DOCSLIB.ORG

Handbook of Polysaccharides

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Handbook of Polysaccharides Handbook of Polysaccharides Toolbox for Polymeric sugars Polysaccharide Review I 2 Global Reach witzerland - taad lovakia - Bratislava Synthetic laboratories Synthetic laboratories Large-scale manufacture Large-scale manufacture Distribution hub Distribution hub apan - Tokyo Sales office United Kingdom - Compton India - Chennai Synthetic laboratories Sales office United tates - an iego Distribution hub Distribution hub China - Beijing, inan, uzhou outh Korea - eoul Synthetic laboratories Sales office Large-scale manufacture Distribution hub Table of contents Section Page Section Page 1.0 Introduction 1 6.2 Examples of Secondary & Tertiary Polysaccharide Structures 26 About Biosynth Carbosynth 2 6.2.1 Cellulose 26 Product Portfolio 3 6.2.2 Carrageenan 27 Introduction 4 6.2.3 Alginate 27 2.0 Classification 5 6.2.4 Xanthan Gum 28 3.0 Properties and Applications 7 6.2.5 Pectin 28 4.0 Polysaccharide Isolation and Purification 11 6.2.6 Konjac Glucomannan 28 4.1 Isolation Techniques 12 7.0 Binary & Ternary Interactions Between Polysaccharides 29 4.2 Purification Techniques 12 7.1 Binary Interactions 30 5.0 Polysaccharide Structure Determination 13 7.2 Ternary Interactions 30 5.1 Covalent Primary Structure 13 8.0 Polysaccharide Review 31 5.1.1 Basic Structural Components 13 Introduction 32 5.1.2 Monomeric Structural Units and Substituents 13 8.1 Polysaccharides from Higher Plants 32 5.2 Linkage Positions, Branching & Anomeric Configuration 15 8.1.1 Energy Storage Polysaccharides 32 5.2.1 Methylation Analysis 16 8.1.2 Structural Polysaccharides 33 5.2.2 Retro Analysis by Partial Degradation 17 8.1.3 Polysaccharides from Seeds & Legumes 39 5.2.3 Spectroscopic Methods of Analysis 17 8.1.4 Exudate Gums 41 5.3 Molecular Weight Determination 19 8.1.5 Polysaccharides from Tubers 43 5.3.1 Light Scattering 19 8.2 Polysaccharides from Lichens 44 5.3.2 Size Exclusion Chromatography 20 8.2.1 Lichenan and Isolichenan 44 5.3.3 Ultracentrifugation 20 8.2.2 Pustulan 45 5.3.4 Viscosity 20 8.3 Polysaccharides from Algae 45 5.4 Polysaccharide Physical Properties 21 8.3.1 Polysaccharides from Rhodophyceae (Red algae) 45 5.4.1 Rheology 21 8.3.2 Polysaccharides from Phaeophyceae (Brown algae) 48 5.4.2 Gelation 22 8.3.3 Polysaccharides from Chlorophyceae (Green algae) 49 5.4.3 Surface, Emulsification and Film-Forming Properties 23 8.4 Polysaccharides from Microorganisms 50 6.0 Secondary/Tertiary Structure and Function 25 8.4.1 Polysaccharides from Gram-negative Bacteria 50 6.1 Introduction 26 8.4.2 Polysaccharides from Gram-positive Bacteria 53 Section Page Section Page 8.5 Polysaccharides from Yeasts & Fungi 53 8.7.14 Carboxymethyl Dextran 68 8.5.1 Beta Glucans 53 8.7.15 Diethylaminoethyl Dextran 68 8.5.2 Mannan from Saccharomyces cerevisiae 54 8.7.16 Fluorescein Isothiocyanate Dextran 69 8.5.3 Curdlan 54 8.7.17 Carboxymethyl Curdlan 69 8.5.4 Pullulan 55 8.7.18 Propylene Glycol Alginate 69 8.5.5 Schizophyllan 55 8.8 Formulated Polysaccharides 70 8.5.6 Scleroglucan 56 8.8.1 Danaparoid 70 8.5.7 Glucuronoxylomannan from Cyptococcus neoformans 56 8.8.2 Polyglycoplex 70 8.5.8 Nigeran 56 8.9 Artificial Polysaccharides 70 8.6 Polysaccharides from Animal or Fish Tissues 57 8.9.1 Polydextrose 70 8.6.1 Energy Storage Polysaccharides 57 9.0 References 71 8.6.2 Structural Polysaccharides 58 Acknowledgements 79 8.6.3 Polysaccharides with Key Physiological Functions 60 8.7 Functionally Modified Polysaccharides 62 8.7.1 Methyl and Ethyl Cellulose 62 8.7.2 Hydroxypropyl Cellulose, Hydroxyethyl Cellulose and Ethyl Hydroxyethyl Cellulose 62 8.7.3 Hydroxypropyl Methyl Cellulose 63 8.7.4 Hydroxypropyl Methylcellulose Phthalate 64 8.7.5 Sodium Carboxymethyl Cellulose 64 8.7.6 Cellouronic Acid 65 8.7.7 Cellulose Acetete Hydrogen Phthalate 65 8.7.8 