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Helsana Arzneimittelreport 2019 Ausgabe 2019 Helsana- Arzneimittel- Report Ausgabe 2019 Helsana-Arzneimittelreport The rise of antimicro- bial resistance is a global crisis, that must be managed with the utmost urgency Dr. Margaret Chan, Former Director-General of the World Health Organization (2006 – 2017) Der Helsana-Arzneimittelreport wird im Auftrag von Helsana vom Universitätsspital Basel (USB) und dem Institut für Pharmazeutische Medizin (ECPM) der Universität Basel erstellt. Unser Dank gilt den Mitarbeiterinnen und Mitarbeitern des USB und des ECPM für alle vorgenommenen Auswertungen und für die Erstellung des Reports. Helsana-Arzneimittelreport 2019 3 November 2019 Helsana-Arzneimittelreport für die Schweiz 2019 Auswertungsergebnisse der Helsana Arzneimitteldaten aus den Jahren 2015 bis 2018 Rahel Schneider 1,2 Nadine Schur 3 Daphne Reinau 1,2 Matthias Schwenkglenks 3 Christoph R. Meier 1,2,4 1 Basel Pharmacoepidemiology Unit Abteilung Klinische Pharmazie und Epidemiologie Departement Pharmazeutische Wissenschaften Universität Basel & 2 Spital-Pharmazie Universitätsspital Basel & 3 Institut für Pharmazeutische Medizin (ECPM) Universität Basel & 4 Boston Collaborative Drug Surveillance Program (BCSDP) Lexington, MA, USA Helsana-Arzneimittelreport 2019 4 Helsana-Arzneimittelreport 2019 5 Inhaltsverzeichnis Vorwort .................................................................................................................................................................................... 7 Préface .................................................................................................................................................................................... 8 Preface .................................................................................................................................................................................... 9 Zusammenfassung ............................................................................................................................................................... 10 Résumé ................................................................................................................................................................................. 14 Summary ............................................................................................................................................................................... 18 1 Einleitung ................................................................................................................................................................... 22 2 Methoden ................................................................................................................................................................... 24 2.1 Datenquelle: Die Helsana-Gruppe ........................................................................................................................... 24 2.2 Population und Studiensetting ................................................................................................................................ 26 2.3 Analysen .................................................................................................................................................................... 27 2.3.1 Anatomisch-therapeutisch-chemisches Klassifikationssystem (ATC-Klassifikation) ................................................... 28 3 Ergebnisse allgemeiner Teil ..................................................................................................................................... 30 3.1 Gesamtmarkt der Medikamente in der Schweiz ..................................................................................................... 30 3.2 Bezüge und Kosten nach anatomischen Hauptgruppen (Ebene 1 der ATC-Klassifikation)............................... 35 3.3 Bezüge und Kosten der wichtigsten therapeutischen Medikamentengruppen (Ebene 2 der ATC-Klassifikation) ................................................................................................................................................... 40 3.4 Bezüge und Kosten der wichtigsten Wirkstoffe (Ebene 5 der ATC-Klassifikation) ............................................. 47 3.5 Präparate und Generika ............................................................................................................................................ 53 3.6 Potentielle Innovationen und Biosimilars ............................................................................................................... 57 3.6.1 Potentielle Innovationen 2018 ..................................................................................................................................... 57 3.6.2 Biosimilars ................................................................................................................................................................... 61 4 Ergebnisse spezifischer Teil .................................................................................................................................... 66 4.1 Arzneimittelinteraktionen ......................................................................................................................................... 66 4.1.1 Einleitung .................................................................................................................................................................... 67 4.1.2 Methoden .................................................................................................................................................................... 68 Helsana-Arzneimittelreport 2019 6 4.1.3 Resultate und Diskussion ............................................................................................................................................ 71 4.1.4 Fazit ............................................................................................................................................................................ 75 4.2 Therapie der Osteoporose in der Schweiz zwischen 2012 und 2018 ................................................................... 76 4.2.1 Einleitung .................................................................................................................................................................... 77 4.2.2 Methoden .................................................................................................................................................................... 79 4.2.3 Resultate und Diskussion ............................................................................................................................................ 80 4.2.4 Fazit ............................................................................................................................................................................ 94 4.3 Antibiotika ................................................................................................................................................................. 95 4.3.1 Einleitung .................................................................................................................................................................... 96 4.3.2 Methoden .................................................................................................................................................................... 97 4.3.3 Resultate ..................................................................................................................................................................... 99 4.3.4 Diskussion und Fazit ................................................................................................................................................. 111 5 Schlusswort und Ausblick ..................................................................................................................................... 114 6 Literaturverzeichnis ................................................................................................................................................ 116 7 Autoren .................................................................................................................................................................... 121 8 Anhang ..................................................................................................................................................................... 125 8.1 Detaillierte Resultate: Bezüge und Kosten der wichtigsten therapeutischen Medikamentengruppen (Ebene 2 der ATC-Klassifikation)................................................................................... 125 8.2 Detaillierte Resultate: Bezüge und Kosten der wichtigsten Wirkstoffe (Ebene 5 der ATC- Klassifikation).......................................................................................................................................................... 127 8.3 Abbildungsverzeichnis ........................................................................................................................................... 130 8.4 Tabellenverzeichnis ................................................................................................................................................ 132 Helsana-Arzneimittelreport 2019 7 Vorwort «Wie viel darf ein Medikament kosten?» Diese Frage bewegt mehr denn je. Innovative Therapien erobern den Gesundheitsmarkt – das hat seinen Preis. Die Medikamentenkosten zu Lasten der Grundversicherung
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