Mycobacteriology
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A Case of Miliary Tuberculosis Presenting with Whitlow of the Thumb
A Case of Miliary Tuberculosis Presenting with Whitlow of the Thumb Romaric Larcher, Albert Sotto, Jean-Marc Mauboussin, Jean-Philippe Lavigne, François-Xavier Blanc, Didier Laureillard To cite this version: Romaric Larcher, Albert Sotto, Jean-Marc Mauboussin, Jean-Philippe Lavigne, François-Xavier Blanc, et al.. A Case of Miliary Tuberculosis Presenting with Whitlow of the Thumb. Acta Dermato- Venereologica, Society for Publication of Acta Dermato-Venereologica, 2016, 96 (4), pp.560 - 561. 10.2340/00015555-2285. hal-01909474 HAL Id: hal-01909474 https://hal.archives-ouvertes.fr/hal-01909474 Submitted on 25 May 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution - NonCommercial| 4.0 International License Acta Derm Venereol 2016; 96: 560–561 SHORT COMMUNICATION A Case of Miliary Tuberculosis Presenting with Whitlow of the Thumb Romaric Larcher1, Albert Sotto1*, Jean-Marc Mauboussin1, Jean-Philippe Lavigne2, François-Xavier Blanc3 and Didier Laureillard1 1Infectious Disease Department, 2Department of Microbiology, University Hospital Caremeau, Place du Professeur Robert Debré, FR-0029 Nîmes Cedex 09, and 3L’Institut du Thorax, Respiratory Medicine Department, University Hospital, Nantes, France. *E-mail: [email protected] Accepted Nov 10, 2015; Epub ahead of print Nov 11, 2015 Tuberculosis remains a major public health concern, accounting for millions of cases and deaths worldwide. -
Role of the Laboratory in TB Diagnosis and Management
Role of the Laboratory in TB Diagnosis and Management Michael Pentella, Ph.D., D(ABMM), CIC Associate Director University Hygienic Lab Clinical Associate Professor, College of Public Health, University of Iowa Objectives • At the completion of this TB webinar, participants will: – Be familiar with the tests to diagnose latent tuberculosis and active tuberculosis – Recognize the tests available to detect Mycobacterium tuberculosis in clinical specimens – Understand the value of molecular tests to detect TB History of TB Diagnostics • Robert Koch announced in 1882 that he had found a microbe, Mycobacterium tuberculosis, that was the cause of "White Death", a disease responsible for one-seventh of all deaths in Europe in the late part of the 1800's. 1 Timeline of TB Infection Exposure 4-6 wks Latent Lifelong Adaptive Yrs-decades Containment T cell TB response (LTBI)* Active TB *Prevention efforts focus on detecting LTBI, most LTBI do not advance to active disease but those patients are at high risk particularly if they become immunocompromised. TB Infection vs. TB Disease TB in the body TB in the body Chest X-ray normal Chest X-ray abnormal Sputum not done Sputum smear and culture positive No symptoms Symptoms: cough, fever, weight loss Not infectious Infectious Not a case of TB Case of TB TB Algorithm • Collect sputum specimens at 3 different times and 8 hours apart (at least one must be a first morning specimen) for AFB smear and mycobacterial culture. • Perform MTD or NAAT test on the first smear positive sputum specimen 2 Diagnosis of -
Mycobacterium Caprae – the First Case of the Human Infection in Poland
Annals of Agricultural and Environmental Medicine 2020, Vol 27, No 1, 151–153 CASE REPORT www.aaem.pl Mycobacterium caprae – the first case of the human infection in Poland Monika Kozińska1,A-D , Monika Krajewska-Wędzina2,B , Ewa Augustynowicz-Kopeć1,A,C-E 1 Department of Microbiology, National Tuberculosis and Lung Diseases Research Institute (NTLD), Warsaw, Poland 2 Department of Microbiology, National Veterinary Research Institute (NVRI), Puławy, Poland A – Research concept and design, B – Collection and/or assembly of data, C – Data analysis and interpretation, D – Writing the article, E – Critical revision of the article, F – Final approval of article Kozińska M, Augustynowicz-Kopeć E, Krajewska-Wędzina M. Mycobacterium caprae – the first case of the human infection in Poland. Ann Agric Environ Med. 2020; 27(1): 151–153. doi: 10.26444/aaem/108442 Abstract The strain of tuberculous mycobacteria called Mycobacterium caprae infects many wild and domestic animals; however, because of its zoonotic potential and possibility of transmission between animals and humans, it poses a serious threat