Cellulose Acetate 65 8.7.9 Carboxymethyl Chitosan 66 8.7.10 Glycol Chitosan 66 8.7.11 Hyaluronate Fluorescein 66 8.7.12 Dextran Biotin and Rhodamine 67 8.7.13 Dextran Sulphate 68 Section1 & 2 Introduction and Classification Introduction and Classification I 1 1 About Biosynth Carbosynth The Carbohydrate and Nucleoside Experts We pride ourselves in being the world-leading experts in the field of enzyme substrates, carbohydrate and nucleoside chemistry. Our mission is to expand the reach of our world-leading expertise in carbohydrates and nucleosides, and to provide it to innovators developing cutting-edge products that will improve the quality of life for millions of people worldwide. We are committed to continuous improvement and are working towards becoming the favourite resource for scientists developing revolutionary medicines and diagnostics. With sites on three continents, we have a global reach and serve customers around the globe. The two divisions Pharmaceutical & Diagnostic Products Division Research Products Division We are here to tailor products and services to your needs. We are here to support innovators with their cutting-edge research. We have extensive experience in serving customers on high- profile projects with rich internal know-how and process We are proud of opening the door to new discoveries by development skills across all our sites. We are proud of offering rare carbohydrates and nucleosides as well as being extremely successful in project work by providing newly characterised biochemical probes. Our products the solutions to a very high standard. support scientists working in organic chemistry, glycobiology, microbiology, immunology, cancer and neuroscience research. Our P&D team is composed of highly qualified professionals with extensive experience of working with pharmaceutical Our R&D team ensures that our diverse selection of research and diagnostics customers. products is of the highest quality and on the way to your lab. Services Ordering • Our offering of services include: You can conveniently order products online via our website www.biosynth-carbosynth.com Chemistry • Custom synthesis You can also place an order or make a product • Large-scale manufacturing enquiry via email at [email protected] • API manufacturing • Quality control and quality assurance For more information, please visit our website • CDMO services www.biosynth-carbosynth.com • Custom filling and packaging • Logistics and warehousing • Sourcing Biology 2 I About Biosynth Carbosynth 1 Product Portfolio Carbohydrates Fine Chemicals Nucleosides Enzyme Substrates Chemistry Reducing Agent Phospholipids Antimicrobials Natural Products Detergents Biology Product Portfolio I 3 1 Introduction Welcome to the Biosynth Carbosynth(R) toolbox and catalogue of polysaccharides and related biopolymers. These important products have a huge range of uses that exploit their unique functionalities across the food, pharmaceutical and industrial sectors. However, due to their complexity and diverse attributes, other laboratory suppliers have included them in general biochemical listings. In recognition of this, Biosynth Carbosynth(R) has assembled these products in a dedicated toolbox and catalogue to provide comprehensive support for your research, development and application requirements. Biosynth Carbosynth(R) has recently acquired the speciality polysaccharide business Glycomix and the combined strengths of products, applications, analysis and process development will provide you with a fully integrated range of products and services. This new toolbox and catalogue will guide you through the complexities of these important carbohydrates in some detail including sources, properties, applications and the relationship between their primary, secondary & tertiary structures and functionality. The most important analytical procedures for structural determination will also be discussed. As an additional tool to provide background detail, a review section has been included covering the product range. Each polysaccharide has been examined in some detail outlining the source, covalent structure, important functionalities and key references. Finally, the catalogue section contains the comprehensive range of polysaccharides that Biosynth Carbosynth(R) now offers for research and development. 