Statement of Academic Contributions, Goals and Plans

Publications by Year Faculty Name, Ph.D. Assistant Professor of Department University of Southern California Keck School of Medicine

Year Publications First author Second author Senior author Other 1998 1 1 2000 3 2 1 2001 3 2 1 2002 2 1 1 2003 1 1 2004 1 1 2006 1 1 2007 3 2 1 2008 3 2 1 2009 4 1 3*

Total 22 7 3 7 5

* Two of these are in press Publications: Impact Factors and Citation Counts Faculty Name, Ph.D. Assistant Professor of Department University of Southern California Keck School of Medicine

Publication Journal Impact Citation Factor Counts 1. Rice et al., 1998 Oncogene 6.44 113 2. Domann et al., 2000 Int J Cancer 4.56 109 3. Rice et al., 2000 Nucleic Acids Res 6.95 43 4. Rice et al., 2000 Carcinogenesis 5.41 59 5. Nakayama et al. 2001 Science 26.37 634 Rice et al., 2001 Curr Opin Cell Biol (review) 13.44 238 Rice et al., 2001 Nature (review) 28.75 62 6. Nishioka et al., 2002 Mol Cell 13.16 150 7. Rice et al., 2002 Genes & Dev 14.80 83 8. Rice et al., 2003 Mol Cell 13.16 240 Grewal et al., 2004 Curr Opin Cell Biol (review) 13.44 90 9. Sims et al., 2006 J Biol Chem 5.58 32 10. Wu et al., 2007 FEBS Letts 3.26 7 11. Jensky et al., 2007 Euro J Applied Physiol 1.75 2 Spektor et al., 2007 Nature Cell Biol (review) 17.62 0 12. Sims et al., 2008 Mol Cell Biol 6.42 1 13. Houston et al., 2008 J Biol Chem 5.58 10 14. Kalakonda et al., 2008 Oncogene 6.44 8 15. Dieli et al., 2009 J Appl Physiol 3.66 0 16. Spektor et al., 2009 Proc Nat Acad Sci USA 9.38 0 Dieli et al., 2009 Acta Physiologica 2.46 In press Dieli et al., 2009 J Appl Physiol 3.66 In press

Average: 9.65 86/pub Research Grants Awarded Faculty Name, Ph.D. Assistant Professor of Department University of Southern California Keck School of Medicine

1. Cancer Research Scholar Award 07/01/04 – 06/30/06 Total Direct Costs: $200,000 Total F&A: $16,000** Genome-wide analysis of histone methylation as an indicator of cancer progression The goal of this project was to utilize high throughput ChIP-chip technology to identify specific changes in histone H3 Lys9 modifications during the progression of breast cancer to a malignant state. Principal Investigator, 5% effort (**Also provided a GM vehicle to USC for $31,000 MSRP) 2. The Foundation Award 08/01/04 – 07/31/05 Total Direct Costs: $50,000 Total F&A: $0 Genome-wide analysis of heterochromatic alterations during sporadic breast cancer progression The goal of this project was to identify specific heterochromatic changes, by investigating various histone modifications, that were altered during sporadic breast cancer progression. Principal Investigator, 0% effort 3. Department of Defense (IDEA PC040160) 10/01/04 – 09/30/07 Total Direct Costs: $610,313 Total F&A: $381,446 Androgen receptor-mediated escape from androgen ablation therapy The major goal of this project is to determine the mechanisms by which hormone refractory prostate cancer is still affected by signaling via the androgen receptor. Co-Investigator (PI: Gerhard Coetzee, Ph.D.), 5% effort 4. American Cancer Society (IRG-58-007-45) 01/01/05 – 12/31/05 Total Direct Costs: $20,000 Total F&A: $0 Histone H4 methylation in cancer The main goal of this pilot project was to determine the endogenous target genes affected by the histone H4 methylation silencing pathway. Principal Investigator, 0% effort 5. The Foundation 07/01/05 – 06/30/06 Total Direct Costs: $100,000 Total F&A: $0 Using innovative technologies to improve the detection and treatment of sporadic breast cancer The goal of this project was to identify putative histone markers that are indicative of sporadic breast cancer. Principal Investigator, 0% effort 6. California Breast Cancer Research Program (IDEA 11IB-0085) 08/01/05 – 07/31/06 Total Direct Costs: $100,000 Total F&A: $62,500 Histone methylation as a marker of breast cancer progression The goal of this project was to identify genomic changes in H4 Lys20 methylation during breast cancer progression to be used as diagnostic markers. Principal Investigator, 5% effort 7. Pew Scholar Award 07/01/06 – 06/30/10 Total Direct Costs: $220,800 Total F&A: $19,200 Signaling to the epigenome: reading the histone code The goals of this project are to define the genomic regions of H4K20 methylation by ChIP-chip and identify novel histone modification-specific binding proteins in vivo using mammalian tethered catalysis (MTeC). Principal Investigator, 8.25% effort 8. Faculty Research Award 07/01/06 – 06/30/07 Total Direct Costs: $25,000 Total F&A: $0 Identification of histone H3 lysine 9 methyl-binding proteins The goal of this proposal is to further develop our novel mammalian tethered catalysis (MTeC) method to identify histone H3 lysine 9 methyl-specific binding proteins in vivo. Principal Investigator, 0% effort 9. NIH: National Cancer Institute (1 R01 GM075094) 08/01/07 – 07/31/12 Total Direct Costs: $950,000 Total F&A: $598,500 Molecular mechanisms of gene silencing by H4 methylation The major goals of this proposal are to elucidate the key components and genes controlled by the histone H4 lysine 20 methylation gene silencing pathway. Principal Investigator, 42% effort

Grants Pending 1. NIH: National Cancer Institute (1 R01 ES018860) 04/01/10 – 03/31/13 Total Direct Costs: $1,000,000 Total F&A: $630,000 Role of PR-Set7 and histone H4K20me1 in DNA repair and genomic stability The goals of this project are to determine the molecular roles of PR-Set7 and its monomethylation of histone H4 lysine 20 (H4K20me1) in suppressing DNA damage and genomic instability. Principal Investigator, 33% effort 2. Medical Research Trust 01/01/10 – 12/31/11 Total Direct Costs: $125,000 Total F&A: $25,000 Elucidating the role of PR-Set7 in protection against DNA damage, genomic instability and oncogenesis The goals of this project are to determine the molecular roles of PR-Set7 in protecting the human genome against DNA damage and genomic instability. Principal Investigator, 0% effort

Grants Awarded to Personnel 1. USC/Norris Breast Cancer Research Training Program Fellowship Awarded to 10/01/05 – 9/30/06 2. NIH GMCB Training Program Fellowship Awarded to 07/01/06 – 06/30/08 3. Predoctoral Scholarship Award Awarded to 07/01/08 – 6/30/09 4. NIH National Research Service Award Awarded to 09/01/08 – 08/31/11 5. California Institute for Regenerative Medicine (CIRM) Scholar Fellowship Awarded to 07/01/08 – 06/30/10