to public health. Due to diagnostic limitations regarding identification of MTB strains available data regarding the incidence of M. caprae, human infection does not reflect the actual size of the problem. Despite the fact that the possible routes of tuberculosis transmission are known, the epidemiological map of this zoonosis remains underestimated. The progress in diagnostic techniques, application of advanced methods of mycobacterium genome differentiation and cooperation between scientists in the field of veterinary medicine and microbiology, have a profound meaning for understanding the phenomenon of bovine tuberculosis and its supervise its incidence. This is the first bacteriologically confirmed case of human infection of M. -
Species of Mycobacterium Tuberculosis Complex and Nontuberculous Mycobacteria in Respiratory Specimens from Serbia
Arch. Biol. Sci., Belgrade, 66 (2), 553-561, 2014 DOI:10.2298/ABS1402553Z SPECIES OF MYCOBACTERIUM TUBERCULOSIS COMPLEX AND NONTUBERCULOUS MYCOBACTERIA IN RESPIRATORY SPECIMENS FROM SERBIA IRENA ŽIVANOVIĆ1, DRAGANA VUKOVIĆ1, IVANA DAKIĆ1 and BRANISLAVA SAVIĆ1 1 Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia Abstract - This study aimed to provide the first comprehensive report into the local pattern of mycobacterial isolation. We used the GenoType MTBC and CM/AS assays (Hain Lifescience) to perform speciation of 1 096 mycobacterial cultures isolated from respiratory specimens, one culture per patient, in Serbia over a 12-month period. The only species of the Mycobacterium tuberculosis complex (MTBC) identified in our study was M. tuberculosis, with an isolation rate of 88.8%. Ten different species of nontuberculous mycobacteria (NTM) were recognized, and the five most frequently isolated spe- cies were, in descending order, M. xenopi, M. peregrinum, M. gordonae, M. avium and M. chelonae. In total, NTM isolates accounted for 11.2% of all isolates of mycobacteria identified in pulmonary specimens. Our results suggest that routine differentiation among members of the MTBC is not necessary, while routine speciation of NTM is required. Key words: Mycobacterium tuberculosis, nontuberculous mycobacteria, identification, GenoType MTBC, GenoType CM/AS INTRODUCTION M. mungi in banded mongooses (Alexander et al., 2010), and M. orygis in animals of the Bovidae family Currently, the genus Mycobacterium encompasses (van Ingen et al., 2012) have recently been described. 163 species and 13 subspecies described in the list of Although all members of the complex are considered bacterial species with approved names (www.bacte- tubercle bacilli, the most important causative agent rio.cict.fr/m/mycobacterium.html). -
Bison Bonasus
Annals of Agricultural and Environmental Medicine ORIGINAL ARTICLE www.aaem.pl Microbiological and molecular monitoring for ONLINE FIRST bovine tuberculosis inONLINE the Polish population FIRST of European bison (Bison bonasus) Anna Didkowska1,A-F , Blanka Orłowska1,A-C,F , Monika Krajewska-Wędzina2,A,C,F , Ewa Augustynowicz-Kopeć3,A-C,F , Sylwia Brzezińska3,B-C,E-F , Marta Żygowska1,A-B,D,F , Jan Wiśniewski1,B-C,F , Stanisław Kaczor4,B,F , Mirosław Welz5,A,C,F , Wanda Olech6,A,E-F , Krzysztof Anusz1,A-F 1 Department of Food Hygiene and Public Health Protection, Institute of Veterinary Medicine, University of Life Sciences (SGGW), Warsaw, Poland 2 Department of Microbiology, National Veterinary Research Institute, Puławy, Poland ONLINE FIRST ONLINE3 FIRST Department of Microbiology, National Tuberculosis Reference Laboratory, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland 4 County Veterinary Inspectorate, Sanok, Poland 5 General Veterinary Inspectorate, Warsaw, Poland 6 Department of Animal Genetics and Conservation, Institute of Animal Sciences, University of Life Sciences (SGGW), Warsaw, Poland A – Research concept and design, B – Collection and/or assembly of data, C – Data analysis and interpretation, D – Writing the article, E – Critical revision of the article, F – Final approval of article Didkowska A, Orłowska B, Krajewska-Wędzina M, Augustynowicz-Kopeć E, Brzezińska S, Żygowska M, Wiśniewski J, Kaczor S, Welz M, Olech W, Anusz K. Microbiological and molecular monitoring for bovine tuberculosis in the Polish population of European bison (Bison bonasus). Ann Agric Environ Med. doi: 10.26444/aaem/130822 Abstract Introduction and objective. In recent years, bovine tuberculosis (BTB) has become one of the major health hazards facing the European bison (EB, Bison bonasus), a vulnerable species that requires active protection, including regular and effective health monitoring. -
