoa—are those associated with than any other age group, with at least a twofold increase human and animal waste. For instance, giardiasis is caused occurring over the summer swimming months.2 There is by the protozoan Giardia lambia, North America’s leading usually a delay of several days to two weeks between contact 1 reported intestinal parasite. Swimmers in sewage-polluted with contaminated water and expression of symptoms, and water can contract any illness that is spread by fecal contact, most people who get sick from swimming are not aware of including stomach flu, respiratory infection, and ear and the link. -
And Waterborne Infections Or Sexually Transmitted Infections Among Finnish International T Travellers, 1995–2015
Travel Medicine and Infectious Disease 25 (2018) 35–41 Contents lists available at ScienceDirect Travel Medicine and Infectious Disease journal homepage: www.elsevier.com/locate/tmaid Destination specific risks of acquisition of notifiable food- and waterborne infections or sexually transmitted infections among Finnish international T travellers, 1995–2015 ∗ Viktor Zöldia,b, , Jussi Sanea, Anu Kantelec,d, Ruska Rimhanen-Finnea, Saara Salmenlinnaa, Outi Lyytikäinena a Department of Health Security, National Institute for Health and Welfare (THL), Helsinki, Finland b European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden c Infectious Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, Finland d Unit of Infectious Diseases, Karolinska Institutet, Solna, Stockholm, Sweden ARTICLE INFO ABSTRACT Keywords: Background: Overnight international travels made by Finns more than doubled during 1995–2015. To estimate Travel risks and observe trends of travel-related notifiable sexually transmitted and food- and water-borne infections Communicable diseases (STIs and FWIs) among travellers, we analysed national reports of gonorrhoea, syphilis, hepatitis A, shigellosis, Sexually transmitted diseases campylobacteriosis and salmonellosis cases and related them to travel statistics. Foodborne diseases Method: Cases notified as travel-related to the Finnish infectious diseases register were used as numerators and Waterborne diseases overnight stays of Statistics Finland surveys as denominator. We calculated overall risks (per 100,000 travellers) and assessed trends (using regression model) in various geographic regions. Results: Of all travel-related cases during 1995–2015, 2304 were STIs and 70,929 FWIs. During 2012–2015, Asia-Oceania showed highest risk estimates for gonorrhoea (11.0; 95%CI, 9.5–13), syphilis (1.4; 0.93–2.1), salmonellosis (157; 151–164), and campylobacteriosis (135; 129–141), and Africa for hepatitis A (4.5; 2.5–7.9), and shigellosis (35; 28–43). -
Zoonotic Diseases Fact Sheet
ZOONOTIC DISEASES FACT SHEET s e ion ecie s n t n p is ms n e e s tio s g s m to a a o u t Rang s p t tme to e th n s n m c a s a ra y a re ho Di P Ge Ho T S Incub F T P Brucella (B. Infected animals Skin or mucous membrane High and protracted (extended) fever. 1-15 weeks Most commonly Antibiotic melitensis, B. (swine, cattle, goats, contact with infected Infection affects bone, heart, reported U.S. combination: abortus, B. suis, B. sheep, dogs) animals, their blood, tissue, gallbladder, kidney, spleen, and laboratory-associated streptomycina, Brucellosis* Bacteria canis ) and other body fluids causes highly disseminated lesions bacterial infection in tetracycline, and and abscess man sulfonamides Salmonella (S. Domestic (dogs, cats, Direct contact as well as Mild gastroenteritiis (diarrhea) to high 6 hours to 3 Fatality rate of 5-10% Antibiotic cholera-suis, S. monkeys, rodents, indirect consumption fever, severe headache, and spleen days combination: enteriditis, S. labor-atory rodents, (eggs, food vehicles using enlargement. May lead to focal chloramphenicol, typhymurium, S. rep-tiles [especially eggs, etc.). Human to infection in any organ or tissue of the neomycin, ampicillin Salmonellosis Bacteria typhi) turtles], chickens and human transmission also body) fish) and herd animals possible (cattle, chickens, pigs) All Shigella species Captive non-human Oral-fecal route Ranges from asymptomatic carrier to Varies by Highly infective. Low Intravenous fluids primates severe bacillary dysentery with high species. 16 number of organisms and electrolytes, fevers, weakness, severe abdominal hours to 7 capable of causing Antibiotics: ampicillin, cramps, prostration, edema of the days. -
The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus Aureus
antibiotics Communication The Resistance to Host Antimicrobial Peptides in Infections Caused by Daptomycin-Resistant Staphylococcus aureus Md Saruar Bhuiyan 1,† , Jhih-Hang Jiang 1,† , Xenia Kostoulias 1, Ravali Theegala 1, Graham J. Lieschke 2 and Anton Y. Peleg 1,3,* 1 Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC 3800, Australia; [email protected] (M.S.B.); [email protected] (J.-H.J.); [email protected] (X.K.); [email protected] (R.T.) 2 Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia; [email protected] 3 Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC 3004, Australia * Correspondence: [email protected] † These authors contributed equally to this work. Abstract: Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial Citation: Bhuiyan, M.S.; Jiang, J.-H.; peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R Kostoulias, X.; Theegala, R.; Lieschke, S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen. G.J.; Peleg, A.Y. The Resistance to Host Antimicrobial Peptides in Keywords: S. -
Chapter 2 Disease and Disease Transmission