4 I Introduction 2 Classification Polysaccharides have been recognized and exploited by man for centuries. As far as is known, they occur as energy reserves and structural materials in the tissues of all living things. In animals their structural role is performed in connective tissue, in plants in the cell walls, and in microorganisms as cell-wall materials and extracellular capsules. A large number of polysaccharides obtained from plants, animals and microorganisms including seeds, algae, fruits, plant cell walls, animal tissues, bacteria and fungi have been developed into commercially important products known collectively as industrial gums (Whistler, 1993) and, in Table 1, examples of these are listed and categorized according to source and type. In addition, a large number of carbohydrate polymers have been developed as reaction products of the natural polysaccharides listed in Table 1. Examples of these are the ethers, esters and sulphated derivatives of cellulose, starch, dextran, chitin and curdlan. Other derivatives are the creation of fluorescent derivatives that are used as markers in medical scanning procedures. Other products are the result of random polymerisation of sugar residues through the treatment of starch with acid under conditions of low water activity. Polydextrose is an example of this type of product. Classification I 5 Table 1 Classification of polysaccharides Origin Source Type Example Higher plants Trees Celluloses Cotton Hemicelluloses
Load more

Recommended publications
  • Biological Values of Cultivated Mushrooms – a Review
    Acta Alimentaria, Vol. 48 (2), pp. 229–240 (2019) DOI: 10.1556/066.2019.48.2.11 BIOLOGICAL VALUES OF CULTIVATED MUSHROOMS – A REVIEW J. VETTER* Department of Botany, University of Veterinary Sciences, H-1077 Budapest, Rottenbiller u. 50. Hungary (Received: 3 July 2018; accepted: 11 October 2018) Cultivated mushrooms are not only valuable foods of our age (functional foods) but contain certain benefi cial chemical components (high level of K and P, very low content of Na, considerable quantities of some microelements, high and valuable protein but low fat contents). Some cultivated mushrooms have anti-carcinogenic effects caused fi rst of all by polysaccharides (Lentinan: Lentinula edodes) and by triterpenoids (ganoderic acids: Ganoderma lucidum or unsaturated fatty acids: linoleic, linolenic acids); antidiabetic effects, which can improve the sugar metabolism of patients (Coprinus comatus, Ganoderma lucidum, Agaricus bisporus); anti-microbial effects, caused partly by smaller triterpenoids or by higher molecules, i.e. by direct or indirect effects: via stimulation of the immune system. Certain mushrooms have antioxidant effects, provided mostly by higher radical scavenging activity of phenolic (fl avonoid) components. The chemical composition and its biological effects form together the biological values of the cultivated mushrooms. The following review would like to summarize the most important facts of this topic. Keywords: cultivated mushrooms, chemical components, nutritional values, anti-carcinogenic, antidiabetic, antimicrobial, antioxidant effects Mushrooms have been consumed since earliest historical times; Greeks believed that mushrooms provided strength for warriors, the Romans named them as the “Food of the Gods”. In countries of the Orient, certain mushrooms were believed “elixir of life” etc.