Detection, Survival and Infectious Potential of Mycobacterium Tuberculosis in the Environment: a Review of the Evidence and Epidemiological Implications
REVIEW TUBERCULOSIS Detection, survival and infectious potential of Mycobacterium tuberculosis in the environment: a review of the evidence and epidemiological implications Leonardo Martinez1, Renu Verma1, Julio Croda2,3, C. Robert Horsburgh Jr4,5, Katharine S. Walter1, Nicholas Degner1, Keren Middelkoop6,7, Anastasia Koch8, Sabine Hermans6,9, Digby F. Warner 8,10, Robin Wood6, Frank Cobelens9 and Jason R. Andrews1 Affiliations: 1Division of Infectious Diseases and Geographic Medicine, School of Medicine, Stanford University, Stanford, CA, USA. 2Oswaldo Cruz Foundation, Campo Grande and Salvador, Brazil. 3School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Brazil. 4Dept of Medicine, Boston University School of Medicine, Boston, MA, USA. 5Dept of Epidemiology, Biostatistics and Global Health, Boston University School of Public Health, Boston, MA, USA. 6The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. 7Dept of Medicine, University of Cape Town, Cape Town, South Africa. 8SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Dept of Pathology and Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. 9Dept of Global Health, Amsterdam Institute for Global Health and Development, Academic Medical Center, Amsterdam, The Netherlands. 10Wellcome Center for Infectious Diseases Research in Africa, Institute of Infectious Diseases -
Epidemiological Characterization of Mycobacterium Caprae Strains
Orłowska et al. BMC Veterinary Research (2020) 16:362 https://doi.org/10.1186/s12917-020-02581-3 RESEARCH ARTICLE Open Access Epidemiological characterization of Mycobacterium caprae strains isolated from wildlife in the Bieszczady Mountains, on the border of Southeast Poland Blanka Orłowska1*, Monika Krajewska-Wędzina2, Ewa Augustynowicz-Kopeć3, Monika Kozińska3, Sylwia Brzezińska3, Anna Zabost3, Anna Didkowska1, Mirosław Welz4, Stanisław Kaczor5, Piotr Żmuda6 and Krzysztof Anusz1 Abstract Background: The majority of animal tuberculosis (TB) cases reported in wildlife in Poland over the past 20 years have concerned the European bison inhabiting the Bieszczady Mountains in Southeast Poland: an area running along the border of Southeast Poland. As no TB cases have been reported in domestic animals in this region since 2005, any occurrence of TB in the free-living animals inhabiting this area might pose a real threat to local livestock and result in the loss of disease-free status. The aim of the study was to describe the occurrence of tuberculosis in the wildlife of the Bieszczady Mountains and determine the microbiological and molecular characteristics of any cultured strains. Lymph node samples were collected for analysis from 274 free-living animals, including European bison, red foxes, badgers, red deer, wild boar and roe deer between 2011 and 2017. Löwenstein–Jensen and Stonebrink media were used for culture. Molecular identification of strains was performed based on hsp65 sequence analysis, the GenoType®MTBC (Hain Lifescience, Germany) test, spoligotyping and MIRU-VNTR analysis. Results: Mycobacterium caprae was isolated from the lymph nodes of 21 out of 55 wild boar (38.2%; CI 95%: 26.5%, 51.4%) and one roe deer. -
The Paleopathological Evidence on the Origins of Human Tuberculosis: a Review
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Journal of Preventive Medicine and Hygiene (JPMH) J PREV MED HYG 2020; 61 (SUPPL. 