DISEASE AND DISEASE TRANSMISSION Chapter 2 Disease and disease transmission An enormous variety of organisms exist, including some which can survive and even develop in the body of people or animals. If the organism can cause infection, it is an infectious agent. In this manual infectious agents which cause infection and illness are called pathogens. Diseases caused by pathogens, or the toxins they produce, are communicable or infectious diseases (45). In this manual these will be called disease and infection. This chapter presents the transmission cycle of disease with its different elements, and categorises the different infections related to WES. 2.1 Introduction to the transmission cycle of disease To be able to persist or live on, pathogens must be able to leave an infected host, survive transmission in the environment, enter a susceptible person or animal, and develop and/or multiply in the newly infected host. The transmission of pathogens from current to future host follows a repeating cycle. This cycle can be simple, with a direct transmission from current to future host, or complex, where transmission occurs through (multiple) intermediate hosts or vectors. This cycle is called the transmission cycle of disease, or transmission cycle. The transmission cycle has different elements: The pathogen: the organism causing the infection The host: the infected person or animal ‘carrying’ the pathogen The exit: the method the pathogen uses to leave the body of the host Transmission: how the pathogen is transferred from host to susceptible person or animal, which can include developmental stages in the environment, in intermediate hosts, or in vectors 7 CONTROLLING AND PREVENTING DISEASE The environment: the environment in which transmission of the pathogen takes place. -
Variation in Antimicrobial Susceptibility Among Borrelia Burgdorferi Strains? Emir Hodzic*
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES REVIEW WWW.BJBMS.ORG Lyme Borreliosis: is there a preexisting (natural) variation in antimicrobial susceptibility among Borrelia burgdorferi strains? Emir Hodzic* Real-Time PCR Research and Diagnostic Core Facility, School of Veterinary Medicine, University of California at Davis, California, United States of America ABSTRACT The development of antibiotics changed the world of medicine and has saved countless human and animal lives. Bacterial resistance/tolerance to antibiotics have spread silently across the world and has emerged as a major public health concern. The recent emergence of pan-resistant bacteria can overcome virtually any antibiotic and poses a major problem for their successful control. Selection for antibiotic resistance may take place where an antibiotic is present: in the skin, gut, and other tissues of humans and animals and in the environment. Borrelia burgdorferi, the etiological agents of Lyme borreliosis, evades host immunity and establishes persistent infections in its mammalian hosts. The persistent infection poses a challenge to the effective antibiotic treatment, as demonstrated in various animal models. An increasingly heterogeneous sub- population of replicatively attenuated spirochetes arises following treatment, and these persistent antimicrobial tolerant/resistant spirochetes are non-cultivable. The non-cultivable spirochetes resurge in multiple tissues at 12 months after treatment, withB. burgdorferi-specific DNA copy levels nearly equivalent to those found in shame-treated experimental animals. These attenuated spirochetes remain viable, but divide slowly, thereby being tolerant to antibiotics. Despite the continued non-cultivable state, RNA transcription of multiple B. burgdorferi genes was detected in host tissues, spirochetes were acquired by xenodiagnostic ticks, and spirochetal forms could be visualized within ticks and mouse tissues. -
STD (Sexually Transmitted Disease) Or STI (Sexually Transmitted Infection): Should We Choose? Janet Byron Anderson, Phd
STD (sexually transmitted disease) or STI (sexually transmitted infection): Should we choose? Janet Byron Anderson, PhD 1. Clinical foundation of the problem Another surprise: Documented incidence had shown Each of the terms—“sexual(ly)”, “transmitted”, “disease”, that the two routes of sexual transmission were male-to- and “infection”—is problematic independently, as this female and male-to-male. However, on 15 July 2016 the study will show. Moreover, co-occurring variants, used CDC reported the first case of suspected female-to-male as synonyms in English medical articles worldwide, ag- sexual transmission in New York City [4]. Since 2008, gravate the problem. The purpose of this study is to pro- then, the Zika virus has shown that it is now sexually pose a single term that can stimulate discussion about transmissible. “Transmissible” denotes a potential, and is whether the co-occurring variants are clinically and lin- distinct from “transmitted”, which denotes a reality. guistically justifiable—especially now, when STDs/STIs To say that Zika has proved to be transmissible through have become a global health problem, and public health sexual contact means that it can be transmitted through agencies in every country are scrambling to educate their sex but that it need not be (Zika remains a chiefly vec- citizens. [Until the presentation advances to the point tor-borne disease). However, cases reported since 2008 where the question posed in the title can be definitively document the reality of transmittedness through sexual answered, I’ll use the expression “STD/STI” or the terms contact. “illness(es)” and “condition(s)”.] The predisposing epidemiologic context will first be clar- This carefully differentiated language is used by the ified, for it sheds light on two of the problematic terms: European Centre for Disease Prevention and Control chiefly “transmitted” but also “sexual(ly)”. -