    [Show full text]
  • Immunological Approaches to Biomass Characterization and Utilization
    REVIEW published: 28 October 2015 doi: 10.3389/fbioe.2015.00173 Immunological approaches to biomass characterization and utilization Sivakumar Pattathil1,2* , Utku Avci1,2 , Tiantian Zhang1 , Claudia L. Cardenas1† and Michael G. Hahn1,2 1 Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA, 2 Oak Ridge National Laboratory, BioEnergy Science Center (BESC), Oak Ridge, TN, USA Plant biomass is the major renewable feedstock resource for sustainable generation of alternative transportation fuels to replace fossil carbon-derived fuels. Lignocellulosic cell walls are the principal component of plant biomass. Hence, a detailed understanding of plant cell wall structure and biosynthesis is an important aspect of bioenergy research. Cell walls are dynamic in their composition and structure, varying considerably among Edited by: Jason Lupoi, different organs, cells, and developmental stages of plants. Hence, tools are needed that University of Queensland, USA are highly efficient and broadly applicable at various levels of plant biomass-based bioen- Reviewed by: ergy research. The use of plant cell wall glycan-directed probes has seen increasing use Xu Fang, Shandong University, China over the past decade as an excellent approach for the detailed characterization of cell Arumugam Muthu, walls. Large collections of such probes directed against most major cell wall glycans are Council of Scientific and Industrial currently available worldwide. The largest and most diverse set of such probes consists Research, India of cell wall glycan-directed monoclonal antibodies (McAbs). These McAbs can be used *Correspondence: Sivakumar Pattathil as immunological probes to comprehensively monitor the overall presence, extractability, [email protected] and distribution patterns among cell types of most major cell wall glycan epitopes using †Present address: two mutually complementary immunological approaches, glycome profiling (an in vitro Claudia L.
    [Show full text]
  • Shiitake Mushroom: a Tool of Medicine
    REVIEW ARTICLE Shiitake Mushroom: A Tool of Medicine Taufiqur Rahman1, MBK Choudhury2 1National Mushroom Development Project, Savar, Dhaka 2Directorate General of Health Services, Dhaka ABSTRACT Medicinal mushrooms have an established history of use in traditional oriental therapies. Contemporary research has validated and documented much of the ancient knowledge. Over the last three decades, the interdisciplinary fields of science that study medicinal mushrooms has sprung up and has increasingly demonstrated the potent and unique properties of compounds extracted from a range of species. Currently, the field is being developed into a very fruitful area. Modern clinical practice in Japan, China, Korea and other Asian countries rely on mushroom-derived preparations. Mushrooms have been studied for nutritional and medical purposes for its various potential anti-tumoral and immunomodulatory componests like polysaccharides that have been identified. For medical purposes, mushrooms have been consumed to prevent cancer and cardiac diseases, to improve blood circulation and to reduce blood cholesterol level. Some of these mushrooms have also been used for the treatment of physical and emotional stress, osteoporosis, gastric ulcers and chronic hepatitis, for the improvement of the quality of life of patients with diabetes and especially for the stimulation of immunity. Shiitake has a history of medicinal uses. The mushroom is used as anticarcinogenic, anti- inflammatory, antioxidant, antifungal, antibacterial, antiviral as well as antithrombotic in cardiovascular disorders. This article has been written to throw some light on Shiitake mushroom which has many nutritional values. Many Shiitake preparations came in market containing the active ingredients which can replace many other marketed synthetic medicines and may prove to have promising results with fewer side effects.