1): E3-E8 OPEN ACCESS The paleopathological evidence on the origins of human tuberculosis: a review I. BUZIC1,2, V. GIUFFRA1 1 Division of Paleopathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy; 2 Doctoral School of History, “1 Decembrie 1918” University of Alba Iulia, Romania Keywords Tuberculosis • Paleopathology • History • Neolithic Summary Tuberculosis (TB) has been one of the most important infectious TB has a human origin. The researches show that the disease was diseases affecting mankind and still represents a plague on a present in the early human populations of Africa at least 70000 global scale. In this narrative review the origins of tuberculosis years ago and that it expanded following the migrations of Homo are outlined, according to the evidence of paleopathology. In par- sapiens out of Africa, adapting to the different human groups. The ticular the first cases of human TB in ancient skeletal remains demographic success of TB during the Neolithic period was due to are presented, together with the most recent discoveries result- the growth of density and size of the human host population, and ing from the paleomicrobiology of the tubercle bacillus, which not the zoonotic transfer from cattle, as previously hypothesized. provide innovative information on the history of TB. The paleo- pathological evidence of TB attests the presence of the disease These data demonstrate a long coevolution of the disease and starting from Neolithic times. -
Mycobacterium Caprae Is a Pathogen That Can Infect Animals and Humans
DISPATCHES spoligotyping (9). The relative contribution of each animal Mycobacterium and its role in animal tuberculosis are discussed. caprae Infection in The Study This study included 791 M. caprae isolates from Livestock and domestic goats (Capra aegagrus hircus, n = 542), sheep (Ovis aries, n = 2), cattle (Bos taurus, n = 229), domestic Wildlife, Spain pigs (S. scrofa domestica, n = 2), wild boars (S. scrofa, n Sabrina Rodríguez, Javier Bezos, = 14), red deer (Cervus elaphus, n = 1), and a fox (Vulpes Beatriz Romero, Lucía de Juan, Julio Álvarez, vulpes, n = 1). The samples originated from skin test– Elena Castellanos, Nuria Moya, positive animals identifi ed within the national or regional Francisco Lozano, M. Tariq Javed, eradication programs, from abattoir surveillance, and from José L. Sáez-Llorente, Ernesto Liébana, postmortem inspections of wildlife, and were collected Ana Mateos, Lucas Domínguez, Alicia Aranaz, from 1992 through June 2009 in different geographic and The Spanish Network on Surveillance and areas in Spain (Figure 1). Spoligotyping was performed Monitoring of Animal Tuberculosis1 as described (9), and authoritative names for spoligotype Mycobacterium caprae is a pathogen that can infect animals and humans. To better understand the epidemiology of M. caprae, we spoligotyped 791 animal isolates. Results suggest infection is widespread in Spain, affecting 6 domestic and wild animal species. The epidemiology is driven by infections in caprids, although the organism has emerged in cattle. ycobacterium caprae is a cluster within the M. M tuberculosis complex (online Technical Appendix, www.cdc.gov/EID/content/17/3/532-Techapp.pdf). This pathogen has been recognized mainly in central Europe, where it has been occasionally isolated from tuberculous lesions from cattle (1–5), pigs (4), red deer (Cervus elaphus) (4,5), and wild boars (Sus scrofa) (3). -
A Surgical Revisitation of Pott Distemper of the Spine Larry T
The Spine Journal 3 (2003) 130–145 Review Articles A surgical revisitation of Pott distemper of the spine Larry T. Khoo, MD, Kevin Mikawa, MD, Richard G. Fessler, MD, PhD* Institute for Spine Care, Chicago Institute of Neurosurgery and Neuroresearch, Rush Presbyterian Medical Center, Chicago, IL 60614, USA Received 21 January 2002; accepted 2 July 2002 Abstract Background context: Pott disease and tuberculosis have been with humans for countless millennia. Before the mid-twentieth century, the treatment of tuberculous spondylitis was primarily supportive and typically resulted in dismal neurological, functional and cosmetic outcomes. The contemporary development of effective antituberculous medications, imaging modalities, anesthesia, operative techniques and spinal instrumentation resulted in quantum improvements in the diagnosis, manage- ment and outcome of spinal tuberculosis. With the successful treatment of tuberculosis worldwide, interest in Pott disease has faded from the surgical forefront over the last 20 years. With the recent unchecked global pandemic of human immunodeficiency virus, the number of tuberculosis and sec- ondary spondylitis cases is again increasing at an alarming rate. A surgical revisitation of Pott dis- ease is thus essential to prepare spinal surgeons for this impending resurgence of tuberculosis. Purpose: To revisit the numerous treatment modalities for Pott disease and their outcomes. From this information, a critical reappraisal of surgical nuances with regard to decision making, timing, operative approach, graft types and the use of instrumentation were conducted. Study design: A concise review of the diagnosis, management and surgical treatment of Pott disease. Methods: A broad review of the literature was conducted with a particular focus on the different surgical treatment modalities for Pott disease and their outcomes regarding neurological deficit, ky- phosis and spinal stability. -
