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Postlumbar Puncture Arachnoiditis Mimicking Epidural Abscess Mehmet Sabri Gürbüz,1 Barıs Erdoğan,2 Mehmet Onur Yüksel,2 Hakan Somay2

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Postlumbar Puncture Arachnoiditis Mimicking Epidural Abscess Mehmet Sabri Gürbüz,1 Barıs Erdoğan,2 Mehmet Onur Yüksel,2 Hakan Somay2 Learning from errors CASE REPORT Postlumbar puncture arachnoiditis mimicking epidural abscess Mehmet Sabri Gürbüz,1 Barıs Erdoğan,2 Mehmet Onur Yüksel,2 Hakan Somay2 1Department of Neurosurgery, SUMMARY and had increased gradually before the patient was ğ ı ğ ı A r Public Hospital, A r , Lumbar spinal arachnoiditis occurring after diagnostic referred to us. On our examination, the body tem- Turkey 2Department of Neurosurgery, lumbar puncture is a very rare condition. Arachnoiditis perature was 38.5°C. There was no neurological Haydarpasa Numune Training may also present with fever and elevated infection deficit but a slight tenderness in the low back. The and Research Hospital, markers and may mimic epidural abscess, which is one examination of the other systems was unremarkable. Istanbul, Turkey of the well known infectious complications of lumbar puncture. We report the case of a 56-year-old man with Correspondence to INVESTIGATIONS Dr Mehmet Sabri Gürbüz, lumbar spinal arachnoiditis occurring after diagnostic Laboratory examination revealed elevated erythro- [email protected] lumbar puncture who was operated on under a cyte sedimentation rate (80 mm/h) and C reactive misdiagnosis of epidural abscess. In the intraoperative protein level (23 mg/L) with 9.5×109/L white blood and postoperative microbiological and histopathological cells. Preoperative blood culture for Mycobacterium examination, no epidural abscess was detected. To our and other microorganisms and sputum culture for knowledge, this is the first case of a patient with Mycobacterium were all negative. Non-contrast- postlumbar puncture arachnoiditis operated on under a enhanced T1-weighted sagittal MRI of the patient misdiagnosis of epidural abscess reported in the demonstrated a nearly biconcave lesion resembling literature. The authors suggest that arachnoiditis may an abscess (figure 2A). The entrance site of the mimic epidural abscess due to its clinical and lumbar puncture was seen between the spinous pro- radiological features and should be considered in the cesses of L3 and L4 (figure 2B). In contrast- differential diagnosis of complications of lumbar enhanced T1-weighted MRI, a biconcave-shaped puncture. and peripherally enhanced lesion was seen with some irregular contrast enhancement (figure 2B,C). The roots were displaced peripherally and adherent BACKGROUND to the meninges forming a cerebrospinal fluid Spinal arachnoiditis is an insidious disease caused (CSF) filled cavity in the centre (figure 2D). by an inflammatory process of the arachnoid mem- brane resulting from many possible causes, such as DIFFERENTIAL DIAGNOSIS infection, intrathecal injection of steroids or anaes- Our differential diagnosis was arachnoiditis and thetic agents, trauma, subarachnoid haemorrhage, epidural abscess. Irregular contrast-enhanced ionic myelographic contrast materials, multiple regions directed us towards arachnoiditis, but the 12 back surgeries and lumbar puncture. Diagnosis is contrast-enhanced biconcave region of the lesion, 34 based on clinical symptoms and MRI findings. together with fever and elevated infection markers Arachnoiditis can also mimic the symptoms of suggested epidural abscess. However, the radiology other diseases, such as spinal cord tumours, cauda department insisted on an epidural abscess and the equina syndrome, arachnoiditis ossificans and syr- patient underwent operation. ingomyelia.5 Arachnoiditis mimicking lumbar spinal epidural abscess is another possibility since epidural TREATMENT abscess is one of the potential complications of 56 Sulbactam ampicilin was started empirically 3 days lumbar puncture. Owing to the fact that arachnoi- before surgery and continued 5 days postopera- ditis may present with the signs of an infection such tively until the preoperative tissue cultures were as epidural abscess, differentiating between arachnoi- confirmed negative by the microbiology depart- ditis and infectious complications such as epidural 78 ment. During the operation, there was no purulant abscess is mandatory. material or anything suggesting an abscess other than some irregular granulation tissue over the CASE PRESENTATION dura. We did not open the dura to avoid any further A 56-year-old male patient was admitted to our complication. Those granulation tissues were sent clinic with a 2-week history of low back pain. It for microbiological examination for Mycobacterium was learnt from the history that the patient had as well as other microorganisms and they were all been admitted to a neurology clinic for bilateral negative. In the histopathological examination, no To cite: Gürbüz