    [Show full text]
  • Effect of Intake of Food Hydrocolloids of Bacterial Origin on the Glycemic Response in Humans: Systematic Review and Narrative Synthesis
    nutrients Review Effect of Intake of Food Hydrocolloids of Bacterial Origin on the Glycemic Response in Humans: Systematic Review and Narrative Synthesis Norah A. Alshammari 1,2, Moira A. Taylor 3, Rebecca Stevenson 4 , Ourania Gouseti 5, Jaber Alyami 6 , Syahrizal Muttakin 7,8, Serafim Bakalis 5, Alison Lovegrove 9, Guruprasad P. Aithal 2 and Luca Marciani 2,* 1 Department of Clinical Nutrition, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia; [email protected] 2 Translational Medical Sciences and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham NG7 2UH, UK; [email protected] 3 Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen’s Medical Centre, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham NG7 2UH, UK; [email protected] 4 Precision Imaging Beacon, University of Nottingham, Nottingham NG7 2UH, UK; [email protected] 5 Department of Food Science, University of Copenhagen, DK-1958 Copenhagen, Denmark; [email protected] (O.G.); [email protected] (S.B.) 6 Department of Diagnostic Radiology, Faculty of Applied Medical Science, King Abdulaziz University (KAU), Jeddah 21589, Saudi Arabia; [email protected] 7 Indonesian Agency for Agricultural Research and Development, Jakarta 12540, Indonesia; Citation: Alshammari, N.A.; [email protected] Taylor, M.A.; Stevenson, R.; 8 School of Chemical Engineering, University of Birmingham, Birmingham B15 2TT, UK Gouseti, O.; Alyami, J.; Muttakin, S.; 9 Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK; [email protected] Bakalis, S.; Lovegrove, A.; Aithal, G.P.; * Correspondence: [email protected]; Tel.: +44-115-823-1248 Marciani, L.
    [Show full text]
  • Some Nutritional Properties of Starch and Dietary Fiber in Barley Genotypes Containing Different Levels of Amylose
    Some Nutritional Properties of Starch and Dietary Fiber in Barley Genotypes Containing Different Levels of Amylose 2 I. BJORCK,' A.-C. ELIASSON, A. DREWS,' M. GUDMUNDSSON, 2 and R. KARLSSON3 ABSTRACT Cereal Chem. 67(4):327-333 The nutritional properties of starch and dietary fiber (DF) were studied differences in rate of starch hydrolysis were seen between boiled barley in barley genotypes containing different amylose contents: Waxy Campana flours. In contrast, autoclaving produced a slower course of amylolysis (-8% amylose); Alva, Lina, and Glacier normal (normal varieties, 25-27% in Glacier high, despite complete gelatinization. This material also amylose); and Glacier high (-35% amylose). On an equivalent starch contained a somewhat higher level of retrograded enzyme-resistant starch, basis, all barley varieties showed a somewhat higher availability to a- 3% (starch basis). The content of soluble DF was lower in Alva and amylase than a wheat reference. Among the barley flours, starch in the Lina (4.8%) compared with 6.5% in the other genotypes (dwb). The waxy variety was most available to a-amylase when tested raw. With viscosity of suspensions of isolated DF (1.6%, w/v) correlated to the excess water (90% H2 0), the gelatinization was completed at about 80 C, proportion of soluble DF and was in decreasing order: Waxy > Glacier as measured with differential scanning calorimetry, irrespective of high > Alva. When added to a starch suspension, isolated barley DF amylose content. At lower moisture (50% H2 0), the temperature interval preparations were equally effective in reducing the rate of gastric emptying for gelatinization was considerably broadened.