Impact of Babesia Microti Infection on the Initiation and Course Of
Tołkacz et al. Parasites Vectors (2021) 14:132 https://doi.org/10.1186/s13071-021-04638-0 Parasites & Vectors RESEARCH Open Access Impact of Babesia microti infection on the initiation and course of pregnancy in BALB/c mice Katarzyna Tołkacz1,2*, Anna Rodo3, Agnieszka Wdowiarska4, Anna Bajer1† and Małgorzata Bednarska5† Abstract Background: Protozoa in the genus Babesia are transmitted to humans through tick bites and cause babesiosis, a malaria-like illness. Vertical transmission of Babesia spp. has been reported in mammals; however, the exact timing and mechanisms involved are not currently known. The aims of this study were to evaluate the success of vertical transmission of B. microti in female mice infected before pregnancy (mated during the acute or chronic phases of Babesia infection) and that of pregnant mice infected during early and advanced pregnancy; to evaluate the pos- sible infuence of pregnancy on the course of parasite infections (parasitaemia); and to assess pathological changes induced by parasitic infection. Methods: The frst set of experiments involved two groups of female mice infected with B. microti before mating, and inseminated on the 7th day and after the 40th day post infection. A second set of experiments involved female mice infected with B. microti during pregnancy, on the 4th and 12th days of pregnancy. Blood smears and PCR targeting the 559 bp 18S rRNA gene fragment were used for the detection of B. microti. Pathology was assessed histologically. Results: Successful development of pregnancy was recorded only in females mated during the chronic phase of infection. The success of vertical transmission of B. -
MODELING the SPREAD of the 1918 INFLUENZA PANDEMIC in a NEWFOUNDLAND COMMUNITY a Dissertation Presented to the Faculty of the Gr
MODELING THE SPREAD OF THE 1918 INFLUENZA PANDEMIC IN A NEWFOUNDLAND COMMUNITY A Dissertation presented to the Faculty of the Graduate School at the University of Missouri In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy By JESSICA LEA DIMKA Dr. Lisa Sattenspiel, Dissertation Supervisor MAY 2015 The undersigned, appointed by the dean of the Graduate School, have examined the dissertation entitled MODELING THE SPREAD OF THE 1918 INFLUENZA PANDEMIC IN A NEWFOUNDLAND COMMUNITY Presented by Jessica Lea Dimka A candidate for the degree of Doctor of Philosophy And hereby certify that, in their opinion, it is worthy of acceptance. Professor Lisa Sattenspiel Professor Gregory Blomquist Professor Mary Shenk Professor Enid Schatz ACKNOWLEDGEMENTS This research could not have been completed without the support and guidance of many people who deserve recognition. Dr. Lisa Sattenspiel provided the largest amount of assistance and insight into this project, from initial development through model creation and data analysis to the composition of this manuscript. She has been an excellent mentor over the last seven years. I would also like to extend my gratitude to my committee members – Dr. Greg Blomquist, Dr. Mary Shenk, and Dr. Enid Schatz – for their advice, comments, patience and time. I also would like to thank Dr. Craig Palmer for his insight and support on this project. Additionally, I am grateful to Dr. Allison Kabel, who has provided me with valuable experience, advice and support in my research and education activities while at MU. Many thanks go to the librarians and staff of the Provincial Archives of Newfoundland and Labrador and the Centre for Newfoundland Studies at Memorial University of Newfoundland. -
Waterborne Diseases Paul R
Conference Panel Summaries Waterborne Diseases Paul R. Hunter,* Jack M. Colford,† Mark W. LeChevallier‡ Sue Binder,‡ and Paul S. Berger§ *World Health Organization, Geneva, Switzerland; †National Institutes of Health, Bethesda, Maryland, USA; ‡Centers for Disease Control and Prevention, Atlanta, Georgia, USA; and §U.S. Environmental Protection Agency, Washington, DC, USA Waterborne Disease Outbreaks Methodologic Issues in the In the United States, 127 drinking water outbreaks, most Evaluation of Waterborne Disease of them associated with groundwater systems, were reported Jack M. Colford, assistant professor of epidemiology, at to CDC from 1990 through 1998. The number of outbreaks has the University of California-Berkeley, discussed methods for declined over the last 20 years, probably as a result of actions estimating the incidence of infectious diseases attributable to by the U.S. Environmental Protection Agency (EPA), water the consumption of tap water. In a previously published utilities, and public health officials; however, changes in study, investigators in Canada compared the incidence of reporting practices may also have contributed to this trend. gastroenteritis in homes with and without a reverse-osmosis filter. The study showed that 35% of gastrointestinal illness World Water Issues in the community studied was attributable to drinking water. Paul R. Hunter, consultant medical microbiologist and The study was randomized, but participants knew in which director of the Chester Public Health Laboratory and group they were enrolled. As a partial consequence of this honorary professor of epidemiology and public health at the study, when Congress amended the Safe Drinking Water Act University of Central Lancashire, presented World Health in 1996, it required that EPA and CDC develop a national Organization data that showed high morbidity and death estimate of waterborne disease occurrence in the United rates worldwide due to consumption of unsafe drinking water.