Molecular Typing of Mycobacterium Tuberculosis Isolated from Adult Patients with Tubercular Spondylitis
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Journal of Microbiology, Immunology and Infection (2013) 46,19e23 Available online at www.sciencedirect.com journal homepage: www.e-jmii.com ORIGINAL ARTICLE Molecular typing of Mycobacterium tuberculosis isolated from adult patients with tubercular spondylitis Ching-Yun Weng a, Cheng-Mao Ho b,c,d, Horng-Yunn Dou e, Mao-Wang Ho b, Hsiu-Shan Lin c, Hui-Lan Chang c, Jing-Yi Li c, Tsai-Hsiu Lin c, Ni Tien c, Jang-Jih Lu c,d,f,* a Section of Infectious Diseases, Department of Internal Medicine, Lin-Shin Hospital, Taichung, Taiwan b Section of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan c Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan d Graduate institute of Clinical Medical Science, China Medical University, Taichung, Taiwan e Division of Clinical Research, National Health Research Institutes, Zhunan, Taiwan f Department of Laboratory Medicine, Linkou Chang-Gung Memorial Hospital, Taoyuan, Taiwan Received 30 April 2011; received in revised form 1 August 2011; accepted 31 August 2011 KEYWORDS Background/Purpose: Tuberculosis (TB) is endemic in Taiwan and usually affects the lung, Drug resistance; spinal TB accounting for 1e3% of all TB infections. The manifestations of spinal TB are Spoligotyping; different from those of pulmonary TB. The purpose of this study was to define the epidemio- Spondylitis; logical molecular types of mycobacterial strains causing spinal TB. Tuberculosis Methods: We retrospectively reviewed the medical charts of adult patients diagnosed with spinal TB from January 1998 to December 2007. -
Mycobacteria in Northern Tanzania: Exposure and Risk of Disease Among Agropastoralists and Programmatic Challenges in Investigation of Re-Treatment Cases
0\FREDFWHULDLQQRUWKHUQ7DQ]DQLD ([SRVXUHDQGULVNRIGLVHDVHDPRQJDJURSDVWRUDOLVWVDQG SURJUDPPDWLFFKDOOHQJHVLQLQYHVWLJDWLRQRIUHWUHDWPHQWFDVHV $QGUHZ0DUWLQ.LODOH Dissertation for the degree of philosophiae doctor (PhD) at the University of Bergen Dissertation date: © Copyright: Andrew Martin Kilale, 2015 The material in this publication is protected by copyright law Title: Mycobacteria in northern Tanzania: Exposure and risk of disease among agropastoralists and programmatic challenges in investigation of re-treatment cases Author: Andrew Martin Kilale Print: AiT Bjerch AS / University of Bergen ii Dedication To the memory of my beloved Father, the late Martin Meza and my Mother, Twingilage Mwandawila Sanga iii Acknowledgements I thank His Almighty God for blessing me with this opportunity and keeping me strong throughout the period of my studies. My heartfelt acknowledgement goes to the University of Bergen, Centre for International Health for providing me the opportunity for this training. I wish to express my deepest sincere gratitude to my supervisors Prof. Sven Gudmund Hinderaker and Dr. Bernard James Ngowi for their tireless efforts, encouragement, support and always being available for the guidance. My special thanks goes to Dr. Godfrey Sayoki Mfinanga the Director at Muhimbili Medical Research Centre and Afrique One Consortium Deputy Director whose love and dedication to health research appointed me to join the consortium as a PhD student. My compliment goes to my family, my wife Elina, my son Audphas, and my daughters Irene and Doris for their intimate love, endless support, encouragement, prayers and endurance during my absence have been essential. I would like to express my earnest thanks to my employer, the National Institute for Medical Research and Welcome Trust through Afrique One Consortium for their financial support for research and my studies.