    [Show full text]
  • Lorne Bair :: Catalog 21
    LORNE BAIR :: CATALOG 21 1 Lorne Bair Rare Books, ABAA PART 1: AFRICAN-AMERICAN HISTORY & LITERATURE 2621 Daniel Terrace Winchester, Virginia USA 22601 (540) 665-0855 Email: [email protected] Website: www.lornebair.com TERMS All items are offered subject to prior sale. Unless prior arrangements have been made, payment is expected with order and may be made by check, money order, credit card (Visa, MasterCard, Discover, American Express), or direct transfer of funds (wire transfer or Paypal). Institutions may be billed. Returns will be accepted for any reason within ten days of receipt. ALL ITEMS are guaranteed to be as described. Any restorations, sophistications, or alterations have been noted. Autograph and manuscript material is guaranteed without conditions or restrictions, and may be returned at any time if shown not to be authentic. DOMESTIC SHIPPING is by USPS Priority Mail at the rate of $9.50 for the first item and $3 for each additional item. Overseas shipping will vary depending upon destination and weight; quotations can be supplied. Alternative carriers may be arranged. WE ARE MEMBERS of the ABAA (Antiquarian Bookseller’s Association of America) and ILAB (International League of Antiquarian Book- sellers) and adhere to those organizations’ standards of professionalism and ethics. PART ONE African American History & Literature ITEMS 1-54 PART TWO Radical, Social, & Proletarian Literature ITEMS 55-92 PART THREE Graphics, Posters & Original Art ITEMS 93-150 PART FOUR Social Movements & Radical History ITEMS 151-194 2 PART 1: AFRICAN-AMERICAN HISTORY & LITERATURE 1. CUNARD, Nancy (ed.) Negro Anthology Made by Nancy Cunard 1931-1933. London: Nancy Cunard at Wishart & Co., 1934.
    [Show full text]
  • Prebiotics: a Novel Approach to Treat Hepatocellular Carcinoma
    Hindawi Canadian Journal of Gastroenterology and Hepatology Volume 2017, Article ID 6238106, 11 pages https://doi.org/10.1155/2017/6238106 Review Article Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma Naz Fatima,1 Tasleem Akhtar,1 and Nadeem Sheikh1,2 1 Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Q-A Campus, Lahore 54590, Pakistan 2Cell and Applied Molecular Biology (CAMB), University of the Punjab, Q-A Campus, Lahore 54590, Pakistan Correspondence should be addressed to Nadeem Sheikh; [email protected] Received 13 February 2017; Accepted 19 April 2017; Published 10 May 2017 Academic Editor: JoseL.Mauriz´ Copyright © 2017 Naz Fatima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hepatocellular carcinoma is one of the fatal malignancies and is considered as the third leading cause of death. Mutations, genetic modifications, dietary aflatoxins, or impairments in the regulation of oncogenic pathways may bring about liver cancer.An effective barrier against hepatotoxins is offered by gut-liver axis as a change in gut permeability and expanded translocation of lipopolysaccharides triggers the activation of Toll-like receptors which stimulate the process of hepatocarcinogenesis. Prebiotics, nondigestible oligosaccharides, have a pivotal role to play when it comes to inducing an antitumor effect. A healthy gut flora balance is imperative to downregulation of inflammatory cytokines and reducing lipopolysaccharides induced endotoxemia, thus inducing the antitumor effect. 1. Introduction pathway are deregulated as well, but on a marginal scale.
    [Show full text]
  • A Study of the Glass Transition of Amylopectin-Sugar Mixtures
    A study of the glass transition of amylopectin-sugar mixtures M. T. Kalichevsky, E. M. Jaroszkiewicz and J. M. V. Blanshard* Departmentof Applied Biochemistry and Food Science, Nottingham University, School of Agriculture, Sutton Bonington, Loughborough LEI25RD, UK (Received 31 October 1991; revised 30 March 1992) Amylopectin-sugar mixtures in the ratio of 10:1 have been studied using fructose, glucose, sucrose and xylose. Samples of amylopectin containing glucose in the ratio of 5:1 and fructose in the ratio of 2:1 (amylopectin-sugar) were also prepared. The glass transition as a function of water content was studied using d.m.t.a., d.s.c., pulsed n.m.r, and a three-point bend test. Small amounts of sugar were found to reduce the glass transition temperature of starch in accordance with or in excess of the predictions of a Couchman-Karasz equation. For the sample containing the greatest amount of sugar, less plasticization than predicted was observed; this appeared to be due to a substantial degree of phase separation. (Keywords: glass transition; free volume; amylopeetin) INTRODUCTION relative to water. It is misleading to compare a 1:1 starch-water mixture, with a 1:1:1 starch-sugar-water A study of the glass transition region of amylopectin from waxy maize starch as a function of water content has mixture, as the resulting water content is decreased from already been carried out, using n.m.r.d.s.c., d.m.t.a. 50% of the total weight to 33.3% of the total weight. It will be shown here that in samples containing the same and an Instron texturometer 1.