MS, numbness of the lower extremities. Spinal MRI had sign of infection was seen. Examinations of CSF ğ Erdo an B, Yüksel MO, been performed to exclude any spinal lesion. On taken by lumbar puncture for the likelihood of et al. BMJ Case Rep fi – Published online: [please normal spinal MRI ( gure 1A,B), a lumbar puncture Guillain Barré syndrome were negative. include Day Month Year] had been performed for the purpose of further evalu- Postoperative recovery was uneventful and the doi:10.1136/bcr-2013- ation to rule out Guillain–Barré syndrome. The low patient was discharged from the hospital with no 200169 back pain had started 10 days after lumbar puncture neurological deficit. Gürbüz MS, et al. BMJ Case Rep 2013. doi:10.1136/bcr-2013-200169 1 Learning from errors Figure 2 (A) Non-contrast-enhanced T1-weighted sagittal MRI of the lumbar spine taken 15 days after lumbar puncture demonstrates a nearly biconcave lesion resembling an abscess. (B) Contrast-enhanced T1-weighted sagittal MRI of the lumbar spine taken 15 days after lumbar puncture demonstrates the entrance site of the needle (black arrow) and a biconcave-shaped contrast-enhanced lesion (white arrow) leading to the misdiagnosis of epidural abscess. (C) T1-weighted Figure 1 (A) Non-enhanced T2-weighted sagittal MRI of the lumbar sagittal MRI of the lumbar spine demonstrates an irregular spine taken before lumbar puncture demonstrates no prompt pathology contrast-enhanced lesion suggesting arachnoiditis. (D) and the nerve roots and subarachnoid space are seen in their normal Contrast-enhanced T1-weighted axial MRI of the lumbar spine locations. (B) Non-enhanced T2-weighted axial MRI of the lumbar spine demonstrates the roots which are displaced peripherally adherent to the taken before lumbar puncture demonstrates no prompt pathology and the meninges forming a cerebrospinal fluid filled cavity in the centre. nerve roots and subarachnoid space are seen in their normal locations. OUTCOME AND FOLLOW-UP process involves all three meningeal layers as well as the nerve The clinical condition showed progressive improvement with no roots.1 recurrence or related discomfort over 1 year of follow-up. Various aetiological factors have been implicated in the develop- ment of spinal arachnoiditis. Although spinal surgery is the most common antecedent associated with arachnoiditis, multiple causes DISCUSSION have been reported, including infection, intrathecal administration Symptomatic spinal arachnoiditis is an inflammatory process of of steroids, anaesthetic agents and ionic myelographic contrast the arachnoid membrane in which there is a scar formation material, trauma and subarachnoid haemorrhage.11011One within and between the leptomeninges.29This inflammatory example of iatrogenic trauma causing arachnoiditis is lumbar 2 Gürbüz MS, et al. BMJ Case Rep 2013. doi:10.1136/bcr-2013-200169 Learning from errors puncture. Although lumbar puncture, one of the spinal interven- epidural abscess was detected and the diagnosis was lumbar tions, is generally considered safe, it may lead to complications spinal arachnoiditis. such as arachnoiditis, various infectious diseases, radiculopathy In conclusion, arachnoiditis may result from lumbar puncture and myelopathy.29In contrast to the fact that arachnoiditis gener- and may mimic epidural abscess with respect to its clinical mani- ally occurs as a result of the introduction of drugs or contrast festations and radiological appearance and it should be consid- materials into the subarachnoid space, arachnoiditis which occurs ered in the differential diagnosis of complications of lumbar after diagnostic lumbar puncture without injection of any drug or puncture to avoid an incorrect diagnosis and unnecessary surgi- substance into the subarachnoid space, as seen in our case, is very cal intervention. rare. In our case, the trace of the needle was clearly seen at the site of the arachnoiditis, strongly suggesting that arachnoiditis had been caused by lumbar puncture. Learning points The pathogenesis of spinal arachnoiditis is similar to the repair process of serous membranes, such as the peritoneum, ▸ with a negligible inflammatory cellular exudate and a prominent Spinal arachnoiditis may result from infection, intrathecal fibrinous exudate.11 The inflammation of the arachnoid mater injection of steroids or anaesthetic agents, trauma, may produce a fibrinous exudate around the roots that causes subarachnoid haemorrhage, ionic myelographic contrast them to adhere to the dural sheath.2 As a result of inflammatory materials, multiple back surgeries and lumbar puncture. ▸ tissue, the nerves are displaced and the cord appears separated by Arachnoiditis can also mimic the symptoms of other arachnoid septates. CSF filled cavities form within the cord and diseases, such as spinal cord tumours, cauda equina fi they may enlarge gradually giving rise to extensive syrinx forma- syndrome, arachnoiditis ossi cans
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