    [Show full text]
  • SYNTHESIS and FUNCTIONALITY STUDY of NOVEL BIOMIMETIC N-GLYCAN POLYMERS KA KEUNG CHAN Bachelor of Science Appalachian State Univ
    SYNTHESIS AND FUNCTIONALITY STUDY OF NOVEL BIOMIMETIC N-GLYCAN POLYMERS KA KEUNG CHAN Bachelor of Science Appalachian State University May 2014 submitted in partial fulfillment of requirements for the degree of DOCTOR OF PHILOSOPHY IN CLINICAL AND BIOANALYTICAL CHEMISTRY at the CLEVELAND STATE UNIVERSITY May 2021 We hereby approve this dissertation for KA KEUNG CHAN Candidate for the Doctor of Philosophy in Clinical and Bioanalytical Chemistry degree for the Department of Chemistry and Cleveland State University’s College of Graduate Studies by ______________________________________________________ Xue-Long Sun, Ph.D., Dissertation Committee Chairperson Chemistry, 4/22/2021 Department & Date ____________________________________________________________ Aimin Zhou, Ph.D., Dissertation Committee Member Chemistry, 4/22/2021 Department & Date ____________________________________________________________ Bin Su, Ph.D., Dissertation Committee Member Chemistry, 4/22/2021 Department & Date ____________________________________________________________ David Anderson, Ph.D., Dissertation Committee Member Chemistry, 4/22/2021 Department & Date ____________________________________________________________ Moo-Yeal Lee, Ph.D., Dissertation Committee Member Chemical & Biomedical Engineering, 4/22/2021 Department & Date ____________________________________________________________ Aaron Severson, Ph.D., Dissertation Committee Member Biological, Geological and Environmental Sciences, 4/22/2021 Department & Date Date of Defense: 22 APRIL 2021 DEDICATION I dedicate the entirety of this degree to my family. My mother, Mrs. Yu Hung Cheung, to whom I owe the world and I unreservedly dedicate the entire of my life and achievements – thank you for everything that you have done for me. My fiancée, Ms. Mengni Xu, to whom I dedicate the rest of my life with my undying love – you deserve all of my achievements as much as I do. ACKNOWLEDGEMENT I extend my most sincere gratitude to Dr.
    [Show full text]
  • Medieval Glues Upto 1600 CE Class Notes - SCA Estrella 23 Collegium, Feb 18, 2007 C
    Medieval Glues Upto 1600 CE Class Notes - SCA Estrella 23 Collegium, Feb 18, 2007 C. M. Helm-Clark, Ph.D. Overview of Medieval Glues There are many glues which were used in period. Several glues and glue ingredients are as follows: Cheese glue wood natural must be made up and polymer made used immediately, sets up of globular permanently, subject to polypeptide attack by casein protein microorganisms in molecules damp conditions, stronger in thin coats, impervious when cured Hide Glue general all-around glue, natural rehydration undoes the sizing, vellum, paper, polymer made adhesive, stores forever wood, gilding mordant up of strands in the dried state, can ingredient of polypeptide make stronger bonds colloid protein than cheese glue but is molecules not impervious or permanent, brittle Wheatpaste vellum, paper, Natural Weak glue, edible, bookbinding polymer made subject to attack by up of gluten microorganisms or proteins water Gum Arabic Vellum, paper, pigment A true weak glue, edible binder, food binder, vegetable gum medicine binder Gum Vellum, paper, universal An oleoresin Weak glue, can be Ammoniac gilding mordant rehydrated to a tacky state, dries hard, is flexible Turpentine Vellum, paper, pigment An oleoresin Moderate glue, dries (real period binder, gilding mordant, hard, flexible when turpentine, not wood, wood filler young, may yellow or the modern cloud with age spirit turpentine) Plasters Stone, brick, tile, Calcined Moderate to strong ceramics, masonry filler, gypsum adhesive qualities, sets mordant ingredient compounds permanently Sugar, honey mordant ingredient, food hygroscopic Weak glue, can be and medicine binder sugars rehydrated to a tacky state, subject to mold Medieval Glues class notes, copyright 2007 by Catherine Helm-Clark.
    [Show full text]
  • Designing Tools for Studying the Dynamic Glycome John F
    Marshall University Marshall Digital Scholar Chemistry Faculty Research Chemistry Winter 12-2012 Designing Tools for Studying the Dynamic Glycome John F. Rakus Marshall University, [email protected] Follow this and additional works at: http://mds.marshall.edu/chemistry_faculty Part of the Organic Chemistry Commons Recommended Citation Rakus, J. F. (2012, December). Designing tools for studying the dynamic glycome. Invited Lecture at Sonoma State University, Rohnert Park, CA. This Presentation is brought to you for free and open access by the Chemistry at Marshall Digital Scholar. It has been accepted for inclusion in Chemistry Faculty Research by an authorized administrator of Marshall Digital Scholar. For more information, please contact [email protected]. NYU Cover Cells are primarily compose of three types of biomolecules Protein (50% dry weight) HeLa cell Nucleic acid (25% dry weight) Carbohydrate (10% dry weight) Carbohydrates are pervasive and involved in many cellular interactions Holgersson et al, Immuno Cell Biol, 2005 Laughlin et al, Science, 2008 Nucleic acids and proteins are synthesized with a defined template and dedicated polymerases Macromolecule: Nucleic acid Macromolecule: polypeptide Polymerase: DNA Pol or RNA Pol Polymerase: Ribosome Template: DNA strand Template: mRNA strand Glycan biosynthesis lacks a dedicated polymerase and genetic template Formation of Glc3Man9GlcNAc2-DolPP, an intermediate in the N-linked glycosylation pathway, requires 12 separate enzymes Essentially, each linkage in an oligosaccharide is
    [Show full text]
  • Combinatorial Glycomic Analyses to Direct Cazyme Discovery for the Tailored Degradation of Canola Meal Non-Starch Dietary Polysaccharides
    microorganisms Article Combinatorial Glycomic Analyses to Direct CAZyme Discovery for the Tailored Degradation of Canola Meal Non-Starch Dietary Polysaccharides Kristin E. Low 1 , Xiaohui Xing 1,2, Paul E. Moote 1,3, G. Douglas Inglis 1,3,4 , Sivasankari Venketachalam 5,6, Michael G. Hahn 5,6,7 , Marissa L. King 1, Catherine Y. Tétard-Jones 8, Darryl R. Jones 1, William G. T. Willats 8, Bogdan A. Slominski 9 and D. Wade Abbott 1,2,4,* 1 Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, AB T1J 4B1, Canada; [email protected] (K.E.L.); [email protected] (X.X.); [email protected] (P.E.M.); [email protected] (G.D.I.); [email protected] (M.L.K.); [email protected] (D.R.J.) 2 Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada 3 Department of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada 4 Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada 5 Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA; [email protected] (S.V.); [email protected] (M.G.H.) 6 Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA 7 Department of Plant Biology, University of Georgia, Athens, GA 30602, USA 8 School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK; [email protected] (C.Y.T.-J.); [email protected] (W.G.T.W.) 9 Department of Animal Science, University of Manitoba, Winnipeg, MB R3T 2N2, Canada; [email protected] * Correspondence: [email protected] Received: 30 September 2020; Accepted: 20 November 2020; Published: 29 November 2020 Abstract: Canola meal (CM), the protein-rich by-product of canola oil extraction, has shown promise as an alternative feedstuff and protein supplement in poultry diets, yet its use has been limited due to the abundance of plant cell wall fibre, specifically non-starch polysaccharides (NSP) and lignin.
    [Show full text]